NCD Risk Factor Collaboration, Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19.2 million participants. Lancet 2016; 387: 1377–96.

Kahn CR, Wang G, Lee KY. Altered adipose tissue and adipocyte function in the pathogenesis of metabolic syndrome. J Clin Invest. 2019;129:3990–4000.

Article  PubMed  PubMed Central  Google Scholar 

Chen FJ, Yin Y, Chua BT, Li P. CIDE family proteins control lipid homeostasis and the development of metabolic diseases. Traffic. 2020;21:94–105.

Article  CAS  PubMed  Google Scholar 

Zhou Z, Toh SY, Chen Z, Guo K, Ng CP, Ponniah S, et al. Cidea-deficient mice have lean phenotype and are resistant to obesity. Nat Genet. 2003;35:49–56.

Article  PubMed  Google Scholar 

Li JZ, Ye J, Xue B, Qi J, Zhang J, Zhou Z, et al. Cideb regulates diet-induced obesity, liver steatosis, and insulin sensitivity by controlling lipogenesis and fatty acid oxidation. Diabetes. 2007;56:2523–32.

Article  CAS  PubMed  Google Scholar 

Nishino N, Tamori Y, Tateya S, Kawaguchi T, Shibakusa T, Mizunoya W, et al. FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets. J Clin Invest. 2008;118:2808–21.

CAS  PubMed  PubMed Central  Google Scholar 

Toh SY, Gong J, Du G, Li JZ, Yang S, Ye J, et al. Up-regulation of mitochondrial activity and acquirement of brown adipose tissue-like property in the white adipose tissue of fsp27 deficient mice. PLoS One. 2008;3:e2890.

Article  PubMed  PubMed Central  Google Scholar 

Gummesson A, Jernås M, Svensson PA, Larsson I, Glad CAM, Schéle E, et al. Relations of adipose tissue CIDEA gene expression to basal metabolic rate, energy restriction, and obesity: population-based and dietary intervention studies. J Clin Endocrinol Metab. 2007;92:4759–65.

Article  CAS  PubMed  Google Scholar 

Magnusson B, Gummesson A, Glad CAM, Goedecke JH, Jernås M, Lystig TC, et al. Cell death-inducing DFF45-like effector C is reduced by caloric restriction and regulates adipocyte lipid metabolism. Metabolism. 2008;57:1307–13.

Article  CAS  PubMed  Google Scholar 

Dahlman I, Kaaman M, Jiao H, Kere J, Laakso M, Arner P, et al. The CIDEA gene V115F polymorphism is associated with obesity in Swedish subjects. Diabetes. 2005;54:3032–4.

Article  CAS  PubMed  Google Scholar 

Wu J, Zhang L, Zhang J, Dai Y, Bian L, Song M, et al. The genetic contribution of CIDEA polymorphisms, haplotypes and loci interaction to obesity in a Han Chinese population. Mol Biol Rep. 2013;40:5691–9.

Article  CAS  PubMed  Google Scholar 

Zhang L, Miyaki K, Nakayama T, Muramatsu M. Cell death-inducing DNA fragmentation factor alpha-like effector A (CIDEA) gene V115F (G→T) polymorphism is associated with phenotypes of metabolic syndrome in Japanese men. Metabolism. 2008;57:502–5.

Article  CAS  PubMed  Google Scholar 

Zhang L, Dai Y, Bian L, Wang W, Muramatsu M, Hua Q. Association of the cell death-inducing DNA fragmentation factor alpha-like effector A (CIDEA) gene V115F (G/T) polymorphism with phenotypes of metabolic syndrome in a Chinese population. Diabetes Res Clin Pract. 2011;91:233–8.

Article  CAS  PubMed  Google Scholar 

Puri V, Ranjit S, Konda S, Nicoloro SMC, Straubhaar J, Chawla A, et al. Cidea is associated with lipid droplets and insulin sensitivity in humans. Proc Natl Acad Sci USA. 2008;105:7833–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rubio-Cabezas O, Puri V, Murano I, Saudek V, Semple RK, Dash S, et al. Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation in CIDEC. EMBO Mol Med. 2009;1:280–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Verweij N, Haas ME, Nielsen JB, Sosina OA, Kim M, Akbari P, et al. Germline mutations in CIDEB and protection against liver disease. N Engl J Med. 2022;387:332–44.

Article  CAS  PubMed  Google Scholar 

Seino Y, Nanjo K, Tajima N, Kadowaki T, Kashiwagi A, Araki E, et al. Report of the committee on the classification and diagnostic criteria of diabetes mellitus. J Diabetes Investig. 2010;1:212–28.

Article  PubMed  PubMed Central  Google Scholar 

Park CY, Kim D, Seo MK, Kim J, Choe H, Kim JH, et al. Dysregulation of lipid droplet protein expression in adipose tissues and association with metabolic risk factors in adult females with obesity and type 2 diabetes. J Nutr. 2023;153:691–702.

Article  CAS  PubMed  Google Scholar 

Moreno-Navarrete JM, Ortega F, Serrano M, Rodriguez-Hermosa JI, Ricart W, Mingrone G, et al. CIDEC/FSP27 and PLIN1 gene expression run in parallel to mitochondrial genes in human adipose tissue, both increasing after weight loss. Int J Obes (Lond). 2014;38:865–72.

Article  CAS  PubMed  Google Scholar 

Kosaka K, Kubota Y, Adachi N, Akita S, Sasahara Y, Kira T, et al. Human adipocytes from the subcutaneous superficial layer have greater adipogenic potential and lower PPAR-γ DNA methylation levels than deep layer adipocytes. Am J Physiol Cell Physiol. 2016;311:C322–9.

Article  PubMed  Google Scholar 

Kim YJ, Cho SY, Yun CH, Moon YS, Lee TR, Kim SH, et al. Transcriptional activation of Cidec by PPARgamma2 in adipocyte. Biochem Biophys Res Commun. 2008;377:297–302.

Article  CAS  PubMed  Google Scholar 

Viswakarma N, Yu S, Naik S, Kashireddy P, Matsumoto K, Sarkar J, et al. Transcriptional regulation of Cidea, mitochondrial cell death-inducing DNA fragmentation factor alpha-like effector A, in mouse liver by peroxisome proliferator-activated receptor alpha and gamma. J Biol Chem. 2007;282:18613–24.

Article  CAS  PubMed  Google Scholar 

Torres JL, Usategui-Martín R, Hernández-Cosido L, Bernardo E, Manzanedo-Bueno L, Hernández-García I, et al. PPAR-γ gene expression in human adipose tissue is associated with weight loss after sleeve gastrectomy. J Gastrointest Surg. 2022;26:286–97.

Article  PubMed  Google Scholar 

Li YH, Lei T, Chen XD, Xia T, Peng Y, Long QQ, et al. Molecular cloning, chromosomal location and expression pattern of porcine CIDEa and CIDEc. Mol Biol Rep. 2009;36:575–82.

Article  PubMed  Google Scholar 

Li YH, Li AH, Yang ZQ. Molecular cloning, genomic organization, chromosome mapping, tissues expression pattern and identification of a novel splicing variant of porcine CIDEb gene. Biochem Biophys Res Commun. 2016;478:486–93.

Article  CAS  PubMed  Google Scholar 

Gong J, Sun Z, Wu L, Xu W, Schieber N, Xu D, et al. Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites. J Cell Biol. 2011;195:953–63.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun Z, Gong J, Wu H, Xu W, Wu L, Xu D, et al. Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes. Nat Commun. 2013;4:1594.

Article  PubMed  Google Scholar 

Ganeva I, Lim K, Boulanger J, Hoffmann PC, Muriel O, Borgeaud AC, et al. The architecture of Cidec-mediated interfaces between lipid droplets. Cell Rep. 2023;42:112107.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nishimoto Y, Tamori Y. CIDE family-mediated unique lipid droplet morphology in white adipose tissue and brown adipose tissue determines the adipocyte energy metabolism. J Atheroscler Thromb. 2017;24:989–98.

Article  CAS  PubMed  PubMed Central  Google Scholar