Triglyceride–glucose index and the risk of in-hospital and ICU all-cause mortality: a systematic review and meta-analysis of observational studies

Vincent J-L, Sakr Y, Singer M, Martin-Loeches I, Machado FR, Marshall JC, et al. Prevalence and outcomes of infection among patients in intensive care units in 2017. JAMA. 2020;323:1478–87.

Article  PubMed  PubMed Central  Google Scholar 

Fleischmann-Struzek C, Mellhammar L, Rose N, Cassini A, Rudd K, Schlattmann P, et al. Incidence and mortality of hospital-and ICU-treated sepsis: results from an updated and expanded systematic review and meta-analysis. Intensive Care Med. 2020;46:1552–62.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Phua J, Faruq MO, Kulkarni AP, Redjeki IS, Detleuxay K, Mendsaikhan N, et al. Critical care bed capacity in Asian countries and regions. Crit Care Med. 2020;48:654–62.

Article  PubMed  Google Scholar 

Liao Y, Zhang R, Shi S, Zhao Y, He Y, Liao L, et al. Triglyceride-glucose index linked to all-cause mortality in critically ill patients: a cohort of 3026 patients. Cardiovasc Diabetol. 2022;21:1–14.

Isaias GC, Duenas C, Perales K, Juan ETD, Andres SG, Yohan EPO, et al. Approach to patient management in critical condition. Health Sci J. 2022;16:1–26.

Google Scholar 

Picod A, Morisson L, de Roquetaillade C, Sadoune M, Mebazaa A, Gayat E, et al. Systemic inflammation evaluated by Interleukin-6 or C-reactive protein in critically ill patients: results from the FROG-ICU study. Front Immunol. 2022;13:868348.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Becker CD, Sabang RL, Cordeiro MFN, Hassan IF, Goldberg MD, Scurlock CS. Hyperglycemia in medically critically ill patients: risk factors and clinical outcomes. Am J Med. 2020;133:e568–e74.

Article  CAS  PubMed  Google Scholar 

Baker L, Maley JH, Arévalo A, DeMichele IIIF, Mateo-Collado R, Finkelstein S, et al. Real-world characterization of blood glucose control and insulin use in the intensive care unit. Sci Rep. 2020;10:10718.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Naderi-Behdani F, Heydari F, Ala S, Abediankenari S, Asgarirad H. Effect of melatonin on stress-induced hyperglycemia and insulin resistance in critically-ill patients: a randomized double-blind, placebo-controlled clinical trial. Casp J Intern Med. 2022;13:51.

Google Scholar 

Cai W, Xu J, Wu X, Chen Z, Zeng L, Song X, et al. Association between triglyceride-glucose index and all-cause mortality in critically ill patients with ischemic stroke: analysis of the MIMIC-IV database. Cardiovasc Diabetol. 2023;22:138.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tao L-C, Xu J-n, Wang T-t, Hua F, Li J-J. Triglyceride-glucose index as a marker in cardiovascular diseases: landscape and limitations. Cardiovasc Diabetol. 2022;21:68.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Muhammad IF, Bao X, Nilsson PM, Zaigham S. Triglyceride-glucose (TyG) index is a predictor of arterial stiffness, incidence of diabetes, cardiovascular disease, and all-cause and cardiovascular mortality: a longitudinal two-cohort analysis. Front Cardiovasc Med. 2023;9:1035105.

Article  PubMed  PubMed Central  Google Scholar 

Qin G, Sun Z, Jin Y, Ren X, Zhang Z, Wang S, et al. The association between the triglyceride–glucose index and prognosis in postoperative renal cell carcinoma patients: a retrospective cohort study. Front Endocrinol. 2024;15:1301703.

Article  Google Scholar 

Gao Q, Lin Y, Xu R, Luo F, Chen R, Li P, et al. Positive association of triglyceride-glucose index with new-onset hypertension among adults: a national cohort study in China. Cardiovasc Diabetol. 2023;22:58.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang BJ, Liu LL, Ruan HF, Zhu Q, Yu DF, Yang Y, et al. Triglyceride-Glucose Index Linked to Hospital Mortality in Critically Ill Stroke: An Observational Multicentre Study on eICU Database. Front Med. 2020;7:1–9.

Chen T, Qian Y, Deng X. Triglyceride glucose index is a significant predictor of severe disturbance of consciousness and all-cause mortality in critical cerebrovascular disease patients. Cardiovasc Diabetol. 2023;22:156.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu H, Tao L, Li Y-G, Yang L, Liu D, Wang Y, et al. Association between triglyceride-glucose index trajectories and carotid atherosclerosis progression. Cardiovasc Diabetol. 2023;22:130.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nabipoorashrafi SA, Seyedi SA, Rabizadeh S, Ebrahimi M, Ranjbar SA, Reyhan SK, et al. The accuracy of triglyceride-glucose (TyG) index for the screening of metabolic syndrome in adults: a systematic review and meta-analysis. Nutr Metab Cardiovasc Dis. 2022;32:2677–88.

Article  CAS  PubMed  Google Scholar 

Greenland S, Longnecker MP. Methods for trend estimation from summarized dose-response data, with applications to meta-analysis. Am J Epidemiol. 1992;135:1301–9.

Article  CAS  PubMed  Google Scholar 

Orsini N, Bellocco R, Greenland S. Generalized least squares for trend estimation of summarized dose–response data. stata J. 2006;6:40–57.

Article  Google Scholar 

Cheng L, Zhang F, Xue W, Yu P, Wang X, Wang H, et al. Association of dynamic change of triglyceride-glucose index during hospital stay with all-cause mortality in critically ill patients: a retrospective cohort study from MIMIC IV2.0. Cardiovasc Diabetol. 2023;22:1–13.

Saylik F, Çinar T, Selçuk M, Tanboga IH. The predictive value of triglyceride-glucose index for in-hospital and one-year mortality in elderly non-diabetic patients with ST-segment elevation myocardial infarction. J Geriatr Cardiol. 2022;19:610–7.

CAS  PubMed  PubMed Central  Google Scholar 

Boshen Y, Yuankang Z, Xinjie Z, Taixi L, kaifan N, Zhixiang W, et al. inTriglyceride-glucose index is associated with the occurrence and prognosis of cardiac arrest: a multicenter retrospective observational study. Cardiovasc Diabetol. 2023;22: 1–15.

Cheng H, Huang W, Huang X, Miao W, Huang Y, Hu Y. The triglyceride glucose index predicts short-term mortality in non-diabetic patients with acute heart failure. Adv Clin Exp Med. 2023; 33:103.

Dai L, Yu Y, Wang K, Hu C, Wu D, Shan S. Association between TyG index and long-term mortality of critically ill patients: a retrospective study based on the MIMIC Database. BMJ Open. 2023;13:1–6.

Ding Z, Ge M, Tan Y, Chen C, Hei Z. The triglyceride-glucose index: a novel predictor of stroke and all-cause mortality in liver transplantation recipients. Cardiovasc Diabetol. 2024;23:27.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fu R, Zhao YY, Cui KY, Yang JG, Xu HY, Yin D, et al. Triglyceride glucose index predicts in-hospital mortality in patients with ST-segment elevation myocardial infarction who underwent primary angiography. J Geriatr Cardiol. 2023;20:185–94.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo J, Ji Z, Carvalho A, Qian L, Ji J, Jiang Y, et al. The triglycerides-glucose index and the triglycerides to high-density lipoprotein cholesterol ratio are both effective predictors of in-hospital death in non-diabetic patients with AMI. PeerJ. 2022;10:1–17.

Jiang Y, Chen P, Zhao Y, Cai J, Liang J, Cheng S, et al. Association between triglyceride glucose index and all-cause mortality in patients with cerebrovascular disease: a retrospective study. Diabetol Metab Syndr. 2024;16:1.

Article  PubMed  PubMed Central  Google Scholar 

Liao Z, Lin H, Liu S, Krafft PR. Admission triglyceride-glucose index predicts long-term mortality patients with subarachnoid hemorrhage a retrospective analysis of the MIMIC-IV database. Brain Hemorrhages. 2023; 5:29–37.

Miao M, Bi Y, Hao L, Bao A, Sun Y, Du H, et al. Triglyceride-glucose index and short-term functional outcome and in-hospital mortality in patients with ischemic stroke. Nutr Metab Cardiovasc Dis. 2023;33:399–407.

Article  CAS  PubMed  Google Scholar 

Ye Z, An S, Gao Y, Xie E, Zhao X, Guo Z, et al. Association between the triglyceride glucose index and in-hospital and 1-year mortality in patients with chronic kidney disease and coronary artery disease in the intensive care unit. Cardiovasc Diabetol. 2023;22:1–10.

Zhai G, Wang J, Liu Y, Zhou Y. Triglyceride-Glucose Index Linked to In-Hospital Mortality in Critically Ill Patients with Heart Disease. Rev Cardiovasc Med. 2022;23:263.

Zhang R, Shi S, Chen W, Wang Y, Lin X, Zhao Y, et al. Independent effects of the triglyceride-glucose index on all-cause mortality in critically ill patients with coronary heart disease: analysis of the MIMIC-III database. Cardiovasc Diabetol. 2023;22: 1–12.

Zhang T, Liu Y, Ge Z, Tian D, Lin L, Zhao Z, et al. Predictive value of triglyceride-glucose index for in-hospital mortality in patients with severe fever with thrombocytopenia syndrome: a multi-center observational study. Front Med. 2021;8:768101.

Article  Google Scholar 

Zheng R, Qian S, Shi Y, Lou C, Xu H, Pan J. Association between triglyceride-glucose index and in-hospital mortality in critically ill patients with sepsis: analysis of the MIMIC-IV database. Cardiovasc Diabetol. 2023;22: 1–12

Preiser J-C, Ichai C, Orban J-C, Groeneveld A. Metabolic response to the stress of critical illness. Br J Anaesth. 2014;113:945–54.

Article  CAS  PubMed  Google Scholar 

Tappy L, Schwarz J-M, Schneiter P, Cayeux C, Revelly J-P, Fagerquist CK, et al. Effects of isoenergetic glucose-based or lipid-based parenteral nutrition on glucose metabolism, de novo lipogenesis, and respiratory gas exchanges in critically ill patients. Crit Care Med. 1998;26:860–7.

Article  CAS  PubMed  Google Scholar 

Cuesta JM, Singer M. The stress response and critical illness: a review. Crit Care Med. 2012;40:3283–9.

Article  PubMed  Google Scholar 

Scheen M, Giraud R, Bendjelid K. Stress hyperglycemia, cardiac glucotoxicity, and critically ill patient outcomes current clinical and pathophysiological evidence. Physiol Rep. 2021;9:e14713.

Article  CAS  PubMed  PubMed Central  Google Scholar 

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