Christenson SA, Smith BM, Bafadhel M, Putcha N. Chronic obstructive pulmonary disease. Lancet. 2022;399:2227–42.

Article  PubMed  Google Scholar 

Holtjer JCS, Bloemsma LD, Beijers R, Cornelissen MEB, Hilvering B, Houweling L et al. Identifying risk factors for COPD and adult-onset asthma: an umbrella review. Eur Respir Rev. 2023;32.

Xiong T, Bai X, Wei X, Wang L, Li F, Shi H, et al. Exercise rehabilitation and chronic respiratory diseases: effects, mechanisms, and therapeutic benefits. Int J Chron Obstruct Pulmon Dis. 2023;18:1251–66.

Article  PubMed  PubMed Central  Google Scholar 

Guarnier LP, Moro LG, Livero F, de Faria CA, Azevedo MF, Roma BP et al. Regenerative and translational medicine in COPD: hype and hope. Eur Respir Rev. 2023;32.

Calzetta L, Aiello M, Frizzelli A, Camardelli F, Cazzola M, Rogliani P et al. Stem Cell-Based regenerative therapy and derived products in COPD: A systematic review and Meta-Analysis. Cells. 2022;11.

Sun Z, Li F, Zhou X, Chung KF, Wang W, Wang J. Stem cell therapies for chronic obstructive pulmonary disease: current status of pre-clinical studies and clinical trials. J Thorac Dis. 2018;10:1084–98.

Article  PubMed  PubMed Central  Google Scholar 

Zhidu S, Ying T, Rui J, Chao Z. Translational potential of mesenchymal stem cells in regenerative therapies for human diseases: challenges and opportunities. Stem Cell Res Ther. 2024;15:266.

Article  PubMed  PubMed Central  Google Scholar 

Li X, Zhang Y, Yeung SC, Liang Y, Liang X, Ding Y, et al. Mitochondrial transfer of induced pluripotent stem cell-derived mesenchymal stem cells to airway epithelial cells attenuates cigarette smoke-induced damage. Am J Respir Cell Mol Biol. 2014;51:455–65.

Article  PubMed  Google Scholar 

Islam MN, Das SR, Emin MT, Wei M, Sun L, Westphalen K, et al. Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury. Nat Med. 2012;18:759–65.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abbaszadeh H, Ghorbani F, Abbaspour-Aghdam S, Kamrani A, Valizadeh H, Nadiri M, et al. Chronic obstructive pulmonary disease and asthma: mesenchymal stem cells and their extracellular vesicles as potential therapeutic tools. Stem Cell Res Ther. 2022;13:262.

Article  PubMed  PubMed Central  Google Scholar 

Behnke J, Kremer S, Shahzad T, Chao CM, Bottcher-Friebertshauser E, Morty RE et al. MSC based Therapies-New perspectives for the injured lung. J Clin Med. 2020;9.

Jin T, Liu X, Li G, Sun S, Xie L. Intravenous injection of BMSCs modulate TsRNA expression and ameliorate lung remodeling in COPD mice. Stem Cell Res Ther. 2024;15:450.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Song L, Peng J, Guo X. Exosomal LncRNA TCONS_00064356 derived from injured alveolar epithelial type II cells affects the biological characteristics of mesenchymal stem cells. Life Sci. 2021;278:119568.

Article  CAS  PubMed  Google Scholar 

Tirelli C, Mira S, Belmonte LA, De Filippi F, De Grassi M, Italia M et al. Exploring the potential role of metabolomics in COPD: A concise review. Cells. 2024;13.

Zhang X, Hu T, Yu X, Wang T, Jiang L, Sun L, et al. Human umbilical cord mesenchymal stem cells improve lung function in chronic obstructive pulmonary disease rat model through regulating lung microbiota. Stem Cells. 2024;42:346–59.

Article  PubMed  Google Scholar 

Sun J, Zhao N, Zhang R, Li Y, Yu T, Nong Q, et al. Metabolic landscape of human alveolar type II epithelial cells undergoing epithelial-mesenchymal transition induced directly by silica exposure. J Environ Sci (China). 2025;149:676–87.

Article  CAS  PubMed  Google Scholar 

Roy RM, Allawzi A, Burns N, Sul C, Rubio V, Graham J, et al. Lactate produced by alveolar type II cells suppresses inflammatory alveolar macrophages in acute lung injury. FASEB J. 2023;37:e23316.

Article  CAS  PubMed  Google Scholar 

Di Vincenzo S, Heijink IH, Noordhoek JA, Cipollina C, Siena L, Bruno A, et al. SIRT1/FoxO3 axis alteration leads to aberrant immune responses in bronchial epithelial cells. J Cell Mol Med. 2018;22:2272–82.

Article  PubMed  PubMed Central  Google Scholar 

Kim D, Langmead B, Salzberg SL. HISAT: a fast spliced aligner with low memory requirements. Nat Methods. 2015;12:357–60.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pertea M, Kim D, Pertea GM, Leek JT, Salzberg SL. Transcript-level expression analysis of RNA-seq experiments with HISAT, stringtie and ballgown. Nat Protoc. 2016;11:1650–67.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Robinson MD, Oshlack A. A scaling normalization method for differential expression analysis of RNA-seq data. Genome Biol. 2010;11:R25.

Article  PubMed  PubMed Central  Google Scholar 

Tafer H, Hofacker IL. RNAplex: a fast tool for RNA-RNA interaction search. Bioinformatics. 2008;24:2657–63.

Article  CAS  PubMed  Google Scholar 

Li H, Chen Y. Serum uric acid level as a biomarker for chronic obstructive pulmonary disease: a meta-analysis. J Int Med Res. 2021;49:300060520983705.

Article  CAS  PubMed  Google Scholar 

Yang H, Wang Z, Xiao S, Dai C, Wen X, Wu F, et al. Association between serum uric acid and lung function in people with and without chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2022;17:1069–80.

Article  PubMed  PubMed Central  Google Scholar 

Kobayashi T, Nakagome K, Noguchi T, Kobayashi K, Ueda Y, Soma T, et al. Elevated uric acid and adenosine triphosphate concentrations in Bronchoalveolar lavage fluid of eosinophilic pneumonia. Allergol Int. 2017;66S:S27–34.

Article  PubMed  Google Scholar 

Li Y, Liu Y, Peng X, Liu W, Zhao F, Feng D, et al. NMDA receptor antagonist attenuates Bleomycin-Induced acute lung injury. PLoS ONE. 2015;10:e0125873.

Article  PubMed  PubMed Central  Google Scholar 

Huang P, Zhou Y, Li XH, Zhang YN, Cheng HP, Fu JF, et al. N-methyl-D-aspartate receptor blockers attenuate bleomycin-induced pulmonary fibrosis by inhibiting endogenous mesenchymal stem cells senescence. Ann Transl Med. 2022;10:642.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peng XP, Li XH, Li Y, Huang XT, Luo ZQ. The protective effect of oleanolic acid on NMDA-induced MLE-12 cells apoptosis and lung injury in mice by activating SIRT1 and reducing NF-kappaB acetylation. Int Immunopharmacol. 2019;70:520–9.

Article  CAS  PubMed  Google Scholar 

D’Aniello G, Tolino A, D’Aniello A, Errico F, Fisher GH, Di Fiore MM. The role of D-aspartic acid and N-methyl-D-aspartic acid in the regulation of prolactin release. Endocrinology. 2000;141:3862–70.

Article  PubMed  Google Scholar 

D’Aniello A, De Simone A, Spinelli P, D’Aniello S, Branno M, Aniello F, et al. A specific enzymatic high-performance liquid chromatography method to determine N-methyl-D-aspartic acid in biological tissues. Anal Biochem. 2002;308:42–51.

Article  PubMed  Google Scholar 

Witkowski M, Weeks TL, Hazen SL. Gut microbiota and cardiovascular disease. Circ Res. 2020;127:553–70.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu J, Pan T, Qi X, Tan R, Wang X, Liu Z, et al. Increased mortality of acute respiratory distress syndrome was associated with high levels of plasma phenylalanine. Respir Res. 2020;21:99.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nemet I, Saha PP, Gupta N, Zhu W, Romano KA, Skye SM, et al. A cardiovascular Disease-Linked gut microbial metabolite acts via adrenergic receptors. Cell. 2020;180:862–77. e22.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Saha PP, Gogonea V, Sweet W, Mohan ML, Singh KD, Anderson JT, et al. Gut microbe-generated Phenylacetylglutamine is an endogenous allosteric modulator of beta2-adrenergic receptors. Nat Commun. 2024;15:6696.

Article  CAS  PubMed  PubMed Central