2-[18F]Fluoropropionic Acid PET Imaging of Doxorubicin-Induced Cardiotoxicity

Herrmann J (2020) Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia. Nat Rev Cardiol 17(8):474–502

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ping Z, Peng Y, Lang H et al (2020) Oxidative stress in radiation-induced cardiotoxicity. Oxid Med Cell Longev 2020:3579143

Article  PubMed  PubMed Central  Google Scholar 

Bhagat A, Kleinerman ES (2020) Anthracycline-induced cardiotoxicity: causes, mechanisms, and prevention. Adv Exp Med Biol 1257:181–192

Article  PubMed  CAS  Google Scholar 

Rawat PS, Jaiswal A, Khurana A, Bhatti JS, Navik U (2021) Doxorubicin-induced cardiotoxicity: An update on the molecular mechanism and novel therapeutic strategies for effective management. Biomed Pharmacother 139:111708

Article  PubMed  CAS  Google Scholar 

Carvalho RA, Sousa RPB, Cadete VJJ et al (2010) Metabolic remodeling associated with subchronic doxorubicin cardiomyopathy. Toxicology 270(2–3):92–98

Article  PubMed  CAS  Google Scholar 

Lewandowski ED, Kudej RK, White LT, O’Donnell JM, Vatner SF (2002) Mitochondrial preference for short chain fatty acid oxidation during coronary artery constriction. Circulation 105(3):367–372

Article  PubMed  CAS  Google Scholar 

Carley AN, Maurya SK, Fasano M et al (2021) Short-chain fatty acids outpace ketone oxidation in the failing heart. Circulation 143:1797–1808

Article  PubMed  PubMed Central  CAS  Google Scholar 

Palm CL, Nijholt KT, Bakker BM, Westenbrink BD (2022) Short-chain fatty acids in the metabolism of heart failure – rethinking the fat stigma. Front Cardiovasc Med 9:915102

Article  PubMed  PubMed Central  CAS  Google Scholar 

Schönfeld P, Wojtczak L (2016) Short- and medium-chain fatty acids in energy metabolism: the cellular perspective. J Lipid Res 57(6):943

Article  PubMed  PubMed Central  Google Scholar 

Pillarsetty NVK, Punzalan B, Larson SM (2009) 2–18F-Fluoropropionic acid as a PET imaging agent for prostate cancer. J Nucl Med 50(10):1709–1714

Article  PubMed  CAS  Google Scholar 

Zhang Z, Liu S, Ma H et al (2019) Validation of R-2-[18F]Fluoropropionic acid as a potential tracer for PET imaging of liver cancer. Mol imaging Biol 21(6):1127–1137

Article  PubMed  CAS  Google Scholar 

Zhao J, Zhang Z, Nie D et al (2019) PET imaging of hepatocellular carcinomas: 18F-Fluoropropionic acid as a complementary radiotracer for 18F-Fluorodeoxyglucose. Mol Imaging 18:1536012118821032

Article  PubMed  PubMed Central  Google Scholar 

Zhang Z, Liu S, Tang X et al (2018) Radiosynthesis and preliminary biological evaluation of the 2-[18F]fluoropropionic acid enantiomers for tumor PET imaging. J Radioanal Nucl Chem 316(1):153–159

Article  CAS  Google Scholar 

Zhang Z, Liu S, Ma H et al (2021) Propionic acid-based PET imaging of prostate cancer. Mol Imaging Biol 23(6):836–845

Article  PubMed  CAS  Google Scholar 

De Martino M, Daviaud C, Minns HE et al (2023) Radiation therapy promotes unsaturated fatty acids to maintain survival of glioblastoma. Cancer Lett 570:216329

Article  PubMed  Google Scholar 

Surasi DS, Bhambhvani P, Baldwin JA, Almodovar SE, O’Malley JP (2014) 18F-FDG PET and PET/CT patient preparation: a review of the literature. J Nucl Med Technol 42(1):5–13

Article  PubMed  Google Scholar 

Srinivasan S, Crandall JP, Gajwani P et al (2020) Human radiation dosimetry for orally and intravenously administered 18F-FDG. J Nucl Med 61(4):613–619

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gnesin S, Cicone F, Mitsakis P et al (2018) First in-human radiation dosimetry of the gastrin-releasing peptide (GRP) receptor antagonist 68 Ga-NODAGA-MJ9. EJNMMI Res 8(1):1–10

Article  Google Scholar 

Mitry MA, Edwards JG (2016) Doxorubicin induced heart failure: Phenotype and molecular mechanisms. IJC Hear Vasc 10:17–24

Google Scholar 

Podyacheva EY, Kushnareva EA, Karpov AA, Toropova YG (2021) Analysis of models of doxorubicin-induced cardiomyopathy in rats and mice. A modern view from the perspective of the pathophysiologist and the clinician. Front Pharmacol 12:670479

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gavila J, Seguí M, Calvo L et al (2017) Evaluation and management of chemotherapy-induced cardiotoxicity in breast cancer: a Delphi study. Clin Transl Oncol 19(1):91–104

Article  PubMed  CAS  Google Scholar 

Groot PH (1975) The activation of short-chain fatty acids by the soluble fraction of guinea-pig heart and liver mitochondria. The search for a distinct propionyl-CoA synthetase. Biochim Biophys Acta 380(1):12–20

Article  PubMed  CAS  Google Scholar 

Colak D, Kaya N, Al-Zahrani J et al (2009) Left ventricular global transcriptional profiling in human end-stage dilated cardiomyopathy. Genomics 94(1):20

Article  PubMed  CAS  Google Scholar 

Laursen AH, Elming MB, Ripa RS et al (2020) Rubidium-82 positron emission tomography for detection of acute doxorubicin-induced cardiac effects in lymphoma patients. J Nucl Cardiol 27(5):1698–1707

Article  PubMed  Google Scholar 

Nehmeh SA, Fox JJ, Schwartz J et al (2020) A pilot study of 13N-ammonia cardiac PET imaging to assess subacute cardiotoxicity following adjuvant intensity-modulated radiotherapy for locally advanced breast cancer. Clin Imaging 68:283–290

Article  PubMed  PubMed Central  Google Scholar 

Marzlin N, Hays AG, Peters M et al (2023) Myocardial work in echocardiography. Circ Cardiovasc Imaging 16(2):E014419

Article  PubMed  Google Scholar 

Santini F, Gui L, Lorton O et al (2020) Ultrasound-driven cardiac MRI. Phys Medica 70:161–168

Article  Google Scholar 

Takala TO, Nuutila P, Pulkki K et al (2002) 14(R, S)-[18F]Fluoro-6-thia-heptadecanoic acid as a tracer of free fatty acid uptake and oxidation in myocardium and skeletal muscle. Eur J Nucl Med 29(12):1617–1622

Article  CAS  Google Scholar 

Armbrecht JJ, Buxton DB, Brunken RC, Phelps ME, Schelbert HR (1989) Regional myocardial oxygen consumption determined noninvasively in humans with [1-11C]acetate and dynamic positron tomography. Circulation 80(4):863–872

Article  PubMed  CAS  Google Scholar 

Herrero P, Dence CS, Coggan AR, Kisrieva-Ware Z, Eisenbeis P, Gropler RJ (2007) L-3-11C-lactate as a PET tracer of myocardial lactate metabolism: a feasibility study. J Nucl Med 48(12):2046–2055

Article  PubMed  CAS  Google Scholar 

Sobel BE, Weiss ES, Welch MJ, Siegel BA, Ter-Pogossian MM (1977) Detection of remote myocardial infarction in patients with positron emission transaxial tomography and intravenous 11C-palmitate. Circulation 55(6):853–857

Article  PubMed  CAS  Google Scholar 

Kemp CD, Conte JV (2012) The pathophysiology of heart failure. Cardiovasc Pathol 21(5):365–371

Article  PubMed  CAS  Google Scholar 

Doenst T, Nguyen TD, Abel ED (2013) Cardiac metabolism in heart failure. Circ Res 113(6):709–724

Article 

Comments (0)

No login
gif