Suppression of skin lesions and SLE nephritis by increasing Treg in MRL/FASlpr mice by administration of bee venom Apitoxin®

Ameer MA, Chaudhry H, Mushtaq J, Khan OS, Babar M, Hashim T, et al. An overview of systemic lupus erythematosus (SLE) pathogenesis, classification, and management. Cureus. 2022;14(10).

Chan OT, Madaio MR, Shlomchik MJ, Chan OI, Madaio MP. The central and multiple roles of B cells in lupus pathogenesis. Immunol Rev. 1999;169(1):107–21.

Article  CAS  PubMed  Google Scholar 

Mok C, Lau C. Pathogenesis of systemic lupus erythematosus. J Clin Pathol. 2003;56(7):481–90.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moulton VR, Suarez-Fueyo A, Meidan E, Li H, Mizui M, Tsokos GC. Pathogenesis of human systemic lupus erythematosus: a cellular perspective. Trends Mol Med. 2017;23(7):615–35.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pan L, Lu M-P, Wang J-H, Xu M, Yang S-R. Immunological pathogenesis and treatment of systemic lupus erythematosus. World J Pediatr. 2020;16:19–30.

Article  PubMed  Google Scholar 

Morand EF, Vital EM, Petri M, van Vollenhoven R, Wallace DJ, Mosca M, et al. Baricitinib for systemic lupus erythematosus: a double-blind, randomised, placebo-controlled, phase 3 trial (SLE-BRAVE-I). Lancet. 2023;401(10381):1001–10.

Article  CAS  PubMed  Google Scholar 

Parra Sánchez AR, Voskuyl AE, van Vollenhoven RF. Treat-to-target in systemic lupus erythematosus: advancing towards its implementation. Nat Rev Rheumatol. 2022;18(3):146–57.

Article  PubMed  Google Scholar 

De Groof A, Hémon P, Mignen O, Pers J-O, Wakeland EK, Renaudineau Y, et al. Dysregulated lymphoid cell populations in mouse models of systemic lupus erythematosus. Clin Rev Allergy Immunol. 2017;53(2):181–97.

Article  PubMed  Google Scholar 

Ali M. Studies on bee venom and its medical uses. Int J Adv Res Technol. 2012;1(2):69–83.

CAS  Google Scholar 

Elieh Ali Komi D, Shafaghat F, Zwiener RD. Immunology of bee venom. Clin Rev Allergy Immunol. 2018;54:386–96.

Article  CAS  PubMed  Google Scholar 

Oršolić N. Bee venom in cancer therapy. Cancer Metastasis Rev. 2012;31:173–94.

Article  PubMed  Google Scholar 

Wehbe R, Frangieh J, Rima M, El Obeid D, Sabatier J-M, Fajloun Z. Bee venom: Overview of main compounds and bioactivities for therapeutic interests. Molecules. 2019;24(16):2997.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jo M, Park MH, Kollipara PS, An BJ, Song HS, Han SB, et al. Anti-cancer effect of bee venom toxin and melittin in ovarian cancer cells through induction of death receptors and inhibition of JAK2/STAT3 pathway. Toxicol Appl Pharmcol. 2012;258(1):72–81.

Article  CAS  Google Scholar 

Liu C-c, Hao D-j, Zhang Q, An J, Zhao J-j, Chen B, et al. Application of bee venom and its main constituent melittin for cancer treatment. Cancer Chemother Pharmacol. 2016;78:1113–30.

Article  CAS  PubMed  Google Scholar 

Rady I, Siddiqui IA, Rady M, Mukhtar H. Melittin, a major peptide component of bee venom, and its conjugates in cancer therapy. Cancer Lett. 2017;402:16–31.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee G, Bae H. Anti-inflammatory applications of melittin, a major component of bee venom: Detailed mechanism of action and adverse effects. Molecules. 2016;21(5):616.

Article  PubMed  PubMed Central  Google Scholar 

Park HJ, Son DJ, Lee CW, Choi MS, Lee US, Song HS, et al. Melittin inhibits inflammatory target gene expression and mediator generation via interaction with IκB kinase. Biochem Pharmacol. 2007;73(2):237–47.

Article  CAS  PubMed  Google Scholar 

Park HJ, Lee HJ, Choi MS, Son DJ, Song HS, Song MJ, et al. JNK pathway is involved in the inhibition of inflammatory target gene expression and NF-kappaB activation by melittin. J Inflamm. 2008;5:1–13.

Article  Google Scholar 

He S-d, Tan N, Sun C-x, Liao K-h, Zhu H-j, Luo X-g, et al. Treatment with melittin induces apoptosis and autophagy of fibroblast-like synoviocytes in patients with rheumatoid arthritis. Curr Pharm Biotechnol. 2020;21(8):734–40.

Article  CAS  PubMed  Google Scholar 

Kim S-K, Park K-Y, Yoon W-C, Park S-H, Park K-K, Yoo D-H, et al. Melittin enhances apoptosis through suppression of IL-6/sIL-6R complex-induced NF-κB and STAT3 activation and Bcl-2 expression for human fibroblast-like synoviocytes in rheumatoid arthritis. Joint Bone Spine. 2011;78(5):471–7.

Article  CAS  PubMed  Google Scholar 

Nah S-S, Ha E, Mun SH, Won H-J, Chung J-H. Effects of melittin on the production of matrix metalloproteinase-1 and-3 in rheumatoid arthritic fibroblast-like synoviocytes. J Pharmacol Sci. 2008;106(1):162–6.

Article  CAS  PubMed  Google Scholar 

Fennell JF, Shipman WH, Cole LJ. Antibacterial action of melittin, a polypeptide from bee venom. Proc Soc Exp Biol Med. 1968;127(3):707–10.

Article  CAS  PubMed  Google Scholar 

Baek H, Park S-Y, Ku SJ, Ryu K, Kim Y, Bae H, et al. Bee venom phospholipase A2 induces regulatory T cell populations by suppressing apoptotic signaling pathway. Toxins. 2020;12(3):198.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Choi G-M, Lee B, Hong R, Park S-Y, Cho D-E, Yeom M, et al. Bee venom phospholipase A2 alleviates collagen-induced polyarthritis by inducing Foxp3 + regulatory T cell polarization in mice. Sci Rep. 2021;11(1):3511.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee G, Kang G-H, Bae H. Bee venom phospholipase A2 suppression of experimental autoimmune encephalomyelitis is dependent on its enzymatic activity. Mol Cell Toxicol. 2019;15:307–13.

Article  CAS  Google Scholar 

Son DJ, Lee JW, Lee YH, Song HS, Lee CK, Hong JT. Therapeutic application of anti-arthritis, pain-releasing, and anti-cancer effects of bee venom and its constituent compounds. Pharmacol Ther. 2007;115(2):246–70.

Article  CAS  PubMed  Google Scholar 

Stuhlmeier KM. Apis mellifera venom and melittin block neither NF-κB-p50-DNA interactions nor the activation of NF-κB, instead they activate the transcription of proinflammatory genes and the release of reactive oxygen intermediates. J Immunol. 2007;179(1):655–64.

Article  CAS  PubMed  Google Scholar 

Kwon Y-B, Kim J-H, Yoon J-H, Lee J-D, Han H-J, Mar W-C, et al. The analgesic efficacy of bee venom acupuncture for knee osteoarthritis: a comparative study with needle acupuncture. Am J Chin Med. 2001;29(02):187–99.

Article  CAS  PubMed  Google Scholar 

Choi MS, Park S, Choi T, Lee G, Haam K-K, Hong M-C, et al. Bee venom ameliorates ovalbumin induced allergic asthma via modulating CD4 + CD25 + regulatory T cells in mice. Cytokine. 2013;61(1):256–65.

Article  CAS  PubMed  Google Scholar 

Eggenhuizen PJ, Ng BH, Ooi JD. Treg enhancing therapies to treat autoimmune diseases. Int J Mol Sci. 2020;21(19):7015.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Scheinecker C, Göschl L, Bonelli M. Treg cells in health and autoimmune diseases: new insights from single cell analysis. J Autoimmun. 2020;110:102376.

Article  CAS  PubMed  Google Scholar 

Spence A, Klementowicz JE, Bluestone JA, Tang Q. Targeting Treg signaling for the treatment of autoimmune diseases. Curr Opin Immunol. 2015;37:11–20.

Article 

Comments (0)

No login
gif