Nutritional Support of Crocin on Neurobehavioral Disabilities Induced by Cisplatin-Based Chemotherapy in Rats

Alfarouk KO, Stock C-M, Taylor S, Walsh M, Muddathir AK, Verduzco D, Bashir AH, Mohammed OY, Elhassan GO, Harguindey S (2015) Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp. Cancer Cell Int 15:1–13

Article  CAS  Google Scholar 

Taillibert S, Le Rhun E, Chamberlain MC (2016) Chemotherapy-related neurotoxicity. Curr Neurol Neurosci Rep 16:1–14

Article  CAS  Google Scholar 

Oun R, Moussa YE, Wheate NJ (2018) The side effects of platinum-based chemotherapy Drugs: a review for chemists. Dalton Trans 47:6645–6653

Article  CAS  PubMed  Google Scholar 

Zhu J, Carozzi VA, Reed N, Mi R, Marmiroli P, Cavaletti G, Hoke A (2016) Ethoxyquin provides neuroprotection against cisplatin-induced neurotoxicity. Sci Rep 6:28861

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hoebers FJ, Pluim D, Verheij M, Balm AJ, Bartelink H, Schellens JH, Begg AC (2006) Prediction of treatment outcome by cisplatin-DNA adduct formation in patients with stage III/IV head and neck squamous cell carcinoma, treated by concurrent cisplatin‐radiation (RADPLAT). Int J Cancer 119:750–756

Article  CAS  PubMed  Google Scholar 

Köberle B, Tomicic MT, Usanova S, Kaina B (2010) Cisplatin resistance: preclinical findings and clinical implications. Biochim et Biophys Acta (BBA)-Reviews Cancer 1806:172–182

Article  Google Scholar 

Sears CR, Turchi JJ (2012) Complex cisplatin-double strand break (DSB) lesions directly impair cellular non-homologous end-joining (NHEJ) Independent of downstream damage response (DDR) pathways. J Biol Chem 287:24263–24272

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peng B, Tilby M, English M, Price L, Pearson A, Boddy A, Newell D (1997) Platinum-DNA adduct formation in leucocytes of children in relation to pharmacokinetics after cisplatin and carboplatin therapy. Br J Cancer 76:1466–1473

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Y, Zheng M, Sah SK, Mishra A, Singh Y (2019) Neuroprotective influence of sitagliptin against cisplatin-induced neurotoxicity, biochemical and behavioral alterations in Wistar rats. Mol Cell Biochem 455:91–97

Article  CAS  PubMed  Google Scholar 

Zhang A, Shen Y, Cen M, Hong X, Shao Q, Chen Y, Zheng B (2019) Polysaccharide and crocin contents, and antioxidant activity of saffron from different origins. Ind Crops Prod 133:111–117

Article  CAS  Google Scholar 

Ighodaro O, Akinloye O (2018) First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): their fundamental role in the entire antioxidant defence grid. Alexandria J Med 54:287–293

Article  Google Scholar 

Leone S, Recinella L, Chiavaroli A, Orlando G, Ferrante C, Leporini L, Brunetti L, Menghini L (2018) Phytotherapic use of the Crocus sativus L.(Saffron) and its potential applications: a brief overview. Phytother Res 32:2364–2375

Article  CAS  PubMed  Google Scholar 

Srivastava R, Ahmed H, Dixit RK, Saraf S (2010) Crocus sativus L.: a comprehensive review. Pharmacogn Rev 4:200

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kapucu A (2021) Crocin ameliorates oxidative stress and suppresses renal damage in streptozotocin induced diabetic male rats. Biotech Histochem 96:153–160

Article  CAS  PubMed  Google Scholar 

Chen Y, Zhang H, Tian X, Zhao C, Cai L, Liu Y, Jia L, Yin H-X, Chen C (2008) Antioxidant potential of crocins and ethanol extracts of Gardenia jasminoides ELLIS and Crocus sativus L.: a relationship investigation between antioxidant activity and crocin contents. Food Chem 109:484–492

Article  CAS  Google Scholar 

Wang K, Zhang L, Rao W, Su N, Hui H, Wang L, Peng C, Tu Y, Zhang S, Fei Z (2015) Neuroprotective effects of crocin against traumatic brain injury in mice: involvement of notch signaling pathway. Neurosci Lett 591:53–58

Article  CAS  PubMed  Google Scholar 

Mehri S, Abnous K, Mousavi SH, Shariaty VM, Hosseinzadeh H (2012) Neuroprotective effect of crocin on acrylamide-induced cytotoxicity in PC12 cells. Cell Mol Neurobiol 32:227–235

Article  CAS  PubMed  Google Scholar 

Morelli S, Salerno S, Piscioneri A, Tasselli F, Drioli E, De Bartolo L (2016) Neuronal membrane bioreactor as a tool for testing crocin neuroprotective effect in Alzheimer’s Disease. Chem Eng J 305:69–78

Article  CAS  Google Scholar 

Vakili A, Einali MR, Bandegi AR (2014) Protective effect of crocin against cerebral ischemia in a dose-dependent manner in a rat model of ischemic Stroke. J Stroke Cerebrovasc Dis 23:106–113

Article  PubMed  Google Scholar 

Asadi F, Jamshidi AH, Khodagholi F, Yans A, Azimi L, Faizi M, Vali L, Abdollahi M, Ghahremani MH, Sharifzadeh M (2015) Reversal effects of crocin on amyloid β-induced memory deficit: modification of autophagy or apoptosis markers. Pharmacol Biochem Behav 139:47–58

Article  CAS  PubMed  Google Scholar 

Khalili M, Hamzeh F (2010) Effects of active constituents of Crocus sativus L., crocin on streptozocin-induced model of sporadic Alzheimer’s Disease in male rats. Iran Biomed J 14:59

CAS  PubMed  PubMed Central  Google Scholar 

Wang J, Xiao B, Han F, Shi Y (2017) Metformin alleviated the neuronal oxidative stress in hippocampus of rats under single prolonged stress. J Mol Neurosci 63:28–35

Article  CAS  PubMed  Google Scholar 

Delkhosh-Kasmaie F, Farshid AA, Tamaddonfard E, Imani M (2018) The effects of safranal, a constitute of saffron, and metformin on spatial learning and memory impairments in type-1 diabetic rats: behavioral and hippocampal histopathological and biochemical evaluations. Biomed Pharmacother 107:203–211

Article  CAS  PubMed  Google Scholar 

Bandegi AR, Rashidy-Pour A, Vafaei AA, Ghadrdoost B (2014) Protective effects of Crocus sativus L. extract and crocin against chronic-stress induced oxidative damage of brain, liver and kidneys in rats. Adv Pharm Bull 4:493

PubMed  PubMed Central  Google Scholar 

Oz M, Atalik KEN, Yerlikaya FH, Demir EA (2015) Curcumin alleviates cisplatin-induced learning and memory impairments. Neurobiol Learn Mem 123:43–49

Article  CAS  PubMed  Google Scholar 

Shabani M, Nazeri M, Parsania S, Razavinasab M, Zangiabadi N, Esmaeilpour K, Abareghi F (2012) Walnut consumption protects rats against cisplatin-induced neurotoxicity. Neurotoxicology 33:1314–1321

Article  CAS  PubMed  Google Scholar 

Ghotbeddin Z, Moazedi AA, Parham GA (2007) Effect of combined administration of zinc chloride and aluminum chloride on memory and motor activity of young rats. Physiol Pharmacol 11:146–152

CAS  Google Scholar 

Aliheydari M, Ghotbeddin Z, Khazaeil K, Tabandeh MR (2020) Effect of fish oil treatment during chronic hypoxia in pregnancy on memory impairment, brain morphometry changes and oxidative stress in adult male rat offspring. KAUMS J (FEYZ) 24:170–180

Google Scholar 

Nooraei A, Khazaeel K, Darvishi M, Ghotbeddin Z, Basir Z (2022) Dimorphic evaluation of hippocampal changes in rat model of demyelination: a comparative functional, morphometric, and histological study. Brain and Behavior 12:e32723

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ghotbeddin Z, Khazaeel K, Tabandeh M-R, Aliheydari M, Yaghoubi H (2022) Effects of omega-3 fatty acid supplementation during chronic maternal hypoxia on behavioral disorders in male rat offspring: the role of trk family and oxidative stress. Metab Brain Dis 37:1959–1967

Article  CAS  PubMed  Google Scholar 

Zhou JY, Prognon P (2006) Raw material enzymatic activity determination: a specific case for validation and comparison of analytical methods—the example of superoxide dismutase (SOD). J Pharm Biomed Anal 40:1143–1148

Article  CAS  PubMed  Google Scholar 

Buege JA, Aust SD (1978) Microsomal lipid peroxidation. Methods in enzymology. Elsevier, Amsterdam, pp 302–310

Google Scholar 

Anderson-Hanley C, Sherman ML, Riggs R, Agocha VB, Compas BE (2003) Neuropsychological effects of treatments for adults with cancer: a meta-analysis and review of the literature. J Int Neuropsychol Soc 9:967–982

Article  PubMed  Google Scholar 

Rzeski W, Pruskil S, Macke A, Felderhoff-Mueser U, Reiher AK, Hoerster F, Jansma C, Jarosz B, Stefovska V, Bittigau P (2004) Anticancer agents are potent neurotoxins in vitro and in vivo. Ann Neurol 56:351–360

Article  CAS  PubMed  Google Scholar 

Mustafa S, Walker A, Bennett G, Wigmore PM (2008) 5-Fluorouracil chemotherapy affects spatial working memory and newborn neurons in the adult rat hippocampus. Eur J Neurosci 28:323–330

Article  PubMed  Google Scholar 

Correa DD, Ahles TA (2008) Neurocognitive changes in cancer survivors. Cancer J 14:396–400

Article  PubMed  Google Scholar 

Krarup-Hansen A, Helweg-Larsen S, Schmalbruch H, Rørth M, Krarup C (2007) Neuronal involvement in cisplatin neuropathy: prospective clinical and neurophysiological studies. Brain 130:1076–1088

Article  CAS  PubMed  Google Scholar 

Callizot N, Andriambeloson E, Glass J, Revel M, Ferro P, Cirillo R, Vitte P-A, Dreano M (2008) Interleukin-6 protects against paclitaxel, cisplatin and vincristine-induced neuropathies without impairing chemotherapeutic activity. Cancer Chemother Pharmacol 62:995–1007

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