Iron-catalyzed activation of conventional thioglycosides using iodonium ion enabled the selective synthesis of 1,2-cis furanosides. This strategy accommodates diverse furanosyl donors (D-ribose, D-arabinose, L-arabinose) and various O-nucleophiles (1°, 2°, 3°). Additionally, 1,2-cis hexaribofuranoside was synthesized, and the influence of the C2 functional group on selectivity was investigated.

This article is Open Access

Please wait while we load your content... Something went wrong. Try again?