Abdelhak A, Foschi M, Abu-Rumeileh S, Yue JK, D’Anna L, Huss A, Oeckl P, Ludolph AC, Kuhle J, Petzold A, Manley GT, Green AJ, Otto M, Tumani H (2022) Blood GFAP as an emerging biomarker in brain and spinal cord disorders. Nat Rev Neurol 18(3):158–172. https://doi.org/10.1038/s41582-021-00616-3. (Epub 2022 Feb 3; PMID: 35115728)

Article  CAS  PubMed  Google Scholar 

Bhatia KP, Bain P, Bajaj N, Elble RJ, Hallett M, Louis ED, Raethjen J, Stamelou M, Testa CM, Deuschl G, Tremor Task Force of the International Parkinson and Movement Disorder Society (2018) Consensus statement on the classification of tremors. From the task force on tremor of the International Parkinson and Movement Disorder Society. Mov Disord 33(1):75–87. https://doi.org/10.1002/mds.27121. (Epub 2017 Nov 30; PMID: 29193359; PMCID: PMC6530552)

Article  PubMed  Google Scholar 

Deuschl G, Petersen I, Lorenz D, Christensen K (2015) Tremor in the elderly: essential and aging-related tremor. Mov Disord 30(10):1327–1334. https://doi.org/10.1002/mds.26265. (Epub 2015 Jun 22; PMID: 26095699; PMCID: PMC4779797)

Article  PubMed  PubMed Central  Google Scholar 

Erro R, Pilotto A, Esposito M, Olivola E, Nicoletti A, Lazzeri G, Magistrelli L, Dallocchio C, Marchese R, Bologna M, Tessitore A, Misceo S, Gigante AF, Terranova C, Moschella V, di Biase L, Di Giacopo R, Morgante F, Valentino F, De Rosa A, Trinchillo A, Malaguti MC, Brusa L, Matinella A, Di Biasio F, Paparella G, De Micco R, Contaldi E, Modugno N, Di Fonzo A, Padovani A, Barone P, TITAN Study Group (2022) The Italian tremor Network (TITAN): rationale, design and preliminary findings. Neurol Sci 43(9):5369–5376. https://doi.org/10.1007/s10072-022-06104-w. (Epub 2022 May 24; Erratum in: Neurol Sci. 2022 Dec;43(12):7013-7014; 10.1007/s10072-022-06216-3; PMID: 35608737; PMCID: PMC9385818)

Article  PubMed  PubMed Central  Google Scholar 

Fahn S, Tolosa E, Marín C (1988) Clinical rating Scale for Tremor. In: Jankovik J, Tolosa E (eds) Parkinson’s disease and movement disorders. Urban & Schwarzenberg, Baltimore, pp 225–234

Google Scholar 

Faust PL, McCreary M, Musacchio JB, Kuo SH, Vonsattel JG, Louis ED (2024) Pathologically based criteria to distinguish essential tremor from controls: analyses of the human cerebellum. Ann Clin Transl Neurol 11(6):1514–1525. https://doi.org/10.1002/acn3.52068. (Epub 2024 Apr 22; PMID: 38644741; PMCID: PMC11187833)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Franthal S, Khalil M, Kern D, Gattermeyer L, Buchmann A, Katschnig-Winter P, Kögl M, Demjaha R, Tafrali C, Hofer E, Schmidt R, Schwingenschuh P (2024) Elevated serum neurofilament light chain protein in patients with essential tremor. Eur J Neurol 31(2):e16143. https://doi.org/10.1111/ene.16143. (Epub 2023 Nov 17; PMID: 37975778; PMCID: PMC11235714)

Article  PubMed  Google Scholar 

Gonzales MM, Vela G, Philip V, Trevino H, LaRoche A, Wang CP, Parent DM, Kautz T, Satizabal CL, Tanner J, O’Bryant S, Maestre G, Tracy RP, Seshadri S (2023) Demographic and clinical characteristics associated with serum GFAP levels in an ethnically diverse cohort. Neurology 101(15):e1531–e1541. https://doi.org/10.1212/WNL.0000000000207706. (PMID: 37813589; PMCID: PMC10585700)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Holtbernd F, Shah NJ (2021) Imaging the pathophysiology of essential tremor—a systematic review. Front Neurol 12:680254. https://doi.org/10.3389/fneur.2021.680254. (PMID: 34220687; PMCID: PMC8244929)

Article  PubMed  PubMed Central  Google Scholar 

Hopfner F, Deuschl G (2018) Is essential tremor a single entity? Eur J Neurol 25(1):71–82. https://doi.org/10.1111/ene.13454. (Epub 2017 Oct 16; PMID: 28905504)

Article  CAS  PubMed  Google Scholar 

Hopfner F, Ahlf A, Lorenz D, Klebe S, Zeuner KE, Kuhlenbäumer G, Deuschl G (2016) Early- and late-onset essential tremor patients represent clinically distinct subgroups. Mov Disord 31(10):1560–1566. https://doi.org/10.1002/mds.26708. (PMID: 27384030)

Article  PubMed  Google Scholar 

Huang Y, Huang C, Zhang Q, Shen T, Sun J (2022) Serum NFL discriminates Parkinson disease from essential tremor and reflect motor and cognition severity. BMC Neurol 22(1):39. https://doi.org/10.1186/s12883-022-02558-9. (PMID: 35086487; PMCID: PMC8793176)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khalil M, Teunissen CE, Otto M, Piehl F, Sormani MP, Gattringer T, Barro C, Kappos L, Comabella M, Fazekas F, Petzold A, Blennow K, Zetterberg H, Kuhle J (2018) Neurofilaments as biomarkers in neurological disorders. Nat Rev Neurol 14(10):577–589. https://doi.org/10.1038/s41582-018-0058-z. (PMID: 30171200)

Article  CAS  PubMed  Google Scholar 

Khalil M, Teunissen CE, Lehmann S, Otto M, Piehl F, Ziemssen T, Bittner S, Sormani MP, Gattringer T, Abu-Rumeileh S, Thebault S, Abdelhak A, Green A, Benkert P, Kappos L, Comabella M, Tumani H, Freedman MS, Petzold A, Blennow K, Zetterberg H, Leppert D, Kuhle J (2024) Neurofilaments as biomarkers in neurological disorders—towards clinical application. Nat Rev Neurol 20(5):269–287. https://doi.org/10.1038/s41582-024-00955-x. (Epub 2024 Apr 12; PMID: 38609644)

Article  PubMed  Google Scholar 

Kimura A, Takekoshi A, Shimohata T (2022) Characteristics of movement disorders in patients with autoimmune GFAP astrocytopathy. Brain Sci 12(4):462. https://doi.org/10.3390/brainsci12040462. (PMID: 35447992; PMCID: PMC9028698)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kuhle J, Leppert D, Comi G, de Stefano N, Kappos L, Freedman MS, Seitzinger A, Roy S (2024) Serum neurofilament light chain correlations in patients with a first clinical demyelinating event in the REFLEX study: a post hoc analysis. Ther Adv Neurol Disord 17:17562864241239100. https://doi.org/10.1177/17562864241239101. (PMID: 38560407; PMCID: PMC10981258)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lleó A (2021) Biomarkers in neurological disorders: a fast-growing market. Brain Commun 3(2):fcab086. https://doi.org/10.1093/braincomms/fcab086. (PMID: 33977270; PMCID: PMC8096602)

Article  PubMed  PubMed Central  Google Scholar 

Louis ED (2016) Essential tremor: a common disorder of purkinje neurons? Neuroscientist 22(2):108–118. https://doi.org/10.1177/1073858415590351. (Epub 2015 Jun 4; PMID: 26044399; PMCID: PMC5467972)

Article  PubMed  Google Scholar 

Louis ED (2018) Essential tremor: “Plus” or “Minus”. Perhaps now is the time to adopt the term “the essential tremors.” Parkinsonism Relat Disord 56:111–112. https://doi.org/10.1016/j.parkreldis.2018.06.026. (Epub 2018 Jun 19; PMID: 29937098)

Article  PubMed  Google Scholar 

Louis ED, Faust PL (2020) Essential tremor: the most common form of cerebellar degeneration? Cereb Ataxias 7:12. https://doi.org/10.1186/s40673-020-00121-1. (PMID: 32922824; PMCID: PMC7427947)

Article  Google Scholar 

Louis ED, Bares M, Benito-Leon J, Fahn S, Frucht SJ, Jankovic J, Ondo WG, Pal PK, Tan EK (2020) Essential tremor-plus: a controversial new concept. Lancet Neurol 19(3):266–270. https://doi.org/10.1016/S1474-4422(19)30398-9. (Epub 2019 Nov 22; PMID: 31767343; PMCID: PMC10686582)

Article  PubMed  Google Scholar 

Louis ED, Huey ED, Cosentino S (2021) Features of “ET plus” correlate with age and tremor duration: “ET plus” may be a disease stage rather than a subtype of essential tremor. Parkinsonism Relat Disord 91:42–47. https://doi.org/10.1016/j.parkreldis.2021.08.017. (Epub 2021 Sep 1; PMID: 34482193)

Article  PubMed  Google Scholar 

Louis ED, Martuscello RT, Gionco JT, Hartstone WG, Musacchio JB, Portenti M, McCreary M, Kuo SH, Vonsattel JG, Faust PL (2023) Histopathology of the cerebellar cortex in essential tremor and other neurodegenerative motor disorders: comparative analysis of 320 brains. Acta Neuropathol 145(3):265–283. https://doi.org/10.1007/s00401-022-02535-z. (Epub 2023 Jan 6; PMID: 36607423; PMCID: PMC10461794)

Article  PubMed  PubMed Central  Google Scholar 

Louis ED, Sharma VD, Hajjar I, Hernandez N (2024) Serum neurofilament light-chain levels in essential tremor: a replication study. Neurodegener Dis 24(3–4):141–147. https://doi.org/10.1159/000542922. (Epub 2024 Dec 3; PMID: 39626650)

Article  CAS  PubMed  Google Scholar 

Madelein van der Stouwe AM, Nieuwhof F, Helmich RC (2020) Tremor pathophysiology: lessons from neuroimaging. Curr Opin Neurol 33(4):474–481. https://doi.org/10.1097/WCO.0000000000000829. (PMID: 32657888)

Article  CAS  PubMed  Google Scholar 

Mostile G, Terranova R, Rascunà C, Terravecchia C, Cicero CE, Giuliano L, Davì M, Chisari C, Luca A, Preux PM, Jankovic J, Zappia M, Nicoletti A (2021) Clinical-instrumental patterns of neurodegeneration in essential tremor: a data-driven approach. Parkinsonism Relat Disord 87:124–129. https://doi.org/10.1016/j.parkreldis.2021.05.011. (Epub 2021 May 14; PMID: 34030068)

Article  PubMed  Google Scholar 

Rajalingam R, Breen DP, Lang AE, Fasano A (2018) Essential tremor plus is more common than essential tremor: Insights from the reclassification of a cohort of patients with lower limb tremor. Parkinsonism Relat Disord 56:109–110. https://doi.org/10.1016/j.parkreldis.2018.06.029. (Epub 2018 Jun 21; PMID: 29958776)

Article  PubMed  Google Scholar 

Ruff DS, Balbo I, Lai RY, Dieng D, Hennessey C, Vennam K, Dwork AJ, McCreary M, Louis ED, Faust PL, Kuo SH (2024) Reduced Bergmann glial process terminations and lateral appendages in essential tremor. Ann Clin Transl Neurol 11(2):377–388.