Beyond existing rating scales: development of a novel nomogram for predicting severe clinical bleeding associated with low-molecular-weight heparin in hospitalized medical patients

Cohen AT, Tapson VF, Bergmann JF, et al. Venous thromboembolism risk and prophylaxis in the acute hospital care setting (ENDORSE study): a multinational cross-sectional study. Lancet. 2008;371:387–94.

Article  PubMed  Google Scholar 

Zhen K, Dong F, Fang F, et al. Evaluation of in-hospital venous thromboembolism prevention and management system using hospital-level metrics: a nationwide cross-sectional survey in China. J Patient Saf. 2022;18:e626–32.

Article  PubMed  Google Scholar 

Schrag D, Uno H, Rosovsky R, et al. Direct oral anticoagulants vs low-molecular-weight heparin and recurrent VTE in patients with cancer: a randomized clinical trial. JAMA. 2023;329:1924–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guan T, Laguna A, Soares A, et al. Evaluation of direct oral anticoagulants versus low molecular weight heparins for venous thromboembolism treatment in patients with gastrointestinal malignancies. J Thromb Thrombolysis. 2023;56:439–46.

Article  CAS  PubMed  Google Scholar 

Crowther MA, Warkentin TE. Bleeding risk and the management of bleeding complications in patients undergoing anticoagulant therapy: focus on new anticoagulant agents. Blood. 2008;111:4871–9.

Article  CAS  PubMed  Google Scholar 

Petersen JL, Mahaffey KW, Hasselblad V, et al. Efficacy and bleeding complications among patients randomized to enoxaparin or unfractionated heparin for antithrombin therapy in non-ST-segment elevation acute coronary syndromes: a systematic overview. JAMA. 2004;292:89–96.

Article  CAS  PubMed  Google Scholar 

Fu D, Li L, Li Y, et al. Fondaparinux sodium and low molecular weight heparin for venous thromboembolism prophylaxis in Chinese patients with major orthopedic surgery or trauma: a real-world study. BMC Surg. 2022;22:243.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fernando SM, Mok G, Castellucci LA, et al. Impact of anticoagulation on mortality and resource utilization among critically ill patients with major bleeding. Crit Care Med. 2020;48:515–24.

Article  PubMed  Google Scholar 

Gorog DA, Gue YX, Chao TF, et al. Assessment and mitigation of bleeding risk in atrial fibrillation and venous thromboembolism: executive summary of a European and Asia-Pacific expert consensus paper. Thromb Haemost. 2022;122:1625–52.

Article  PubMed  Google Scholar 

Zhang Z, Lei J, Zhai Z, et al. Comparison of prediction value of four bleeding risk scores for pulmonary embolism with anticoagulation: a real-world study in Chinese patients. Clin Respir J. 2019;13:139–47.

Article  CAS  PubMed  Google Scholar 

Pisters R, Lane DA, Nieuwlaat R, et al. A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey. Chest. 2010;138(5):1093–100.

Article  PubMed  Google Scholar 

O’Brien EC, Simon DN, Thomas LE, et al. The ORBIT bleeding score: a simple bedside score to assess bleeding risk in atrial fibrillation. Eur Heart J. 2015;36(46):3258–64.

CAS  PubMed  PubMed Central  Google Scholar 

Fang MC, Go AS, Chang Y, et al. A new risk scheme to predict warfarin-associated hemorrhage: the ATRIA (Anticoagulation and Risk Factors in Atrial Fibrillation) Study. J Am Coll Cardiol. 2011;58(4):395–401.

Article  PubMed  PubMed Central  Google Scholar 

Gage BF, Yan Y, Milligan PE, et al. Clinical classification schemes for predicting hemorrhage: results from the National Registry of Atrial Fibrillation (NRAF). Am Heart J. 2006;151(3):713–9.

Article  PubMed  Google Scholar 

vShireman TI, Mahnken JD, Howard PA, et al. Development of a contemporary bleeding risk model for elderly warfarin recipients. Chest. 2006;130(5):1390–6.

Beyth RJ, Quinn LM, Landefeld CS. Prospective evaluation of an index for predicting the risk of major bleeding in outpatients treated with warfarin. Am J Med. 1998;105(2):91–9.

Article  CAS  PubMed  Google Scholar 

Kearon C, Akl EA, Ornelas J, et al. Antithrombotic therapy for VTE disease: CHEST guideline and expert panel report. Chest. 2016;149(2):315–52.

Article  PubMed  Google Scholar 

Klok FA, Hösel V, Clemens A, et al. Prediction of bleeding events in patients with venous thromboembolism on stable anticoagulation treatment. Eur Respir J. 2016;48(5):1369–76.

Article  CAS  PubMed  Google Scholar 

Di Nisio M, Raskob G, Büller HR, et al. Prediction of major and clinically relevant bleeding in patients with VTE treated with edoxaban or vitamin K antagonists. Thromb Haemost. 2017;117(4):784–93.

Article  PubMed  Google Scholar 

Seiler E, Limacher A, Mean M, et al. Derivation and validation of a novel bleeding risk score for elderly patients with venous thromboembolism on extended anticoagulation. Thromb Haemost. 2017;117(10).

Decousus H, Tapson VF, Bergmann JF, et al. Factors at admission associated with bleeding risk in medical patients. Chest. 2011;139(1):69–79.

Article  PubMed  Google Scholar 

Ruíz-Giménez N, Suárez C, González R, et al. Predictive variables for major bleeding events in patients presenting with documented acute venous thromboembolism. Findings from the RIETE Registry. Thromb Haemost. 2008;100(1):26–31.

Article  PubMed  Google Scholar 

de Winter MA, Dorresteijn J, Ageno W, et al. Estimating bleeding risk in patients with cancer-associated thrombosis: evaluation of existing risk scores and development of a new risk score. Thromb Haemost. 2022;122:818–29.

Article  PubMed  Google Scholar 

Frei AN, Stalder O, Limacher A, et al. Comparison of bleeding risk scores in elderly patients receiving extended anticoagulation with vitamin K antagonists for venous thromboembolism. Thromb Haemost. 2021;121:1512–22.

Article  PubMed  Google Scholar 

Nopp S, Ay C. Bleeding risk assessment in patients with venous thromboembolism. Hamostaseologie. 2021;41:267–74.

Article  PubMed  Google Scholar 

Levine MN, Raskob G, Beyth RJ, et al. Hemorrhagic complications of anticoagulant treatment: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 2004;126:287S-310S.

Article  CAS  PubMed  Google Scholar 

Tchen S, Ryba N, Patel V, et al. Validation of bleeding risk prediction scores for patients with major bleeding on direct oral anticoagulants. Ann Pharmacother. 2020;54:1175–84.

Article  CAS  PubMed  Google Scholar 

Alammari M, Sultana K, Alturaiki A, et al. The development and validation of a multivariable model to predict the bleeding risk score for patients with non-valvular atrial fibrillation using direct oral anticoagulants in the Arab population. PLoS ONE. 2021;16:e250502.

Article  Google Scholar 

Fernando SM, Tran A, Cheng W, et al. VTE prophylaxis in critically ill adults. Chest. 2022;161:418–28.

Article  CAS  PubMed  Google Scholar 

Gorog DA, Gue YX, Chao TF, et al. Assessment and mitigation of bleeding risk in atrial fibrillation and venous thromboembolism: a position paper from the ESC Working Group on Thrombosis, in collaboration with the European Heart Rhythm Association, the Association for Acute CardioVascular Care and the Asia-Pacific Heart Rhythm Society. Europace. 2022;24:1844–71.

Article  PubMed  PubMed Central  Google Scholar 

Glise SK, Schulman S, Rosengren A, et al. Association of type of oral anticoagulation with risk of bleeding in 45,114 patients with venous thromboembolism during initial and extended treatment-A nationwide register-based study. J Intern Med. 2023;294:743–60.

Article  Google Scholar 

Zulkifly H, Lip G, Lane DA. Bleeding risk scores in atrial fibrillation and venous thromboembolism. Am J Cardiol. 2017;120:1139–45.

Article  PubMed  Google Scholar 

Guo Y, Zhu H, Chen Y, et al. Comparing bleeding risk assessment focused on modifiable risk factors only versus validated bleeding risk scores in atrial fibrillation. Am J Med. 2018;131:185–92.

Article  PubMed  Google Scholar 

de Winter MA, van Es N, Buller HR, et al. Prediction models for recurrence and bleeding in patients with venous thromboembolism: a systematic review and critical appraisal. Thromb Res. 2021;199:85–96.

Article  PubMed  Google Scholar 

Vicente-Ibarra N, Marin F, Pernias-Escrig V, et al. Impact of anemia as risk factor for major bleeding and mortality in patients with acute coronary syndrome. Eur J Intern Med. 2019;61:48–53.

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