Amir RE, Zoghbi HY (2000) Rett syndrome: methyl-CpG-binding protein 2 mutations and phenotype–genotype correlations. Am J Med Genet 97(2):147–152
Article PubMed CAS Google Scholar
Laurvick CL, De Klerk N, Bower C, Christodoulou J, Ravine D, Ellaway C, Leonard H (2006) Rett syndrome in Australia: a review of the epidemiology. J Pediatr 148(3):347–352
Ben Zeev B, Yaron Y, Schanen NC, Wolf H, Brandt N, Ginot N, Shomrat Ruth, Orr-Urtreger A (2002) Rett syndrome: clinical manifestations in males with MECP2 mutations. J Child Neurol 17(1):20–24
Gold WA, Krishnarajy R, Ellaway C, Christodoulou J (2018) Rett syndrome: a genetic update and clinical review focusing on comorbidities. ACS Chem Neurosci 9(2):167–176
Article PubMed CAS Google Scholar
Symons FJ, Byiers B, Tervo R, Beisang A (2013) Parent reported pain in rett syndrome. Clin J Pain 29(8):744
Article PubMed PubMed Central Google Scholar
Hagberg B (2002) Clinical manifestations and stages of Rett syndrome. Ment Retard Dev Disabil Res Rev 8(2):61–65
Good KV, Vincent JB, Ausió J (2021) MeCP2: the genetic driver of Rett syndrome epigenetics. Front Genet 12:620859
Article PubMed PubMed Central CAS Google Scholar
Irfan J, Febrianto M, Sharma A, Rose T, Mahmudzade Y, Di Giovanni S, Nagy I, Torres-Perez J (2022) DNA methylation and non-coding RNAs during tissue-injury associated pain. Int J Mol Sci. https://doi.org/10.3390/ijms23020752
Article PubMed PubMed Central Google Scholar
Guy J, Hendrich B, Holmes M, Martin JE, Bird A (2001) A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome. Nat Genet 27(3):322–326
Article PubMed CAS Google Scholar
Flores Gutiérrez J, De Felice C, Natali G, Leoncini S, Signorini C, Hayek J, Tongiorgi E (2020) Protective role of mirtazapine in adult female Mecp2+/− mice and patients with Rett syndrome. J Neurodev Disord 12(1):1–20
Flores Gutiérrez J, Natali G, Giorgi J, De Leonibus E, Tongiorgi E (2022) Mirtazapine treatment in a young female mouse model of Rett syndrome identifies time windows for the rescue of early phenotypes. Exp Neurol 353:114056
Abellán-Álvaro M, Stork O, Agustín-Pavón C, Santos M (2021) MeCP2 haplodeficiency and early-life stress interaction on anxiety-like behavior in adolescent female mice. J Neurodev Disord 13:1–12
Mykins M, Layo-Carris D, Dunn LR, Skinner DW, McBryar AH, Perez S, Shultz Trinity Rose, Willems Andrew, Lau Billy You Bun, Hong Tian, Krishnan K (2023) Wild-type MECP2 expression coincides with age-dependent sensory phenotypes in a female mouse model for Rett syndrome. J Neurosci Res 101(8):1236–1258
Article PubMed PubMed Central CAS Google Scholar
Orefice LL, Zimmerman AL, Chirila AM, Sleboda SJ, Head JP, Ginty DD (2016) Peripheral mechanosensory neuron dysfunction underlies tactile and behavioral deficits in mouse models of ASDs. Cell 166(2):299–313
Article PubMed PubMed Central CAS Google Scholar
Vigli D, Cosentino L, Pellas M, De Filippis B (2021) Chronic treatment with cannabidiolic acid (CBDA) reduces thermal pain sensitivity in male mice and rescues the hyperalgesia in a mouse model of Rett syndrome. Neuroscience 453:113–123
Article PubMed CAS Google Scholar
Samaco RC, McGraw CM, Ward CS, Sun Y, Neul JL, Zoghbi HY (2013) Female Mecp2+/− mice display robust behavioral deficits on two different genetic backgrounds providing a framework for pre-clinical studies. Hum Mol Genet 22(1):96–109
Article PubMed CAS Google Scholar
Bhattacherjee A, Mu Y, Winter MK, Knapp JR, Eggimann LS, Gunewardena SS, Kobayashi K, Kato S, Krizsan-Agbas D, Smith PG (2017) Neuronal cytoskeletal gene dysregulation and mechanical hypersensitivity in a rat model of Rett syndrome. Proc Natl Acad Sci U S A 114(33):E6952–E6961
Article PubMed PubMed Central CAS Google Scholar
Bushlin I, Rozenfeld R, Devi LA (2010) Cannabinoid–opioid interactions during neuropathic pain and analgesia. Curr Opin Pharmacol 10(1):80–86
Article PubMed CAS Google Scholar
Vigli D, Cosentino L, Raggi C, Laviola G, Woolley-Roberts M, De Filippis B (2018) Chronic treatment with the phytocannabinoid Cannabidivarin (CBDV) rescues behavioural alterations and brain atrophy in a mouse model of Rett syndrome. Neuropharmacology 140:121–129
Article PubMed CAS Google Scholar
Zamberletti E, Gabaglio M, Woolley-Roberts M, Bingham S, Rubino T, Parolaro D (2019) Cannabidivarin treatment ameliorates autism-like behaviors and restores hippocampal endocannabinoid system and glia alterations induced by prenatal valproic acid exposure in rats. Front Cell Neurosci 13:367
Article PubMed PubMed Central CAS Google Scholar
Garriga-Canut M, Agustín-Pavón C, Herrmann F, Sánchez A, Dierssen M, Fillat C, Isalan M (2012) Synthetic zinc finger repressors reduce mutant huntingtin expression in the brain of R6/2 mice. Proc Natl Acad Sci U S A 109(45):E3136–E3145
Article PubMed PubMed Central CAS Google Scholar
Santos M, Summavielle T, Teixeira-Castro A, Silva-Fernandes A, Duarte-Silva S, Marques F, Dierssen M, Oliveira P, Sousa N, Maciel P (2010) Monoamine deficits in the brain of methyl-CpG binding protein 2 null mice suggest the involvement of the cerebral cortex in early stages of Rett syndrome. Neuroscience 170(2):453–467
Article PubMed CAS Google Scholar
Vogel Ciernia A, Yasui DH, Pride MC, Durbin-Johnson B, Noronha AB, Chang A, LaSalle JM (2018) MeCP2 isoform e1 mutant mice recapitulate motor and metabolic phenotypes of Rett syndrome. Hum Mol Genet 27(23):4077–4093. https://doi.org/10.1093/hmg/ddy301
Article PubMed PubMed Central CAS Google Scholar
Bonin RP, Bories C, De Koninck Y (2014) A simplified up-down method (SUDO) for measuring mechanical nociception in rodents using von Frey filaments. Mol Pain. https://doi.org/10.1186/1744-8069-10-26
Article PubMed PubMed Central Google Scholar
Cuitavi J, Lorente JD, Campos-Jurado Y, Polache A, Hipólito L (2021) Neuroimmune and mu-opioid receptor alterations in the mesocorticolimbic system in a sex-dependent inflammatory pain-induced alcohol relapse-like rat model. Front Immunol 12:689453
Article PubMed PubMed Central CAS Google Scholar
Lorente JD, Cuitavi J, Campos-Jurado Y, Montón-Molina R, González-Romero JL, Hipólito L (2022) Kappa opioid receptor blockade in the nucleus accumbens shell prevents sex-dependent alcohol deprivation effect induced by inflammatory pain. Pain 163(1):e137–e147
Article PubMed CAS Google Scholar
R Core Team, R. (2013). R: A language and environment for statistical computing. n/a
Verbeke, G., Molenberghs, G., & Verbeke, G. (1997). Linear mixed models for longitudinal data (pp. 63-153). Springer New York. n/a
Gelman A, Rubin DB (1992) Inference from iterative simulation using multiple sequences. Stat Sci 7(4):457–472
O’Callaghan JP, Holtzman SG (1975) Quantification of the analgesic activity of narcotic antagonists by a modified hot-plate procedure. J Pharmacol Exp Ther 192(3):497–505
Article PubMed CAS Google Scholar
Refsgaard LK, Hoffmann-Petersen J, Sahlholt M, Pickering DS, Andreasen JT (2016) Modelling affective pain in mice: effects of inflammatory hypersensitivity on place escape/avoidance behaviour, anxiety and hedonic state. J Neurosci Methods 262:85–92
Article PubMed CAS Google Scholar
Christodoulou CEJ (2001) Rett syndrome: clinical characteristics and recent genetic advances. Disabil Rehabil 23(3–4):98–106
Comments (0)