World Health Organization. Ageing and health. World Health Organization. 2022. https://libguides.liberty.edu/ama/whoreports. Accessed 30 June 2024.

Health AIo, Welfare. Older Australians. 2023. https://www.aihw.gov.au/reports/older-people/older-australians. Accessed 30 June 2024.

Caplan Z. US older population grew from 2010 to 2020 at fastest rate since 1880 to 1890. United States Census Bureau. 2023. 2020 Census: 1 in 6 People in the United States Were 65 and Over. Accessed 30 June 2024.

World Health Organization. Life expectancy and healthy life expectancy. World Health Organization. 2020. https://www.who.int/data/gho/data/indicators/indicator-details/GHO/life-expectancy-at-birth-(years). Accessed 30 June 2024.

Malani P, Kullgren J, Solway E, et al. National poll on healthy aging: older adults’ preparedness to age in place. April 2022. https://doi.org/10.7302/4278.

US. Dept of Health and Human Services. 2023 profile of older Americans. The Administration for Community Living; 2024. https://acl.gov/sites/default/files/Profile%20of%20OA/ACL_ProfileOlderAmericans2023_508.pdf. Accessed 30 June 2024.

Kantor ED, Rehm CD, Haas JS, Chan AT, Giovannucci EL. Trends in prescription drug use among adults in the United States from 1999–2012. JAMA. 2015;314(17):1818–31. https://doi.org/10.1001/jama.2015.13766.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Innes GK, Ogden CL, Crentsil V, Concato J, Fakhouri TH. Prescription medication use among older adults in the US. JAMA Intern Med. Published online July 1, 2024. https://doi.org/10.1001/jamainternmed.2024.2781.

Sirois C, Domingues NS, Laroche ML, et al. Polypharmacy definitions for multimorbid older adults need stronger foundations to guide research, clinical practice and public health. Pharmacy (Basel). 2019. https://doi.org/10.3390/pharmacy7030126.

Article  PubMed  PubMed Central  Google Scholar 

Gebreyohannes EA, Gebresillassie BM, Mulugeta F, Dessu E, Abebe TB. Treatment burden and health-related quality of life of patients with multimorbidity: a cross-sectional study. Qual Life Res. 2023;32(11):3269–77. https://doi.org/10.1007/s11136-023-03473-3.

Article  PubMed  PubMed Central  Google Scholar 

Van Wilder L, Devleesschauwer B, Clays E, Pype P, Vandepitte S, De Smedt D. Polypharmacy and health-related quality of life/psychological distress among patients with chronic disease. Prev Chronic Dis. 2022;19:E50. https://doi.org/10.5888/pcd19.220062.

Article  PubMed  PubMed Central  Google Scholar 

Yue Z, Xue X, Qian J. The association between polypharmacy and health-related quality of life among older adults with prostate cancer. J Geriatr Oncol. 2024;15(5): 101772. https://doi.org/10.1016/j.jgo.2024.101772.

Article  CAS  PubMed  Google Scholar 

Shalihin SE, Fauzi A, Zulkifli NA, Aziz AA. Anti-diabetic medication burden amongst older persons with diabetes and associated quality of life. Med J Malays. 2020;75(5):525–30.

CAS  Google Scholar 

Al-Mansouri A, Hamad AI, Al-Ali FS, et al. Pill-burden and its association with treatment burden among patients with advanced stages of chronic kidney disease. Saudi Pharm J. 2023;31(5):678–86. https://doi.org/10.1016/j.jsps.2023.03.008.

Article  PubMed  PubMed Central  Google Scholar 

Hughes CM, Cooper JA, Ryan C. Going beyond the numbers—a call to redefine polypharmacy. Br J Clin Pharmacol. 2014;77(6):915–6. https://doi.org/10.1111/bcp.12284.

Article  PubMed  PubMed Central  Google Scholar 

Vyas A, Kang F, Barbour M. Association between polypharmacy and health-related quality of life among US adults with cardiometabolic risk factors. Qual Life Res. 2020;29(4):977–86. https://doi.org/10.1007/s11136-019-02377-5.

Article  PubMed  Google Scholar 

Babcock ZR, Kogut SJ, Vyas A. Association between polypharmacy and health-related quality of life among cancer survivors in the United States. J Cancer Surviv. 2020;14(1):89–99. https://doi.org/10.1007/s11764-019-00837-y.

Article  PubMed  Google Scholar 

Aljeaidi MS, Haaksma ML, Tan ECK. Polypharmacy and trajectories of health-related quality of life in older adults: an Australian cohort study. Qual Life Res. 2022;31(9):2663–71. https://doi.org/10.1007/s11136-022-03136-9.

Article  PubMed  PubMed Central  Google Scholar 

McNeil JJ, Woods RL, Nelson MR, et al. Baseline characteristics of participants in the ASPREE (ASPirin in Reducing Events in the Elderly) study. J Gerontol A Biol Sci Med Sci. 2017;72(11):1586–93. https://doi.org/10.1093/gerona/glw342.

Article  PubMed  PubMed Central  Google Scholar 

ASPREE Investigator Group. Study design of ASPirin in Reducing Events in the Elderly (ASPREE): a randomized, controlled trial. Contemp Clinl Trials. 2013;36(2):555–64. https://doi.org/10.1016/j.cct.2013.09.014.

Article  Google Scholar 

Ernst ME, Broder JC, Wolfe R, et al. Health characteristics and aspirin use in participants at the baseline of the ASPirin in Reducing Events in the Elderly-eXTension (ASPREE-XT) observational study. Contemp Clin Trials. 2023;130: 107231. https://doi.org/10.1016/j.cct.2023.107231.

Article  PubMed  PubMed Central  Google Scholar 

McNeil JJ, Woods RL, Nelson MR, et al. Effect of aspirin on disability-free survival in the healthy elderly. N Engl J Med. 2018;379(16):1499–508. https://doi.org/10.1056/nejmoa1800722.

Article  CAS  PubMed  PubMed Central  Google Scholar 

McNeil JJ, Wolfe R, Woods RL, et al. Effect of aspirin on cardiovascular events and bleeding in the healthy elderly. N Engl J Med. 2018;379(16):1509–18. https://doi.org/10.1056/nejmoa1805819.

Article  CAS  PubMed  PubMed Central  Google Scholar 

McNeil JJ, Nelson MR, Woods RL, et al. Effect of aspirin on all-cause mortality in the healthy elderly. N Engl J Med. 2018;379(16):1519–28. https://doi.org/10.1056/nejmoa1803955.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ware J Jr, Kosinski M, Keller SD. A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. Med Care. 1996;34(3):220–33. https://doi.org/10.1097/00005650-199603000-00003.

Article  PubMed  Google Scholar 

Ware JE, Kosinski M, Keller SD. SF-12: how to score the SF-12 Physical and Mental Health Summary Score. 2nd ed. Boston: The Health Institute, New England Medical Center; 1995.

Google Scholar 

Irwin M, Artin KH, Oxman MN. Screening for depression in the older adult: criterion validity of the 10-item Center for Epidemiological Studies Depression Scale (CES-D). Arch Intern Med. 1999;159(15):1701–4. https://doi.org/10.1001/archinte.159.15.1701.

Article  CAS  PubMed  Google Scholar 

Andresen EM, Malmgren JA, Carter WB, Patrick DL. Screening for depression in well older adults: evaluation of a short form of the CES-D (Center for Epidemiologic Studies Depression Scale). Am J Prev Med. 1994;10(2):77–84. https://doi.org/10.1016/S07493797(18)30622-6.

Article  CAS  PubMed  Google Scholar 

Wang L, Palmer AJ, Cocker F, Sanderson K. Multimorbidity and health-related quality of life (HRQoL) in a nationally representative population sample: implications of count versus cluster method for defining multimorbidity on HRQoL. Health Qual Life Outcomes. 2017;15(1):7. https://doi.org/10.1186/s12955-016-0580-x.

Article  PubMed  PubMed Central  Google Scholar 

Mauvais-Jarvis F, Bairey Merz N, Barnes PJ, Brinton RD, Carrero JJ, DeMeo DL, De Vries GJ, Epperson CN, Govindan R, Klein SL, Lonardo A, Maki PM, McCullough LD, Regitz-Zagrosek V, Regensteiner JG, Rubin JB, Sandberg K, Suzuki A. Sex and gender: modifiers of health, disease, and medicine. Lancet. 2020;396(10250):565–82. https://doi.org/10.1016/S0140-6736(20)31561-0.

Article  PubMed  PubMed Central  Google Scholar 

Tian F, Chen Z, Zeng Y, Feng Q, Chen X. Prevalence of use of potentially inappropriate medications among older adults worldwide: a systematic review and meta-Analysis. JAMA Netw Open. 2023;6(8): e2326910. https://doi.org/10.1007/s11096-024-01769-z.

Article  PubMed  PubMed Central  Google Scholar 

Hughes JE, Bennett KE, Cahir C. Drug–drug interactions and their association with adverse health outcomes in the older community-dwelling population: a prospective cohort study. Clin Drug Investig. 2024;44(6):439–53. https://doi.org/10.1007/s40261-024-01369-9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gebreyohannes EA, Shibe BS, Taye WA, Lee K, Abdela OA, Ayele EM, Belachew EA, Mengistu SB, Myint PK, Soiza RL. Anticholinergic burden and health-related quality of life among adult patients in a resource-limited setting: a cross-sectional study. Int J Clin Pharm. 2024;46(6):1352–61. https://doi.org/10.1007/s11096-024-01769-z. (Epub 2024 Jul 15).

Article  PubMed  PubMed Central  Google Scholar 

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