Chen R, Shi J, Yin Q, Li X, Sheng Y, Han J, Zhuang P, Zhang Y. Morphological and Pathological Characteristics of Brain in Diabetic Encephalopathy. J Alzheimers Dis. 2018;65(1):15–28.
O’Brien PD, Hinder LM, Callaghan BC, Feldman EL. Lancet Neurol. Neurological consequences of obesity. 2017;16(6):465–77.
Wang J, Li L, Zhang Z, Zhang X, Zhu Y, Zhang C, Bi Y. Extracellular vesicles mediate the communication of adipose tissue with brain and promote cognitive impairment associated with insulin resistance. Cell Metab. 2022;34(9):1264-1279.e8.
Article CAS PubMed Google Scholar
Chen R, Zeng Y, Xiao W, Zhang L, Shu Y. LC-MS-Based Untargeted Metabolomics Reveals Early Biomarkers in STZ-Induced Diabetic Rats With Cognitive Impairment. Front Endocrinol (Lausanne). 2021;12:665309.
El-Sayed NS, Elatrebi S, Said R, Ibrahim HF, Omar EM. Potential mechanisms underlying the association between type II diabetes mellitus and cognitive dysfunction in rats: a link between miRNA-21 and Resveratrol’s neuroprotective action. Metab Brain Dis. 2022;37(7):2375–88.
Article CAS PubMed PubMed Central Google Scholar
Lyu F, Wu D, Wei C, Wu A. Vascular cognitive impairment and dementia in type 2 diabetes mellitus: An overview. Life Sci. 2020;254:117771.
Chen Z, Zhong C. Decoding Alzheimer’s disease from perturbed cerebral glucose metabolism: implications for diagnostic and therapeutic strategies. Prog Neurobiol. 2013;108:21–43.
Article CAS PubMed Google Scholar
Pugazhenthi S, Qin L, Reddy PH. Common neurodegenerative pathways in obesity, diabetes, and Alzheimer’s disease. Biochim Biophys Acta Mol Basis Dis. 2017;1863(5):1037–45.
Article CAS PubMed Google Scholar
Neves G, Cooke SF, Bliss TV. Synaptic plasticity, memory and the hippocampus: a neural network approach to causality. Nat Rev Neurosci. 2008;9(1):65–75.
Article CAS PubMed Google Scholar
McCrimmon RJ, Ryan CM, Frier BM. Diabetes and cognitive dysfunction. Lancet. 2012;379(9833):2291–9.
Logan S, Baier MP, Owen DB, Peasari J, Jones KL, Ranjit R, Yarbrough HP, Masingale AM, Bhandari S, Rice HC, Kinter MT, Sonntag WE. Cognitive heterogeneity reveals molecular signatures of age-related impairment. PNAS Nexus. 2023;2(4):pgad101.
Article PubMed PubMed Central Google Scholar
Wang S, Sun ST, Zhang XY, Ding HR, Yuan Y, He JJ, Wang MS, Yang B, Li YB. The Evolution of Single-Cell RNA Sequencing Technology and Application: Progress and Perspectives. Int J Mol Sci. 2023;24(3):2943.
Article CAS PubMed PubMed Central Google Scholar
Li B, Zhang W, Guo C, Xu H, Li L, Fang M, Hu Y, Zhang X, Yao X, Tang M, Liu K, Zhao X, Lin J, Cheng L, Chen F, Xue T, Qu K. Benchmarking spatial and single-cell transcriptomics integration methods for transcript distribution prediction and cell type deconvolution. Nat Methods. 2022;19(6):662–70.
Article CAS PubMed Google Scholar
Liu X, Huai J, Endle H, Schlüter L, Fan W, Li Y, Richers S, Yurugi H, Rajalingam K, Ji H, Cheng H, Rister B, Horta G, Baumgart J, Berger H, Laube G, Schmitt U, Schmeisser MJ, Boeckers TM, Tenzer S, Vlachos A, Deller T, Nitsch R, Vogt J. PRG-1 Regulates Synaptic Plasticity via Intracellular PP2A/β1-Integrin Signaling. Dev Cell. 2016;38(3):275–90.
Article CAS PubMed Google Scholar
Liu X, Li S, Zhang W, Xie Z, He J, Zhang X, Yu S, Cao S, Yu T, Xiao Z. PRG-1 prevents neonatal stimuli-induced persistent hyperalgesia and memory dysfunction via NSF/Glu/GluR2 signaling. iScience. 2022;25(9):104989.
Article CAS PubMed PubMed Central Google Scholar
Unichenko P, Kirischuk S, Yang JW, Baumgart J, Roskoden T, Schneider P, Sommer A, Horta G, Radyushkin K, Nitsch R, Vogt J, Luhmann HJ. Plasticity-Related Gene 1 Affects Mouse Barrel Cortex Function via Strengthening of Glutamatergic Thalamocortical Transmission. Cereb Cortex. 2016;26(7):3260–72.
Article PubMed PubMed Central Google Scholar
Schneider P, Petzold S, Sommer A, Nitsch R, Schwegler H, Vogt J, Roskoden T. Altered synaptic phospholipid signaling in PRG-1 deficient mice induces exploratory behavior and motor hyperactivity resembling psychiatric disorders. Behav Brain Res. 2018;336:1–7.
Article CAS PubMed Google Scholar
Liu X, Xie Z, Li S, He J, Cao S, Xiao Z. PRG-1 relieves pain and depressive-like behaviors in rats of bone cancer pain by regulation of dendritic spine in hippocampus. Int J Biol Sci. 2021;17(14):4005–20.
Article CAS PubMed PubMed Central Google Scholar
Mohammadi A, Amooeian VG, Rashidi E. Dysfunction in Brain-Derived Neurotrophic Factor Signaling Pathway and Susceptibility to Schizophrenia, Parkinson’s and Alzheimer’s Diseases. Curr Gene Ther. 2018;18(1):45–63.
Article CAS PubMed Google Scholar
Numakawa T, Odaka H. Brain-Derived Neurotrophic Factor Signaling in the Pathophysiology of Alzheimer’s Disease: Beneficial Effects of Flavonoids for Neuroprotection. Int J Mol Sci. 2021;22(11):5719.
Article CAS PubMed PubMed Central Google Scholar
Miryala CSJ, Holland ED, Dent EW. Contributions of microtubule dynamics and transport to presynaptic and postsynaptic functions. Mol Cell Neurosci. 2022;123:103787.
Article CAS PubMed PubMed Central Google Scholar
Hu X, Ballo L, Pietila L, Viesselmann C, Ballweg J, Lumbard D, Stevenson M, Merriam E, Dent EW. BDNF-induced increase of PSD-95 in dendritic spines requires dynamic microtubule invasions. J Neurosci. 2011;31(43):15597–603.
Article CAS PubMed PubMed Central Google Scholar
Sun Y, Ma C, Sun H, Wang H, Peng W, Zhou Z, Wang H, Pi C, Shi Y, He X. Metabolism: A Novel Shared Link between Diabetes Mellitus and Alzheimer’s Disease. J Diabetes Res. 2020;2020:4981814.
Article PubMed PubMed Central Google Scholar
Zou Y, Wang Q, Cheng X. Causal Relationship Between Basal Metabolic Rate and Alzheimer’s Disease: A Bidirectional Two-sample Mendelian Randomization Study. Neurol Ther. 2023;12(3):763–76.
Article PubMed PubMed Central Google Scholar
Tu Y, Chen Q, Guo W, Xiang P, Huang H, Fei H, Chen L, Yang Y, Peng Z, Gu C, Tan X, Liu X, Lu Y, Chen R, Wang H, Luo Y, Yang J. MiR-702–5p ameliorates diabetic encephalopathy in db/db mice by regulating 12/15-LOX. Exp Neurol. 2022;358:114212.
Article CAS PubMed Google Scholar
Chen G, Wang Y, Li Y, Zhang L, Dong M. A novel hippocampus metabolite signature in diabetes mellitus rat model of diabetic encephalopathy. Metab Brain Dis. 2020;35(6):895–904.
Yasin Wayhs CA, Tannhauser Barros HM, Vargas CR. GABAergic Modulation in Diabetic Encephalopathy-Related Depression. Curr Pharm Des. 2015;21(34):4980–8.
Article CAS PubMed Google Scholar
Dejgaard A, Gade A, Larsson H, Balle V, Parving A, Parving HH. Evidence for diabetic encephalopathy. Diabet Med. 1991;8(2):162–7.
Article CAS PubMed Google Scholar
Leger M, Quiedeville A, Bouet V, Haelewyn B, Boulouard M, Schumann-Bard P, Freret T. Object recognition test in mice. Nat Protoc. 2013;8(12):2531–7.
Article CAS PubMed Google Scholar
Mclagan AN, Hales JB. Displaced Object Recognition Memory in Rats. Bio Protoc. 2019;9(8):e3212.
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