Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74:229–63.

Article  PubMed  Google Scholar 

Fang H, Sun Q, Zhou J, Zhang H, Song Q, Zhang H, et al. m(6)A methylation reader IGF2BP2 activates endothelial cells to promote angiogenesis and metastasis of lung adenocarcinoma. Mol Cancer. 2023;22:99.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Miller KD, Nogueira L, Devasia T, Mariotto AB, Yabroff KR, Jemal A, et al. Cancer treatment and survivorship statistics, 2022. CA Cancer J Clin. 2022;72:409–36.

Article  PubMed  Google Scholar 

Guillot L, Nathan N, Tabary O, Thouvenin G, Le Rouzic P, Corvol H, et al. Alveolar epithelial cells: master regulators of lung homeostasis. Int J Biochem cell Biol. 2013;45:2568–73.

Article  CAS  PubMed  Google Scholar 

Hill W, Lim EL, Weeden CE, Lee C, Augustine M, Chen K, et al. Lung adenocarcinoma promotion by air pollutants. Nature. 2023;616:159–67.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Castaldi A, Horie M, Rieger ME, Dubourd M, Sunohara M, Pandit K, et al. Genome-wide integration of microRNA and transcriptomic profiles of differentiating human alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2020;319:L173–l84.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Desai TJ, Brownfield DG, Krasnow MA. Alveolar progenitor and stem cells in lung development, renewal and cancer. Nature. 2014;507:190–4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nabhan AN, Brownfield DG, Harbury PB, Krasnow MA, Desai TJ. Single-cell Wnt signaling niches maintain stemness of alveolar type 2 cells. Sci (N. Y, NY). 2018;359:1118–23.

Article  CAS  Google Scholar 

Lim K, Donovan APA, Tang W, Sun D, He P, Pett JP, et al. Organoid modeling of human fetal lung alveolar development reveals mechanisms of cell fate patterning and neonatal respiratory disease. Cell Stem Cell. 2023;30:20–37.e9.

Article  CAS  PubMed  Google Scholar 

Chen Z, Fillmore CM, Hammerman PS, Kim CF, Wong KK. Non-small-cell lung cancers: a heterogeneous set of diseases. Nat Rev Cancer. 2014;14:535–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sinjab A, Han G, Treekitkarnmongkol W, Hara K, Brennan PM, Dang M, et al. Resolving the spatial and cellular architecture of lung adenocarcinoma by multiregion single-cell sequencing. Cancer Discov. 2021;11:2506–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ferone G, Lee MC, Sage J, Berns A. Cells of origin of lung cancers: lessons from mouse studies. Genes Dev. 2020;34:1017–32.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ten Have-Opbroek AA, Benfield JR, van Krieken JH, Dijkman JH. The alveolar type II cell is a pluripotential stem cell in the genesis of human adenocarcinomas and squamous cell carcinomas. Histol Histopathol. 1997;12:319–36.

PubMed  Google Scholar 

Kitinya JN, Sueishi K, Tanaka K, Katsuda Y. Immunoreactivity of surfactant-apoprotein in adenocarcinomas, large cell and small cell carcinomas of the lung. Acta pathologica japonica. 1986;36:1271–8.

Article  CAS  PubMed  Google Scholar 

He Q, Qu M, Xu C, Wu L, Xu Y, Su J, et al. Smoking-induced CCNA2 expression promotes lung adenocarcinoma tumorigenesis by boosting AT2/AT2-like cell differentiation. Cancer Lett. 2024;592:216922.

Article  CAS  PubMed  Google Scholar 

Wang Z, Li Z, Zhou K, Wang C, Jiang L, Zhang L, et al. Deciphering cell lineage specification of human lung adenocarcinoma with single-cell RNA sequencing. Nat Commun. 2021;12:6500.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Salahudeen AA, Choi SS, Rustagi A, Zhu J, van Unen V, de la OS, et al. Progenitor identification and SARS-CoV-2 infection in human distal lung organoids. Nature. 2020;588:670–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu H, Bai L, Collins JF, Ghishan FK. Molecular cloning, functional characterization, tissue distribution, and chromosomal localization of a human, small intestinal sodium–phosphate (Na+–Pi) transporter (SLC34A2). Genomics. 1999;62:281–4.

Article  CAS  PubMed  Google Scholar 

Manghat P, Sodi R, Swaminathan R. Phosphate homeostasis and disorders. Ann Clin Biochem. 2014;51:631–56.

Article  CAS  PubMed  Google Scholar 

Hernando N, Wagner CA. Mechanisms and regulation of intestinal phosphate absorption. Compr Physiol. 2018;8:1065–90.

Article  PubMed  Google Scholar 

Jacquillet G, Unwin RJ. Physiological regulation of phosphate by vitamin D, parathyroid hormone (PTH) and phosphate (Pi). Pflug Arch. 2019;471:83–98.

Article  CAS  Google Scholar 

Nishimura M, Naito S. Tissue-specific mRNA expression profiles of human solute carrier transporter superfamilies. Drug Metab Pharmacokinet. 2008;23:22–44.

Article  CAS  PubMed  Google Scholar 

Treutlein B, Brownfield DG, Wu AR, Neff NF, Mantalas GL, Espinoza FH, et al. Reconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-seq. Nature. 2014;509:371–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dost AFM, Moye AL, Vedaie M, Tran LM, Fung E, Heinze D, et al. Organoids model transcriptional hallmarks of oncogenic KRAS activation in lung epithelial progenitor cells. Cell Stem Cell. 2020;27:663–78.e8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jacob A, Morley M, Hawkins F, McCauley KB, Jean JC, Heins H, et al. Differentiation of human pluripotent stem cells into functional lung alveolar epithelial cells. cell Stem Cell. 2017;21:472–88.e10.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ruaro B, Salton F, Braga L, Wade B, Confalonieri P, Volpe MC, et al. The history and mystery of alveolar epithelial type II cells: focus on their physiologic and pathologic role in lung. Int J Mol Sci. 2021;22:2566.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jönsson ÅLM, Hilberg O, Simonsen U, Christensen JH, Bendstrup E. New insights in the genetic variant spectrum of SLC34A2 in pulmonary alveolar microlithiasis; a systematic review. Orphanet J Rare Dis. 2023;18:130.

Article  PubMed  PubMed Central  Google Scholar 

Hashimoto M, Wang DY, Kamo T, Zhu Y, Tsujiuchi T, Konishi Y, et al. Isolation and localization of type IIb Na/Pi cotransporter in the developing rat lung. Am J Pathol. 2000;157:21–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kopantzev EP, Monastyrskaya GS, Vinogradova TV, Zinovyeva MV, Kostina MB, Filyukova OB, et al. Differences in gene expression levels between early and later stages of human lung development are opposite to those between normal lung tissue and non-small lung cell carcinoma. Lung cancer (Amst, Neth). 2008;62:23–34.

Article  Google Scholar 

Wang Y, Yang W, Pu Q, Yang Y, Ye S, Ma Q, et al. The effects and mechanisms of SLC34A2 in tumorigenesis and progression of human non-small cell lung cancer. J Biomed Sci. 2015;22:52.

Article  PubMed  PubMed Central