Borlaug BA, Sharma K, Shah SJ, Ho JE. Heart failure with preserved ejection fraction. J Am Coll Cardiol. 2023;81(18):1810–34.

Article  PubMed  Google Scholar 

Bauersachs J, Soltani S. Herzinsuffizienz: Leitlinien-Update der ESC 2023. Herz. 2023;49(1):19–21.

Article  PubMed  Google Scholar 

Liu H, Magaye R, Kaye DM, Wang BH. Heart failure with preserved ejection fraction: the role of inflammation. Eur J Pharmacol 2024, 980.

Abudurexiti M, Abuduhalike R, Naman T, Wupuer N, Duan D, Keranmu M, Mahemuti A. Integrated proteomic and metabolomic profiling reveals novel insights on the inflammation and immune response in HFpEF. BMC Genomics. 2024;25(1):676.

Article  CAS  PubMed  PubMed Central  Google Scholar 

von Haehling S, Assmus B, Bekfani T, Dworatzek E, Edelmann F, Hashemi D, Hellenkamp K, Kempf T, Raake P, Schütt KA, et al. Heart failure with preserved ejection fraction: diagnosis, risk assessment, and treatment. Clin Res Cardiol. 2024;113(9):1287–305.

Article  Google Scholar 

Desai AS, Lam CSP, McMurray JJV, Redfield MM. How to manage heart failure with preserved ejection fraction. JACC: Heart Fail. 2023;11(6):619–36.

CAS  PubMed  Google Scholar 

Abudureyimu M, Luo X, Jiang L, Jin X, Pan C, Yu W, Ge J, Zhang Y, Ren J. FBXL4 protects against HFpEF through Drp1-Mediated regulation of mitochondrial dynamics and the downstream SERCA2a. Redox Biol 2024, 70.

Liu X, Liu X, Wang Y, Sun H, Guo Z, Tang X, Li J, Xiao X, Zheng S, Yu M et al. Proteome characterization of glaucoma aqueous humor. Mol Cell Proteom 2021, 20.

Xu M, Deng J, Xu K, Zhu T, Han L, Yan Y, Yao D, Deng H, Wang D, Sun Y, et al. In-depth serum proteomics reveals biomarkers of psoriasis severity and response to traditional Chinese medicine. Theranostics. 2019;9(9):2475–88.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bermea KC, Lovell JP, Hays AG, Goerlich E, Vungarala S, Jani V, Shah SJ, Sharma K, Adamo L. A machine Learning-Derived score to effectively identify heart failure with preserved ejection fraction. JACC: Adv 2024, 3(7).

Li B, Lei Z, Wu Y, Li B, Zhai M, Zhong Y, Ju P, Kou W, Shi Y, Zhang X et al. The association and pathogenesis of SERPINA3 in coronary artery disease. Front Cardiovasc Med 2021, 8.

Zhao J, Pan J. Circulating Serpina3 might be a new potential biomarker to predict the clinical outcomes in AMI. Int J Cardiol 2020, 312.

Paulus WJ. H(2)FPEF score: at last, a properly validated diagnostic algorithm for heart failure with preserved ejection fraction. Circulation. 2018;138(9):871–3.

Article  PubMed  Google Scholar 

Pieske B, Tschöpe C, de Boer RA, Fraser AG, Anker SD, Donal E, Edelmann F, Fu M, Guazzi M, Lam CSP, et al. How to diagnose heart failure with preserved ejection fraction: the HFA-PEFF diagnostic algorithm: a consensus recommendation from the heart failure association (HFA) of the European society of cardiology (ESC). Eur Heart J. 2019;40(40):3297–317.

Article  PubMed  Google Scholar 

McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Böhm M, Burri H, Butler J, Čelutkienė J, Chioncel O, et al. Corrigendum to: 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: developed by the task force for the diagnosis and treatment of acute and chronic heart failure of the European society of cardiology (ESC) with the special contribution of the heart failure association (HFA) of the ESC. Eur Heart J. 2021;42(48):4901.

Article  PubMed  Google Scholar 

Zhang H, Wang L, Yin D, Zhou Q, Lv L, Dong Z, Shi Y. Integration of proteomic and metabolomic characterization in atrial fibrillation-induced heart failure. BMC Genomics. 2022;23(1):789.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou X, Liang B, Lin W, Zha L. Identification of MACC1 as a potential biomarker for pulmonary arterial hypertension based on bioinformatics and machine learning. Comput Biol Med 2024, 173.

Guan S, Xu Z, Yang T, Zhang Y, Zheng Y, Chen T, Liu H, Zhou J. Identifying potential targets for preventing cancer progression through the PLA2G1B Recombinant protein using bioinformatics and machine learning methods. Int J Biol Macromol 2024, 276.

Ranstam J, Cook JA. LASSO regression. Br J Surg. 2018;105(10):1348–1348.

Article  Google Scholar 

Chen C, Hou J, Tanner JJ, Cheng J. Bioinformatics methods for mass Spectrometry-Based proteomics data analysis. Int J Mol Sci 2020, 21(8).

Kong C, Zhu Y, Xie X, Wu J, Qian M. Six potential biomarkers in septic shock: a deep bioinformatics and prospective observational study. Front Immunol. 2023;14:1184700.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Balachandran VP, Gonen M, Smith JJ, DeMatteo RP. Nomograms in oncology: more than Meets the eye. Lancet Oncol. 2015;16(4):e173–180.

Article  PubMed  PubMed Central  Google Scholar 

Wang K, Li Y, Lin J. Identification of diagnostic biomarkers for osteoarthritis through bioinformatics and machine learning. Heliyon 2024, 10(6).

Zhang W, Landback P, Gschwend AR, Shen B, Long M. New genes drive the evolution of gene interaction networks in the human and mouse genomes. Genome Biol 2015, 16(1).

Lin S, Yan J, Wang W, Luo L. STAT3-Mediated ferroptosis is involved in Sepsis-Associated acute respiratory distress syndrome. Inflammation. 2024;47(4):1204–19.

Article  CAS  PubMed  Google Scholar 

Tian S, Wu L, Zheng H, Zhong X, Yu X, Wu W. Identification of autophagy-related genes in neuropathic pain through bioinformatic analysis. Hereditas 2023, 160(1).

Delrue L, Vanderheyden M, Beles M, Paolisso P, Di Gioia G, Dierckx R, Verstreken S, Goethals M, Heggermont W, Bartunek J. Circulating SERPINA3 improves prognostic stratification in patients with a de Novo or worsened heart failure. ESC Heart Fail. 2021;8(6):4780–90.

Article  PubMed  PubMed Central  Google Scholar 

Jiang Y, Zhang Y, Zhao C. Integrated gene expression profiling analysis reveals SERPINA3, FCN3, FREM1, MNS1 as candidate biomarkers in heart failure and their correlation with immune infiltration. J Thorac Disease. 2022;14(4):1106–19.

Article  Google Scholar 

Ravindran A, Holappa L, Niskanen H, Skovorodkin I, Kaisto S, Beter M, Kiema M, Selvarajan I, Nurminen V, Aavik E, et al. Translatome profiling reveals Itih4 as a novel smooth muscle cell-specific gene in atherosclerosis. Cardiovasc Res. 2024;120(8):869–82.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pihl R, Jensen RK, Poulsen EC, Jensen L, Hansen AG, Thøgersen IB, Dobó J, Gál P, Andersen GR, Enghild JJ et al. ITIH4 acts as a protease inhibitor by a novel inhibitory mechanism. Sci Adv 2021, 7(2).

Insenser M, Vilarrasa N, Vendrell J, Escobar-Morreale HF. Remission of diabetes following bariatric surgery: plasma proteomic profiles. J Clin Med 2021, 10(17).

Park J, Kim H, Kim SY, Kim Y, Lee JS, Dan K, Seong MW, Han D. In-depth blood proteome profiling analysis revealed distinct functional characteristics of plasma proteins between severe and non-severe COVID-19 patients. Sci Rep. 2020;10(1):22418.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tschöpe C, Van Linthout S. New insights in (inter)cellular mechanisms by heart failure with preserved ejection fraction. Curr Heart Fail Rep. 2014;11(4):436–44.

Article  PubMed  PubMed Central  Google Scholar 

Rech M, Barandiarán Aizpurua A, van Empel V, van Bilsen M, Schroen B. Pathophysiological Understanding of HFpEF: MicroRNAs as part of the puzzle. Cardiovasc Res. 2018;114(6):782–93.

Article  CAS  PubMed  Google Scholar 

Yang D, Liu HQ, Liu FY, Tang N, Guo Z, Ma SQ, An P, Wang MY, Wu HM, Yang Z, et al. The roles of noncardiomyocytes in cardiac remodeling. Int J Biol Sci. 2020;16(13):2414–29.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Castillo EC, Vázquez-Garza E, Yee-Trejo D, García-Rivas G, Torre-Amione G. What is the role of the inflammation in the pathogenesis of heart failure?? Curr Cardiol Rep. 2020;22(11):139.

Article  PubMed  PubMed Central  Google Scholar 

Wu D, Guo M, Robinson CV. Connecting single-nucleotide polymorphisms, glycosylation status, and interactions of plasma Serine protease inhibitors. Chem. 2023;9(3):665–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Meijers WC, Maglione M, Bakker SJL, Oberhuber R, Kieneker LM, de Jong S, Haubner BJ, Nagengast WB, Lyon AR, van der Vegt B, et al. Heart failure stimulates tumor growth by Circulating factors. Circulation. 2018;138(7):678–91.

Article  CAS  PubMed  Google Scholar 

Zhao L, Guo Z, Wang P, Zheng M, Yang X, Liu Y, Ma Z, Chen M, Yang X. Proteomics of epicardial adipose tissue in patients with heart failure. J Cell Mol Med. 2019;24(1):511–20.

Article  PubMed  PubMed Central  Google Scholar 

Zhou L, Peng F, Li J, Gong H. Exploring novel biomarkers in dilated cardiomyopathy–induced heart failure by integrated analysis and in vitro experiments. Experimental Therapeutic Med 2023, 26(1).

Attachaipanich T, Chattipakorn SC, Chattipakorn N. Current evidence regarding the cellular mechanisms associated with cancer progression due to cardiovascular diseases. J Translational Med 2024, 22(1).

Hage C, Michaëlsson E, Linde C, Donal E, Daubert J-C, Gan L-M, Lund LH. Inflammatory biomarkers predict heart failure severity and prognosis in patients with heart failure with preserved ejection fraction. Circulation: Cardiovasc Genet 2017, 10(1).

Correction to et al. Sun. A Novel Regulatory Mechanism of Smooth Muscle α-Actin Expression by NRG-1/circACTA2/miR-548f-5p Axis. Circ Res. 2017;121:628–635. https://doi.org/10.1161/CIRCRESAHA.117.311441. Circ Res 2021, 128(1):e25.

Lou R, Cao Y, Li S, Lang X, Li Y, Zhang Y, Shui W. Benchmarking commonly used software suites and analysis workflows for DIA proteomics and phosphoproteomics. Nat Commun 2023, 14(1).

Verdonk C, Verdonk F, Dreyfus G. How machine learning could be used in clinical practice during an epidemic. Crit Care 2020, 24(1).