LncRNA NEAT1 participates in diminished ovarian reserve by affecting granulosa cell apoptosis and estradiol synthesis via the miR-204-5p/ESR1 axis

Li X, Wu X, Zhang H, Liu P, Xia L, Zhang N, Tian L, Li Z, Lu J, Zhao Y, Tan J. Analysis of single-cell RNA sequencing in human oocytes with diminished ovarian reserve uncovers mitochondrial dysregulation and translation deficiency. Reprod Biol Endocrinol. 2024;22:146.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Y, Jiang J, Zhang J, Fan P, Xu J. Research progress on the etiology and treatment of premature ovarian insufficiency. Biomed Hub. 2023;8:97–107.

Article  PubMed  PubMed Central  Google Scholar 

Turathum B, Gao EM, Chian RC. The Function of Cumulus Cells in Oocyte Growth and Maturation and in Subsequent Ovulation and Fertilization. Cells 2021, 10.

Deng J, Tang Y, Li L, Huang R, Wang Z, Ye T, Xiao Z, Hu M, Wei S, Wang Y et al. miR-143-3p promotes ovarian granulosa cell senescence and inhibits estradiol synthesis by targeting UBE2E3 and LHCGR. Int J Mol Sci 2023, 24.

Li P, Dou Q, Zhang D, Xiang Y, Tan L. Melatonin regulates autophagy in granulosa cells from patients with premature ovarian insufficiency via activating Foxo3a. Aging. 2024;16:844–56.

CAS  PubMed  PubMed Central  Google Scholar 

Yang Z, Hong W, Zheng K, Feng J, Hu C, Tan J, Zhong Z, Zheng Y. Chitosan Oligosaccharides Alleviate H(2)O(2)-stimulated Granulosa Cell Damage via HIF-1α Signaling Pathway. Oxid Med Cell Longev 2022, 2022:4247042.

Guan C, Li W, Wang G, Yang R, Zhang J, Zhang J, Wu B, Gao R, Jia C. Transcriptomic analysis of NcRNAs and mRNAs interactions during drought stress in Switchgrass. Plant Sci. 2024;339:111930.

Article  CAS  PubMed  Google Scholar 

Tang Z, Li X, Zheng Y, Liu J, Liu C, Li X. The role of competing endogenous RNA network in the development of hepatocellular carcinoma: potential therapeutic targets. Front Cell Dev Biol. 2024;12:1341999.

Article  PubMed  PubMed Central  Google Scholar 

Wu W, Cao L, Jia Y, Xiao Y, Zhang X, Gui S. Emerging roles of MiRNA, LncRNA, circrna, and their Cross-Talk in pituitary adenoma. Cells 2022, 11.

Yang Y, Xiong Y, Pan Z. Role of CeRNAs in non-tumor female reproductive diseases†. Biol Reprod. 2023;108:363–81.

Article  PubMed  Google Scholar 

Shen J, Liang C, Su X, Wang Q, Ke Y, Fang J, Zhang D, Duan S. Dysfunction and CeRNA network of the tumor suppressor miR-637 in cancer development and prognosis. Biomark Res. 2022;10:72.

Article  PubMed  PubMed Central  Google Scholar 

Zhang D, Tang HY, Tan L, Zhao DM. MALAT1 is involved in the pathophysiological process of PCOS by modulating TGFβ signaling in granulosa cells. Mol Cell Endocrinol. 2020;499:110589.

Article  CAS  PubMed  Google Scholar 

Yao Y, Wang Y, Wang F, Meng C, Niu J, Guo M, Sizhu S, Xu Y. BMP15 modulates the H19/miR-26b/SMAD1 Axis influences Yak granulosa cell proliferation, autophagy, and apoptosis. Reprod Sci. 2023;30:1266–80.

Article  CAS  PubMed  Google Scholar 

Dong L, Xin X, Chang HM, Leung PCK, Yu C, Lian F, Wu H. Expression of long noncoding RNAs in the ovarian granulosa cells of women with diminished ovarian reserve using high-throughput sequencing. J Ovarian Res. 2022;15:119.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ferraretti AP, La Marca A, Fauser BCJM, Tarlatzis B, Nargund G, Gianaroli L. ESHRE consensus on the definition of ‘poor response’ to ovarian stimulation for in vitro fertilization: the Bologna criteria. Hum Reprod. 2011;26:1616–24.

Article  CAS  PubMed  Google Scholar 

Ju W, Zhao S, Wu H, Yu Y, Li Y, Liu D, Lian F, Xiang S. miR-6881-3p contributes to diminished ovarian reserve by regulating granulosa cell apoptosis by targeting SMAD4. Reprod Biol Endocrinol. 2024;22:17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu A, Zhang D, Yang X, Song Y. Estrogen receptor alpha activates MAPK signaling pathway to promote the development of endometrial cancer. J Cell Biochem. 2019;120:17593–601.

Article  CAS  PubMed  Google Scholar 

Yao G, Kong Y, Yang G, Kong D, Xu Y, He J, Xu Z, Bai Y, Fan H, He Q, Sun Y. Lnc-GULP1-2:1 affects granulosa cell proliferation by regulating COL3A1 expression and localization. J Ovarian Res. 2021;14:16.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang F, Chen X, Sun B, Ma Y, Niu W, Zhai J, Sun Y. Hypermethylation-mediated downregulation of LncRNA PVT1 promotes granulosa cell apoptosis in premature ovarian insufficiency via interacting with Foxo3a. J Cell Physiol. 2021;236:5162–75.

Article  CAS  PubMed  Google Scholar 

Jia Y, Liu L, Gong S, Li H, Zhang X, Zhang R, Wang A, Jin Y, Lin P. Hand2os1 regulates the secretion of progesterone in mice Corpus luteum. Vet Sci 2022, 9.

Wang Y, Chen LL. Organization and function of paraspeckles. Essays Biochem. 2020;64:875–82.

Article  CAS  PubMed  Google Scholar 

Ernst EH, Nielsen J, Ipsen MB, Villesen P, Lykke-Hartmann K. Transcriptome analysis of long Non-coding RNAs and genes encoding paraspeckle proteins during human ovarian follicle development. Front Cell Dev Biol. 2018;6:78.

Article  PubMed  PubMed Central  Google Scholar 

Nakagawa S, Shimada M, Yanaka K, Mito M, Arai T, Takahashi E, Fujita Y, Fujimori T, Standaert L, Marine JC, Hirose T. The LncRNA Neat1 is required for corpus luteum formation and the establishment of pregnancy in a subpopulation of mice. Development. 2014;141:4618–27.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li M, Peng J, Zeng Z. Overexpression of long non-coding RNA nuclear enriched abundant transcript 1 inhibits the expression of p53 and improves premature ovarian failure. Exp Ther Med. 2020;20:69.

Article  CAS  PubMed  PubMed Central  Google Scholar 

ElMonier AA, El-Boghdady NA, Fahim SA, Sabry D, Elsetohy KA, Shaheen AA. LncRNA NEAT1 and MALAT1 are involved in polycystic ovary syndrome pathogenesis by functioning as competing endogenous RNAs to control the expression of PCOS-related target genes. Noncoding RNA Res. 2023;8:263–71.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang P, Gao J, Lin S, Lin G, Wang W, Tan C, Liu X, Li X, Zhang L. Long non–coding RNA NEAT1 promotes mouse granulosa cell proliferation and estradiol synthesis by sponging miR–874–3p. Exp Ther Med. 2023;25:32.

Article  PubMed  Google Scholar 

Liu YX, Ke Y, Qiu P, Gao J, Deng GP. LncRNA NEAT1 inhibits apoptosis and autophagy of ovarian granulosa cells through miR-654/STC2-mediated MAPK signaling pathway. Exp Cell Res. 2023;424:113473.

Article  CAS  PubMed  Google Scholar 

Xiao J, Wang R, Zhou W, Cai X, Ye Z. LncRNA NEAT1 regulates the proliferation and production of the inflammatory cytokines in rheumatoid arthritis fibroblast-like synoviocytes by targeting miR-204-5p. Hum Cell. 2021;34:372–82.

Article  CAS  PubMed  Google Scholar 

Shetty A, Suresh PS. A synergy of estradiol with leptin modulates the long non-coding RNA NEAT1/ mmu-miR-204-5p/IGF1 axis in the uterus of high-fat-diet-induced obese ovariectomized mice. J Steroid Biochem Mol Biol. 2021;209:105843.

Article  CAS  PubMed  Google Scholar 

Yang F, Bian Z, Xu P, Sun S, Huang Z. MicroRNA-204-5p: A pivotal tumor suppressor. Cancer Med. 2023;12:3185–200.

Article  CAS  PubMed  Google Scholar 

Chen X, Mangala LS, Mooberry L, Bayraktar E, Dasari SK, Ma S, Ivan C, Court KA, Rodriguez-Aguayo C, Bayraktar R, et al. Identifying and targeting angiogenesis-related MicroRNAs in ovarian cancer. Oncogene. 2019;38:6095–108.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu L, Kolibaba H, Zhang S, Cao M, Niu H, Mei H, Hao Y, Xu Y, Yin Q. MicroRNA-204-5p inhibits ovarian Cancer cell proliferation by Down-Regulating USP47. Cell Transpl. 2019;28:s51–8.

Article  Google Scholar 

Zhong P, Liu J, Li H, Lin S, Zeng L, Luo L, Wu M, Zhang W. MicroRNA-204-5p regulates apoptosis by targeting Bcl2 in rat ovarian granulosa cells exposed to cadmium†. Biol Reprod. 2020;103:608–19.

Article  PubMed  Google Scholar 

Cai Y, Tian J, Su Y, Shi X. MiR-506 targets polypyrimidine tract-binding protein 1 to inhibit airway inflammatory response and remodeling via mediating Wnt/β-catenin signaling pathway. Allergol Immunopathol (Madr). 2023;51:15–24.

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