Examining the safety and side effects of exposure therapy in virtual reality for patients with obsessive-compulsive disorder

Cuijpers P. Targets and outcomes of psychotherapies for mental disorders: An overview. World Psychiatry. 2019;18:276.

Google Scholar 

Herzog P, Lauff S, Rief W, Brakemeier EL. Assessing the unwanted: A systematic review of instruments used to assess negative effects of psychotherapy. Brain Behav. 2019;9.

Wiebe A, Kannen K, Selaskowski B, Mehren A, Thöne AK, Pramme L, et al. Virtual reality in the diagnostic and therapy for mental disorders: A systematic review. Clin Psychol Rev. 2022;98.

Klatte R, Strauss B, Flückiger C, Rosendahl J. Adverse effects of psychotherapy: Protocol for a systematic review and meta-analysis. Syst Rev. 2018;7.

Schneider SC, Knott L, Cepeda SL, Hana LM, McIngvale E, Goodman WK, et al. Serious negative consequences associated with exposure and response prevention for obsessive-compulsive disorder: A survey of therapist attitudes and experiences. Depress Anxiety. 2020;37:418–28.

Article  PubMed  Google Scholar 

Barnard D. History of VR—Timeline of events and tech. development. 2023.

Carl E, Stein AT, Levihn-Coon A, Pogue JR, Rothbaum B, Emmelkamp P, et al. Virtual reality exposure therapy for anxiety and related disorders: A meta-analysis of randomized controlled trials. J Anxiety Disord. 2019;61:27–36.

Article  PubMed  Google Scholar 

Cullen AJ, Dowling NL, Segrave R, Carter A, Yücel M. Exposure therapy in a virtual environment: Validation in obsessive compulsive disorder. J Anxiety Disord. 2021;80:102404.

Article  PubMed  Google Scholar 

Javaherirenani R, Mortazavi SS, Shalbafan M, Ashouri A, Farani AR. Virtual reality exposure and response prevention in the treatment of obsessive-compulsive disorder in patients with contamination subtype in comparison with in vivo exposure therapy: A randomized clinical controlled trial. Bmc Psychiatry. 2022;22:740.

Article  PubMed  PubMed Central  Google Scholar 

Scott J. The science and practice of psychotherapy: the critical need for quality assurance and vigilance to monitor the ratio of benefits to risks of therapies. Acta Psychiatr Scand. 2017;136:233–5.

Article  PubMed  Google Scholar 

Olatunji BO, Deacon BJ, Cruelest Cure AJST. Issues in the implementation of exposure-based treatments. Ethical. 2009.

McKay D, Abramowitz JS, Storch EA. Mechanisms of harmful treatments for obsessive-compulsive disorder. Clinical Psychology. and Practice: Science; 2020.

Google Scholar 

Moritz S, Fieker M, Hottenrott B, Seeralan T, Cludius B, Kolbeck K, et al. No pain, no gain? Adverse effects of psychotherapy in obsessive-compulsive disorder and its relationship to treatment gains. J Obsessive Compuls Relat Disord. 2015;20155:61–6.

Article  Google Scholar 

Ladwig I, Rief W, Nestoriuc Y. What are the risks and side effects of psychotherapy? – Development of an inventory for the assessment of negative effects of psychotherapy (INEP). Verhaltenstherapie. 2014;24:252–63.

Article  Google Scholar 

Hendriks L, de Kleine RA, Broekman TG, Hendriks GJ, van Minnen A. Intensive prolonged exposure therapy for chronic PTSD patients following multiple trauma and multiple treatment attempts. Eur J Psychotraumatol. 2018;9.

Jacobson, N. S., Truax, P. (1991). Clinical Significance: A statistical approach to defining meaningful change in psychotherapy research. J Consult Clin Psychol, 59.

Rolvien L, Lohse L, Borgmann L, Moritz S, Kühn S, Jelinek L, et al. Exposure and response prevention in virtual reality for obsessive-compulsive disorder: a randomized controlled trial. (submitted).

Jelinek L, Peth J, Runde A, Arlt S, Scheunemann J, Gallinat J. Metacognitive Training for Depression: Feasibility, safety and acceptability of two new treatment modules to reduce suicidality. Clin Psychol Psychother. 2020;28:669–81.

Article  PubMed  Google Scholar 

Kennedy RS, Lane NE, Berbaum KS, Lilienthal MG. Simulator sickness questionnaire: An enhanced method of quantifying simulator sickness. Int J Aviat Psychol. 1993;3:203–20.

Article  Google Scholar 

Bouchard S, Berthiaume M, Robillard G, Forget H, Daudelin-Peltier C, Renaud P, et al. Arguing in favor of revising the simulator sickness questionnaire factor structure when assessing side effects induced by immersions in virtual reality. Front Psychiatry. 1926; 2021.

Goodman WK, Price LH, Rasmussen SA, Mazure C, Fleischmann RL, Hill CL, et al. The Yale-Brown Obsessive Compulsive Scale. Arch Gen Psychiatry. 1989;46:1006–11.

Article  CAS  PubMed  Google Scholar 

Hand I, Büttner-Westphal H. Die Yale-Brown Obsessive Compulsive Scale (Y-BOCS): Ein halbstrukturiertes Interview zur Beurteilung des Schweregrades von Denk- und Handlungszwängen. Verhaltenstherapie. 1991;1:223–5.

Article  Google Scholar 

Jacobson NS, Truax P. Clinical significance: A statistical approach to defining meaningful change in psychotherapy research. In A. E. Kazdin (Ed.), Methodological Issues & Strategies in Clinical Research. 2004:631–648.

Google Scholar 

Patterson B, Boyle MH, Kivlenieks M, Van Ameringen M. The use of waitlists as control conditions in anxiety disorders research. J Psychiatr Res. 2016;83:112–20.

Article  PubMed  Google Scholar 

Craske MG, Kircanski K, Zelikowsky M, Mystkowski J, Chowdhury N, Baker A. Optimizing inhibitory learning during exposure therapy. Behav Res Ther. 2008;46:5–27.

Article  PubMed  Google Scholar 

Keijsers GP, Hoogduin CAL, Schaap CPDR. Predictors of treatment outcome in the behavioural treatment of obsessive-compulsive disorder. Br J Psychiatry. 1994;165:781–6.

Article  CAS  PubMed  Google Scholar 

Merling LF, Siev J, Delucia C, Davidtz J. I think I can: The role of self-efficacy in exposure to contamination. J Soc Clin Psychol. 2022;41(5):423–43.

Article  Google Scholar 

Himle JA, Van Etten ML, Janeck AS, Fischer DJ. Insight as a predictor of treatment outcome in behavioral group treatment for obsessive-compulsive disorder. Cognit Ther Res. 2006;30:661–6.

Article  Google Scholar 

Gan J, He J, Fu H, Zhu X. Association between obsession, compulsion, depression and insight in obsessive-compulsive disorder: a meta-analysis. Nord J Psychiatry. 2022;76:489–96.

Article  PubMed  Google Scholar 

Guidi J, Brakemeier EL, Bockting CLH, Cosci F, Cuijpers P, Jarrett RB, et al. Methodological recommendations for trials of psychological interventions. Psychother Psychosom. 2018;87:276–84.

Article  PubMed  Google Scholar 

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