Ferlay J, Ervik M, Lam F, LaveRCanne M, Colombet M, Mery L et al (2024) Global Cancer Observatory: Cancer Today. Lyon, France: International Agency for Research on Cancer. Available from: https://gco.iarc.who.int/today Accessed 24 Apr 2024

Abdollah F, Gandaglia G, Thuret R, Schmitges J, Tian Z, Jeldres C et al (2013) Incidence, survival and mortality rates of stage-specific bladder cancer in United States: a trend analysis. Cancer Epidemiol 37(3):219–225

PubMed  Google Scholar 

Chalasani V, Chin JL, Izawa JI (2009) Histologic variants of urothelial bladder cancer and nonurothelial histology in bladder cancer. Can Urol Assoc J 3:S193–S198

PubMed Central  PubMed  Google Scholar 

Rice KR, Koch MO, Kao CS, Pedrosa JA, Kaimakliotis HZ, MasteRCon TA et al (2015) Lymph node metastases in patients with urothelial carcinoma variants: influence of the specific variant on nodal histology. Urol Oncol 33(20):e23–e29

Google Scholar 

Abd El-Latif A, Watts KE, Elson P, Fergany A, Hansel DE (2013) The sensitivity of initial transurethral resection or biopsy of bladder tumor(s) for detecting bladder cancer variants on radical cystectomy. J Urol 189:1263–1267

PubMed  Google Scholar 

Weizer AZ, Wasco MJ, Wang R, Daignault S, Lee CT, Shah RB (2009) Multiple adverse histological features increase the odds of under staging T1 bladder cancer [published correction appears in J Urol. 2009 Sep;182(3):1237]. J Urol 182(1):59–65

Witjes JA, Babjuk M, Bellmunt J, Bruins HM, De Reijke TM, De Santis M et al (2020) EAU-ESMO Consensus Statements on the Management of Advanced and Variant Bladder Cancer-An International Collaborative Multistakeholder Effort†: Under the Auspices of the EAU-ESMO Guidelines Committees. Eur Urol 77(2):223–250

PubMed  Google Scholar 

Pons F, Orsola A, Morote J, Bellmunt J (2011) Variant forms of bladder cancer: basic considerations on treatment approaches. Curr Oncol Rep 13(3):216–221

PubMed  Google Scholar 

Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM (2016) The 2016 WHO Classification of TumouRC of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular TumouRC. Eur Urol 70(1):93–105

PubMed  Google Scholar 

EAU Guidelines (2025) Edn. presented at the EAU annual congress Madrid 

Deuker M, Martin T, Stolzenbach F, Rosiello G, Collà Ruvolo C, Nocera L et al (2021) Bladder Cancer: A Comparison Between Non-urothelial Variant Histology and Urothelial Carcinoma Across All Stages and Treatment Modalities. Clin Genitourin Cancer 19(1):60-68.e1

PubMed  Google Scholar 

DuRCun F, Elshabrawy A, Wang H, Wu S, Liss MA, Kaushik D et al (2022Jun) Histological variants of non-muscle invasive bladder cancer: Survival outcomes of radical cystectomy vs. bladder preservation therapy. Urol Oncol 40(6):275.e1-275.e10

Google Scholar 

Pyrgidis N, Sokolakis I, Haltmair G, Hatzichristodoulou G (2023) The perioperative and long-term outcomes of patients with variant histology bladder cancer undergoing radical cystectomy: A propensity score-matched analysis with pure urothelial carcinoma. Actas Urol Esp (Engl Ed) 47(10):645–653. English, Spanish

Ramos P, Mateus A, Manso M, Botelho F, Silva A, Silva J et al (2024) Prognostic impact of variant histology in bladder cancer: would early and aggressive treatment shift the paradigm? Urol Oncol 42(5):161.e1-161.e8

PubMed  Google Scholar 

Lin HY, Ye H, Kernen KM, Hafron JM, Krauss DJ (2018) National Cancer Database Comparison of Radical Cystectomy vs Chemoradiotherapy for Muscle-Invasive Bladder Cancer: Implications of Using Clinical vs Pathologic Staging. Cancer Med 7(11):5370–5381

PubMed Central  CAS  PubMed  Google Scholar 

Krasnow RE, Drumm M, Roberts HJ, Niemierko A, Wu CL, Wu S et al (2017) Clinical Outcomes of Patients with Histologic Variants of Urothelial Cancer Treated with Trimodal Bladder-sparing Therapy. Eur Urol 72(1):54–60

PubMed  Google Scholar 

Bamias A, Stenzl A, Brown SL, Albiges L, Babjuk M, Birtle A et al (2023) Definition and Diagnosis of Oligometastatic Bladder Cancer: A Delphi Consensus Study Endorsed by the European Association of Urology, European Society for Radiotherapy and Oncology, and European Society of Medical Oncology Genitourinary Faculty. Eur Urol 84(4):381–389

PubMed  Google Scholar 

Alfred Witjes J, Max Bruins H, Carrión A, Cathomas R, Compérat E, Efstathiou JA et al (2024) European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2023 Guidelines. Eur Urol 85(1):17–31

CAS  PubMed  Google Scholar 

Kouba E, Cheng L (2016) Neuroendocrine tumors of the urinary bladder according to the 2016 World Health Organization classification: molecular and clinical characteristics. Endocr Pathol 27(3):188–199. https://doi.org/10.1007/s12022-016-9444-5

Article  PubMed  Google Scholar 

Jung K, Ghatalia P, Litwin S, Horwitz EM, Uzzo RG, Greenberg RE et al (2017) Small-cell carcinoma of the bladder: 20-year single-institution retrospective review. Clin Genitourin Cancer 15(3):e337–e343. https://doi.org/10.1016/j.clgc.2016.09.005

Article  PubMed  Google Scholar 

Willis DL, Flaig TW, Hansel DE, Milowsky MI, Grubb RL, Al-Ahmadie HA et al (2014) Micropapillary bladder cancer: current treatment patterns and review of the literature. Urol Oncol 32(6):826–832. https://doi.org/10.1016/j.urolonc.2014.01.020

Article  PubMed Central  PubMed  Google Scholar 

Lopez-Beltran A, Requena MJ, Montironi R, Blanca A, Cheng L (2009) Plasmacytoid urothelial carcinoma of the bladder. Hum Pathol 40(7):1023–1028. https://doi.org/10.1016/j.humpath.2009.01.001

Article  PubMed  Google Scholar 

Minato A, Noguchi H, Tomisaki I, Fukuda A, Kubo T, Nakayama T et al (2018) Clinical significance of squamous differentiation in urothelial carcinoma of the bladder. Cancer Control 25(1):1073274818800269. https://doi.org/10.1177/1073274818800269

Article  PubMed Central  PubMed  Google Scholar 

Kachnic LA, Kaufman DS, Heney NM, Althausen AF, Griffin PP, Zietman AL et al (1997) Bladder preservation by combined modality therapy for invasive bladder cancer. J Clin Oncol 15(3):1022–1029. https://doi.org/10.1200/JCO.1997.15.3.1022

Article  CAS  PubMed  Google Scholar