Ahmed F, Tscharke B, O’Brien JW, Thompson J, Zheng Q, Mueller JF, Thomas KV (2021) Quantification of selected analgesics and their metabolites in influent wastewater by liquid chromatography tandem mass spectrometry. Talanta 234:122627. https://doi.org/10.1016/j.talanta.2021.122627
Ajibola AS, Fawole ST, Ajibola FO, Adewuyi GO (2021) Diclofenac and ibuprofen determination in sewage sludge using a QuEChERS approach: occurrence and ecological risk assessment in three Nigerian wastewater treatment plants. Bull Environ Contam Toxicol 106:690–699. https://doi.org/10.1007/s00128-021-03139-1
Al-Asheh S, Bagheri M, Aidan A (2021) Membrane bioreactor for wastewater treatment: a review. Case Stud Chem Environ Eng 4:100109. https://doi.org/10.1016/j.cscee.2021.100109
Al-rimawi F, Daana M, Khamis M, Karaman R, Khoury H, Qurie M (2019) Removal of selected pharmaceuticals from aqueous solutions using natural Jordanian zeolite. Arab J Sci Eng 44:209–215. https://doi.org/10.1007/s13369-018-3406-9
Alkahtani MQ, Morabet RE, Khan RA, Khan AR (2024) Pharmaceuticals removal from hospital wastewater by fluidized aerobic bioreactor in combination with tubesettler. Sci Rep 14:24052. https://doi.org/10.1038/s41598-024-73494-6
Althagafi A, Alshibani M, Alshehri S, Noor A, Baglagel A, Almeleebia T (2022) Assessment of knowledge and awareness of safe disposal of unused or expired medication in Saudi Arabia: a cross-sectional study. Saudi Pharm J 30(11):1672–1678. https://doi.org/10.1016/j.jsps.2022.09.012
Alvear-Daza JJ, Rengifo-Herrera JA, Pizzio LR (2024) Performance and optimization of diclofenac and ibuprofen adsorption onto activated carbon synthesized from sunflower seed shell (Helianthus annuus) in natural groundwater samples. Adsorption 30:783–800. https://doi.org/10.1007/s10450-024-00461-y
Amirimoghadam P, Zihayat B, Dabaghzadeh F, Kiani K, Ebrahimi J, Ghazanfari M, Arjmand S (2017) Evaluation and awareness of over the counter use of non-steroidal anti-inflammatory drugs. J Appl Pharm Sci 7(3):154–159. https://doi.org/10.7324/JAPS.2017.70325
Antal I, Kormosh Z, Kotsan I, Kormosh N, Savchuk T, Korolchuk S, Yurchenko O, Golub S, Suprunovich S, Panchenko Y, Tkach V (2021) Selective extraction-photometric determination of non-steroidal anti-inflammatory drugs. Pharm Chem J 55:516–523. https://doi.org/10.1007/s11094-021-02450-9
Antos J, Zembrzuska J, Jeż-Walkowiak J, Makała A, Ginter-Kramarczyk D, Kruszelnicka I, Uwimpaye F (2023) Monitoring of Contamination of the Warta River in Poznan by Non-Steroidal Anti-Inflammatory Drugs and Antibiotics. Water 15(15):2716. https://doi.org/10.3390/w15152716
Arguello-Pérez MÁ, Ramírez-Ayala E, Mendoza-Pérez JA, Monroy-Mendieta MM, Vázquez-Guevara M, Lezama-Cervantes C, Godínez-Domínguez E, Silva-Bátiz FdA, Tintos-Gómez A (2020) Determination of the bioaccumulative potential risk of emerging contaminants in fish muscle as an environmental quality indicator in coastal lagoons of the Central Mexican Pacific. Water 12(10):2721. https://doi.org/10.3390/w12102721
Ascar L, Ahumada I, López A, Quintanilla F, Leiva K (2013) Nonsteroidal anti-inflammatory drug determination in water samples by HPLC-DAD under isocratic conditions. J Braz Chem Soc 24:1160–1166. https://doi.org/10.5935/0103-5053.20130150
Ashfaq M, Khan KN, Rehman MSU, Mustafa G, Nazar MF, Sun Q, Iqbal J, Mulla SI, Yu CP (2017) Ecological risk assessment of pharmaceuticals in the receiving environment of pharmaceutical wastewater in Pakistan. Ecotoxicol Environ Saf 136:31–39. https://doi.org/10.1016/j.ecoenv.2016.10.029
Aurelio-Soria D, Alvarez-Romero GA, Paez-Hernandez ME, Perez-Silva I, Franco-Guzman M, Islas G, Ibarra IS (2025) Multi-template molecularly imprinted polymers coupled with a solid-phase extraction system in the selective determination of non-steroidal anti-inflammatory drugs (NSAIDs) in environmental water samples. Separations 12(6):140. https://doi.org/10.3390/separations12060140
Ayala Cabana L, de Santiago-Martín A, Meffe R, López-Heras I, de Bustamante I (2024) Pharmaceutical and trace metal interaction within the water–soil–plant continuum: implications for human and soil health. Toxics 12(7):457. https://doi.org/10.3390/toxics12070457
Aziz KHH, Miessner H, Mueller S, Kalass D, Moeller D, Khorshid I, Rashid MAM (2017) Degradation of pharmaceutical diclofenac and ibuprofen in aqueous solution, a direct comparison of ozonation, photocatalysis, and non-thermal plasma. Chem Eng J 313:1033–1041. https://doi.org/10.1016/j.cej.2016.10.137
Azizpourian M, Kouchakzadeh G, Derikvand Z (2023) Removal of pharmaceutical compounds from aqueous solution by clay-based synthesized adsorbents: adsorption kinetics and isotherms studies. Chem Pap 77:4245–4264. https://doi.org/10.1007/s11696-023-02774-8
Azzouz A, Jurado-Sánchez B, Souhail B, Ballesteros E (2011) Simultaneous determination of 20 pharmacologically active substances in cow’s milk, goat’s milk, and human breast milk by gas chromatography–mass spectrometry. J Agri Food Chem 59(9):5125–5132. https://doi.org/10.1021/jf200364w
Bandura L, Białoszewska M, Malinowski S, Franus W (2021) Adsorptive performance of fly ash-derived zeolite modified by β-cyclodextrin for ibuprofen, bisphenol A and caffeine removal from aqueous solutions–equilibrium and kinetic study. Appl Surf Sci 562:150160. https://doi.org/10.1016/j.apsusc.2021.150160
Baranowska I, Kowalski B (2011) Using HPLC method with DAD detection for the simultaneous determination of 15 drugs in surface water and wastewater. Pol J Environ Stud 20(1):21
Beldean-Galea MS, Klein R, Coman MV (2020) Simultaneous determination of four nonsteroidal anti-inflammatory drugs and three estrogen steroid hormones in wastewater samples by dispersive liquid–liquid microextraction based on solidification of floating organic droplet and HPLC. J AOAC Int 103(2):392–398. https://doi.org/10.5740/jaoacint.19-0258
Bekele KM, Abay AM, Mengistu KA, Atsbeha BW, Demeke CA, Belay WS, Yimenu DK (2020) Knowledge, attitude, and practice on over-the-counter drugs among pharmacy and medical students: a facility-based cross-sectional study. Integr Pharm Res Pract. https://doi.org/10.2147/IPRP.S266786
Białk-Bielińska A, Grabarczyk Ł, Mulkiewicz E, Puckowski A, Stolte S, Stepnowski P (2022) Mixture toxicity of six pharmaceuticals towards Aliivibrio fischeri, Daphnia magna, and Lemna minor. Environ Sci Pollut Res 29:26977–26991. https://doi.org/10.1007/s11356-021-17928-y
Bonnefille B, Arpin-Pont L, Gomez E, Fenet H, Courant F (2017) Metabolic profiling identification of metabolites formed in Mediterranean mussels (Mytilus galloprovincialis) after diclofenac exposure. Sci Total Environ 583:257–268. https://doi.org/10.1016/j.scitotenv.2017.01.063
Božić Luburić Đ, Bilandžić N, Varenina I, Varga I, Solomun Kolanović B, Vratarić D, Radojčić Redovniković I (2021) The analysis of acidic and basic non-steroidal anti-inflammatory drugs in milk and muscle samples: a comprehensive analytical approach using UHPLC-MS/MS. Food Addit Contam Part A 39(2):256–271. https://doi.org/10.1080/19440049.2021.1994157
Brune K, Patrignani P (2015) New insights into the use of currently available non-steroidal anti-inflammatory drugs. J Pain Res 8:105–118. https://doi.org/10.2147/jpr.s75160
Calero-Díaz G, Monteoliva-García A, Leyva-Díaz JC, López-López C, Martín-Pascual J, Torres JC, Poyatos JM (2017) Impact of ciprofloxacin, carbamazepine and ibuprofen on a membrane bioreactor system: Kinetic study and biodegradation capacity. J Chem Technol Biotechnol 92(12):2944–2951. https://doi.org/10.1002/jctb.5316
Candido JP, Andrade SJ, Fonseca AL, Silva FS, Silva MR, Kondo MM (2016) Ibuprofen removal by heterogeneous photocatalysis and ecotoxicological evaluation of the treated solutions. Environ Sci Pollut Res 23:19911–19920. https://doi.org/10.1007/s11356-016-6947-z
Casado N, Morante-Zarcero S, Pérez-Quintanilla D, Sierra I (2016) Application of a hybrid ordered mesoporous silica as sorbent for solid-phase multi-residue extraction of veterinary drugs in meat by ultra-high-performance liquid chromatography coupled to ion-trap tandem mass spectrometry. J Chromatogr A 1459:24–37. https://doi.org/10.1016/j.chroma.2016.06.077
Codex Alimentarius (2017) Guidelines on performance criteria for methods of analysis for the determination of pesticide residues in food and feed. CAC/GL 90–2017. Rome: FAO/WHO.
Commission Implementing Decision (EU) 2022/679 of 19 January 2022 establishing a watch list of substances and compounds of concern for water intended for human consumption as provided for in Directive (EU) 2020/2184 of the European Parliament and of the Council (notified under document C(2022) 142). https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX%3A32022D0679. 01 July 2025
Commission Regulation (EU) No 37/2010 of 22 December 2009 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin (Text with EEA relevance). https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32010R0037. Accessed 28 Oct 2024
Cornejo J, González-Pérez DM, Pérez JI, Gómez MA (2019) Ibuprofen removal by a microfiltration membrane bioreactor during the startup phase. J Environ Sci Health A 55(4):374–384. https://doi.org/10.1080/10934529.2019.1697587
Dasenaki ME, Thomaidis NS (2015) Multi-residue determination of 115 veterinary drugs and pharmaceutical residues in milk powder, butter, fish tissue and eggs using liquid chromatography–tandem mass spectrometry. Anal Chim Acta 880:103–121. https://doi.org/10.1016/j.aca.2015.04.013
Davey CJ, Kraak MH, Praetorius A, Ter Laak TL, van Wezel AP (2022) Occurrence, hazard, and risk of psychopharmaceuticals and illicit drugs in European surface waters. Water Res 222:118878. https://doi.org/10.1016/j.watres.2022.118878
Davis JS, Lee HY, Kim J, Advani SM, Peng HL, Banfield E, Hawk ET, Chang S, Frazier-Wood AC (2017) Use of non-steroidal anti-inflammatory drugs in US adults: changes over time and by demographic. Open Heart 4(1):e000550. https://doi.org/10.1136/openhrt-2016-000550
de Melo Pirete L, Camargo FP, Dornelles HS, Granatto CF, Sakamoto IK, Grosseli GM, Fadini PS, Silva EL, Varesche MBA (2022) Biodegradation of diclofenac and ibuprofen in fluidized bed reactor applied to sanitary sewage treatment in acidogenic and denitrifying conditions. J Water Process Eng 49:102964. https://doi.org/10.1016/j.jwpe.2022.102964
Dehmani Y, Mohammed BB, Oukhrib R, Dehbi A, Lamhasni T, Brahmi Y, El-Kordy A, Franco DSP, Georgin J, Lima EC, Alrashdi AA, Tijani N, Abouarnadasse S (2024) Adsorption of various inorganic and organic pollutants by natural and synthetic zeolites: a critical review. Arab J Chem 17(1):105474. https://doi.org/10.1016/j.arabjc.2023.105474
Comments (0)