Abdel-Khalek AE, El-Maghraby MM, Elbialy ZI, Wakeel A, Almadaly RA, Shukry EA, El-Badawy M, Zaghloul AA, H. K., Assar DH (2023) Mitigation of endogenous oxidative stress and improving growth, hemato-biochemical parameters, and reproductive performance of Zaraibi goat bucks by dietary supplementation with Chlorella vulgaris or/and vitamin C. Trop Anim Health Prod 55(4):267. https://doi.org/10.1007/s11250-023-03657-6

Article  PubMed  PubMed Central  Google Scholar 

Abdelwahab SI (2013) Protective mechanism of Gallic acid and its novel derivative against ethanol-induced gastric ulcerogenesis: involvement of Immunomodulation markers, Hsp70 and Bcl-2-associated X protein. Int Immunopharmacol 16:296–305. https://doi.org/10.1016/j.intimp.2013.04.005

Article  PubMed  Google Scholar 

Adinortey MB, Ansah C, Galyuon I (2013) In vivo models used for evaluation of potential antigastroduodenal ulcer agents. Ulcers 2013:1–12. https://doi.org/10.1155/2013/796405

Article  Google Scholar 

Ahmad A, Shah SA, Badshah H, Kim MJ, Ali T, Yoon GH et al (2016) Neuroprotection by vitamin C against ethanol -induced neuroinflammation associated neurodegeneration in developing rat brain. CNS & Neurological Disorders 15(3):360–370

Article  Google Scholar 

Ahmad G, Agarwal A, Esteves SC, Sharma R, Almasry M, Al-Gonaim A, Alhayaza G, Singh N, Kattan A, Sannaa L, W. M., Sabanegh E (2017) Ascorbic acid reduces redox potential in human spermatozoa subjected to heat-induced oxidative stress. Andrologia 49(6):e12773. https://doi.org/10.1111/and.12773

Article  Google Scholar 

Akita M, Nishikawa Y, Shigenobu Y, Ambe D, Morita T, Morioka K, Adachi K (2020) Correlation of proline, hydroxyproline and serine content, denaturation temperature and circular dichroism analysis of type I collagen with the physiological temperature of marine teleosts. Food Chem 329:126775. https://doi.org/10.1016/j.foodchem.2020.126775

Article  PubMed  Google Scholar 

Alberts A, Moldoveanu ET, Niculescu AG, Grumezescu AM (2025) Vitamin C: a comprehensive review of its role in health, disease prevention, and therapeutic potential. Molecules 30(3):748. https://doi.org/10.3390/molecules30030748

Article  PubMed  PubMed Central  Google Scholar 

Alhusaini AM, Fadda LM, Alsharafi H, Alshamary AF, Hasan IH (2022) L-ascorbic acid and curcumin prevent brain damage induced via lead acetate in rats: possible mechanisms. Dev Neurosci 44(2):59–66. https://doi.org/10.1159/000520118

Article  PubMed  Google Scholar 

Almasaudi SB, El-Shitany NA, Abbas AT, Abdel-dayem UA, Ali SS, Al Jaouni SK et al (2016) Antioxidant, anti‐inflammatory, and antiulcer potential of Manuka honey against gastric ulcer in rats. Oxid Med Cell Longev 2016:3643824. https://doi.org/10.1155/2016/3643824

Article  PubMed  Google Scholar 

Anguiano-Sevilla LA, Lugo-Cervantes E, Ordaz-Pichardo C, Rosas-Trigueros JL, Jaramillo-Flores ME (2018) Apoptosis induction of Agave Lechuguilla Torrey extract on human lung adenocarcinoma cells (SK-LU-1). Int J Mol Sci 19(12):3765. https://doi.org/10.3390/ijms19123765

Article  PubMed  PubMed Central  Google Scholar 

Antonisamy P, Duraipandiyan V, Aravinthan A, Al-Dhabi NA, Ignacimuthu S, Choi KC et al (2015) Protective effects of Friedelin isolated from Azima tetracantha lam. Against ethanol-induced gastric ulcer in rats and possible underlying mechanisms. Eur J Pharmacol 750:167–175. https://doi.org/10.1016/j.ejphar.2015.01.015

Article  PubMed  Google Scholar 

Arab HH, Salama SA, Omar HA, Arafa E-SA, Maghrabi IA (2015) Diosmin protects against ethanol-induced gastric injury in rats: novel anti-ulcer actions. PLoS ONE 10(3):e0122417. https://doi.org/10.1371/journal.pone.0122417

Article  PubMed  PubMed Central  Google Scholar 

Arun M, Asha V (2008) Gastroprotective effect of Dodonaea viscosa on various experimental ulcer models. J Ethnopharmacol 118:460–465. https://doi.org/10.1016/j.jep.2008.05.031

Article  PubMed  Google Scholar 

Aziz RS, Siddiqua A, Shahzad M, Shabbir A, Naseem N (2019) Oxyresveratrol ameliorates ethanol-induced gastric ulcer via downregulation of IL-6, TNF-α, NF-ĸB, and COX-2 levels, and upregulation of TFF-2 levels. Biomed Pharmacother 110:554–560. https://doi.org/10.1016/j.biopha.2018.12.002

Article  PubMed  Google Scholar 

Badr AM, El-Orabi NF, Ali RA (2019) The implication of the crosstalk of Nrf2 with noxs, and HMGB1 in ethanol-induced gastric ulcer: potential protective effect is afforded by raspberry ketone. PLoS ONE 14(8):e0220548. https://doi.org/10.1371/journal.pone.0220548

Article  PubMed  PubMed Central  Google Scholar 

Benjamin SW, Ruiqin F, Mohammad Z (2023) Vitamin C Promotes Wound Healing: The Use of in Vitro Scratch Assays to Assess Re-Epithelialization. In Cell Physiology-Annual Volume 2024; Angel, C., Ed.; IntechOpen: Rijeka, Croatia, 2023; Chap. 2

Beserra FP, Vieira AJ, Gushiken LFS, de Souza EO, Hussni MF, Hussni CA et al (2019) Lupeol, a dietary triterpene, enhances wound healing in streptozotocin-induced hyperglycemic rats with modulatory effects on inflammation, oxidative stress, and angiogenesis. Oxidative Medicine and Cellular Longevity, 2019, Article ID 3182627. https://doi.org/10.1155/2019/3182627

Carr AC, Frei B (2001) Vitamin C and cardiovascular diseases. Handbook of antioxidants. CRC, pp 166–185

Carr AC, Maggini S (2017) Vitamin C and immune function. Nutrients 9(11):1211. https://doi.org/10.3390/nu9111211

Article  PubMed  PubMed Central  Google Scholar 

Chaturvedi S, Azmi L, Shukla I et al (2018) Gastroprotective effect of formononetin against ethanol-induced gastric ulceration in rats via augmentation of cytoprotective markers and curtailing apoptotic gene expression. Pharmacogn Mag 14:605–612

Article  Google Scholar 

Chen J, Li L, Yi R, Xu N, Gao R, Hong B (2016) Extraction and characterization of acid-soluble collagen from scales and skin of tilapia (Oreochromis niloticus). LWT 66:453–459

Article  Google Scholar 

Cheng X, Shao Z, Li C, Yu L, Raja MA, Liu C (2017) Isolation, characterization and evaluation of collagen from jellyfish Rhopilema esculentum Kishinouye for use in hemostatic applications. PLoS ONE 12(1):e0169731. https://doi.org/10.1371/journal.pone.0169731

Article  PubMed  PubMed Central  Google Scholar 

Choubey P, Kwatra M, Pandey SN et al (2019) Ameliorative effect of Fisetin against lipopolysaccharide and restraint stress-induced behavioral deficits via modulation of NF-κB and IDO-1. Psychopharmacology 236:741–752. https://doi.org/10.1007/s00213-018-5102-1

Article  PubMed  Google Scholar 

Combs GF (2008) Vitamin C. The vitamins: fundamental aspects in nutrition and health, 3rd edn. Academic, pp 235–263

Coppola D, Lauritano C, Palma Esposito F, Riccio G, Rizzo C, de Pascale D (2021) Fish waste: from problem to valuable resource. Mar Drugs 19(2):116. https://doi.org/10.3390/md19020116

Article  PubMed  PubMed Central  Google Scholar 

Deding U, Ejlskov L, Grabas MPK et al (2016) Perceived stress as a risk factor for peptic ulcers: A register-based cohort study. BMC Gastroenterol 16:140. https://doi.org/10.1186/s12876-016-0535-4

Article  PubMed  PubMed Central  Google Scholar 

Duran Y, Karaboga I, Polat FR, Polat E, Erboga ZF, Ovali MA, Yilmaz A (2020) Royal jelly attenuates gastric mucosal injury in a rat ethanol-induced gastric injury model. Mol Biol Rep 47(11):8867–8879. https://doi.org/10.1007/s11033-020-05880-z

Article  PubMed  Google Scholar 

Durkin E, Moran AP, Hanson PJ (2006) Apoptosis induction in gastric mucous cells in vitro: lesser potency of Helicobacter pylori than Escherichia coli lipopolysaccharide, but positive interaction with ibuprofen. J Endotoxin Res 12(1):47–56. https://doi.org/10.1179/096805106X89080

Article  PubMed  Google Scholar 

Elbialy ZI, Atiba A, Abdelnaby A, Al HII, Elsheshtawy A, El-Serehy HA, Abdel-Daim MM, Fadl SE, Assar DH (2020) Collagen extract obtained from nile tilapia (Oreochromis niloticus L.) skin accelerates wound healing in rat model via up regulating VEGF, bFGF, and alpha-SMA genes expression. BMC Vet Res 16:352. https://doi.org/10.1186/s12917-020-02568-7

Article  PubMed  PubMed Central  Google Scholar 

Ennaas N, Hammami R, Gomaa A, Bédard F, Biron E, Subirade M, Beaulieu L, Fliss I (2016) Collagencin, an antibacterial peptide from fish collagen: activity, structure and interaction dynamics with membrane. Biochem Biophys Res Commun 473(2):642–647. https://doi.org/10.1016/j.bbrc.2016.03.121

Article  PubMed  Google Scholar 

Felician FF, Xia C, Qi W, Xu H (2018) Collagen from marine biological sources and medical applications. Chem Biodivers 15(6):e1700557. https://doi.org/10.1002/cbdv.201700557

Article  PubMed  Google Scholar 

Ferraro V, Anton M, Santé-Lhoutellier V (2016) The sisters α-helices of collagen, Elastin and keratin recovered from animal by-products: functionality, bioactivity and trends of application. Trends Food Sci Technol 51:65–75. https://doi.org/10.1016/j.tifs.2016.03.006

Article  Google Scholar 

Fischer CP, Hiscock NJ, Penkowa M, Basu S, Vessby B, Kallner A, Sjöberg L-B, Pedersen BK (2004) Supplementation with vitamins C and E inhibits the release of interleukin-6 from contracting human skeletal muscle. J Physiol 558(2):633–645. https://doi.org/10.1113/jphysiol.2004.061424

Article  PubMed  PubMed Central  Google Scholar 

Frei B, England L, Ames B (1989) Ascorbate is an outstanding antioxidant in human blood plasma. Proc Natl Acad Sci U S A 86(16):6377–6381. https://doi.org/10.1073/pnas.86.16.6377