Clinical characteristics and associated factors of macrolide-resistant mycoplasma pneumoniae pneumonia in children: a systematic review and meta-analysis

Defilippi A, Silvestri M, Tacchella A, Giacchino R, Melioli G, Di Marco E, Cirillo C, Di Pietro P, Rossi GA (2008) Epidemiology and clinical features of Mycoplasma pneumoniae infection in children. Respir Med 102(12):1762–1768

Article  PubMed  Google Scholar 

Michelow IC, Olsen K, Lozano J, Rollins NK, Duffy LB, Ziegler T, Kauppila J, Leinonen M, McCracken GH Jr (2004) Epidemiology and clinical characteristics of community-acquired pneumonia in hospitalized children. Pediatrics 113(4):701–707

Article  PubMed  Google Scholar 

Azumagawa K, Kambara Y, Murata T, Tamai H (2008) Four cases of arthritis associated with Mycoplasma pneumoniae infection. Pediatr Int 50(4):511–513

Article  PubMed  Google Scholar 

Metz G, Kraft M (2010) Effects of atypical infections with Mycoplasma and Chlamydia on asthma. Immunol Allergy Clin North Am 30(4):575–585

Radisic M, Torn A, Gutierrez P, Defranchi HA, Pardo P (2000) Severe acute lung injury caused by Mycoplasma pneumoniae: potential role for steroid pulses in treatment. Clin Infect Dis 31(6):1507–1511

Article  CAS  PubMed  Google Scholar 

Socan M, Ravnik I, Bencina D, Dovc P, Zakotnik B, Jazbec J (2001) Neurological symptoms in patients whose cerebrospinal fluid is culture- and/or polymerase chain reaction-positive for Mycoplasma pneumoniae. Clin Infect Dis 32(2):E31-35

Article  CAS  PubMed  Google Scholar 

Liu Y, Ye X, Zhang H, Xu X, Li W, Zhu D, Wang M (2010) Characterization of macrolide resistance in Mycoplasma pneumoniae isolated from children in Shanghai, China. Diagn Microbiol Infect Dis 67(4):355–358

Article  CAS  PubMed  Google Scholar 

Dumke R, von Baum H, Lück PC, Jacobs E (2010) Occurrence of macrolide-resistant Mycoplasma pneumoniae strains in Germany. Clin Microbiol Infect 16(6):613–616

Article  CAS  PubMed  Google Scholar 

Wolff BJ, Thacker WL, Schwartz SB, Winchell JM (2008) Detection of macrolide resistance in Mycoplasma pneumoniae by real-time PCR and high-resolution melt analysis. Antimicrob Agents Chemother 52(10):3542–3549

Article  CAS  PubMed  PubMed Central  Google Scholar 

Morozumi M, Hasegawa K, Kobayashi R, Inoue N, Iwata S, Kuroki H, Kawamura N, Nakayama E, Tajima T, Shimizu K, Ubukata K (2005) Emergence of macrolide-resistant Mycoplasma pneumoniae with a 23S rRNA gene mutation. Antimicrob Agents Chemother 49(6):2302–2306

Article  CAS  PubMed  PubMed Central  Google Scholar 

Morozumi M, Takahashi T, Ubukata K (2010) Macrolide-resistant Mycoplasma pneumoniae: characteristics of isolates and clinical aspects of community-acquired pneumonia. J Infect Chemother 16(2):78–86

Article  PubMed  Google Scholar 

Douthwaite S, Hansen LH, Mauvais P (2000) Macrolide-ketolide inhibition of MLS-resistant ribosomes is improved by alternative drug interaction with domain II of 23S rRNA. Mol Microbiol 36(1):183–193

Article  CAS  PubMed  Google Scholar 

Wells GA, Shea B, O'Connell D, Peterson J, Welch V, Losos M, Tugwell P (2021) The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Ottawa Health Research Institute. http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp. Accessed 23 Nov 2024

Ma Q, Fu X, Liu X, Cui F, Xin D (2010) The relationship between the occurrence of extrapulmonary complications in mycoplasma pneumoniae pneumonia in children and drug resistance. Hebei Med J 32(24):3445–3446

Han X, Wen H, Miao N, Wang C (2016) Drug resistance situation and clinical efficiency of azithromycin in children with Mycoplasma pneumoniae pneumonia. J Pediatr Pharm 22(05):18–20

CAS  Google Scholar 

Liu D, Zhang X, Li Y (2016) The infection of Mycoplasma pneumoniae, detection and analysis of drug resistance in children. Med J West China 28(11):1598–1602

Feng X, Li Q, Sun L, Jiao WW, Xu BP, Yin Ju, Guo Y, Shen C, Li JQ (2016) The clinical characteristics of macrolide-resistant Mycoplasma pneumoniae pneumonia in children: a case-control study. Chinese Journal of Evidence-Based Pediatrics 11(5):357–360

Google Scholar 

Zhu MJ, Xu M, Song L, Zhao JH, Zhou F, Ji JH (2016) Clinical analysis of drug-resistant Mycoplasma pneumoniae pneumonia in children. Chin J Clin Res 29(09):1232–1234

CAS  Google Scholar 

Kong J, Chen YJ, Guan MC, Hang JG, Peng CJ, Wang LH (2016) Clinical characteristics and IL-8 expression in bronchoalveolar lavage fLuid of mycoplasma pneumoniae pneumonia in children with MP 23S rRNA resistance gene 2063 locus positive. Chinese J Health Lab Technol 26(23):3385–3388

Chen Y, Hu C (2017) Prevalence of macrolide resistance in children with Mycoplasma pneumoniae infection and the expression and significance of serum WBC, CRP, and ESR. Maternal & Child Health Care of China 32(21):5313–5316

CAS  Google Scholar 

Yang YH, Zhang Y, Huang XM, Chen YL, Shen J, Zhang WY (2018) Clinic analysis of macrolide-resistant Mycoplasma pneumoniae pneumonia in children. Chin J Gen Pract 16 (03):434–436+491

Lu Y, Chen B, Wu M (2018) Detection and clinical significance of drug resistance genes in Mycoplasma pneumonia in children. Chin J Rural Med Pharm 25(12):48–49

Google Scholar 

Li Y, Zhong L, Zhang B, Huang H, Ding X, Lin L, Chen H, Huang Z, Peng L, Lin X (2018) Analysis of clinical features of children with Mycoplasma pneumoniae pneumonia with A 2063 G gene mutation in 23 S rRNA V domain. J Clin Pediatr 36(8):569–574

Google Scholar 

Chen Y, Tian W, Chen Q, Zhao H, Huang P, Lin Z, Chen L (2018) Clinical features and treatment of macrolide-resistant Mycoplasma pneumoniae pneumonia in children. Chinese Journal of Contemporary Pediatrics 20(8):629–634

PubMed  Google Scholar 

Chen C, Huang X, Zhao D, Xie Y, Wu P, Deng L, Lu G (2019) Surveillance of Mycoplasma pneumoniae antibiotic resistance in children from 2014 to 2018. Chin J Sociol 29(12):1850–1855

Google Scholar 

Wu B, Zhang L, Zhang W, Li X, Liu J, Gu Q (2020) Detection and clinical analysis of drug-resistant mutation sites in children with Mycoplasma infectious lobar pneumonia. Chin J Pract Pediatr 35(08):626–630

Google Scholar 

Chen X, Wang J, Hong Y, Zhang L (2020) Risk factors for MA resistance in children with Mycoplasma pneumoniae pneumonia and suggestions for treatment. Journal of Clinical Pulmonary Medicine 25(9):1385–1388

Google Scholar 

Yu C, Lv W, Zhang X (2021) The relationship between clinical phenotype and chest imaging in community-acquired pneumonia with MP 23S rRNA A2063G gene mutation in children. J Clin Pediatr 39(4):265–268

Google Scholar 

Wu C, Wang A, Cai Z (2021) Correlation between 23S rRNA mutation of Mycoplasma pneumoniae and clinical characteristics and drug resistance in children. Chinese Journal of General Practice 19(04):603–606

Google Scholar 

Ren L, Wang X, Zhao T, Liu R (2021) Study on the relationship between the 2063 site mutation of 23S rRNA resistance gene and MP-DNA load and resistance to macrolides in children with MPP. Chin J Birth Health Heredity 29(07):924–927

Google Scholar 

He J, Zhang X, Zhao W, Yang L (2022) Clinical characteristics of macrolide-resistant Mycoplasma pneumoniae pneumonia in children. J Pediatr Pharm 28(08):36–39

Google Scholar 

Guo B, Qiao J, Pang X, Li H, Hou Y, Tian J (2022) Correlation and analysis between 23S rRNA gene mutation and antibiotic resistance of Mycoplasma pneumoniae in children. Chin J Health Lab Technol 32(15):1836–1839

Google Scholar 

Zhang Y, Meng C (2023) Analysis of gene mutation of macrolides resistance in children with refractory Mycoplasma pneumoniae pneumonia. Chin J Pract Pediatr 38(05):376–380

CAS  Google Scholar 

Peng J, Wang Y (2023) Multifactorial analysis of clinical indicators associated with macrolide resistant Mycoplasma pneumoniae infection in children. Chinese Journal of Medicine 58(9):1021–1023

Google Scholar 

Chen P, Liu W (2023) Analysis of risk factors and construction of risk assessment model for macrolide antibiotics resistance in children with Mycoplasma pneumonia. Clinical Medication Journal 21(8):65–70

Google Scholar 

Zhou J, Yuan C (2023) Resistance gene mutations and characteristics of Mycoplasma pneumoniae in children. Chin J Health Lab Technol 33(14):1673–1676

Google Scholar 

Zhang W, Zhang X, Gu W, Yan Y, Ji W, Zhu C, Shao X, Hao C, Chen Z (2021) Role of macrolides resistance in children with refractory Mycoplasma pneumoniae pneumonia. Chin J Appl Clin Pediatr 36(11):822–826

Google Scholar 

Chen J, Zhang H, Shang Y (2022) Clinical and bronchoscopy characteristics of Mycoplasma pneumoniae pneumonia in children with 23S rRNA resistance gene positive in bronchoalveolar lavage fluid. Chin J Appl Clin Pediatr 37(12):897–902

Google Scholar 

Zheng B, Yan C, Xue G, Cao L, Sun H (2017) Analysis of clinical characteristics and epidemic genotypes of children with Mycoplasma pneumoniae pneumonia. Chin J Appl Clin Pediatr 32(10):735–739

Google Scholar 

Bao F, Qu JX, Liu ZJ, Qin XG, Cao B (2013) The clinical characteristics, treatment and outcome of macrolide-resistant Mycoplasma pneumoniae pneumonia in children. Chinese Journal of Tuberculosis and Respiratory Diseases 36(10):756–761

PubMed  Google Scholar 

Wu PS, Chang LY, Lin HC, Chi H, Hsieh YC, Huang YC, Liu CC, Huang YC, Huang LM (2013) Epidemiology and clinical manifestations of children with macrolide-resistant Mycoplasma pneumoniae pneumonia in Taiwan. Pediatr Pulmonol 48(9):904–911

Article  PubMed  Google Scholar 

Kuo CY, Tsai WC, Lee HF, Ho TS, Huang LM, Shen CF, Liu CC (2022) The epidemiology, clinical characteristics, and macrolide susceptibility of Mycoplasma pneumoniae pneumonia in children in Southern Taiwan, 2019–2020. J Microbiol Immunol Infect = Wei mian yu gan ran za zhi 55(4):611–619

Zhou Y, Zhang Y, Sheng Y, Zhang L, Shen Z, Chen Z (2014) More complications occur in macrolide-resistant than in macrolide-sensitive Mycoplasma pneumoniae pneumonia. Antimicrob Agents Chemother 58(2):1034–1038

Article  PubMed  PubMed Central  Google Scholar 

Ma Z, Zheng Y, Deng J, Ma X, Liu H (2014) Characterization of macrolide resistance of Mycoplasma pneumoniae in children in Shenzhen, China. Pediatric pulmonology 49(7):695–700

Article  PubMed  Google Scholar 

Matsubara K, Morozumi M, Okada T, Matsushima T, Komiyama O, Shoji M, Ebihara T, Ubukata K, Sato Y, Akita H, Sunakawa K, Iwata S (2009) A comparative clinical study of macrolide-sensitive and macrolide-resistant Mycoplasma pneumoniae infections in pediatric patients. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 15(6):380–383

Article  PubMed  Google Scholar 

Cheong KN, Chiu SS, Chan BW, To KK, Chan EL, Ho PL (2016) Severe macrolide-resistant Mycoplasma pneumoniae pneumonia associated with macrolide failure. J Microbiol Immunol Infect = Wei mian yu gan ran za zhi 49 (1):127–130

Lung DC, Yip EK, Lam DS, Que TL (2013) Rapid defervescence after doxycycline treatment of macrolide-resistant Mycoplasma pneumoniae-associated community-acquired pneumonia in children. Pediatr Infect Dis J 32(12):1396–1399

Article  PubMed 

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