SUMOylation of RALY promotes vasculogenic mimicry in glioma cells via the FOXD1/DKK1 pathway

Ayala-Dominguez L, Olmedo-Nieva L, Munoz-Bello JO, Contreras-Paredes A, Manzo-Merino J, Martinez-Ramirez I, Lizano M. Mechanisms of vasculogenic mimicry in ovarian cancer. Front Oncol. 2019;9:998.

Article  PubMed  PubMed Central  Google Scholar 

Bellail AC, Olson JJ, Hao C. SUMO1 modification stabilizes CDK6 protein and drives the cell cycle and glioblastoma progression. Nat Commun. 2014;5:4234.

Article  CAS  PubMed  Google Scholar 

Bond KH, Fetting JL, Lary CW, Emery IF, Oxburgh L. FOXD1 regulates cell division in clear cell renal cell carcinoma. BMC Cancer. 2021;21(1):312.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bondy-Chorney E, Baldwin RM, Didillon A, Chabot B, Jasmin BJ, Côté J. RNA binding protein RALY promotes Protein Arginine Methyltransferase 1 alternatively spliced isoform v2 relative expression and metastatic potential in breast cancer cells. Int J Biochem Cell Biol. 2017;91(Pt B):124–35.

Article  CAS  PubMed  Google Scholar 

Cai K, Chen SY, Zhu CZ, Li L, Yu C, He ZW, Sun CY. FOXD1 facilitates pancreatic cancer cell proliferation, invasion, and metastasis by regulating GLUT1-mediated aerobic glycolysis. Cell Death Dis. 2022;13(9):765.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen L, Li M, Li Q, Wang CJ, Xie SQ. DKK1 promotes hepatocellular carcinoma cell migration and invasion through beta-catenin/MMP7 signaling pathway. Mol Cancer. 2013;12:157.

Article  PubMed  PubMed Central  Google Scholar 

Chen SW, Yang MW, Wang CY, Ouyang Y, Chen XF, Bai JW, Hu YM, Song M, Zhang SY, Zhang Q. Forkhead box D1 promotes EMT and chemoresistance by upregulating lncRNA CYTOR in oral squamous cell carcinoma. Cancer Lett. 2021;503:43–53.

Article  CAS  PubMed  Google Scholar 

Cheng P, Wang J, Waghmare I, Sartini S, Coviello V, Zhang Z, Kim SH, Mohyeldin A, Pavlyukov MS, Minata M, Valentim CLL, Chhipa RR, Bhat KPL, Dasgupta B, Motta CL, Kango-Singh M, Nakano I. FOXD1-ALDH1A3 signaling is a determinant for the self-renewal and tumorigenicity of mesenchymal glioma stem cells. Cancer Res. 2016;76(24):7219–30.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chu ZW, Shi X, Chen GY, He XJ, Qian YY, Wang HB, Tao L, Liu YQ, Jiang W, Chen J. COE Inhibits vasculogenic mimicry by targeting EphA2 in hepatocellular carcinoma, a research based on proteomics analysis. Front Pharmacol. 2021;12:619732.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cornella N, Tebaldi T, Gasperini L, Singh J, Padgett RA, Rossi A, Macchi P. The hnRNP RALY regulates transcription and cell proliferation by modulating the expression of specific factors including the proliferation marker E2F1. J Biol Chem. 2017;292(48):19674–92.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Deng R, Zhao X, Qu YY, Chen C, Zhu CH, Zhang HL, Yuan HH, Jin H, Liu X, Wang YL, Chen Q, Huang J, Yu JX. Shp2 SUMOylation promotes ERK activation and hepatocellular carcinoma development. Oncotarget. 2015;6(11):9355–69.

Article  PubMed  PubMed Central  Google Scholar 

Domènech M, Hernández A, Plaja A, Martínez-Balibrea E, Balañà C. Hypoxia: the cornerstone of glioblastoma. Int J Mol Sci. 2021;22(22):12608.

Article  PubMed  PubMed Central  Google Scholar 

Dudley AC, Griffioen AW. Pathological angiogenesis: mechanisms and therapeutic strategies. Angiogenesis. 2023;26(3):313–47.

Article  PubMed  PubMed Central  Google Scholar 

Fernandez-Cortes M, Delgado-Bellido D, Oliver FJ. Vasculogenic mimicry: become an endothelial cell “but not so much.” Front Oncol. 2019;9:803.

Article  PubMed  PubMed Central  Google Scholar 

Gao YF, Zhu T, Mao XY, Mao CX, Li L, Yin JY, Zhou HH, Liu ZQ. Silencing of Forkhead box D1 inhibits proliferation and migration in glioma cells. Oncol Rep. 2017;37(2):1196–202.

Article  CAS  PubMed  Google Scholar 

Gravina GL, Mancini A, Marampon F, Colapietro A, Monache SD, Sferra R, Vitale F, Richardson PJ, Patient L, Burbidge S, Festuccia C. The brain-penetrating CXCR4 antagonist, PRX177561, increases the antitumor effects of bevacizumab and sunitinib in preclinical models of human glioblastoma. J Hematol Oncol. 2017;10(1):5.

Article  PubMed  PubMed Central  Google Scholar 

Guo QD, Fan Y, Wang QT, Li BY, Qiu W, Qi YH, Pan ZW, Zhang SJ, Zhao SL, Yang KH, Xu H, Li M, Gao ZJ, Xu JY, Wang HZ, Wang SB, Tang QL, Qiu JW, Guo X, Deng L, Zhang P, Zhao RR, Xue H, Wang CW, Li G. Glioblastoma upregulates SUMOylation of hnRNP A2/B1 to eliminate the tumor suppressor miR-204-3p, accelerating angiogenesis under hypoxia. Cell Death Dis. 2023;14(2):147.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han ZJ, Feng YH, Gu BH, Li YM, Chen H. The post-translational modification, SUMOylation, and cancer (Review). Int J Oncol. 2018;52(4):1081–94.

CAS  PubMed  PubMed Central  Google Scholar 

Huang J, Yan J, Zhang J, Zhu SQ, Wang YL, Shi T, Zhu CH, Chen C, Liu X, Cheng JK, Mustelin T, Feng GS, Chen GQ, Yu JX. SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane. Nat Commun. 2012;3:911.

Article  PubMed  Google Scholar 

Huang YS, Zhu CC, Liu P, Yang FO, Luo JJ, Lu CJ, Tang B, Yang XJ. L1CAM promotes vasculogenic mimicry formation by miR-143–3p-induced expression of hexokinase 2 in glioma. Mol Oncol. 2023;17(4):664–85.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ju RJ, Zeng F, Liu L, Mu L, Xie H, Zhao Y, Yan Y, Wu JS, Hu YJ, Lu WL. Destruction of vasculogenic mimicry channels by targeting epirubicin plus celecoxib liposomes in treatment of brain glioma. Int J Nanomed. 2016;11:1131–46.

CAS  Google Scholar 

Kagey MH, He X. Rationale for targeting the Wnt signalling modulator Dickkopf-1 for oncology. Br J Pharmacol. 2017;174(24):4637–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lapointe S, Perry A, Butowski NA. Primary brain tumours in adults. Lancet. 2018;392(10145):432–46.

Article  PubMed  Google Scholar 

Lee SW, Lee MH, Park JH, Kang SH, Yoo HM, Ka SH, Oh YM, Jeon YJ, Chung CH. SUMOylation of hnRNP-K is required for p53-mediated cell-cycle arrest in response to DNA damage. EMBO J. 2012;31(23):4441–52.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li CY, Wang T, Gu JW, Qi ST, Li JJ, Chen L, Wu H, Shi LY, Song C, Li H, Zhu LW, Lu YT, Zhou Q. SMARCC2 mediates the regulation of DKK1 by the transcription factor EGR1 through chromatin remodeling to reduce the proliferative capacity of glioblastoma. Cell Death Dis. 2022;13(11):990.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li R, Shao JC, Jin YJ, Kawase H, Ong YT, Troidl K, Quan Q, Wang L, Bonnavion R, Wietelmann A, Helmbacher F, Potente M, Graumann J, Wettschureck N, Offermanns S. Endothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2. Nat Commun. 2023;14(1):1980.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin XH, Pang QQ, Hu J, Sun JQ, Dai SY, Yu YJ, Xu JH. SUMOylation mediates the disassembly of the Smad4 nuclear export complex via RanGAP1 in KELOIDS. J Cell Mol Med. 2023;27(8):1045–55.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin CH, Lee HH, Chang WM, Lee FP, Chen LC, Lu LS, Lin YF. FOXD1 Repression potentiates radiation effectiveness by downregulating G3BP2 expression and promoting the activation of TXNIP-related pathways in oral cancer. Cancers (Basel). 2020;12(9):2690.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu XK, Xu Y, Pang ZG, Guo FC, Qin Q, Yin T, Sang YX, Feng CJ, Li XY, Jiang L, Shu P, Wang YS. Knockdown of SUMO-activating enzyme subunit 2 (SAE2) suppresses cancer malignancy and enhances chemotherapy sensitivity in small cell lung cancer. J Hematol Oncol. 2015;8:67.

Article  PubMed  PubMed Central  Google Scholar 

Long YF, Chong TT, Lyu XM, Chen LJ, Luo LM, Faleti OD, Deng SM, Wang F, He ML, Qian ZP, Zhao HL, Zhou WY, Guo X, Chen CS, Li X. FOXD1-dependent RalA-ANXA2-Src complex promotes CTC formation in breast cancer. J Exp Clin Cancer Res. 2022;41(1):301.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lv Z, Yuan LM, Atkison JH, Williams KM, Vega R, Sessions EH, Divlianska DB, Davies C, Chen Y, Olsen SK. Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme. Nat Commun. 2018;9(1):5145.

Article  PubMed  PubMed Central  Google Scholar 

Malta TM, de Souza CF, Sabedot TS, Silva TC, Mosella MS, Kalkanis SN, Snyder J, Castro AV, Noushmehr H. Glioma CpG island methylator phenotype (G-CIMP): biological and clinical implications. Neuro Oncol. 2018;20(5):608–20.

Article  CAS  PubMed  Google Scholar 

Mo YY, Yu Y, Theodosiou E, Ee PL, Beck WT. A role for Ubc9 in tumorigenesis. Oncogene. 2005;24(16):2677–83.

Article  CAS  PubMed 

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