Sphingosine 1-phosphate signalling in cancer stem cells

Baeyens AAL, Schwab SR. Finding a way out: S1P signaling and immune cell migration. Annu Rev Immunol. 2020;38:759–84.

Article  PubMed  Google Scholar 

McGinley MP, Cohen JA. Sphingosine 1-phosphate receptor modulators in multiple sclerosis and other conditions. Lancet. 2021;398:1184–94.

Article  PubMed  Google Scholar 

Cartier A, Hla T. Sphingosine 1-phosphate: lipid signaling in pathology and therapy. Science. 2019;366:eaar5551.

Article  PubMed  PubMed Central  Google Scholar 

Pitson SM. Regulation of sphingosine kinase and sphingolipid signaling. Trends Biochem Sci. 2011;36:97–107.

Article  PubMed  Google Scholar 

Neubauer HA, Pitson SM. Roles, regulation and inhibitors of sphingosine kinase 2. FEBS J. 2013;280:5317–36.

Article  PubMed  Google Scholar 

Maceyka M, Milstien S, Spiegel S. Sphingosine-1-phosphate: the Swiss army knife of sphingolipid signaling. J Lipid Res. 2009;50:S272–6.

Article  PubMed  PubMed Central  Google Scholar 

Allende ML, Sasaki T, Kawai H, Olivera A, Mi Y, van Echten-Deckert G, et al. Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720. J Biol Chem. 2004;279:52487–92.

Article  PubMed  Google Scholar 

Mizugishi K, Yamashita T, Olivera A, Miller GF, Spiegel S, Proia RL. Essential role for sphingosine kinases in neural and vascular development. Mol Cell Biol. 2005;25:11113–21.

Article  PubMed  PubMed Central  Google Scholar 

Ghaderi S, Levkau B. An erythrocyte-centric view on the MFSD2B sphingosine-1-phosphate transporter. Pharm Ther. 2023;249:108483.

Article  Google Scholar 

Proia RL, Hla T. Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy. J Clin Invest. 2015;125:1379–87.

Article  PubMed  PubMed Central  Google Scholar 

Saba JD. Fifty years of lyase and a moment of truth: sphingosine phosphate lyase from discovery to disease. J Lipid Res. 2019;60:456–63.

Article  PubMed  PubMed Central  Google Scholar 

Tang X, Brindley DN. Lipid phosphate phosphatases and cancer. Biomolecules. 2020;10:1263.

Article  PubMed  PubMed Central  Google Scholar 

Weigel C, Bellaci J, Spiegel S. Sphingosine-1-phosphate and its receptors in vascular endothelial and lymphatic barrier function. J Biol Chem. 2023;299:104775.

Article  PubMed  PubMed Central  Google Scholar 

Obinata H, Hla T. Sphingosine 1-phosphate and inflammation. Int Immunol. 2019;31:617–25.

Article  PubMed  PubMed Central  Google Scholar 

Chun J, Giovannoni G, Hunter SF. Sphingosine 1-phosphate receptor modulator therapy for multiple sclerosis: Differential downstream receptor signalling and clinical profile effects. Drugs. 2021;81:207–31.

Article  PubMed  Google Scholar 

Galvani S, Sanson M, Blaho VA, Swendeman SL, Obinata H, Conger H, et al. HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation. Sci Signal. 2015;8:ra79.

Article  PubMed  PubMed Central  Google Scholar 

Bravo GA, Cedeno RR, Casadevall MP, Ramio-Torrenta L. Sphingosine-1-phosphate (S1P) and S1P signaling pathway modulators, from current insights to future perspectives. Cells. 2022;11:2058.

Article  PubMed  PubMed Central  Google Scholar 

Kitsou K, Kokkotis G, Rivera-Nieves J, Bamias G. Targeting the sphingosine-1-phosphate pathway: New opportunities in inflammatory bowel disease management. Drugs. 2024;84:1179–97.

Article  PubMed  PubMed Central  Google Scholar 

Hait NC, Allegood J, Maceyka M, Strub GM, Harikumar KB, Singh SK, et al. Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. Science. 2009;325:1254–7.

Article  PubMed  PubMed Central  Google Scholar 

Panneer Selvam S, De Palma RM, Oaks JJ, Oleinik N, Peterson YK, Stahelin RV, et al. Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation. Sci Signal. 2015;8:ra58.

Article  PubMed  Google Scholar 

Strub GM, Paillard M, Liang J, Gomez L, Allegood JC, Hait NC, et al. Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration. FASEB J. 2011;25:600–12.

Article  PubMed  PubMed Central  Google Scholar 

Chipuk JE, McStay GP, Bharti A, Kuwana T, Clarke CJ, Siskind LJ, et al. Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosis. Cell. 2012;148:988–1000.

Article  PubMed  PubMed Central  Google Scholar 

Alvarez SE, Harikumar KB, Hait NC, Allegood J, Strub GM, Kim EY, et al. Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. Nature. 2010;465:1084–8.

Article  PubMed  PubMed Central  Google Scholar 

Etemadi N, Chopin M, Anderton H, Tanzer MC, Rickard JA, Abeysekera W, et al. TRAF2 regulates TNF and NF-kappaB signalling to suppress apoptosis and skin inflammation independently of sphingosine kinase 1. Elife. 2015;4:e10592.

Article  PubMed  PubMed Central  Google Scholar 

Parham KA, Zebol JR, Tooley KL, Sun WY, Moldenhauer LM, Cockshell MP, et al. Sphingosine 1-phosphate is a ligand for peroxisome proliferator-activated receptor-gamma that regulates neoangiogenesis. FASEB J. 2015;29:3638–53.

Article  PubMed  PubMed Central  Google Scholar 

Kajimoto T, Caliman AD, Tobias IS, Okada T, Pilo CA, Van AN, et al. Activation of atypical protein kinase C by sphingosine 1-phosphate revealed by an aPKC-specific activity reporter. Sci Signal. 2019;12:eaat6662.

Article  PubMed  PubMed Central  Google Scholar 

de Morree A, Rando TA. Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity. Nat Rev Mol Cell Biol. 2023;24:334–54.

Article  PubMed  PubMed Central  Google Scholar 

Lidgerwood GE, Pitson SM, Bonder C, Pebay A. Roles of lysophosphatidic acid and sphingosine-1-phosphate in stem cell biology. Prog Lipid Res. 2018;72:42–54.

Article  PubMed  Google Scholar 

Pebay A, Bonder CS, Pitson SM. Stem cell regulation by lysophospholipids. Prostaglandins Other Lipid Mediat. 2007;84:83–97.

Article  PubMed  Google Scholar 

Pitson SM. Pebay A. Regulation of stem cell pluripotency and neural differentiation by lysophospholipids. Neurosignals. 2009;17:242–54.

Article  PubMed  Google Scholar 

Lo CG, Xu Y, Proia RL, Cyster JG. Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit. J Exp Med. 2005;201:291–301.

Article  PubMed  PubMed Central  Google Scholar 

Ratajczak MZ, Lee H, Wysoczynski M, Wan W, Marlicz W, Laughlin MJ, et al. Novel insight into stem cell mobilization-plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due to activation of complement cascade/membrane attack complex. Leukemia. 2010;24:976–85.

Article  PubMed  PubMed Central  Google Scholar 

Juarez JG, Harun N, Thien M, Welschinger R, Baraz R, Pena AD, et al. Sphingosine-1-phosphate facilitates trafficking of hematopoietic stem cells and their mobilization by CXCR4 antagonists in mice. Blood. 2012;119:707–16.

Article  PubMed 

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