Bosch FX, Ribes J, Díaz M, et al. Primary liver cancer: worldwide incidence and trends. Gastroenterology. 2004;127:S5-16.

Article  PubMed  Google Scholar 

Rumgay H, Arnold M, Ferlay J, et al. Global burden of primary liver cancer in 2020 and predictions to 2040. J Hepatol. 2022;77:1598–606.

Article  PubMed  PubMed Central  Google Scholar 

Zhang CH, Cheng Y, Zhang S, et al. Changing epidemiology of hepatocellular carcinoma in Asia. Liver Int. 2022;42:2029–41.

Article  PubMed  Google Scholar 

Borzio M, Colloredo G, Pioltelli P, et al. Epidemiology and outcome of hepatocellular carcinoma in Lombardy. Dig Liver Disease. 2007;39:1011–7.

Article  CAS  Google Scholar 

Bruix J, Sherman M, Llovet JM, et al. Clinical management of hepatocellular carcinoma. conclusions of the Barcelona-2000 EASL conference. Eur Assoc for the Study of the Liver. 2001;35:421–30.

CAS  Google Scholar 

Méndez-Sánchez N, Ridruejo E, Alves de Mattos A, et al. Latin American association for the study of the liver (LAASL) clinical practice guidelines: management of hepatocellular carcinoma. Ann Hepatol. 2014;13:S4-40.

PubMed  Google Scholar 

Tang A, Singal AG, Mitchell DG, et al. Introduction to the Liver imaging reporting and data system for hepatocellular carcinoma. Clin Gastroenterol Hepatol. 2019;17:1228–38.

Article  PubMed  Google Scholar 

Bruix J, Sherman M. Management of hepatocellular carcinoma: an update. Hepatology. 2011;53:1020–2.

Article  PubMed  Google Scholar 

Bruix J, Sherman M. AASLD practice guideline. management of hepatocellular carcinoma. Hepatology. 2005;42:1208–36.

Article  PubMed  Google Scholar 

European Association for the Study of the Liver E O. F R a T o C, EASL–EORTC clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol. 2012;56:908–43.

Article  Google Scholar 

Heimbach JK, Kulik LM, Finn RS, et al. AASLD guidelines for the treatment of hepatocellular carcinoma. Hepatology. 2018;67:358–80.

Article  PubMed  Google Scholar 

Marrero JA, Kulik LM, Sirlin CB, et al. Diagnosis, staging, and management of hepatocellular carcinoma: 2018 practice guidance by the American association for the study of liver diseases. Hepatology. 2018;68:723–50.

Article  PubMed  Google Scholar 

Tanaka H, Iijima H, Nouso K, et al. Cost-effectiveness analysis on the surveillance for hepatocellular carcinoma in liver cirrhosis patients using contrast-enhanced ultrasonography. Hepatol Res. 2012;42:376–84.

Article  Google Scholar 

Wang F, Numata K, Nihonmatsu H, et al. Application of new ultrasound techniques for focal liver lesions. J Med Ultrason. 2020;47:215–37.

Article  Google Scholar 

Matsumoto N, Ogawa M, Kaneko M, et al. Contrast-enhanced ultrasonography for blood flow detection in hepatocellular carcinoma during lenvatinib therapy. J Med Ultrason. 2022;49:425–32.

Article  Google Scholar 

Uchikawa S, Kawaoka T, Fujino H, et al. Evaluation of atezolizumab plus bevacizumab combination therapy for hepatocellular carcinoma using contrast-enhanced ultrasonography. J Med Ultrason. 2023;50:57–62.

Article  Google Scholar 

Kim TK, Noh SY, Wilson SR, et al. Contrast-enhanced ultrasound (CEUS) liver imaging reporting and data system (LI-RADS) 2017 - a review of important differences compared to the CT/MRI system. Clin Mol Hepatol. 2017;23:280–9.

Article  PubMed  PubMed Central  Google Scholar 

Lyshchik A, Kono Y, Dietrich CF, et al. Contrast-enhanced ultrasound of the liver: technical and lexicon recommendations from the ACR CEUS LI-RADS working group. Abdom Radiol (NY). 2018;43:861–79.

Article  PubMed  Google Scholar 

Fetzer DT, Rodgers SK, Harris AC, et al. Screening and surveillance of hepatocellular carcinoma: an introduction to ultrasound liver imaging reporting and data system. Radiol Clin North Am. 2017;55:1197–209.

Article  PubMed  Google Scholar 

Chernyak V, Fowler KJ, Kamaya A, et al. Liver imaging reporting and data system (LI-RADS) version 2018: imaging of hepatocellular carcinoma in at-risk patients. Radiology. 2018;289:816–30.

Article  PubMed  Google Scholar 

Takahashi H, Sugimoto K, Kamiyama N, et al. Noninvasive diagnosis of hepatocellular carcinoma on sonazoid-enhanced us: value of the kupffer phase. Diagnostics. 2022. https://doi.org/10.3390/diagnostics12010141.

Article  PubMed  PubMed Central  Google Scholar 

Zhang Y, Numata K, Du Y, et al. Contrast agents for hepatocellular carcinoma imaging: value and progression. Front Oncol. 2022. https://doi.org/10.3389/fonc.2022.921667.

Article  PubMed  PubMed Central  Google Scholar 

Watanabe R, Matsumura M, Chen CJ, et al. Characterization of tumor imaging with microbubble-based ultrasound contrast agent, sonazoid, in rabbit liver. Biol Pharm Bull. 2005;28:972–7.

Article  CAS  PubMed  Google Scholar 

Wang F, Numata K, Nakano M, et al. Diagnostic value of imaging methods in the histological four grading of hepatocellular carcinoma. Diagnostics. 2020. https://doi.org/10.3390/diagnostics10050321.

Article  PubMed  PubMed Central  Google Scholar 

Dong Y, Zuo D, Qiu YJ, et al. Prediction of histological grades and Ki-67 expression of hepatocellular carcinoma based on sonazoid contrast enhanced ultrasound radiomics signatures. Diagnostics. 2022. https://doi.org/10.3390/diagnostics12092175.

Article  PubMed  PubMed Central  Google Scholar 

Minami Y, Kudo M. Hepatic malignancies: correlation between sonographic findings and pathological features. World J Radiol. 2010;2:249–56.

Article  PubMed  PubMed Central  Google Scholar 

Kudo M, Ueshima K, Osaki Y, et al. B-mode ultrasonography versus contrast-enhanced ultrasonography for surveillance of hepatocellular carcinoma: a prospective multicenter randomized controlled trial. Liver Cancer. 2019;8:271–80.

Article  PubMed  PubMed Central  Google Scholar 

Nihonmatsu H, Numata K, Fukuda H, et al. Low mechanical index contrast mode versus high mechanical index contrast mode: which is a more sensitive method for detecting sonazoid microbubbles in the liver of normal subjects? J Med Ultrason. 2016;43:211–7.

Article  Google Scholar 

Goto E, Masuzaki R, Tateishi R, et al. Value of post-vascular phase (Kupffer imaging) by contrast-enhanced ultrasonography using sonazoid in the detection of hepatocellular carcinoma. J Gastroenterol. 2012;47:477–85.

Article  PubMed  Google Scholar 

American Institute of Ultrasound in Medicine. Section 7–Discussion of the mechanical index and other exposure parameters. J Ultrasound Med. 2000;19:143–8, 154–68. https://doi.org/10.7863/jum.2000.19.2.143.

Article  Google Scholar 

Duisyenbi Z, Numata K, Nihonmatsu H, et al. Comparison between low mechanical index and high mechanical index contrast modes of contrast-enhanced ultrasonography: evaluation of perfusion defects of hypervascular hepatocellular carcinomas during the post-vascular phase. J Ultrasound Med. 2019;38:2329–38.

Article  PubMed  Google Scholar 

Chen MH, Yang W, Dai Y, et al. High mechanical index post-contrast ultrasonography improves tissue structural display of hepatocellular carcinoma. Chin Med J (Engl). 2005;118:2046–51.

PubMed  Google Scholar 

Goto E, Masuzaki R, Tateishi R, et al. Value of post-vascular phase (Kupffer imaging) by contrastenhanced ultrasonography using sonazoid in the detection of hepatocellular carcinoma. J Gastroenterol. 2011;47:477–85.

Article  PubMed  Google Scholar 

Fattovich G, Stroffolini T, Zagni I, et al. Hepatocellular carcinoma in cirrhosis: incidence and risk factors. Gastroenterology. 2004;127:S35-50.

Article  PubMed  Google Scholar 

Ballestri S, Nascimbeni F, Baldelli E, et al. NAFLD as a sexual dimorphic disease: role of gender and reproductive status in the development and progression of nonalcoholic fatty liver disease and inherent cardiovascular risk. Adv Ther. 2017;34:1291–326.

Article  PubMed Central  Google Scholar 

Greten TF. Gender disparity in HCC: is it the fat and not the sex? J Exp Med. 2019;216:1014–15.

Article  CAS  PubMed  PubMed Central