Adelborg K, Szépligeti SK, Holland-Bill L, Ehrenstein V, Horváth-Puhó E, Henderson VW et al (2018) Migraine and risk of cardiovascular diseases: Danish population based matched cohort study. BMJ 360:k96

Article  PubMed  PubMed Central  Google Scholar 

Baigent C, Keech A, Kearney PM, Blackwell L, Buck G, Pollicino C et al (2005) Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins. Lancet 366(9493):1267–1278

Article  CAS  PubMed  Google Scholar 

Battle A, Brown CD, Engelhardt BE, Montgomery SB (2017) Genetic effects on gene expression across human tissues. Nature 550(7675):204–213

Article  PubMed  Google Scholar 

Berkovich RR, Sokolov AY, Togasaki DM, Yakupova AA, Cesar PH, Sahai-Srivastava S (2018) Dextromethorphan/quinidine in migraine prophylaxis: an open-label observational clinical study. Clin Neuropharmacol 41(2):64–69

Article  CAS  PubMed  Google Scholar 

Bi Y, Zhu Y, Tang S, Huang Y (2023) Lipids, lipid-modifying drug target genes and migraine: a Mendelian randomization study. J Headache Pain 24(1):112

Article  CAS  PubMed  PubMed Central  Google Scholar 

Buettner C, Nir RR, Bertisch SM, Bernstein C, Schain A, Mittleman MA et al (2015) Simvastatin and vitamin D for migraine prevention: A randomized, controlled trial. Ann Neurol 78(6):970–981

Article  CAS  PubMed  PubMed Central  Google Scholar 

Crisan E, Patil VK (2020) Neuromuscular complications of statin therapy. Curr Neurol Neurosci Rep 20(10):47

Article  CAS  PubMed  Google Scholar 

Davies NM, Holmes MV, Davey SG (2018) Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians. BMJ 362:k601

Article  PubMed  PubMed Central  Google Scholar 

de Klein N, Tsai EA, Vochteloo M, Baird D, Huang Y, Chen CY et al (2023) Brain expression quantitative trait locus and network analyses reveal downstream effects and putative drivers for brain-related diseases. Nat Genet 55(3):377–388

Article  PubMed  PubMed Central  Google Scholar 

Dreier JP, Fabricius M, Ayata C, Sakowitz OW, Shuttleworth CW, Dohmen C et al (2017) Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: review and recommendations of the COSBID research group. J Cereb Blood Flow Metab 37(5):1595–1625

Article  PubMed  Google Scholar 

Eigenbrodt AK, Ashina H, Khan S, Diener HC, Mitsikostas DD, Sinclair AJ et al (2021) Diagnosis and management of migraine in ten steps. Nat Rev Neurol 17(8):501–514

Article  PubMed  PubMed Central  Google Scholar 

Ferrari MD, Goadsby PJ, Burstein R, Kurth T, Ayata C, Charles A et al (2022) Migraine. Nat Rev Dis Primers 8(1):2

Article  PubMed  Google Scholar 

Finan C, Gaulton A, Kruger FA, Lumbers RT, Shah T, Engmann J et al (2017) The druggable genome and support for target identification and validation in drug development. Sci Transl Med 9(383):eaag1166

Article  PubMed  PubMed Central  Google Scholar 

Freshour SL, Kiwala S, Cotto KC, Coffman AC, McMichael JF, Song JJ et al (2021) Integration of the drug-gene interaction database (DGIdb 4.0) with open crowdsource efforts. Nucleic Acids Res 49(D1):D1144–D1151

Article  CAS  PubMed  Google Scholar 

Giambartolomei C, Vukcevic D, Schadt EE, Franke L, Hingorani AD, Wallace C et al (2014) Bayesian test for colocalisation between pairs of genetic association studies using summary statistics. PLoS Genet 10(5):e1004383

Article  PubMed  PubMed Central  Google Scholar 

Guo Y, Daghlas I, Gormley P, Giulianini F, Ridker PM, Mora S et al (2021) Phenotypic and genotypic associations between migraine and lipoprotein subfractions. Neurology 97(22):e2223–e2235

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ha H, Gonzalez A (2019) Migraine headache prophylaxis. Am Fam Physician 99(1):17–24

PubMed  Google Scholar 

Hautakangas H, Winsvold BS, Ruotsalainen SE, Bjornsdottir G, Harder AVE, Kogelman LJA et al (2022) Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles. Nat Genet 54(2):152–160

Article  CAS  PubMed  PubMed Central  Google Scholar 

Headache Classification Committee of the International Headache Society (IHS) (2018) The international classification of headache disorders, 3rd edn. Cephalalgia 38(1):1–211

Kadomatsu K, Bencsik P, Görbe A, Csonka C, Sakamoto K, Kishida S et al (2014) Therapeutic potential of midkine in cardiovascular disease. Br J Pharmacol 171(4):936–944

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kruuse C, Thomsen LL, Birk S, Olesen J (2003) Migraine can be induced by sildenafil without changes in middle cerebral artery diameter. Brain J Neurol 126(Pt 1):241–247

Article  Google Scholar 

Kuo CY, Yen MF, Chen LS, Fann CY, Chiu YH, Chen HH et al (2013) Increased risk of hemorrhagic stroke in patients with migraine: a population-based cohort study. PLoS ONE 8(1):e55253

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kurki MI, Karjalainen J, Palta P, Sipilä TP, Kristiansson K, Donner KM et al (2023) FinnGen provides genetic insights from a well-phenotyped isolated population. Nature 613(7944):508–518

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee KJ, Lee SJ, Bae HJ, Sung J (2022) Exploring the causal inference of migraine on stroke: a Mendelian randomization study. Eur J Neurol 29(1):335–338

Article  PubMed  Google Scholar 

Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A et al (2018) Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nat Genet 50(4):524–537

Article  CAS  PubMed  PubMed Central  Google Scholar 

McKinley EC, Lay CL, Rosenson RS, Chen L, Chia V, Colantonio LD et al (2021) Risk for ischemic stroke and coronary heart disease associated with migraine and migraine medication among older adults. J Headache Pain 22(1):124

Article  PubMed  PubMed Central  Google Scholar 

Medeiros FL, Medeiros PL, Valença MM, Dodick D (2007) Simvastatin for migraine prevention. Headache 47(6):855–856

Article  PubMed  Google Scholar 

Migraine AM (2020) N Engl J Med 383(19):1866–1876

Article  Google Scholar 

Murray CJ, Lopez AD (1997) Mortality by cause for eight regions of the world: global burden of disease study. Lancet 349(9061):1269–1276

Article  CAS  PubMed  Google Scholar 

Neumaier EE, Rothhammer V, Linnerbauer M (2023) The role of midkine in health and disease. Front Immunol 14:1310094

Article  CAS  PubMed  PubMed Central  Google Scholar 

Øie LR, Kurth T, Gulati S, Dodick DW (2020) Migraine and risk of stroke. J Neurol Neurosurg Psychiatry 91(6):593–604

Article  PubMed  Google Scholar 

Otero Uribe JL, López SR (2006) Do statins have benefit on migraine. Med Clin (Barc) 127(8):319

Article  PubMed  Google Scholar 

Piper RD, Lambert GA (1996) Inhalational anesthetics inhibit spreading depression: relevance to migraine. Cephalalgia 16(2):87–92

Article  CAS