Wafa HA, Wolfe CDA, Emmett E, Roth GA, Johnson CO, Wang Y. Burden of Stroke in Europe: Thirty-Year Projections of Incidence, Prevalence, Deaths, and Disability-Adjusted Life Years. Stroke. 2020;51(8):2418–27. https://doi.org/10.1161/STROKEAHA.120.029606.
Article PubMed PubMed Central Google Scholar
Treatment of acute cerebral stroke is a priority in the Medical Guarantee Program (Internet). 2019. https://moz.gov.ua/uk/u-2020-roci-likuvannja-gostrogo-mozkovogo-insultu-e-prioritetom-v-programi-medichnih-garantij, (cited 2025 Apr 28).
World Health Organization. The top 10 causes of death (Internet). 2018. http://www.who.int/mediacentre/factsheets/fs310/en/, (cited 2025 Apr 28).
Li J, Zhang Q, Wang W, Lin F, Wang S, Zhao J. Mesenchymal stem cell therapy for ischemic stroke: A look into treatment mechanism and therapeutic potential. J Neurol. 2021;268(11):4095–107. https://doi.org/10.1007/s00415-020-10138-5.
Chung JW, Chang WH, Bang OY, Moon GJ, Kim SJ, Kim SK, et al. Efficacy and Safety of Intravenous Mesenchymal Stem Cells for Ischemic Stroke. Neurology. 2021;96(7):e1012–e23. https://doi.org/10.1212/WNL.0000000000011440.
Article CAS PubMed Google Scholar
Wang F, Tang H, Zhu J, Zhang JH. Transplanting Mesenchymal Stem Cells for Treatment of Ischemic Stroke. Cell Transplant. 2018;27(12):1825–34. https://doi.org/10.1177/0963689718795424.
Article PubMed PubMed Central Google Scholar
Patel AA, Mohamed AH, Rizaev J, Mallick AK, Qasim MT, Abdulmonem WA, et al. Application of mesenchymal stem cells derived from the umbilical cord or Wharton’s jelly and their extracellular vesicles in the treatment of various diseases. Tissue Cell. 2024;89:102415. https://doi.org/10.1016/j.tice.2024.102415.
Article CAS PubMed Google Scholar
Liau LL, Ruszymah BHI, Ng MH, Law JX. Characteristics and clinical applications of Wharton’s jelly-derived mesenchymal stromal cells. Curr Res Transl Med. 2020;68(1):5–16. https://doi.org/10.1016/j.retram.2019.09.001.
Article CAS PubMed Google Scholar
Oh SH, Choi C, Noh JE, Lee N, Jeong YW, Jeon I, et al. Interleukin-1 receptor antagonist-mediated neuroprotection by umbilical cord-derived mesenchymal stromal cells following transplantation into a rodent stroke model. Exp Mol Med. 2018;50(4):1–12. https://doi.org/10.1038/s12276-018-0041-1.
Article CAS PubMed PubMed Central Google Scholar
Lin W, Hsuan YC, Lin MT, Kuo TW, Lin CH, Su YC, et al. Human Umbilical Cord Mesenchymal Stem Cells Preserve Adult Newborn Neurons and Reduce Neurological Injury after Cerebral Ischemia by Reducing the Number of Hypertrophic Microglia/Macrophages. Cell Transplant. 2017;26(11):1798–810. https://doi.org/10.1177/0963689717728936.
Chen Y, Peng D, Li J, Zhang L, Chen J, Wang L, et al. A comparative study of different doses of bone marrow-derived mesenchymal stem cells improve post-stroke neurological outcomes via intravenous transplantation. Brain Res. 2023;1798:148161. https://doi.org/10.1016/j.brainres.2022.148161.
Article CAS PubMed Google Scholar
Guo Y, Peng Y, Zeng H, Chen G. Progress in Mesenchymal Stem Cell Therapy for Ischemic Stroke. Stem Cells Int. 2021;2021:9923566.https://doi.org/10.1155/2021/9923566.
Article CAS PubMed PubMed Central Google Scholar
Konovalov S, Moroz V, Konovalova N, Deryabina O, Shuvalova N, Toporova O, et al. The effect of mesenchymal stromal cells of various origins on mortality and neurologic deficit in acute cerebral ischemia-reperfusion in rats. Cell Organ Transplantol. 2021;9(2):104–8. https://doi.org/10.22494/cot.v9i2.132.
McGraw CP, Pashayan AG, Wendel OT. Cerebral infarction in the Mongolian gerbil exacerbated by phenoxybenzamine treatment. Stroke. 1976;7(5):485–8. https://doi.org/10.1161/01.STR.7.5.485.
Article CAS PubMed Google Scholar
Vareniuk AM, Dzerzhynskyi ME. Methods of Cyto-Histological Diagnosis. Kyiv: Interservice. Ukrainian. 2019.
Pedachenko E, Moroz V, Yatsyk V, Malyar U, Liubich L, Egorova D. Autologous cell using for the restoration of functional defects in patients with ischemic cerebrovascular accident. Ukr Interv Neuroradiol Surg. 2020;33(3):83–93. https://doi.org/10.26683/2304-9359-2020-3(33).
Toyoshima A, Yasuhara T, Kameda M, Morimoto J, Takeuchi H, Wang F, et al. Intra-Arterial Transplantation of Allogeneic Mesenchymal Stem Cells Mounts Neuroprotective Effects in a Transient Ischemic Stroke Model in Rats. PLoS ONE. 2015;10(6):e127302. https://doi.org/10.1371/journal.pone.0127302.
Article CAS PubMed PubMed Central Google Scholar
Ukrainian patent No. 123557. In: Method of treatment of acute cerebral ischemia using parenteral transplantation of stem cells of various origin. Kyiv. Ukrainian: NPMMU; 2021.
Li Y, Zhong W, Tang X. Strategies to Improve the Efficiency of Transplantation with Mesenchymal Stem Cells for the Treatment of Ischemic Stroke: A Review of Recent Progress. Stem Cells Int. 2021;2021:9929128. https://doi.org/10.1155/2021/9929128.
Article CAS PubMed PubMed Central Google Scholar
Li W, Shi L, Hu B, Hong Y, Zhang H, Li X, et al. Mesenchymal Stem Cell-Based Therapy for Stroke: Current Understanding and Challenges. Front Cell Neurosci. 2021;15:628940. https://doi.org/10.3389/fncel.2021.628940.
Article CAS PubMed PubMed Central Google Scholar
Ntege EH, Sunami H, Shimizu Y. Advances in regenerative therapy: A review of the literature and future directions. Regen Ther. 2020;14:136–53. https://doi.org/10.1016/j.reth.2020.01.004.
Article PubMed PubMed Central Google Scholar
Radak D, Katsiki N, Resanovic I, Jovanovic A, Sudar-Milovanovic E, Zafirovic S, et al. Apoptosis and Acute Brain Ischemia in Ischemic Stroke. Curr Vasc Pharmacol. 2017;15(2):115–22. https://doi.org/10.2174/1570161115666161104095522.
Article CAS PubMed Google Scholar
Li D, Zhang M, Zhang Q, Wang Y, Song X, Zhang Q. Functional recovery after acute intravenous administration of human umbilical cord mesenchymal stem cells in rats with cerebral ischemia-reperfusion injury. Intractable Rare Dis Res. 2015;4(2):98–104. https://doi.org/10.5582/irdr.2015.01010.
Article PubMed PubMed Central Google Scholar
Oppliger B, Joerger-Messerli MS, Simillion C, Mueller M, Surbek DV, Schoeberlein A. Mesenchymal stromal cells from umbilical cord Wharton’s jelly trigger oligodendroglial differentiation in neural progenitor cells through cell-to-cell contact. Cytotherapy. 2017;19(7):829–38. https://doi.org/10.1016/j.jcyt.2017.03.075.
Article CAS PubMed Google Scholar
Pratiwi DIN, Alhajlah S, Alawadi A, Hjazi T, Alawsi T, Almalki SG, et al. Mesenchymal stem cells and their extracellular vesicles as emerging therapeutic tools in the treatment of ischemic stroke. Tissue Cell. 2024;87:102320. https://doi.org/10.1016/j.tice.2024.102320.
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