Maqbool M, Zehravi M (2021) Neuroprotective role of polyphenols in treatment of neurological disorders: a review. Interv Pain Med Neuromod 1:e117170

Article  Google Scholar 

Bredesen DE, Rao RV, Mehlen P (2006) Cell death in the nervous system. Nature 443:796–802

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carregosa D, Mota S, Ferreira S, Alves-Dias B, Loncarevic-Vasiljkovic N, Crespo CL, Menezes R, Teodoro R, Santos CND (2021) Overview of beneficial effects of (poly)phenol metabolites in the context of neurodegenerative diseases on model organisms. Nutrients 13:2940

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jellinger KA (2010) Basic mechanisms of neurodegeneration: a critical update. J Cell Mol Med 14:457–487

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kausar S, Wang F, Cui H (2018) The role of mitochondria in reactive oxygen species generation and its implications for neurodegenerative diseases. Cells 7:274

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin MT, Beal MF (2006) Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443:787–795

Article  CAS  PubMed  Google Scholar 

González-Sarrías A, Núñez-Sánchez MA, Tomás-Barberán FA, Espín JC (2017) Neuroprotective effects of bioavailable polyphenol-derived metabolites against oxidative stress-induced cytotoxicity in human neuroblastoma SH-SY5Y cells. J Agric Food Chem 65:752–758

Article  PubMed  Google Scholar 

Farzaei MH, Tewari D, Momtaz S, Argüelles S, Nabavi SM (2018) Targeting ERK signaling pathway by polyphenols as novel therapeutic strategy for neurodegeneration. Food Chem Toxicol 120:183–195

Article  CAS  PubMed  Google Scholar 

Stout JC, Paulsen JS, Queller S, Solomon AC, Whitlock KB, Campbell JC, Carlozzi N, Duff K, Beglinger LJ, Langbehn DR (2011) Neurocognitive signs in prodromal Huntington disease. Neuropsychology 25:1–14

Article  PubMed  PubMed Central  Google Scholar 

Hinnell C, Hurt CS, Landau S, Brown RG, Samuel M, Group PPS (2012) Nonmotor versus motor symptoms: how much do they matter to health status in Parkinson’s disease? Mov Disord 27:236–241

Article  PubMed  Google Scholar 

Winner B, Winkler J (2015) Adult neurogenesis in neurodegenerative diseases. Cold Spring Harb Perspect Biol 7:a021287

Article  PubMed  PubMed Central  Google Scholar 

Spillantini MG, Bird TD, Ghetti B (1998) Frontotemporal dementia and Parkinsonism linked to chromosome 17: a new group of tauopathies. Brain Pathol 8:387–402

Article  CAS  PubMed  Google Scholar 

Kujawska M, Jodynis-Liebert J (2018) What is the evidence that Parkinson’s disease is a prion disorder, which originates in the gut? Int J Mol Sci 19:3573

Article  PubMed  PubMed Central  Google Scholar 

Gutierrez-Merino C, Lopez-Sanchez C, Lagoa R, Samhan-Arias AK, Bueno C, Garcia-Martinez V (2011) Neuroprotective actions of flavonoids. Curr Med Chem 18:1195–1212

Article  CAS  PubMed  Google Scholar 

Healy DG, Falchi M, O’Sullivan SS, Bonifati V, Durr A, Bressman S, Brice A, Aasly J, Zabetian CP, Goldwurm S (2008) Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson’s disease: a case-control study. Lancet Neurol 7:583–590

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aarsland D, Brønnick K, Larsen J, Tysnes O, Alves G (2009) Cognitive impairment in incident, untreated Parkinson disease: the Norwegian ParkWest study. Neurology 72:1121–1126

Article  CAS  PubMed  Google Scholar 

Ullah F, Ayaz M, Sadiq A, Hussain A, Ahmad S, Imran M, Zeb A (2016) Phenolic, flavonoid contents, anticholinesterase and antioxidant evaluation of Iris germanica var florentina. Nat Prod Res 30:1440–1444

Article  CAS  PubMed  Google Scholar 

Kamal Z, Ullah F, Ayaz M, Sadiq A, Ahmad S, Zeb A, Hussain A, Imran M (2015) Anticholinesterse and antioxidant investigations of crude extracts, subsequent fractions, saponins and flavonoids of atriplex laciniata L.: potential effectiveness in Alzheimer’s and other neurological disorders. Biol Res 48:1–11

Article  Google Scholar 

Lane DJ, Ayton S, Bush AI (2018) Iron and Alzheimer’s disease: an update on emerging mechanisms. J Alzheimers Dis 64:S379–S395

Article  CAS  PubMed  Google Scholar 

Colizzi C (2019) The protective effects of polyphenols on Alzheimer’s disease: a systematic review. Alzheimers Dement (N Y) 5:184–196

Article  PubMed  Google Scholar 

MacDonald ME, Ambrose CM, Duyao MP, Myers RH, Lin C, Srinidhi L, Barnes G, Taylor SA, James M, Groot N (1993) A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington’s disease chromosomes. Cell 72:971–983

Article  Google Scholar 

Pringsheim T, Wiltshire K, Day L, Dykeman J, Steeves T, Jette N (2012) The incidence and prevalence of Huntington’s disease: a systematic review and meta-analysis. Mov Disord 27:1083–1089

Article  PubMed  Google Scholar 

Bhullar KS, Rupasinghe H (2013) Polyphenols: multipotent therapeutic agents in neurodegenerative diseases. Oxid Med Cell Longev 2013:1–18

Article  Google Scholar 

Walker R, Jung H, Dobson-Stone C, Rampoldi L, Sano A, Tison F, Danek A (2007) Neurologic phenotypes associated with acanthocytosis. Neurology 68:92–98

Article  CAS  PubMed  Google Scholar 

Kazantsev A, Walker HA, Slepko N, Bear JE, Preisinger E, Steffan JS, Zhu YZ, Gertler FB, Housman DE, Marsh JL (2002) A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila. Nat Genet 30:367–376

Article  CAS  PubMed  Google Scholar 

Johri A, Beal MF (2012) Antioxidants in Huntington’s disease. Biochim Biophys Acta 1822:664–674

Article  CAS  PubMed  Google Scholar 

Taiz L, Zeiger E, Møller IM, Murphy A (2015) Plant physiology and development, 6th edn. Sunderland, Sinauer Associates Incorporated, pp 1–761

Google Scholar 

Kabera JN, Semana E, Mussa AR, He X (2014) Plant secondary metabolites: biosynthesis, classification, function and pharmacological properties. J Pharm Pharmacol 2:377–392

Google Scholar 

Chiorcea-Paquim AM, Enache TA, De Souza GE, Oliveira-Brett AM (2020) Natural phenolic antioxidants electrochemistry: towards a new food science methodology. Compr Rev Food Sci Food Saf 19:1680–1726

Article  CAS  PubMed  Google Scholar 

de la Luz Cádiz-Gurrea M, Fernández-Ochoa Á, del Carmen V-A, Arráez-Román D, Segura-Carretero A (2022) Therapeutic targets for phenolic compounds from agro-industrial by-products against obesity. Curr Med Chem 29:1083–1098

Article  Google Scholar 

del Carmen Villegas-Aguilar M, Fernández-Ochoa Á, Leyva-Jiménez FJ, Miranda-Segura Á, de la Luz Cádiz-Gurrea M, Segura-Carretero A (2022) Phenolic compounds. In: Cazarin CBB, Bicas JL, Pastore GM, Junior MRM (eds) Bioactive food components activity in mechanistic approach, 1st edn. Elsevier, Amsterdam, pp 27–53

Chapter  Google Scholar 

Ataie A, Shadifar M, Ataee R (2016) Polyphenolic antioxidants and neuronal regeneration. Basic Clin Neurosci 7:81–90

CAS  PubMed  PubMed Central  Google Scholar 

Panickar KS, Jang S (2013) Dietary and plant polyphenols exert neuroprotective effects and improve cognitive function in cerebral ischemia. Recent Pat Food Nutr Agric 5:128–143

Article  CAS  PubMed  Google Scholar 

Holczer M, Besze B, Zámbó V, Csala M, Bánhegyi G, Kapuy O (2018) Epigallocatechin-3-gallate (EGCG) promotes autophagy-dependent survival via influencing the balance of mTOR-AMPK pathways upon endoplasmic reticulum stress. Oxid Med Cell Longev 2018:6721530

Article  PubMed  PubMed Central  Google Scholar 

Annunziata G, Sureda A, Orhan IE, Battino M, Arnone A, Jiménez-García M, Capo X, Cabot J, Sanadgol N, Giampieri F (2021) The neuroprotective effects of polyphenols, their role in innate immunity and the interplay with the microbiota. Neurosci Biobehav Rev 128:437–453

Article  CAS  PubMed  Google Scholar 

Pitozzi V, Jacomelli M, Catelan D, Servili M, Taticchi A, Biggeri A, Dolara P, Giovannelli L (2012) Long-term dietary extra-virgin olive oil rich in polyphenols reverses age-related dysfunctions in motor coordination and contextual memory in mice: role of oxidative stress. Rejuvenation Res 15:601–612

Article  CAS  PubMed  Google Scholar 

Cásedas G, Les F, Gómez-Serranillos MP, Smith C, López V (2017) Anthocyanin profile, antioxidant activity and enzyme inhibiting properties of blueberry and cranberry juices: a comparative study. Food Funct 8:4187–4193

Article  PubMed  Google Scholar 

Imran A, Arshad MU, Sherwani H, Shabir Ahmad R, Arshad MS, Saeed F, Hussain G, Afzaal M, Imran M, Naeem U (2021) Antioxidant capacity and characteristics of theaflavin catechins and ginger freeze-dried extract as affected by extraction techniques. Int j food prop 24:1097–1116

Article  CAS  Google Scholar 

Ehrnhoefer DE, Duennwald M, Markovic P, Wacker JL, Engemann S, Roark M, Legleiter J, Marsh JL, Thompson LM, Lindquist S (2006) Green tea