Sebestyen, Z. et al. RhoB mediates phosphoantigen recognition by Vγ9Vδ2 T cell receptor. Cell Rep. 15, 1973–1985 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rigau, M. et al. Butyrophilin 2A1 is essential for phosphoantigen reactivity by γδ T cells. Science 367, eaay5516 (2020).

Article  CAS  PubMed  Google Scholar 

Karunakaran, M. M. et al. Butyrophilin-2A1 directly binds germline-encoded regions of the Vγ9Vδ2 TCR and is essential for phosphoantigen sensing. Immunity 52, 487–498 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mamedov, M. R. et al. CRISPR screens decode cancer cell pathways that trigger γδ T cell detection. Nature 621, 188–195 (2023).

Article  CAS  PubMed  Google Scholar 

Harly, C. et al. Key implication of CD277/butyrophilin-3 (BTN3A) in cellular stress sensing by a major human γδ T-cell subset. Blood 120, 2269–2279 (2012).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hsiao, C. C. et al. Ligand-induced interactions between butyrophilin 2A1 and 3A1 internal domains in the HMBPP receptor complex. Cell Chem. Biol. 29, 985–995 (2022).

Article  CAS  PubMed  Google Scholar 

Yuan, L. et al. Phosphoantigens glue butyrophilin 3A1 and 2A1 to activate Vγ9Vδ2 T cells. Nature 621, 840–848 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vyborova, A. et al. γ9δ2T cell diversity and the receptor interface with tumor cells. J. Clin. Invest. 130, 4637–4651 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gründer, C. et al. γ9 and δ2CDR3 domains regulate functional avidity of T cells harboring γ9δ2TCRs. Blood 120, 5153–5162 (2012).

Article  PubMed  Google Scholar 

Straetemans, T. et al. Untouched GMP-ready purified engineered immune cells to treat cancer. Clin. Cancer Res. 21, 3957–3968 (2015).

Article  CAS  PubMed  Google Scholar 

de Witte, M. et al. First in human clinical responses and persistence data on TEG001: a next generation of engineered αβ T cells targeting AML and MM with a high affinity γ9δ2TCR. Blood 140, 12737–12739 (2022).

Article  Google Scholar 

Dekkers, J. F. et al. Uncovering the mode of action of engineered T cells in patient cancer organoids. Nat. Biotechnol. 41, 60–69 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Fuertes, M. B., Domaica, C. I. & Zwirner, N. W. Leveraging NKG2D ligands in immuno-oncology. Front. Immunol. 12, 713158 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Marcu-Malina, V. et al. Redirecting αβ T cells against cancer cells by transfer of a broadly tumor-reactive γδ T-cell receptor. Blood 118, 50–59 (2011).

Article  CAS  PubMed  Google Scholar 

Benyamine, A. et al. BTN3A is a prognosis marker and a promising target for Vγ9Vδ2 T cells based-immunotherapy in pancreatic ductal adenocarcinoma (PDAC). Oncoimmunology 7, e1372080 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Palakodeti, A. et al. The molecular basis for modulation of human Vγ9Vδ2 T cell responses by CD277/butyrophilin-3 (BTN3A)-specific antibodies. J. Biol. Chem. 287, 32780–32790 (2012).

Article  CAS  PubMed  PubMed Central  Google Scholar 

De Gassart, A. et al. Development of ICT01, a first-in-class, anti-BTN3A antibody for activating Vγ9Vδ2 T cell-mediated antitumor immune response. Sci. Transl. Med. 13, eabj0835 (2021).

Article  CAS  PubMed  Google Scholar 

Mansilla-Soto, J. et al. HLA-independent T cell receptors for targeting tumors with low antigen density. Nat. Med. 28, 345–352 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oda, S. K. et al. A Fas-4-1BB fusion protein converts a death to a pro-survival signal and enhances T cell therapy. J. Exp. Med. 217, e20191166 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu, X. et al. A chimeric switch-receptor targeting PD1 augments the efficacy of second-generation CAR T cells in advanced solid tumors. Cancer Res. 76, 1578–1590 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Melenhorst, J. J. et al. Decade-long leukaemia remissions with persistence of CD4+ CAR T cells. Nature 602, 503–509 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Anderson, N. D. et al. Transcriptional signatures associated with persisting CD19 CAR-T cells in children with leukemia. Nat. Med. 29, 1700–1709 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xia, A. et al. T cell dysfunction in cancer immunity and immunotherapy. Front. Immunol. 10, 1719 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vandenberghe, P. et al. Ligation of the CD5 or CD28 molecules on resting human T cells induces expression of the early activation antigen CD69 by a calcium- and tyrosine kinase-dependent mechanism. Immunology 78, 210–217 (1993).

CAS  PubMed  PubMed Central  Google Scholar 

Kunzmann, V. et al. Stimulation of γδ T cells by aminobisphosphonates and induction of antiplasma cell activity in multiple myeloma. Blood 96, 384–392 (2000).

Article  CAS  PubMed  Google Scholar 

Weinkove, R. et al. Selecting costimulatory domains for chimeric antigen receptors: functional and clinical considerations. Clin. Transl. Immunol. 8, e1049 (2019).

Article  Google Scholar 

Kuball, J. et al. Cooperation of human tumor-reactive CD4+ and CD8+ T cells after redirection of their specificity by a high-affinity p53A2.1-specific TCR. Immunity 22, 117–129 (2005).

Article  CAS  PubMed  Google Scholar 

Braham, M. V. J. et al. Cellular immunotherapy on primary multiple myeloma expanded in a 3D bone marrow niche model. Oncoimmunology 7, e1434465 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Eagle, R. A., Jafferji, I. & Barrow, A. D. Beyond stressed self: evidence for NKG2D ligand expression on healthy cells. Curr. Immunol. Rev. 5, 22–34 (2009).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Majzner, R. G. & Mackall, C. L. Clinical lessons learned from the first leg of the CAR T cell journey. Nat. Med. 25, 1341–1355 (2019).

Article  CAS  PubMed  Google Scholar 

Kawalekar, O. U. et al. Distinct signaling of coreceptors regulates specific metabolism pathways and impacts memory development in CAR T cells. Immunity 44, 380–390 (2016).

Article  CAS  PubMed  Google Scholar 

Philipson, B. I. et al. 4-1BB costimulation promotes CAR T cell survival through noncanonical NF-κB signaling. Sci. Signal. 13, eaay8248 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Payne, K. K. et al. BTN3A1 governs antitumor responses by coordinating αβ and γδ T cells. Science 369, 942–949 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qi, C. et al. Claudin18.2-specific CAR T cells in gastrointestinal cancers: phase 1 trial interim results. Nat. Med. 28, 1189–1198 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Majzner, R. G. et al. GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas. Nature 603, 934–941 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guerra, N. & Lanier, L. L. Emerging concepts on the NKG2D receptor–ligand axis in health and diseases. Front. Immunol. 11, 562 (2020).

Article  CAS  PubMed  PubMed Central