Pediatric Reference Limits for Holter Monitor Heart Rate Variability Parameters: Defined Using Meta-Analysis

Crawford MH, Bernstein SJ, Deedwania PC, DiMarco JP, Ferrick KJ, Garson A Jr, Green LA, Greene HL, Silka MJ, Stone PH et al (1999) ACC/AHA Guidelines for Ambulatory Electrocardiography. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the Guidelines for Ambulatory Electrocardiography). Developed in collaboration with the North American Society for Pacing and Electrophysiology. J Am Coll Cardiol 34(3):912–948

Article  CAS  PubMed  Google Scholar 

Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology (1996) Heart rate variability: standards of measurement, physiological interpretation, and clinical use. Circulation 93(5):1043–1065

Article  Google Scholar 

Goldberger JJ, Cain ME, Hohnloser SH, Kadish AH, Knight BP, Lauer MS, Maron BJ, Page RL, Passman RS, Siscovick D et al (2008) American Heart Association; American College of Cardiology Foundation; Heart Rhythm Society. American Heart Association/American College of Cardiology Foundation/Heart Rhythm Society scientific statement on noninvasive risk stratification techniques for identifying patients at risk for sudden cardiac death: a scientific statement from the American Heart Association Council on Clinical Cardiology Committee on Electrocardiography and Arrhythmias and Council on Epidemiology and Prevention. Circulation 118(14):1497–1518

Article  PubMed  Google Scholar 

Steinberg JS, Varma N, Cygankiewicz I, Aziz P, Balsam P, Baranchuk A, Cantillon DJ, Dilaveris P, Dubner SJ, El-Sherif N et al (2017) ISHNE-HRS expert consensus statement on ambulatory ECG and external cardiac monitoring/telemetry. Ann Noninvasive Electrocardiol 22(3):e12447

Article  PubMed  PubMed Central  Google Scholar 

Karakurt C, Aytemir K, Karademir S, Sungur M, Oğuz D, Ocal B, Senocak F (2007) Prognostic value of heart rate turbulence and heart rate variability in children with dilated cardiomyopathy. Acta Cardiol 62(1):31–37

Article  PubMed  Google Scholar 

Dalili M, Dastafshan M, Mahdavi M, Shahzadi H, Mortaz Hejri G, Rashidighader F, Brugada P (2025) The influence of arrhythmia on the outcomes of pediatric patients with idiopathic dilated cardiomyopathy. Pediatr Cardiol 46(7):1842–1847

Article  PubMed  Google Scholar 

Lammers AE, Munnery E, Hislop AA, Haworth SG (2010) Heart rate variability predicts outcome in children with pulmonary arterial hypertension. Int J Cardiol 142(2):159–165

Article  PubMed  Google Scholar 

Elaziz OHA, Ahmad GMS, Elgawad SSA, Elhady F, Hamdy RM (2025) The association between systolic and diastolic dysfunction and autonomic nervous system function in children receiving chronic hemodialysis. Pediatr Nephrol 40(8):2599–2610

Article  PubMed  PubMed Central  Google Scholar 

Hon EH, Lee ST (1963) Electronic evaluation of the fetal heart rate. VIII. Patterns preceding fetal death, further observations. Am J Obstet Gynecol 87:814–829

CAS  PubMed  Google Scholar 

Hautala AJ, Karjalainen J, Kiviniemi AM, Kinnunen H, Mäkikallio TH, Huikuri HV, Tulppo MP (2010) Physical activity and heart rate variability measured simultaneously during waking hours. Am J Physiol Heart Circ Physiol 298(3):H874–880

Article  CAS  PubMed  Google Scholar 

Batten LA, Urbina EM, Berenson GS (2000) Interobserver reproducibility of heart rate variability in children (the Bogalusa Heart Study). Am J Cardiol 86(11):1264–1266

Article  CAS  PubMed  Google Scholar 

McNarry MA, Mackintosh KA (2016) Reproducibility of heart rate variability indices in children with cystic fibrosis. PLoS ONE 11(3):e0151464

Article  PubMed  PubMed Central  Google Scholar 

Massin MM, Derkenne B, von Bernuth G (1999) Correlations between indices of heart rate variability in healthy children and children with congenital heart disease. Cardiology 91(2):109–113

Article  CAS  PubMed  Google Scholar 

Koca B, Bakari S, Oztunç F (2013) Correlation among the heart rate variability indices in healthy children and those with atrial septal defect. Turk Kardiyol Dern Ars 41(3):193–198

Article  PubMed  Google Scholar 

Nederend I, Jongbloed MRM, de Geus EJC, Blom NA, Ten Harkel ADJ (2016) Postnatal cardiac autonomic nervous control in pediatric congenital heart disease. J Cardiovasc Dev Dis 3(2):16

PubMed  PubMed Central  Google Scholar 

Siegel L, Murad MH, Riley RD, Bazerbachi F, Wang Z, Chu H (2022) A guide to estimating the reference range from a meta-analysis using aggregate or individual participant data. Am J Epidemiol 191(5):948–956

Article  PubMed  PubMed Central  Google Scholar 

Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, Moher D, Becker BJ, Sipe TA, Thacker SB (2000) Meta-analysis of observational studies in epidemiology. A proposal for reporting. JAMA 283:2008–2012

Article  CAS  PubMed  Google Scholar 

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71

Article  PubMed  PubMed Central  Google Scholar 

Mandigout S, Melin A, Fauchier L, N’Guyen LD, Courteix D, Obert P (2002) Physical training increases heart rate variability in healthy prepubertal children. Eur J Clin Invest 32(7):479–487

Article  CAS  PubMed  Google Scholar 

Cardoso S, Silva MJ, Guimarães H (2017) Autonomic nervous system in newborns: a review based on heart rate variability. Childs Nerv Syst 33(7):1053–1063

Article  PubMed  Google Scholar 

Weir CJ, Butcher I, Assi V, Lewis SC, Murray GD, Langhorne P, Brady MC (2018) Dealing with missing standard deviation and mean values in meta-analysis of continuous outcomes: a systematic review. BMC Med Res Methodol 18(1):25

Article  PubMed  PubMed Central  Google Scholar 

Wan X, Wang W, Liu J, Tong T (2014) Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. BMC Med Res Methodol 14:135

Article  PubMed  PubMed Central  Google Scholar 

Munn Z, Moola S, Lisy K, Riitano D, Tufanaru C (2015) Methodological guidance for systemic reviews of observational epidemiological studies reporting prevalence and cumulative incidence data. Int J Evid Based Healthc 13:147–153

Article  PubMed  Google Scholar 

Akçaboy M, Atalay S, Uçar T, Tutar E (2011) Heart rate variability during asymptomatic periods in children with recurrent neurocardiogenic syncope. Turk J Pediatr 53(1):59–66

PubMed  Google Scholar 

Ahmadi M, Ghahremani B, Habibi D, Sadrnia S, Ghandi Y (2022) Effects of mitral valve prolapse on heart rate variability, and the autonomic nervous system in children. J Tehran Heart Cent 17(3):140–146

PubMed  PubMed Central  Google Scholar 

Al-Shahawy A, El Amrousy D, Abo Elezz A (2019) Evaluation of heart rate variability in children with breath-holding episodes. Pediatr Neurol 93:34–38

Article  PubMed  Google Scholar 

Argun M, Gul H, Çelebı S, Elmalı F, Narin N (2019) Effect of fluoxetine and psychotherapy on heart rate variability in children and adolescents diagnosed with panic disorder: 24-hour Holter monitoring study before and after treatment. Turk Kardiyol Dern Ars 47(6):458–465

PubMed  Google Scholar 

Arinc AF, Arici S, Akalin F (2024) Heart rate variability in children and adolescents with incidentally found early repolarization pattern. Interven Cardiol 16,S22:555–563

Google Scholar 

Azak E, Cetin II (2021) Premature cardiac beats in children with structurally normal heart: autonomic dysregulation. Pediatr Int 63(12):1433–1440

Article  CAS  PubMed  Google Scholar 

Aziz W, Schlindwein FS, Wailoo M, Biala T, Rocha FC (2012) Heart rate variability analysis of normal and growth restricted children. Clin Auton Res 22(2):91–97

Article  PubMed  Google Scholar 

Babaoglu K, Altun G, Binnetoğlu K (2011) P-wave dispersion and heart rate variability in children with mitral valve prolapse. Pediatr Cardiol 32(4):449–454

Article  PubMed  Google Scholar 

Bakari S, Koca B, Oztunç F, Abuhandan M (2013) Heart rate variability in patients with atrial septal defect and healthy children. J Cardiol 61(6):436–439

Article  PubMed  Google Scholar 

Bjelakovic B, Ilic S, Dimitrijevic L, Milovanovic B, Kostic G, Bjelakovic L, Lukic S (2010) Heart rate variability in infants with central coordination disturbance. Early Hum Dev 86(2):77–81

Article  PubMed 

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