Zhao Z (2018) The application of CAR-T cell therapy in hematological malignancies: advantages and challenges. Acta Pharm Sin B 8(4):539–551
Article PubMed PubMed Central Google Scholar
OHSU Knitght Cancer Institute Available from: https://www.ohsu.edu/knight-cancer-institute/car-t-cell-therapy-cancer
Liu G (2021) Enhancing CAR-T cell efficacy in solid tumors by targeting the tumor microenvironment. Cell Mol Immunol 18(5):1085–1095
Article CAS PubMed PubMed Central Google Scholar
Singh AP et al (2020) Development of a quantitative relationship between CAR-affinity, antigen abundance, tumor cell depletion and CAR-T cell expansion using a multiscale systems PK-PD model. In MAbs. Taylor & Francis
Zhu H et al (1996) Physiologically based kinetic model of effector cell biodistribution in mammals: implications for adoptive immunotherapy. Cancer Res 56(16):3771–3781
Khot A et al (2019) Measurement and quantitative characterization of whole-body pharmacokinetics of exogenously administered T cells in mice. J Pharmacol Exp Ther 368(3):503–513
Article CAS PubMed PubMed Central Google Scholar
Owens K, Bozic I (2021) Modeling CAR T-cell therapy with patient preconditioning. Bull Math Biol 83(5):1–36
Shah DK, Betts AM (2012) Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human. J Pharmacokinet Pharmacodyn 39(1):67–86
Article CAS PubMed Google Scholar
Strati P et al (2021) Preliminary results of a phase I trial of FT516, an off-the-shelf natural killer (NK) cell therapy derived from a clonal master induced pluripotent stem cell (iPSC) line expressing high-affinity, non-cleavable CD16 (hnCD16), in patients (pts) with relapsed/refractory (R/R) B-cell lymphoma (BCL). J Clin Oncol 39(15suppl):7541–7541
Haas AR (2019) Phase I study of lentiviral-transduced chimeric antigen receptor-modified T cells recognizing mesothelin in advanced solid cancers. Mol Ther 27(11):1919–1929
Article CAS PubMed PubMed Central Google Scholar
Therapeutics T (2020) Interim Clinical Data from Gavo-cel (TC-210) Patients. Available from: https://investors.tcr2.com/static-files/3ca4958f-17a7-4fd7-a1c3-4790d2cb9c3d
Narayan V et al (2019) A phase I clinical trial of PSMA-directed/TGFβ-insensitive CAR-T cells in metastatic castration-resistant prostate cancer. American Society of Clinical Oncology
Shi D (2020) Chimeric antigen receptor-glypican-3 T-cell therapy for advanced hepatocellular carcinoma: results of phase i trials. Clin Cancer Res 26(15):3979–3989
Article CAS PubMed Google Scholar
Ribeiro RM et al (2002) In vivo dynamics of T cell activation, proliferation, and death in HIV-1 infection: why are CD4 + but not CD8 + T cells depleted? Proceedings of the National Academy of Sciences, 99(24): pp. 15572–15577
Singh AP et al (2021) Bench-to‐bedside translation of chimeric antigen receptor (CAR) T cells using a multiscale systems pharmacokinetic‐pharmacodynamic model: A case study with anti‐BCMA CAR‐T, vol 10. pharmacometrics & systems pharmacology, CPT, pp 362–376. 4
Watanabe K (2018) Expanding the therapeutic window for CAR T cell therapy in solid tumors: the knowns and unknowns of CAR T cell biology. Front Immunol. https://doi.org/10.3389/fimmu.2018.02486
Article PubMed PubMed Central Google Scholar
Chan PL (2011) The use of the SAEM algorithm in MONOLIX software for estimation of population pharmacokinetic-pharmacodynamic-viral dynamics parameters of Maraviroc in asymptomatic HIV subjects. J Pharmacokinet Pharmacodyn 38(1):41–61
Rohatgi A, Webplotdigitizer (2021) Version 4.5. ; Available from: https://automeris.io/WebPlotDigitizer
Wickham H (2016) ggplot2: elegant graphics for data analysis. Springer-, New York
Schmid HP, McNeal JE, Stamey TA (1993) Observations on the doubling time of prostate cancer. The use of serial prostate-specific antigen in patients with untreated disease as a measure of increasing cancer volume. Cancer 71(6):2031–2040
Article CAS PubMed Google Scholar
Patel U (2022) CAR T cell therapy in solid tumors: a review of current clinical trials. EJHaem 3:24–31
Jones H (2015) Physiologically based pharmacokinetic modeling in drug discovery and development: a pharmaceutical industry perspective. Clin Pharmacol Ther 97(3):247–262
Article CAS PubMed Google Scholar
Zhang X (2020) Application of PBPK modeling and simulation for regulatory decision making and its impact on US prescribing information: an update on the 2018-2019 submissions to the US fda’s office of clinical pharmacology. J Clin Pharmacol 60:S160–S178
Lymphodepletion optimization for CAR T-cell therapy Available from: https://multiplemyelomahub.com/medical-information/lymphodepletion-optimization-for-car-t-cell-therapy
An C (2015) Growth rate of early-stage hepatocellular carcinoma in patients with chronic liver disease. Clin Mol Hepatol 21(3):279
Article PubMed PubMed Central Google Scholar
Mazaheri Y et al (2009) Prostate tumor volume measurement with combined T2-weighted imaging and diffusion-weighted MR: correlation with pathologic tumor volume. Radiology 252(2):449–457
Article PubMed PubMed Central Google Scholar
Beaupierre A, Lundberg R, Marrero L, Jain M, Wang T, Alencar MC (2019) Management across settings: an ambulatory and community perspective for patients undergoing CAR T-cell therapy in multiple care settings. Clin J Oncol Nurs 23(2):27–34. https://doi.org/10.1188/19.CJON.S1.27-34
Neelapu SS (2019) CAR-T efficacy: is conditioning the key? Blood 133(17):1799–1800. https://doi.org/10.1182/blood-2019-03-900928
Article CAS PubMed Google Scholar
Schwartz LH, Litière S, de Vries E, Ford R, Gwyther S, Mandrekar S, Shankar L, Bogaerts J, Chen A, Dancey J, Hayes W, Hodi FS, Hoekstra OS, Huang EP, Lin N, Liu Y, Therasse P, Wolchok JD, Seymour L (2016) RECIST 1.1-Update and clarification: from the RECIST committee. Eur J Cancer 62:132–137 Epub 2016 May 14. PMID: 27189322; PMCID: PMC5737828
Article PubMed PubMed Central Google Scholar
Byrne MJ, Nowak AK (2004) Modified RECIST criteria for assessment of response in malignant pleural mesothelioma. Ann Oncol 15(2):257–60. https://doi.org/10.1093/annonc/mdh059
Article CAS PubMed Google Scholar
Salem AM, Mugundu GM, Singh AP (2023) Development of a multiscale mechanistic modeling framework integrating differential cellular kinetics of CAR T-cell subsets and immunophenotypes in cancer patients. CPT: Pharmacometrics & Systems Pharmacology 12(9):1285–1304. https://doi.org/10.1002/psp4.13009
Lickefett B, Chu L, Ortiz-Maldonado V, Warmuth L, Barba P, Doglio M, Henderson D, Hudecek M, Kremer A, Markman J, Nauerth M, Negre H, Sanges C, Staber PB, Tanzi R, Delgado J, Busch DH, Kuball J, Luu M, Jäger U (2023) Lymphodepletion - an essential but undervalued part of the chimeric antigen receptor T-cell therapy cycle. Front Immunol 14:1303935. https://doi.org/10.3389/fimmu.2023.1303935
Article CAS PubMed PubMed Central Google Scholar
Paolo Strati et al (2021) Preliminary results of a phase I trial of FT516, an off-the-shelf natural killer (NK) cell therapy derived from a clonal master induced pluripotent stem cell (iPSC) line expressing high-affinity, non-cleavable CD16 (hnCD16), in patients (pts) with relapsed/refractory (R/R) B-cell lymphoma (BCL). JCO 39, 7541–7541
Demin O Jr et al (2022) Application of Semi-mechanistic Mathematicaml Modeling to Optimize Lymphodepletion Regimen Administered before Infusion of Genetically Modified T Cells. PW-014, ASCPT
Derippe T, Fouliard S, Marchiq I, Dupouy S, Almena-Carrasco M, Geronimi J, Declèves X, Chenel M, Mager DE (2022) Mechanistic modeling of the interplay between host immune system, IL-7 and UCART19 allogeneic CAR-T cells in adult B-cell acute lymphoblastic leukemia. Cancer Res Commun 2(11):1532–1544. https://doi.org/10.1158/2767-9764.CRC-22-0176
Article CAS PubMed PubMed Central Google Scholar
Stein AM, Grupp SA, Levine JE, Laetsch TW, Pulsipher MA, Boyer MW, August KJ, Levine BL, Tomassian L, Shah S, Leung M, Huang PH, Awasthi R, Mueller KT, Wood PA, June CH (2019) Tisagenlecleucel Model-Based cellular kinetic analysis of chimeric antigen Receptor-T cells. CPT Pharmacometrics Syst Pharmacol 8(5):285–295 Epub 2019 Mar 7. PMID: 30848084; PMCID: PMC6539725
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