Remission Outcomes Following Hysterectomy in Gestational Trophoblastic Neoplasia: A Systematic Review and Meta-Analysis

Horowitz NS, Eskander RN, Adelman MR, Burke W (2021) Epidemiology, diagnosis, and treatment of gestational trophoblastic disease: a society of gynecologic oncology evidenced-based review and recommendation. Gynecol Oncol 163(3):605–613

PubMed  CAS  Google Scholar 

Ngan HYS, Seckl MJ, Berkowitz RS, Xiang Y, Golfier F, Sekharan PK et al (2021) Diagnosis and management of gestational trophoblastic disease: 2021 update. Int J Gynaecol Obstet 155(S1):86–93

PubMed  PubMed Central  CAS  Google Scholar 

Ramesan CK, Thomas DS, Sebastian A, Thomas V, Thomas A, George R et al (2021) Role of hysterectomy in gestational trophoblastic neoplasia. Indian J Surg Oncol 12(2):386–390

PubMed  PubMed Central  CAS  Google Scholar 

Lurain JR (2011) Gestational trophoblastic disease part II: classification and management of gestational trophoblastic neoplasia. Am J Obstet Gynecol 204(1):11–18

PubMed  Google Scholar 

Eysbouts YK, Massuger LFAG, IntHout J, Lok CAR, Sweep FCGJ, Ottevanger PB (2017) The added value of hysterectomy in the management of gestational trophoblastic neoplasia. Gynecol Oncol 145(3):536–542

PubMed  CAS  Google Scholar 

National Comprehensive Cancer Network. Gestational trophoblastic neoplasia. NCCN Clinical practice guidelines in oncology (NCCN Guidelines®), Version 3.2025

Pisal N, North C, Tidy J, Hancock B (2002) Role of hysterectomy in management of gestational trophoblastic disease. Gynecol Oncol 87(2):190–192

PubMed  Google Scholar 

Page M, McKenzie J, Bossuyt P, Boutron I, Hoffman T, Mulrow C (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71

PubMed  PubMed Central  Google Scholar 

Brooke BS, Schwartz TA, Pawlik TM (2021) Moose reporting guidelines for meta-analyses of observational studies. JAMA Surg 156(8):787–788

PubMed  Google Scholar 

MedCalc Statistical Software version 19.5.1 MedCalc Software Ltd., Ostend. https://www.medcalc.org

Clark RM, Nevadunsky NS, Ghosh S, Goldstein DP, Berkowitz RS (2010) The evolving role of hysterectomy in gestational trophoblastic neoplasia at the New England trophoblastic disease center. J Reprod Med 55(5–6):194–198

PubMed  Google Scholar 

Pires LV, Uberti EM, Fajardo Mdo C, et al (2012) Role of hysterectomy in the management of patients with gestational trophoblastic neoplasia: importance of receiving treatment in reference centers. J Reprod Med 57(7-8):359–368

Fang J, Wang S, Han X, An R, Wang W, Xue Y (2012) Role of adjuvant hysterectomy in management of high-risk gestational trophoblastic neoplasia. Int J Gynecol Cancer 22(3):509–514

PubMed  Google Scholar 

Kulhan NG, Kulhan M, Nayki UA, Nayki C, Ata N, Ulug P et al (2017) The role of hysterectomy in the treatment of gestational trophoblastic neoplasms: a single-center experience. Archives of Medical Science – Civilization Diseases 2(1):37–40

Google Scholar 

Bolze PA, Mathe M, Hajri T, You B, Dabi Y, Schott AM et al (2018) First-line hysterectomy for women with low-risk non-metastatic gestational trophoblastic neoplasia no longer wishing to conceive. Gynecol Oncol 150(2):282–287

PubMed  Google Scholar 

Seckl MJ, Sebire NJ, Fisher RA, Golfier F, Massuger L, Sessa C et al (2013) Gestational trophoblastic disease: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol Off J Eur Soc Med Oncol 24(Suppl 6):vi39-50

Google Scholar 

Berkowitz RS, Goldstein DP (2009) Current management of gestational trophoblastic diseases. Gynecol Oncol 112(3):654–662

PubMed  CAS  Google Scholar 

Lima LDLA, Padron L, Câmara R, Sun SY, Rezende Filho J, Braga A (2017) The role of surgery in the management of women with gestational trophoblastic disease. Rev Colégio Bras Cir 44(1):94–101

Google Scholar 

Ghaemmaghami F, Ashrafgangooei T, Gillani MM, Mosavi A, Behtash N (2011) Major surgeries performed for gestational trophoblastic neoplasms in a teaching hospital in Tehran, Iran. J Gynecol Oncol 22(2):97–102

PubMed  PubMed Central  Google Scholar 

Eoh KJ, Chung YS, Yim GW, Nam EJ, Kim S, Kim SW et al (2015) Role of surgical therapy in the management of gestational trophoblastic neoplasia. Obstet Gynecol Sci 58(4):277

PubMed  PubMed Central  Google Scholar 

Cagayan MSFS (2012) High-risk metastatic gestational trophoblastic neoplasia. Primary management with EMA-CO (etoposide, methotrexate, actinomycin D, cyclophosphamide and vincristine) chemotherapy. J Reprod Med 57(5–6):231–6

PubMed  CAS  Google Scholar 

Lurain JR, Singh DK, Schink JC (2006) Role of surgery in the management of high-risk gestational trophoblastic neoplasia. J Reprod Med 51(10):773–776

PubMed  Google Scholar 

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