Hashimoto T., Horikawa D.D., Saito Y., et al. 2016. Extremotolerant tardigrade genome and improved radiotolerance of human cultured cells by tardigrade-unique protein. Nat. Commun. 7 (1), 1–14. https://doi.org/10.1038/ncomms12808

Article  CAS  Google Scholar 

Hashimoto T., Kunieda T. 2017. DNA protection protein, a novel mechanism of radiation tolerance: Lessons from tardigrades. Life. 7 (2), 1–11. https://doi.org/10.3390/life7020026

Article  CAS  Google Scholar 

Zarubin M., Azorskaya T., Kuldoshina O., Alekseev S., Mitrofanov S., Kravchenko E. 2023. The tardigrade Dsup protein enhances radioresistance in Drosophila melanogaster and acts as an unspecific repressor of transcription. iScience. 26 (7), 1–20. https://doi.org/10.1016/j.isci.2023.106998

Del Casino C., Conti V., Licata S., Cai G., Cantore A., Ricci C., Cantara S. 2024. Mitigation of UV-B radiation stress in tobacco pollen by expression of the tardigrade damage suppressor protein (Dsup). Cells. 13 (10), 1–21. https://doi.org/10.3390/CELLS13100840

Article  Google Scholar 

Chavez C., Cruz-Becerra G., Fei J., et al. 2019. The tardigrade damage suppressor protein binds to nucleosomes and protects DNA from hydroxyl radicals. Elife. 8, 1–20. https://doi.org/10.7554/eLife.47682

Article  Google Scholar 

Zarubin M., Murugova T., Ryzhykau Y., Ivankov O., Uversky V.N., Kravchenko E. 2024. Structural study of the intrinsically disordered tardigrade damage suppressor protein (Dsup) and its complex with DNA. Sci. Rep. 14 (1), 1–13. https://doi.org/10.1038/S41598-024-74335-2

Article  Google Scholar 

Durante M., Orecchia R., Loeffler J.S. 2017. Charged-particle therapy in cancer: Clinical uses and future perspectives. Nat. Rev. Clin. Oncol. 14 (8), 483–495. https://doi.org/10.1038/nrclinonc.2017.30

Article  PubMed  Google Scholar 

Kirtane A. R., Bi J., Rajesh N. U., et al. 2025. Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades. Nat. Biomed. Eng. 1–14. https://doi.org/10.1038/s41551-025-01360-5

Syresin E.M., Bokor J., Breev V.M., et al. 2015. Project of the demonstration center of proton therapy at DLNP JINR. Phys. Part. Nucl. Lett. 12, 628–636. https://doi.org/10.1134/S1547477115040238

Article  CAS  Google Scholar 

Karamyshev O.V., Bunyatov K.S., Gibinsky. A.L., et al. 2021. Research and development of the SC230 superconducting cyclotron for proton therapy. Phys. Part. Nucl. Lett. 18, 63–74. https://doi.org/10.1134/S1547477121010088

Article  CAS  Google Scholar 

Kovalchuk M.V., Dyakova Y.A., Maksimov V.I., Klenov G.I., Granin D.I., Orlov D.G., Sergunova K.A., Khoroshkov V.S., Khalikov A.I., Chernykh A.N. 2023. Trends and ways of developing proton beam therapy in Russia. Nanobiotechnology Reports. 18 (4), 542–558. https://doi.org/10.1134/S2635167623600232

Article  Google Scholar 

Agapov A., Gaevsky V., Kizhaev E., et al. 2019. Experience of proton radiotherapy at the Joint Institute for Nuclear Research, Dubna. Med. Radiol. Radiat. Saf. 64 (2), 61–69. https://doi.org/10.12737/article_5ca6027479faf5.57356528

Article  Google Scholar 

Deperas-Kaminska M., Zaytseva E.M., Deperas-Standylo J., Mitsyn G.V., Molokanov A.G., Timoshenko G.N., Wojcik A. 2010. Inter-chromosomal variation in aberration frequencies in human lymphocytes exposed to charged particles of LET between 0.5 and 55 keV/μm. Int. J. Radiat. Biol. 86 (11), 975–985. https://doi.org/10.3109/09553002.2010.496028

Article  CAS  PubMed  Google Scholar 

Savchenko O.V. 1996. Status and prospects of new clinical methods of cancer diagnostics and treatment based on particle and ion beams available at JINR. JINR Report. 28 (1), 1–35.

Google Scholar 

Palmer E., Freeman T. 2004. Investigation into the use of C- and N-terminal GFP fusion proteins for subcellular localization studies using reverse transfection microarrays. Comp. Funct. Genomics. 5 (4), 342–353. https://doi.org/10.1002/CFG.405

Article  CAS  PubMed  PubMed Central  Google Scholar