Fan CW, Chen PH, Jhou HJ, Cheng YC. Negative pressure wound management in perineal wound status post abdominoperineal resection and extralevator abdominoperineal excision: a meta-analysis and trial sequential analysis. Int J Colorectal Dis. 2023;38(1):73.

PubMed  Google Scholar 

Althumairi AA, Canner JK, Gearhart SL, Safar B, Sacks J, Efron JE. Predictors of perineal wound complications and prolonged time to perineal wound healing after abdominoperineal resection. World J Surg. 2016;40(7):1755–62.

PubMed  Google Scholar 

Yamamoto T, Kobayashi Y, Miyata H, Konno H, Mori M, Watanabe M, et al. 2023 National Clinical Database Annual Report by the Japan Surgical Society. Surg Today. 2025;55(3):295–334.

PubMed  PubMed Central  Google Scholar 

Salmenkylä T, Kilpivaara K, Ohtonen P, Rautio T, Mäkäräinen E. Case control study investigating the clinical utility of NPWT in the perineal region following abdominoperineal resection for rectal adenocarcinoma: a single center study. BMC Surg. 2022;22(1):296.

PubMed  PubMed Central  Google Scholar 

Musters GD, Sloothaak DA, Roodbeen S, van Geloven AA, Bemelman WA, Tanis PJ. Perineal wound healing after abdominoperineal resection for rectal cancer: a two-centre experience in the era of intensified oncological treatment. Int J Colorectal Dis. 2014;29(9):1151–7.

PubMed  Google Scholar 

Hoare D, Maw A, Gollins S. Does pre-operative chemoradiotherapy cause wound complications after abdominoperineal excision for rectal cancer? An observational study. Int J Surg. 2013;11(5):395–9.

PubMed  Google Scholar 

Hultman CS, Sherrill MA, Halvorson EG, Lee CN, Boggess JF, Meyers MO, et al. Utility of the omentum in pelvic floor reconstruction following resection of anorectal malignancy: patient selection, technical caveats, and clinical outcomes. Ann Plast Surg. 2010;64(5):559–62.

CAS  PubMed  Google Scholar 

Benedict KC, Songcharoen SJ, Stephens KL, Winter AL, Edwards SR, Campbell CA, et al. Comparison of inferior gluteal artery perforator flaps versus vertical rectus abdominis musculocutaneous flaps in the reconstruction of perineal wounds. J Plast Reconstr Aesthet Surg. 2023;84:514–20.

PubMed  Google Scholar 

Gultekin S, Gartrell R, Lu L, Croxford M, Faragher I, Chan STF, et al. Outcomes of perineal reconstruction with inferior gluteal artery myocutaneous flaps and primary closure following abdominoperineal resection. ANZ J Surg. 2022;92(11):2968–73.

PubMed  Google Scholar 

Morykwas MJ, Argenta LC, Shelton-Brown EI, McGuirt W. Vacuum-assisted closure: a new method for wound control and treatment: animal studies and basic foundation. Ann Plast Surg. 1997;38(6):553–62.

CAS  PubMed  Google Scholar 

Argenta LC, Morykwas MJ. Vacuum-assisted closure: a new method for wound control and treatment: clinical experience. Ann Plast Surg. 1997;38(6):563–76.

CAS  PubMed  Google Scholar 

Walma MS, Burbach JP, Verheijen PM, Pronk A, van Grevenstein WM. Vacuum-assisted closure therapy for infected perineal wounds after abdominoperineal resection. A retrospective cohort study. Int J Surg. 2016;26:18–24.

CAS  PubMed  Google Scholar 

Komono A, Yoshimatsu G, Kajitani R, Matsumoto Y, Aisu N, Hasegawa S. Reconstruction with omental flap and negative pressure wound therapy after total pelvic exenteration of anal fistula cancer: a case report. Surg Case Rep. 2022;8(1):116.

PubMed  PubMed Central  Google Scholar 

Kaneko T, Funahashi K, Ushigome M, Kagami S, Goto M, Koda T, et al. Incisional negative pressure wound therapy to reduce perineal wound infection after abdominoperineal resection. Int Wound J. 2021;18(1):103–11.

PubMed  Google Scholar 

Javed AA, Teinor J, Wright M, Ding D, Burkhart RA, Hundt J, et al. Negative pressure wound therapy for surgical-site infections: a randomized trial. Ann Surg. 2019;269(6):1034–40.

PubMed  Google Scholar 

Yoshida Y, Tanaka S, Fujimoto T, Nakagawa Y, Kinoshita M, Takahashi M, et al. Effectiveness of negative pressure wound therapy in preventing incisional surgical site infection after stoma closure: a single institutional retrospective study. Surg Today. 2024;54(2):123–31.

Google Scholar 

Meyer J, Roos E, Abbassi Z, Toso C, Ris F, Buchs NC. The role of perineal application of prophylactic negative-pressure wound therapy for prevention of wound-related complications after abdomino-perineal resection: a systematic review. Int J Colorectal Dis. 2021;36(1):19–26.

PubMed  Google Scholar 

National Healthcare Safety Network, Centers for Disease Control and Prevention: Surgical Site Infection Event. 2023.

Horan TC, Andrus M, Dudeck MA. CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control. 2008;36(5):309–32.

PubMed  Google Scholar 

Nakamura T, Sato T, Hayakawa K, Takayama Y, Naito M, Yamanashi T, et al. Risk factors for perineal wound infection after abdominoperineal resection of advanced lower rectal cancer. Ann Med Surg (Lond). 2017;15:14–8.

PubMed  Google Scholar 

Feeney G, Sehgal R, Sheehan M, Hogan A, Regan M, Joyce M, et al. Neoadjuvant radiotherapy for rectal cancer management. World J Gastroenterol. 2019;25(33):4850–69.

PubMed  PubMed Central  Google Scholar 

Leitao MM, Zhou QC, Schiavone MB, Cowan RA, Smith ES, Iasonos A, et al. Prophylactic negative pressure wound therapy after laparotomy for gynecologic surgery: a randomized controlled trial. Obstet Gynecol. 2021;137(2):334–41.

CAS  PubMed  PubMed Central  Google Scholar 

Wilkes RP, Kilpadi DV, Zhao Y, Kazala R, McNulty A. Closed incision management with negative pressure wound therapy (CIM): biomechanics. Surg Innov. 2012;19(1):67–75.

PubMed  Google Scholar 

Sugamata N, Okuyama T, Takeshita E, Oi H, Hakozaki Y, Miyazaki S, et al. Surgical site infection after laparoscopic resection of colorectal cancer is associated with compromised long-term oncological outcome. World J Surg Oncol. 2022;20(1):111.

PubMed  PubMed Central  Google Scholar 

Lawler J, Choynowski M, Bailey K, Bucholc M, Johnston A, Sugrue M. Meta-analysis of the impact of postoperative infective complications on oncological outcomes in colorectal cancer surgery. BJS Open. 2020;4(5):737–47.

CAS  PubMed  PubMed Central  Google Scholar 

Koedam TWA, Bootsma BT, Deijen CL, van de Brug T, Kazemier G, Cuesta MA, et al. Oncological outcomes after anastomotic leakage after surgery for colon or rectal cancer: increased risk of local recurrence. Ann Surg. 2022;275(2):e420–7.

PubMed  Google Scholar