Ballard C, et al. Alzheimer’s disease. Lancet. 2011;377(9770):1019–31.

Google Scholar 

Sery O, et al. Molecular mechanisms of neuropathological changes in alzheimer’s disease: a review. Folia Neuropathol. 2013;51(1):1–9.

CAS  Google Scholar 

Murphy MP, LeVine H 3rd. Alzheimer’s disease and the amyloid-beta peptide. J Alzheimers Dis. 2010;19(1):311–23.

Google Scholar 

Sun BL, et al. Clinical research on alzheimer’s disease: progress and perspectives. Neurosci Bull. 2018;34(6):1111–8.

CAS  Google Scholar 

Sasaguri H, et al. APP mouse models for alzheimer’s disease preclinical studies. Embo J. 2017;36(17):2473–87.

CAS  Google Scholar 

Kim JH, et al. Long-term treatment of cuban policosanol attenuates abnormal oxidative stress and inflammatory response via amyloid plaques reduction in 5xFAD mice. Antioxidants. 2021;10(8):1321. https://doi.org/10.3390/antiox10081321.

Dorigatti AO, et al. Primary neuron and astrocyte cultures from postnatal callithrix jacchus: a non-human primate in vitro model for research in neuroscience, nervous system aging, and neurological diseases of aging. GeroScience. 2021;43:115–24.

Google Scholar 

Penney J, Ralvenius WT, Tsai L-H. Modeling alzheimer’s disease with iPSC-derived brain cells. Mol Psychiatry. 2020;25(1):148–67.

Google Scholar 

Rosenau C, et al. Umbrella review and delphi study on modifiable factors for dementia risk reduction. Alzheimer’s Dementia. 2024;20(3):2223–39.

Google Scholar 

Puzzo D, et al. Behavioral assays with mouse models of alzheimer’s disease: practical considerations and guidelines. Biochem Pharmacol. 2014;88(4):450–67.

CAS  Google Scholar 

Norton S, et al. Potential for primary prevention of alzheimer’s disease: an analysis of population-based data. Lancet Neurol. 2014;13(8):788–94.

Google Scholar 

Diamond DM, et al. Exposing rats to a predator impairs spatial working memory in the radial arm water maze. Hippocampus. 1999;9(5):542–52.

CAS  Google Scholar 

Chen Z, Zhong C. Decoding alzheimer’s disease from perturbed cerebral glucose metabolism: implications for diagnostic and therapeutic strategies. Prog Neurobiol. 2013;108:21–43.

CAS  Google Scholar 

Ganju N, Eastman A. Zinc inhibits bax and bak activation and cytochrome c release induced by chemical inducers of apoptosis but not by death-receptor-initiated pathways. Cell Death Differ. 2003;10(6):652–61.

CAS  Google Scholar 

Fraker PJ, Telford WG. A reappraisal of the role of zinc in life and death decisions of cells. Proc Soc Exp Biol Med. 1997;215(3):229–36.

CAS  Google Scholar 

Jiang L-F, et al. Impacts of cd (II) on the conformation and self-aggregation of alzheimer’s tau fragment corresponding to the third repeat of microtubule-binding domain. Biochimica Et Biophys Acta bba-proteins Proteomics. 2007;1774(11):1414–21.

CAS  Google Scholar 

Shati AA, Alfaifi MY. Trans-resveratrol inhibits tau phosphorylation in the brains of control and cadmium chloride-treated rats by activating PP2A and PI3K/Akt induced-inhibition of GSK3β. Neurochem Res. 2019;44:357–73.

CAS  Google Scholar 

Notarachille G, et al. Heavy metals toxicity: effect of cadmium ions on amyloid beta protein 1–42. Possible implications for alzheimer’s disease. Biometals. 2014;27:371–88.

CAS  Google Scholar 

Meleleo D, et al. Evidence of cadmium and mercury involvement in the Aβ42 aggregation process. Biophys Chem. 2020;266:106453.

CAS  Google Scholar 

Hao R, et al. Caffeic acid phenethyl ester reversed cadmium-induced cell death in hippocampus and cortex and subsequent cognitive disorders in mice: involvements of AMPK/SIRT1 pathway and amyloid-tau-neuroinflammation axis. Food Chem Toxicol. 2020;144:111636.

CAS  Google Scholar 

El-Kott AF, et al. Cadmium chloride induces memory deficits and hippocampal damage by activating the JNK/p66Shc/NADPH oxidase axis. Int J Toxicol. 2020;39(5):477–90.

CAS  Google Scholar 

Vorhees CV, Williams MT. Assessing spatial learning and memory in rodents. Ilar J. 2014;55(2):310–32.

CAS  Google Scholar 

Nassiri-Asl M, et al. The effects of rutin on a passive avoidance test in rats. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34(1):204–7.

CAS  Google Scholar 

Branchi I, Ricceri L. Active and passive avoidance. Behav Genet Mouse. 2013;1:291–8.

Google Scholar 

Webster SJ, et al. Using mice to model alzheimer’s dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models. Front Genet. 2014;5:88.

Google Scholar 

Yin Q-Q, et al. Pioglitazone improves cognitive function via increasing insulin sensitivity and strengthening antioxidant defense system in fructose-drinking insulin resistance rats. PLoS ONE. 2013;8(3):e59313.

CAS  Google Scholar 

Quan Q, et al. Pioglitazone reduces β amyloid levels via inhibition of PPARγ phosphorylation in a neuronal model of alzheimer’s disease. Front Aging Neurosci. 2019;11:178.

CAS  Google Scholar 

Prakash A, Kumar A. Role of nuclear receptor on regulation of BDNF and neuroinflammation in hippocampus of β-amyloid animal model of alzheimer’s disease. Neurotox Res. 2014;25:335–47.

CAS  Google Scholar 

Elshama SS, El-Kenawy AE-M, Osman H-EH. Toxicological evaluation of subchronic use of pioglitazone in mice. Iran J Basic Med Sci. 2016;19(7):712.

Google Scholar 

Lovell MA, Xie C, Markesbery WR. Protection against amyloid beta peptide toxicity by zinc. Brain Res Brain Res Protoc. 1999;823(1-2):88–95.

CAS  Google Scholar 

Bush AI, et al. The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily. J Biol Chem. 1994;269(43):26618–21.

CAS  Google Scholar 

Brewer GJ. Alzheimer’s disease causation by copper toxicity and treatment with zinc. Front Aging Neurosci. 2014;6:92.

Google Scholar 

Brewer GJ. Copper excess, zinc deficiency, and cognition loss in alzheimer’s disease. Biofactors. 2012;38(2):107–13.

CAS  Google Scholar 

Ebokaiwe AP, et al. The mechanism of the neuroprotective effect of zinc against cadmium-induced behavioral impairments in male Wister rats: focus on tryptophan degradation pathway, oxidative-inflammatory stress, and histologic evidence. Toxicology. 2022;472:153191.

CAS  Google Scholar 

Aughey E, et al. The effects of oral zinc supplementation in the mouse. J Comp Pathol. 1977;87(1):1–14.

CAS  Google Scholar 

Yanagisawa H, et al. Zinc-excess intake causes the deterioration of renal function accompanied by an elevation in systemic blood pressure primarily through superoxide radical-induced oxidative stress. Int J Toxicol. 2014;33(4):288–96.

CAS  Google Scholar 

Manns JR, Eichenbaum H. A cognitive map for object memory in the hippocampus. Learn Mem. 2009;16(10):616–24.

Google Scholar 

Satler C, et al. Emotion processing for arousal and neutral content in alzheimer’ s disease. Int J Alzheimer’s Dis. 2009;2009(1):278615.

Google Scholar 

Trang A, Khandhar P. physiology, Acetylcholinesterase.(updated 2023 Jan 19). statpearls (Internet). (FL): StatPearls Publishing: Treasure Island; 2023.

Google Scholar 

Fendt M, Fanselow MS. The neuroanatomical and neurochemical basis of conditioned fear. Fear Anxiety. 2013; 223–40.