Risk analysis and mediation analysis of stress hyperglycemia ratio and all-cause mortality in patients with acute kidney injury

Singbartl K, Kellum JA. AKI in the ICU: definition, epidemiology, risk stratification, and outcomes. Kidney Int. 2012;81(9):819–25.

CAS  PubMed  Google Scholar 

Bellomo R, Kellum JA, Ronco C. Acute kidney injury. Lancet (London England). 2012;380(9843):756–66.

PubMed  Google Scholar 

Uchino S, Kellum JA, Bellomo R, Doig GS, Morimatsu H, Morgera S, Schetz M, Tan I, Bouman C, Macedo E, et al. Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA. 2005;294(7):813–8.

CAS  PubMed  Google Scholar 

Mehta RL, Cerdá J, Burdmann EA, Tonelli M, García-García G, Jha V, Susantitaphong P, Rocco M, Vanholder R, Sever MS, et al. International society of nephrology’s 0by25 initiative for acute kidney injury (zero preventable deaths by 2025): a human rights case for nephrology. Lancet (London England). 2015;385(9987):2616–43.

PubMed  Google Scholar 

Chishiki T, Nagatomo Y, Saji M, Takei M, Goda A, Kohno T, Nakano S, Nishihata Y, Ikegami Y, Shiraishi Y, et al. Divergent effect of blood glucose dysregulation on long-term clinical outcome in acute decompensated heart failure: A reappraisal in contemporary practice. Int J Cardiol. 2022;365:91–9.

PubMed  Google Scholar 

de Miguel-Yanes JM, Gonzalo-Hernando C, Muñoz-Rivas N, Méndez-Bailón M, Cava-Valenciano F, Torres-Macho J. First plasma glucose value after urgent admission and in-hospital mortality in acutely decompensated heart failure. Heart Lung: J Crit Care. 2015;44(2):137–40.

Google Scholar 

Liu J, Zhou Y, Huang H, Liu R, Kang Y, Zhu T, Wu J, Gao Y, Li Y, Wang C, et al. Impact of stress hyperglycemia ratio on mortality in patients with critical acute myocardial infarction: insight from American MIMIC-IV and the Chinese CIN-II study. Cardiovasc Diabetol. 2023;22(1):281.

CAS  PubMed  PubMed Central  Google Scholar 

Zhou Q, Yang J, Wang W, Shao C, Hua X, Tang Y-D. The impact of the stress hyperglycemia ratio on mortality and rehospitalization rate in patients with acute decompensated heart failure and diabetes. Cardiovasc Diabetol. 2023;22(1):189.

CAS  PubMed  PubMed Central  Google Scholar 

Mi D, Li Z, Gu H, Jiang Y, Zhao X, Wang Y, Wang Y. Stress hyperglycemia is associated with in-hospital mortality in patients with diabetes and acute ischemic stroke. CNS Neurosci Ther. 2022;28(3):372–81.

CAS  PubMed  PubMed Central  Google Scholar 

Li L, Ding L, Zheng L, Wu L, Hu Z, Liu L, Yao Y. Relationship between stress hyperglycemia ratio and acute kidney injury in patients with congestive heart failure. Cardiovasc Diabetol. 2024;23:29.

CAS  PubMed  PubMed Central  Google Scholar 

Ülger P, Yildiz E, Tyczynski B, Findeisen H, Kribben A, Janssen OE, Herget-Rosenthal S. Effect of stress hyperglycaemia on acute kidney injury in non-diabetic critically ill patients? Int Urol Nephrol. 2023;55(12):3253–9.

PubMed  Google Scholar 

Roberts GW, Quinn SJ, Valentine N, Alhawassi T, O’Dea H, Stranks SN, Burt MG, Doogue MP. Relative hyperglycemia, a marker of critical illness: introducing the stress hyperglycemia ratio. J Clin Endocrinol Metab. 2015;100(12):4490–7.

CAS  PubMed  Google Scholar 

Lundberg SM, Erion G, Chen H, DeGrave A, Prutkin JM, Nair B, Katz R, Himmelfarb J, Bansal N, Lee S-I. From local explanations to global Understanding with explainable AI for trees. Nat Mach Intell. 2020;2(1):56–67.

PubMed  PubMed Central  Google Scholar 

Gao S, Huang S, Lin X, Xu L, Yu M. Prognostic implications of stress hyperglycemia ratio in patients with myocardial infarction with nonobstructive coronary arteries. Ann Med. 2023;55(1):990–9.

CAS  PubMed  PubMed Central  Google Scholar 

Xia W, Li C, Kuang M, Wu Y, Xu L, Hu H. Predictive value of glycemic gap and stress glycemia ratio among critically ill patients with acute kidney injury: a retrospective analysis of the MIMIC-III database. BMC Nephrol. 2023;24(1):227.

CAS  PubMed  PubMed Central  Google Scholar 

Shan Y, Lin M, Gu F, Ying S, Bao X, Zhu Q, Tao Y, Chen Z, Li D, Zhang W, et al. Association between fasting stress hyperglycemia ratio and contrast-induced acute kidney injury in coronary angiography patients: a cross-sectional study. Front Endocrinol. 2023;14:1300373.

Google Scholar 

Li Y, Zhang L, Liu W, Deng J, Liu J, Zhou Y, Feng L, Chen J. The impact of the stress hyperglycemia ratio on the risk of contrast-associated acute kidney injury in patients undergoing coronary angiography: a large real-world cohort study. Diabetol Metab Syndr. 2024;16(1):107.

CAS  PubMed  PubMed Central  Google Scholar 

Marik PE, Bellomo R. Stress hyperglycemia: an essential survival response! Crit Care. 2013;17(2):305.

PubMed  PubMed Central  Google Scholar 

Monnier L, Mas E, Ginet C, Michel F, Villon L, Cristol J-P, Colette C. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA. 2006;295(14):1681–7.

CAS  PubMed  Google Scholar 

Couto SMF, da Fonseca CD, Watanabe M, de Fátima Fernandes Vattimo M. Protection of coenzyme Q10 against contrast-induced acute kidney injury in male diabetic rats. Diabetol Metab Syndr. 2021;13(1):69.

CAS  PubMed  PubMed Central  Google Scholar 

Marik PE, Preiser J-C. Toward Understanding tight glycemic control in the ICU: a systematic review and metaanalysis. Chest. 2010;137(3):544–51.

CAS  PubMed  Google Scholar 

Aksu U, Demirci C, Ince C. The pathogenesis of acute kidney injury and the toxic triangle of oxygen, reactive oxygen species and nitric oxide. Contrib Nephrol. 2011;174:119–28.

PubMed  Google Scholar 

Kanwar YS, Sun L, Xie P, Liu F-Y, Chen S. A glimpse of various pathogenetic mechanisms of diabetic nephropathy. Annu Rev Pathol. 2011;6:395–423.

CAS  PubMed  PubMed Central  Google Scholar 

Busch M, Franke S, Rüster C, Wolf G. Advanced glycation end-products and the kidney. Eur J Clin Invest. 2010;40(8):742–55.

CAS  PubMed  Google Scholar 

Dungan KM, Braithwaite SS, Preiser JC. Stress hyperglycaemia. Lancet. 2009;373(9677):1798–807.

CAS  PubMed  PubMed Central  Google Scholar 

Guvercin G, Karakus V, Aksit M, Dere Y, Aktar M, Alpay H, Bozkaya G, Tatar E. Matrix metalloproteinase-9, 10, and stress hyperglycaemia in acute kidney injury. Eur J Clin Invest. 2018;48(7):e12963.

PubMed  Google Scholar 

Sechterberger MK, Bosman RJ, Oudemans-van Straaten HM, Siegelaar SE, Hermanides J, Hoekstra JBL, De Vries JH. The effect of diabetes mellitus on the association between measures of glycaemic control and ICU mortality: a retrospective cohort study. Crit Care (London England). 2013;17(2):R52.

Google Scholar 

Liu B, Chen Y, Yu L, Zhou M. Stress hyperglycemia ratio is associated with systemic inflammation and clinical outcomes in diabetic inpatients with pneumonia on admission. J Diabetes. 2023;15(7):545–56.

CAS  PubMed  PubMed Central  Google Scholar 

Edriss H, Molehin AJ, Gavidia R, Selvan K, Nugent K. Association between acute respiratory failure requiring mechanical ventilation and the production of advanced glycation end products. J Invest Medicine: Official Publication Am Federation Clin Res. 2020;68(7):1235–40.

Google Scholar 

Kountouri A, Korakas E, Ikonomidis I, Raptis A, Tentolouris N, Dimitriadis G, Lambadiari V. Type 1 diabetes mellitus in the SARS-CoV-2 pandemic: oxidative stress as a major pathophysiological mechanism linked to adverse clinical outcomes. Antioxid (Basel Switzerland). 2021;10(5):752.

CAS  Google Scholar 

Joannidis M, Forni LG, Klein SJ, Honore PM, Kashani K, Ostermann M, Prowle J, Bagshaw SM, Cantaluppi V, Darmon M, et al. Lung-kidney interactions in critically ill patients: consensus report of the acute disease quality initiative (ADQI) 21 workgroup. Intensive Care Med. 2020;46(4):654–72.

PubMed  Google Scholar 

Kulvichit W, Sarnvanichpitak K, Peerapornratana S, Tungsanga S, Lumlertgul N, Praditpornsilpa K, Tungsanga K, Eiam-Ong S, Kellum JA, Srisawat N, et al. In-hospital mortality of critically ill patients with interactions of acute kidney injury and acute respiratory failure in the resource-limited settings: results from SEA-AKI study. J Crit Care. 2022;71:154103.

PubMed  Google Scholar 

Ko C-H, Lan Y-W, Chen Y-C, Cheng T-T, Yu S-F, Cidem A, Liu Y-H, Kuo C-W, Yen C-C, Chen W et al. Effects of Mean Artery Pressure and Blood pH on Survival Rate of Patients with Acute Kidney Injury Combined with Acute Hypoxic Respiratory Failure: A Retrospective Study. Medicina (Kaunas, Lithuania): 2021, 57(11):1243.

Chertow GM, Christiansen CL, Cleary PD, Munro C, Lazarus JM. Prognostic stratification in critically ill patients with acute renal failure requiring Dialysis. Arch Intern Med. 1995;155(14):1505–11.

CAS  PubMed  Google Scholar 

Mehta RL, Pascual MT, Soroko S, Savage BR, Himmelfarb J, Ikizler TA, Paganini EP, Chertow GM. Program to improve care in acute renal D: spectrum of acute renal failure in the intensive care unit: the PICARD experience. Kidney Int. 2004;66(4):1613–21.

PubMed  Google Scholar 

Komaru Y, Bai YZ, Kreisel D, Herrlich A. Interorgan communication networks in the kidney-lung axis. Nat Rev Nephrol. 2024;20(2):120–36.

PubMed  Google Scholar 

Chen D, Jiang L, Li J, Tan Y, Ma M, Cao C, Zhao J, Wan X. Interaction of acute respiratory failure and acute kidney injury on in-Hospital mortality of patients with acute exacerbation COPD. Int J Chronic Obstr Pulm Dis. 2021;16:3309–16.

Google Scholar 

Liu KD, Glidden DV, Eisner MD, Parsons PE, Ware LB, Wheeler A, Korpak A, Thompson BT, Chertow GM, Matthay MA, et al. Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury. Crit Care Med. 2007;35(12):2755–61.

PubMed  PubMed Central 

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