Arain M, Haque M, Johal L, Mathur P, Nel W, Rais A, Sandhu R, Sharma S (2013) Maturation of the adolescent brain. Neuropsychiatr Dis Treat 9:449–461. https://doi.org/10.2147/ndt.S39776
Article PubMed PubMed Central Google Scholar
Bakhshani NM (2014) Impulsivity: a predisposition toward risky behaviors. Int J High Risk Behav Addict 3(2):e20428. https://doi.org/10.5812/ijhrba.20428
Article PubMed PubMed Central Google Scholar
Bates MLS, Hofford RS, Emery MA, Wellman PJ, Eitan S (2018) The role of the vasopressin system and dopamine D1 receptors in the effects of social housing condition on morphine reward. Drug Alcohol Depend 188:113–118. https://doi.org/10.1016/j.drugalcdep.2018.03.021
Article CAS PubMed Google Scholar
Behan AT, Hryniewiecka M, O’Tuathaigh CM, Kinsella A, Cannon M, Karayiorgou M, Gogos JA, Waddington JL, Cotter DR (2012) Chronic adolescent exposure to delta-9-tetrahydrocannabinol in COMT mutant mice: impact on indices of dopaminergic, endocannabinoid and GABAergic pathways. Neuropsychopharmacology 37(7):1773–1783. https://doi.org/10.1038/npp.2012.24
Article CAS PubMed PubMed Central Google Scholar
Bloomfield MA, Ashok AH, Volkow ND, Howes OD (2016) The effects of Δ(9)-tetrahydrocannabinol on the dopamine system. Nature 539(7629):369–377. https://doi.org/10.1038/nature20153
Article CAS PubMed PubMed Central Google Scholar
Bouchard JF, Horn KE, Stroh T, Kennedy TE (2008) Depolarization recruits DCC to the plasma membrane of embryonic cortical neurons and enhances axon extension in response to netrin-1. J Neurochem 107(2):398–417. https://doi.org/10.1111/j.1471-4159.2008.05609.x
Article CAS PubMed Google Scholar
Calipari ES, Juarez B, Morel C, Walker DM, Cahill ME, Ribeiro E, Roman-Ortiz C, Ramakrishnan C, Deisseroth K, Han MH, Nestler EJ (2017) Dopaminergic dynamics underlying sex-specific cocaine reward. Nat Commun 8:13877. https://doi.org/10.1038/ncomms13877
Article CAS PubMed PubMed Central Google Scholar
Carrara-Nascimento PF, Hoffmann LB, Flório JC, Planeta CS, Camarini R (2020) Effects of ethanol exposure during adolescence or adulthood on locomotor sensitization and dopamine levels in the reward system. Front Behav Neurosci 14:31. https://doi.org/10.3389/fnbeh.2020.00031
Article CAS PubMed PubMed Central Google Scholar
Castillo-Paterna M, Moreno-Juan V, Filipchuk A, Rodríguez-Malmierca L, Susín R, López-Bendito G (2015) DCC functions as an accelerator of thalamocortical axonal growth downstream of spontaneous thalamic activity. EMBO Rep 16(7):851–862. https://doi.org/10.15252/embr.201439882
Article CAS PubMed PubMed Central Google Scholar
Corruble E, Benyamina A, Bayle F, Falissard B, Hardy P (2003) Understanding impulsivity in severe depression? A psychometrical contribution. Prog Neuropsychopharmacol Biol Psychiatry 27(5):829–833. https://doi.org/10.1016/s0278-5846(03)00115-5
Counotte DS, Spijker S, Van de Burgwal LH, Hogenboom F, Schoffelmeer ANM, De Vries TJ, Smit AB, Pattij T (2009) Long-lasting cognitive deficits resulting from adolescent nicotine exposure in rats. Neuropsychopharmacology 34(2):299–306. https://doi.org/10.1038/npp.2008.96
Article CAS PubMed Google Scholar
Cuesta S, Restrepo-Lozano JM, Silvestrin S, Nouel D, Torres-Berrío A, Reynolds LM, Arvanitogiannis A, Flores C (2018) Non-Contingent exposure to amphetamine in adolescence recruits miR-218 to regulate Dcc expression in the VTA. Neuropsychopharmacology 43(4):900–911. https://doi.org/10.1038/npp.2017.284
Article CAS PubMed Google Scholar
Cuesta S, Restrepo-Lozano JM, Popescu C, He S, Reynolds LM, Israel S, Hernandez G, Rais R, Slusher BS, Flores C (2020) DCC-related developmental effects of abused- versus therapeutic-like amphetamine doses in adolescence. Addict Biol 25(4):e12791. https://doi.org/10.1111/adb.12791
Article CAS PubMed Google Scholar
Dalsgaard S, Thorsteinsson E, Trabjerg BB, Schullehner J, Plana-Ripoll O, Brikell I, Wimberley T, Thygesen M, Madsen KB, Timmerman A, Schendel D, McGrath JJ, Mortensen PB, Pedersen CB (2020) Incidence rates and cumulative incidences of the full spectrum of diagnosed mental disorders in childhood and adolescence. JAMA Psychiat 77(2):155–164. https://doi.org/10.1001/jamapsychiatry.2019.3523
De Felice M, Renard J, Hudson R, Szkudlarek HJ, Pereira BJ, Schmid S, Rushlow WJ, Laviolette SR (2021) l-Theanine prevents long-term affective and cognitive side effects of adolescent Δ-9-tetrahydrocannabinol exposure and blocks associated molecular and neuronal abnormalities in the mesocorticolimbic circuitry. J Neurosci 41(4):739–750. https://doi.org/10.1523/jneurosci.1050-20.2020
Article CAS PubMed PubMed Central Google Scholar
Dichter GS, Damiano CA, Allen JA (2012) Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings. J Neurodev Disord 4(1):19. https://doi.org/10.1186/1866-1955-4-19
Article PubMed PubMed Central Google Scholar
Drug Overdose Death Rates (2023) National institute on drug abuse. https://nida.nih.gov/research-topics/trends-statistics/overdose-death-rates#FAQs. Accessed Aug 29 2023
Drug Use Among Youth: Facts & Statistics. (2023) National center for drug abuse statistics. https://drugabusestatistics.org/teen-drug-use/. Accessed Aug 29 2023
Enoch MA (2012) The influence of gene-environment interactions on the development of alcoholism and drug dependence. Curr Psychiatry Rep 14(2):150–158. https://doi.org/10.1007/s11920-011-0252-9
Article PubMed PubMed Central Google Scholar
Feltenstein MW, See RE (2008) The neurocircuitry of addiction: an overview. Br J Pharmacol 154(2):261–274. https://doi.org/10.1038/bjp.2008.51
Article CAS PubMed PubMed Central Google Scholar
Fergusson DM, Horwood LJ, Swain-Campbell NR (2003) Cannabis dependence and psychotic symptoms in young people. Psychol Med 33(1):15–21. https://doi.org/10.1017/s0033291702006402
Article CAS PubMed Google Scholar
French ED (1997) Δ9-Tetrahydrocannabinol excites rat VTA dopamine neurons through activation of cannabinoid CB1 but not opioid receptors. Neurosci Lett 226(3):159–162. https://doi.org/10.1016/S0304-3940(97)00278-4
Article CAS PubMed Google Scholar
French ED, Dillon K, Wu X (1997) Cannabinoids excite dopamine neurons in the ventral tegmentum and substantia nigra. NeuroReport 8(3):649–652. https://doi.org/10.1097/00001756-199702100-00014
Article CAS PubMed Google Scholar
Gulley JM, Juraska JM (2013) The effects of abused drugs on adolescent development of corticolimbic circuitry and behavior. Neuroscience 249:3–20. https://doi.org/10.1016/j.neuroscience.2013.05.026
Article CAS PubMed Google Scholar
Gysling K, Wang RY (1983) Morphine-induced activation of A10 dopamine neurons in the rat. Brain Res 277(1):119–127. https://doi.org/10.1016/0006-8993(83)90913-7
Article CAS PubMed Google Scholar
Henquet C, Murray R, Linszen D, van Os J (2005) The environment and schizophrenia: the role of cannabis use. Schizophr Bull 31(3):608–612. https://doi.org/10.1093/schbul/sbi027
Hernandez G, Capolicchio T, Giroux M, Estrada K, Flores C (2022) THC in adolescence dysregulates microRNA pathways involved in dopamine development. J Psychiatry Neurosci 47(3 Suppl 1):S6. https://doi.org/10.1503/jpn.220043
Herting MM, Maxwell EC, Irvine C, Nagel BJ (2011) The impact of sex, puberty, and hormones on white matter microstructure in adolescents. Cereb Cortex 22(9):1979–1992. https://doi.org/10.1093/cercor/bhr246
Article PubMed PubMed Central Google Scholar
Hines LA, Morley KI, Mackie C, Lynskey M (2015) Genetic and environmental interplay in adolescent substance use disorders. Curr Addict Rep 2(2):122–129. https://doi.org/10.1007/s40429-015-0049-8
Article PubMed PubMed Central Google Scholar
Hoops D, Reynolds LM, Restrepo-Lozano J-M, Flores C (2018) Dopamine development in the mouse orbital prefrontal cortex is protracted and sensitive to amphetamine in adolescence. Eneuro 5(1):ENEURO.0372-0317.2017. https://doi.org/10.1523/eneuro.0372-17.2017
Horn Katherine E, Glasgow Stephen D, Gobert D, Bull S-J, Luk T, Girgis J, Tremblay M-E, McEachern D, Bouchard J-F, Haber M, Hamel E, Krimpenfort P, Murai Keith K, Berns A, Doucet G, Chapman CA, Ruthazer Edward S, Kennedy Timothy E (2013) DCC expression by neurons regulates synaptic plasticity in the adult brain. Cell Rep 3(1):173–185. https://doi.org/10.1016/j.celrep.2012.12.005
Article CAS PubMed Google Scholar
Hughes AR, Grusing S, Lin A, Hendrickson RG, Sheridan DC, Marshall R, Zane Horowitz B (2023) Trends in intentional abuse and misuse ingestions in school-aged children and adolescents reported to US poison centers from 2000–2020. Clin Toxicol 61(1):64–71. https://doi.org/10.1080/15563650.2022.2120818
Jalabert M, Bourdy R, Courtin J, Veinante P, Manzoni OJ, Barrot M, Georges F (2011) Neuronal circuits underlying acute morphine action on dopamine neurons. Proc Natl Acad Sci U S A 108(39):16446–16450. https://doi.org/10.1073/pnas.1105418108
Article PubMed PubMed Central Google Scholar
Jentsch JD, Taylor JR (1999) Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli. Psychopharmacology 146(4):373–390. https://doi.org/10.1007/pl00005483
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