Liao, J. et al. Single-cell RNA sequencing of human kidney. Sci. Data 7, 4 (2020).
Article CAS PubMed PubMed Central Google Scholar
Agarwal, R. et al. Finerenone with empagliflozin in chronic kidney disease and type 2 diabetes. N. Engl. J. Med. 393, 533–543 (2025).
Article CAS PubMed Google Scholar
Bassanese, G., Wlodkowski, T., Servais, A., Heidet, L., Roccatello, D. & Emma, F. et al. The European Rare Kidney Disease Registry (ERKReg): objectives, design and initial results. Orphanet. J. Rare Dis. 16, 251 (2021).
Article PubMed PubMed Central Google Scholar
Ng, M. S. Y., Kaur, G., Francis, R. S., Hawley, C. M. & Johnson, D. W. Drug repurposing for glomerular diseases: an underutilized resource. Nat. Rev. Nephrol. 20, 707–721 (2024).
Ashuntantang, G., Miljeteig, I. & Luyckx, V. A. Bedside rationing and moral distress in nephrologists in sub-Saharan Africa. BMC Nephrol. 23, 196 (2022).
Article PubMed PubMed Central Google Scholar
World Health Organization. Reducing the burden of noncommunicable diseases through promotion of kidney health and strengthening prevention and control of kidney disease. WHO https://apps.who.int/gb/ebwha/pdf_files/EB156/B156_(20)-en.pdf (accessed 10 February 2025).
World Heart Federation. Driving sustainable action for circulatory health: white paper on circulatory health. World Heart Federation https://world-heart-federation.org/resource/white-paper-for-circulatory-health/drivingsustainableactionforcirculatoryhealth (2018).
Chen, T. K. et al. Advances in the management of chronic kidney disease. BMJ 383, e074216 (2023).
Beck, L. H. et al. M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. N. Engl. J. Med. 361, 11–21 (2009).
Article CAS PubMed PubMed Central Google Scholar
Remuzzi, G. et al. Rituximab for idiopathic membranous nephropathy. Lancet 360, 923–924 (2002).
Article CAS PubMed Google Scholar
Noris, M., Mescia, F. & Remuzzi, G. STEC-HUS, atypical HUS and TTP are all diseases of complement activation. Nat. Rev. Nephrol. 8, 622–633 (2012).
Article CAS PubMed Google Scholar
Pullen, L. C. Xenotransplantation moves toward clinical trials. Am. J. Transplant. 24, 509–511 (2024).
Palmer, B. F. & Clegg, D. J. Kidney-protective effects of SGLT2 inhibitors. Clin. J. Am. Soc. Nephrol. 18, 279–289 (2022).
Article PubMed PubMed Central Google Scholar
Devarajan, P. M. et al. Emerging role of clinical genetics in CKD. Kidney Med. 4, 100435 (2022).
Article PubMed PubMed Central Google Scholar
Hu, T., Chitnis, N., Monos, D. & Dinh, A. Next-generation sequencing technologies: an overview. Hum. Immunol. 82, 801–811 (2021).
Article CAS PubMed Google Scholar
World Health Organization. Hypertension. WHO https://www.who.int/news-room/fact-sheets/detail/hypertension (accessed 27 February 2025).
Liu, H. et al. Kidney multiome-based genetic scorecard reveals convergent coding and regulatory variants. Science 387, eadp4753 (2025).
Article CAS PubMed PubMed Central Google Scholar
Park, J. et al. Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease. Science 360, 758–763 (2018).
Article CAS PubMed PubMed Central Google Scholar
Lake, B. B. et al. An atlas of healthy and injured cell states and niches in the human kidney. Nature 619, 585–594 (2023).
Article CAS PubMed PubMed Central Google Scholar
Abedini, A. et al. Single-cell multi-omic and spatial profiling of human kidneys implicates the fibrotic microenvironment in kidney disease progression. Nat. Genet. 56, 1712–1724 (2024).
Article CAS PubMed PubMed Central Google Scholar
Neuen, B. L. et al. Estimated lifetime cardiovascular, kidney, and mortality benefits of combination treatment with SGLT2 inhibitors, GLP-1 receptor agonists, and nonsteroidal MRA compared with conventional care in patients with type 2 diabetes and albuminuria. Circulation 149, 450–462 (2024).
Article CAS PubMed Google Scholar
Berns, J. S., Glickman, A. & McCoy, M. S. Dialysis-facility joint-venture ownership — hidden conflicts of interest. N. Engl. J. Med. 379, 1295–1297 (2018).
Gregg, E. W. et al. Changes in diabetes-related complications in the United States, 1990–2010. N. Engl. J. Med. 370, 1514–1523 (2014).
Article CAS PubMed Google Scholar
Ranchin, B. et al. Devices for long-term hemodialysis in small children — a plea for action. Kidney Int. 103, 1038–1040 (2023).
Deesker, L. J. et al. Global access to management of primary hyperoxaluria: a survey on behalf of OxalEurope, G&K working group of the ERA, and ESPN. Nephrol. Dial. Transplant. https://doi.org/10.1093/ndt/gfaf035 (2025).
Article PubMed PubMed Central Google Scholar
Rubin, R. It takes an average of 17 years for evidence to change practice — the burgeoning field of implementation science seeks to speed things up. JAMA 329, 1333–1336 (2023).
Neuen, B. L. et al. Estimating the population-level impacts of improved uptake of SGLT2 inhibitors in patients with chronic kidney disease: a cross-sectional observational study using routinely collected Australian primary care data. Lancet Reg. Health West Pac. 43, 100988 (2024).
Moore, T. J., Zhang, H., Anderson, G. & Alexander, G. C. Estimated costs of pivotal trials for novel therapeutic agents approved by the US food and drug administration, 2015–2016. JAMA Intern. Med. 178, 1451–1457 (2018).
Article PubMed PubMed Central Google Scholar
Tolvaptan (Jinarc) and polycystic kidney disease. Too many adverse effects, uncertain efficacy. Prescrire Int. 26, 262 (2017).
GBD 2021 Causes of Death Collaborators. Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet 403, 2100–2132 (2024).
Lou-Meda, R. & Pérez, J. B. Reducing the burden of chronic kidney disease in the world. Lancet 405, 1810 (2025).
Nangaku, M. et al. International Society of Nephrology first consensus guidance for preclinical animal studies in translational nephrology. Kidney Int. 104, 36–45 (2023).
Vivante, A. Genetics of chronic kidney disease. N. Engl. J. Med. 391, 627–639 (2024).
Article CAS PubMed Google Scholar
Tasca, P. et al. Application of spatial-omics to the classification of kidney biopsy samples in transplantation. Nat. Rev. Nephrol. 20, 755–766 (2024).
Reznichenko, A. et al. Unbiased kidney-centric molecular categorization of chronic kidney disease as a step towards precision medicine. Kidney Int 105, 1263–1278 (2024).
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