Wardlaw JM et al (2019) Small vessel disease: mechanisms and clinical implications. Lancet Neurol 18(7):684–696
Tian Y et al (2022) The underlying role of the glymphatic system and meningeal lymphatic vessels in cerebral small vessel disease. Biomolecules 12(6):748
Article CAS PubMed PubMed Central Google Scholar
Wardlaw JM et al (2020) Perivascular spaces in the brain: anatomy, physiology and pathology. Nat Rev Neurol 16(3):137–153
Taoka T et al (2017) Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in alzheimer’s disease cases. Jpn J Radiol 35(4):172–178
Taoka T et al (2024) Diffusion tensor image analysis along the perivascular space (DTI-ALPS): revisiting the meaning and significance of the method. Magn Reson Med Sci 23(3):268–290
Article PubMed PubMed Central Google Scholar
Duering M et al (2018) Free water determines diffusion alterations and clinical status in cerebral small vessel disease. Alzheimers Dement 14(6):764–774
Li H et al (2024) Perivascular spaces, diffusivity along perivascular spaces, and free water in cerebral small vessel disease. Neurology 102(9):e209306
Article CAS PubMed Google Scholar
Kamagata K et al (2022) Association of MRI indices of glymphatic system with amyloid deposition and cognition in mild cognitive impairment and Alzheimer disease. Neurology 99(24):E2648–E2660
Article CAS PubMed PubMed Central Google Scholar
Duering M et al (2013) Neuroimaging standards for research into small vessel disease-advances since 2013. Lancet Neurol 12(8):822–838
PubMed PubMed Central Google Scholar
Smith EE et al (2019) Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration. Alzheimers Dement (Amst) 11:191–204
Fazekas F et al (1987) MR signal abnormalities at 1.5 T in Alzheimer’s dementia and normal aging. AJR Am J Roentgenol 149(2):351–356
Article CAS PubMed Google Scholar
Potter GM et al (2015) Cerebral perivascular spaces visible on magnetic resonance imaging: development of a qualitative rating scale and its observer reliability. Cerebrovasc Dis 39(3–4):224–231
Article PubMed PubMed Central Google Scholar
Staals J et al (2014) Stroke subtype, vascular risk factors, and total MRI brain small-vessel disease burden. Neurology 83(14):1228–1234
Article PubMed PubMed Central Google Scholar
Clancy U et al (2021) Rationale and design of a longitudinal study of cerebral small vessel diseases, clinical and imaging outcomes in patients presenting with mild ischaemic stroke: mild stroke study 3. Eur Stroke J 6(1):81–88
Barnes A et al (2022) Topological relationships between perivascular spaces and progression of white matter hyperintensities: a pilot study in a sample of the Lothian Birth Cohort 1936. Front Neurol 13:889884
Article PubMed PubMed Central Google Scholar
Duarte Coello R et al (2023) Detectability and accuracy of computational measurements of in-silico and physical representations of enlarged perivascular spaces from magnetic resonance images. J Neurosci Methods 403:110039
del Valdés Hernández C et al (2010) New multispectral MRI data fusion technique for white matter lesion segmentation: method and comparison with thresholding in FLAIR images. Eur Radiol 20(7):1684–1691
Article PubMed Central Google Scholar
Toh CH, Siow TY (2021) Glymphatic dysfunction in patients with ischemic stroke. Front Aging Neurosci 13:756249
Article PubMed PubMed Central Google Scholar
Pasternak O, Shenton ME, Westin CF (2012) Estimation of extracellular volume from regularized multi-shell diffusion MRI. Med Image Comput Comput Assist Interv 15(Pt 2):305–312
PubMed PubMed Central Google Scholar
Kamagata K et al (2024) Noninvasive magnetic resonance imaging measures of glymphatic system activity. J Magn Reson Imaging 59(5):1476–1493
Harding IH et al (2023) STAREE-Mind imaging study: a randomised placebo-controlled trial of atorvastatin for prevention of cerebrovascular decline and neurodegeneration in older individuals. BMJ Neurol Open 5(2):e000541
Article PubMed PubMed Central Google Scholar
Nakaya M et al (2022) Free water derived by multi-shell diffusion MRI reflects tau/neuroinflammatory pathology in alzheimer’s disease. Alzheimers Dement (N Y) 8(1):e12356
Tian Y et al (2023) Impaired glymphatic system as evidenced by low diffusivity along perivascular spaces is associated with cerebral small vessel disease: a population-based study. Stroke Vasc Neurol svn-2022-002191
Shen T et al (2022) Diffusion along perivascular spaces as marker for impairment of glymphatic system in Parkinson’s disease. NPJ Parkinsons Dis 8(1):174
Article CAS PubMed PubMed Central Google Scholar
Ma X et al (2021) Diffusion tensor imaging along the perivascular space index in different stages of Parkinson’s disease. Front Aging Neurosci 13:773951
Article CAS PubMed PubMed Central Google Scholar
Liu H et al (2022) Associations among diffusion tensor image along the perivascular space (DTI-ALPS), enlarged perivascular space (ePVS), and cognitive functions in asymptomatic patients with carotid plaque. Front Neurol 12:789918
Article PubMed PubMed Central Google Scholar
Zhang W et al (2021) Glymphatic clearance function in patients with cerebral small vessel disease. NeuroImage 238:118257
Bown CW et al (2022) Physiology and clinical relevance of enlarged perivascular spaces in the aging brain. Neurology 98(3):107–117
Article PubMed PubMed Central Google Scholar
Geurts LJ et al (2019) Higher pulsatility in cerebral perforating arteries in patients with small vessel disease related stroke, a 7T MRI study. Stroke 50(1):62–68
Ke Z et al (2022) Glymphatic dysfunction mediates the influence of white matter hyperintensities on episodic memory in cerebral small vessel disease. Brain Sci 12(12):1611
Article PubMed PubMed Central Google Scholar
Markus HS et al (2022) Framework for clinical trials in Cerebral Small Vessel Disease (FINESSE): a review. JAMA Neurol 79(11):1187–1198
Article PubMed PubMed Central Google Scholar
Siow TY et al (2022) Association of sleep, neuropsychological performance, and gray matter volume with glymphatic function in community-dwelling older adults. Neurology 98(8):e829–e838
Lee HJ et al (2022) Glymphatic system dysfunction in obstructive sleep apnea evidenced by DTI-ALPS. Sleep Med 89:176–181
Sozzi C et al (2024) Clinical relevance of different loads of perivascular spaces according to their localization in patients with a recent small subcortical infarct. J Cardiovasc Dev Dis 11(11):345
PubMed PubMed Central Google Scholar
Xie L et al (2013) Sleep drives metabolite clearance from the adult brain. Science 342(6156):373–377
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