Sung H et al (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 Countries. CA Cancer J Clin 71(3):209–249
Siegel RL et al (2023) Cancer statistics, 2023. CA Cancer J Clin 73(1):17–48
Moolgavkar SH et al (2012) Impact of reduced tobacco smoking on lung cancer mortality in the United States during 1975–2000. J Natl Cancer Inst 104(7):541–548
Article PubMed PubMed Central Google Scholar
Klemperer EM et al (2021) Tobacco and nicotine use among US adult “Never Smokers” in wave 4 (2016–2018) of the population assessment of tobacco and health study. Nicotine Tob Res 23(7):1199–1207
Article CAS PubMed PubMed Central Google Scholar
Parkin DM et al (2005) Global cancer statistics, 2002. CA Cancer J Clin 55(2):74–108
Boeckx B et al (2020) The genomic landscape of nonsmall cell lung carcinoma in never smokers. Int J Cancer 146(11):3207–3218
Article CAS PubMed Google Scholar
Yano T et al (2008) Never-smoking nonsmall cell lung cancer as a separate entity: clinicopathologic features and survival. Cancer 113(5):1012–1018
Siegel RL et al (2022) Cancer statistics, 2022. CA Cancer J Clin 72(1):7–33
Miao E et al (2023) Hypothesized explanations for the observed lung cancer survival benefit among hispanics/latinos in the United States. J Racial Ethn Health Disparities 10(3):1339–1348
Ou SH, Ziogas A, Zell JA (2009) Asian ethnicity is a favorable prognostic factor for overall survival in non-small cell lung cancer (NSCLC) and is independent of smoking status. J Thorac Oncol 4(9):1083–1093
Wakelee HA et al (2007) Lung cancer incidence in never smokers. J Clin Oncol 25(5):472–478
Boffetta P et al (2001) Incidence of lung cancer in a large cohort of non-smoking men from Sweden. Int J Cancer 94(4):591–593
Article CAS PubMed Google Scholar
Thun MJ et al (2008) Lung cancer occurrence in never-smokers: an analysis of 13 cohorts and 22 cancer registry studies. PLoS Med 5(9):e185
Article PubMed PubMed Central Google Scholar
Clement-Duchene C et al (2010) Characteristics of never smoker lung cancer including environmental and occupational risk factors. Lung Cancer 67(2):144–150
Vineis P et al (2007) Lung cancers attributable to environmental tobacco smoke and air pollution in non-smokers in different European countries: a prospective study. Environ Health 6:7
Article PubMed PubMed Central Google Scholar
Asomaning K et al (2008) Second hand smoke, age of exposure and lung cancer risk. Lung Cancer 61(1):13–20
Olivo-Marston SE et al (2009) Childhood exposure to secondhand smoke and functional mannose binding lectin polymorphisms are associated with increased lung cancer risk. Cancer Epidemiol Biomarkers Prev 18(12):3375–3383
Article CAS PubMed PubMed Central Google Scholar
Kurahashi N et al (2008) Passive smoking and lung cancer in Japanese non-smoking women: a prospective study. Int J Cancer 122(3):653–657
Article CAS PubMed Google Scholar
Wang A et al (2015) Active and passive smoking in relation to lung cancer incidence in the Women’s Health Initiative Observational Study prospective cohort. Ann Oncol 26(1):221–230
Article CAS PubMed Google Scholar
Hackshaw AK, Law MR, Wald NJ (1997) The accumulated evidence on lung cancer and environmental tobacco smoke. BMJ 315(7114):980–988
Article CAS PubMed PubMed Central Google Scholar
Park MB (2020) Living with parents who smoke predicts levels of toxicant exposure in children. Sci Rep 10(1):11173
Article CAS PubMed PubMed Central Google Scholar
Devarakonda S et al (2021) Genomic profiling of lung adenocarcinoma in never-smokers. J Clin Oncol 39(33):3747–3758
Article CAS PubMed PubMed Central Google Scholar
Ernst SM et al (2023) Tobacco smoking-related mutational signatures in classifying smoking-associated and nonsmoking-associated NSCLC. J Thorac Oncol 18(4):487–498
Article CAS PubMed Google Scholar
Leuraud K et al (2011) Radon, smoking and lung cancer risk: results of a joint analysis of three European case-control studies among uranium miners. Radiat Res 176(3):375–387
Article CAS PubMed Google Scholar
Darby S et al (2005) Radon in homes and risk of lung cancer: collaborative analysis of individual data from 13 European case-control studies. BMJ 330(7485):223
Article CAS PubMed PubMed Central Google Scholar
Gottschall EB (2002) Occupational and environmental thoracic malignancies. J Thorac Imaging 17(3):189–197
van Loon AJ et al (1997) Occupational exposure to carcinogens and risk of lung cancer: results from The Netherlands cohort study. Occup Environ Med 54(11):817–824
Article PubMed PubMed Central Google Scholar
Chen CL et al (2004) Ingested arsenic, cigarette smoking, and lung cancer risk: a follow-up study in arseniasis-endemic areas in Taiwan. JAMA 292(24):2984–2990
Article CAS PubMed Google Scholar
Feskanich D et al (2000) Prospective study of fruit and vegetable consumption and risk of lung cancer among men and women. J Natl Cancer Inst 92(22):1812–1823
Article CAS PubMed Google Scholar
Hamra GB et al (2014) Outdoor particulate matter exposure and lung cancer: a systematic review and meta-analysis. Environ Health Perspect 122(9):906–911
Article PubMed PubMed Central Google Scholar
Turner MC et al (2011) Long-term ambient fine particulate matter air pollution and lung cancer in a large cohort of never-smokers. Am J Respir Crit Care Med 184(12):1374–1381
Liu Y et al (2005) Reproductive factors, hormone use and the risk of lung cancer among middle-aged never-smoking Japanese women: a large-scale population-based cohort study. Int J Cancer 117(4):662–666
Article CAS PubMed Google Scholar
Stabile LP et al (2002) Human non-small cell lung tumors and cells derived from normal lung express both estrogen receptor alpha and beta and show biological responses to estrogen. Cancer Res 62(7):2141–2150
Fasco MJ, Hurteau GJ, Spivack SD (2002) Gender-dependent expression of alpha and beta estrogen receptors in human nontumor and tumor lung tissue. Mol Cell Endocrinol 188(1–2):125–140
Article CAS PubMed Google Scholar
Chlebowski RT et al (2009) Oestrogen plus progestin and lung cancer in postmenopausal women (Women’s Health Initiative trial): a post-hoc analysis of a randomised controlled trial. Lancet 374(9697):1243–1251
Article CAS PubMed PubMed Central Google Scholar
Schabath MB et al (2004) Hormone replacement therapy and lung cancer risk: a case-control analysis. Clin Cancer Res 10(1 Pt 1):113–123
Article CAS PubMed Google Scholar
Kabat GC, Miller AB, Rohan TE (2007) Reproductive and hormonal factors and risk of lung cancer in women: a prospective cohort study. Int J Cancer 120(10):2214–2220
Article CAS PubMed Google Scholar
Brenner DR et al (2010) Lung cancer risk in never-smokers: a population-based case-control study of epidemiologic risk factors. BMC Cancer 10:285
Article PubMed PubMed Central Google Scholar
Alavanja MC et al (1992) Preexisting lung disease and lung cancer among nonsmoking women. Am J Epidemiol 136(6):623–632
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