CSF Leukocytes in Intracranial Infections: Diagnostic, Mechanistic, and Therapeutic Insights for Neurocritical Care

Abadier M, Haghayegh Jahromi N, Alves L, Boscacci R, Vestweber D, Barnum S, Deutsch U, Engelhardt B, Lyck R (2014) Cell surface levels of endothelial ICAM-1 influence thetranscellular or paracellularT-celldiapedesis across the blood-brain barrier. Eur J Immunol. https://doi.org/10.1002/eji.201445125

Article  Google Scholar 

Ahlawat S, Chaudhary R, Dangi M, Bala K, Singh M, Chhillar AK (2020) Advances in tuberculous meningitis diagnosis. Expert Rev Mol Diagn 20(12):1229–1241. https://doi.org/10.1080/14737159.2020.1858805

Article  PubMed  CAS  Google Scholar 

Ahlbrecht J, Hillebrand LK, Schwenkenbecher P, Ganzenmueller T, Heim A, Wurster U, Stangel M, Sühs K-W, Skripuletz T (2018) Cerebrospinal fluid features in adults with enteroviral nervous system infection. Int J Infect Dis 68:94–101. https://doi.org/10.1016/j.ijid.2018.01.022

Article  PubMed  Google Scholar 

Ajith Kumar AK, Bhutta BS, Mendez MD (2024) Herpes simplex encephalitis. StatPearls [Internet]. StatPearls Publishing

Google Scholar 

Alloo J, Leleu I, Grangette C, Pied S (2022) Parasite infections, neuroinflammation, and potential contributions of gut microbiota. Front Immunol 13:1024998. https://doi.org/10.3389/fimmu.2022.1024998

Article  PubMed  PubMed Central  CAS  Google Scholar 

de Almeida SM, Castoldi JR, Riechi SC (2023) Comparison between cerebrospinal fluid biomarkers for differential diagnosis of acute meningitis. Diagnosis (Berl) 10(3):298–308. https://doi.org/10.1515/dx-2023-0013

Article  PubMed  CAS  Google Scholar 

Amarante-Mendes GP, Adjemian S, Branco LM, Zanetti LC, Weinlich R, Bortoluci KR (2018) Pattern recognition receptors and the host cell death molecular machinery [Review]. Front Immunol 2018. https://doi.org/10.3389/fimmu.2018.02379

Article  PubMed  PubMed Central  Google Scholar 

Arafa ZAA, Gabr MS, Kamel EM, ElMasry SA, Fahim NA (2023) Cerebrospinal fluid lactate as a differential biomarker for bacterial and viral meningitis. Egypt J Immunol 30(3):148–161

Article  PubMed  Google Scholar 

Archibald LK, Quisling RG (2013) Central nervous system infections. Textbook of neurointensive care. Springer, pp 427–517

Chapter  Google Scholar 

Arja RD, Kuo J, Youssef D (2025) Unusual presentation of West Nile virus meningitis with cerebrospinal fluid (CSF) neutrophilia in a 68-year-old male. Cureus 17(6):e85520. https://doi.org/10.7759/cureus.85520

Article  PubMed  PubMed Central  Google Scholar 

Arumugham VB, Gujarathi R, Cascella M (2023) Third-generation cephalosporins. StatPearls [Internet]. StatPearls Publishing

Google Scholar 

Aten Q, Killeffer J, Seaver C, Reier L (2020) Causes, complications, and costs associated with external ventricular drainage catheter obstruction. World Neurosurg 134:501–506. https://doi.org/10.1016/j.wneu.2019.10.105

Article  PubMed  Google Scholar 

Azargoonjahromi A (2023) Dual role of nitric oxide in Alzheimer’s disease. Nitric Oxide 134:23–37. https://doi.org/10.1016/j.niox.2023.03.003

Article  PubMed  CAS  Google Scholar 

Bahr N, Boulware DR, Marais S, Scriven J, Wilkinson RJ, Meintjes G (2013) Central nervous system immune reconstitution inflammatory syndrome. Curr Infect Dis Rep 15(6):583–593. https://doi.org/10.1007/s11908-013-0378-5

Article  PubMed  PubMed Central  Google Scholar 

Bailey C, Mach J, Kataria S, Tandon M, Lakhani DA, Sriwastava S (2020) West Nile virus encephalitis: a report of two cases and review of neuroradiological features. Radiol Case Rep 15(11):2422–2426. https://doi.org/10.1016/j.radcr.2020.09.023

Article  PubMed  PubMed Central  Google Scholar 

Bariola JR, Perry P, Pappas PG, Proia L, Shealey W, Wright PW, Sizemore JM, Robinson M, Bradsher RW Jr. (2010) Blastomycosis of the central nervous system: a multicenter review of diagnosis and treatment in the modern era. Clin Infect Dis 50(6):797–804. https://doi.org/10.1086/650579

Article  PubMed  Google Scholar 

Barp N, Trentini A, Di Nuzzo M, Mondardini V, Francavilla E, Contini C (2020) Clinical and laboratory findings in tick-borne encephalitis virus infection. Parasite Epidemiol Control 10:e00160. https://doi.org/10.1016/j.parepi.2020.e00160

Article  PubMed  PubMed Central  Google Scholar 

Benson PC, Swadron SP (2006) Empiric acyclovir is infrequently initiated in the emergency department to patients ultimately diagnosed with encephalitis. Ann Emerg Med 47(1):100–105

Article  PubMed  Google Scholar 

Bentivoglio M, Grassi-Zucconi G, Olsson T, Kristensson K (1994) Trypanosoma brucei and the nervous system. Trends Neurosci 17(8):325–329. https://doi.org/10.1016/0166-2236(94)90170-8

Article  PubMed  CAS  Google Scholar 

Bentzer P, Fisher J, Kong HJ, Mörgelin M, Boyd JH, Walley KR, Russell JA, Linder A (2016) Heparin-binding protein is important for vascular leak in sepsis. Intensive Care Med Exp 4(1):33. https://doi.org/10.1186/s40635-016-0104-3

Article  PubMed  PubMed Central  Google Scholar 

Bicanic T, Wood R, Meintjes G, Rebe K, Brouwer A, Loyse A, Bekker LG, Jaffar S, Harrison T (2008) High-dose amphotericin B with flucytosine for the treatment of cryptococcal meningitis in HIV-infected patients: a randomized trial. Clin Infect Dis 47(1):123–130. https://doi.org/10.1086/588792

Article  PubMed  CAS  Google Scholar 

Boulware DR, Bonham SC, Meya DB, Wiesner DL, Park GS, Kambugu A, Janoff EN, Bohjanen PR (2010) Paucity of initial cerebrospinal fluid inflammation in cryptococcal meningitis is associated with subsequent immune reconstitution inflammatory syndrome. J Infect Dis 202(6):962–970. https://doi.org/10.1086/655785

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bourgi K, Fiske C, Sterling TR (2017) Tuberculosis meningitis. Curr Infect Dis Rep 19(11):39

Article  PubMed  Google Scholar 

Bouvier DS, Murai KK (2015) Synergistic actions of microglia and astrocytes in the progression of Alzheimer’s disease. J Alzheimers Dis 45(4):1001–1014. https://doi.org/10.3233/jad-143156

Article  PubMed  Google Scholar 

Brisse ME, Hickman HD (2025) Viral infection and dissemination through the lymphatic system. Microorganisms. https://doi.org/10.3390/microorganisms13020443

Article  PubMed  PubMed Central  Google Scholar 

Brouwer MC, Beek D, Heckenberg SG, Spanjaard L, Gans J (2006) Community-acquired Listeria monocytogenes meningitis in adults. Clin Infect Dis 43(10):1233–1238

Article  PubMed  Google Scholar 

Busl KM (2019) Healthcare-associated infections in the neurocritical care unit. Curr Neurol Neurosci Rep 19(10):76. https://doi.org/10.1007/s11910-019-0987-y

Article  PubMed  Google Scholar 

van Buul JD, Timmerman I (2016) Small Rho GTPase-mediated actin dynamics at endothelial adherens junctions. Small GTPases 7(1):21–31. https://doi.org/10.1080/21541248.2015.1131802

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bylund J, Karlsson A, Boulay F, Dahlgren C (2002) Lipopolysaccharide-induced granule mobilization and priming of the neutrophil response to Helicobacter pylori peptide Hp(2–20), which activates formyl peptide receptor-like 1. Infect Immun 70(6):2908–2914. https://doi.org/10.1128/iai.70.6.2908-2914.2002

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cabral-Pacheco GA, Garza-Veloz I, la Castruita-De Rosa C, Ramirez-Acuña JM, Perez-Romero BA, Guerrero-Rodriguez JF, Martinez-Avila N, Martinez-Fierro ML (2020) The roles of matrix metalloproteinases and their inhibitors in human diseases. Int J Mol Sci. https://doi.org/10.3390/ijms21249739

Article  PubMed  PubMed Central  Google Scholar 

Carpio A, Romo ML, Parkhouse RM, Short B, Dua T (2016) Parasitic diseases of the central nervous system: lessons for clinicians and policy makers. Expert Rev Neurother 16(4):401–414. https://doi.org/10.1586/14737175.2016.1155454

Article  PubMed 

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