Cathenaut L, Leonardon B, Kuster R et al (2022) Inhibitory interneurons with differential plasticities at their connections tune excitatory-inhibitory balance in the spinal nociceptive system. Pain 163(5):e675–e688

Article  CAS  PubMed  Google Scholar 

Huang Y, Chen SR, Pan HL (2022) Calcineurin regulates synaptic plasticity and nociceptive transmission at the spinal cord level. Neuroscientist 28(6):628–638

Article  CAS  PubMed  Google Scholar 

Li HL, Guo RJ, Guan Y et al (2022) Modulation of trans-synaptic neurexin-neuroligin interaction in pathological pain. Cells 11(12):1940

Article  CAS  PubMed  PubMed Central  Google Scholar 

Prange O, Wong TP, Gerrow K et al (2004) A balance between excitatory and inhibitory synapses is controlled by PSD-95 and neuroligin. Proc Natl Acad Sci USA 101(38):13915–13920

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ali H, Marth L, Krueger-Burg D (2020) Neuroligin-2 as a central organizer of inhibitory synapses in health and disease. Sci Signal 13(663):eabd8379

Article  CAS  PubMed  Google Scholar 

Liu X, Hua F, Yang D et al (2022) Roles of neuroligins in central nervous system development: focus on glial neuroligins and neuron neuroligins. J Transl Med 20(1):418

Article  PubMed  PubMed Central  Google Scholar 

Wu XB, Zhu Q, Gao YJ (2021) CCL2/CCR2 contributes to the altered excitatory-inhibitory synaptic balance in the nucleus accumbens shell following peripheral nerve injury-induced neuropathic pain. Neurosci Bull 37(7):921–933

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dolique T, Favereaux A, Roca-Lapirot O et al (2013) Unexpected association of the “inhibitory” neuroligin 2 with excitatory PSD95 in neuropathic pain. Pain 154(11):2529–2546

Article  CAS  PubMed  Google Scholar 

Guo RJ, Li HL, Li XY et al (2018) Increased neuroligin 2 levels in the postsynaptic membrane in spinal dorsal horn may contribute to postoperative pain. Neuroscience 382(2018):14–22

Article  CAS  Google Scholar 

Connor SA, Elegheert J, Xie Y et al (2019) Pumping the brakes: suppression of synapse development by MDGA-neuroligin interactions. Curr Opin Neurobiol 57(2019):71–80

Article  CAS  PubMed  Google Scholar 

Kim JA, Kim D, Won SY et al (2017) Structural insights into modulation of neurexin-neuroligin trans-synaptic adhesion by MDGA1/neuroligin-2 complex. Neuron 94(6):1121–1131

Article  CAS  PubMed  Google Scholar 

Elegheert J, Cvetkovska V, Clayton AJ et al (2017) Structural mechanism for modulation of synaptic neuroligin-neurexin signaling by MDGA proteins. Neuron 95(4):896–913

Article  CAS  PubMed  PubMed Central  Google Scholar 

Elegheert J, Cvetkovska V, Clayton AJ et al (2021) Structural mechanism for modulation of synaptic neuroligin-neurexin signaling by MDGA proteins. Neuron 109(1):189–190

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim J, Kim S, Kim H et al (2022) MDGA1 negatively regulates amyloid precursor protein-mediated synapse inhibition in the hippocampus. Proc Natl Acad Sci USA 119(4):e2115326119

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee K, Kim Y, Lee SJ et al (2013) MDGAs interact selectively with neuroligin-2 but not other neuroligins to regulate inhibitory synapse development. Proc Natl Acad Sci USA 110(1):336–341

Article  CAS  PubMed  Google Scholar 

Toledo A, Letellier M, Bimbi G et al (2022) (2022) MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior. Elife 11:e75233

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ho KS, Mo CJ (1992) An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 50(3):355–363

Article  Google Scholar 

Guo RJ, Li HL, Shi R et al (2021) Intrathecal injection of GRIP-siRNA reduces postoperative synaptic abundance of kainate receptor GluK2 subunits in rat dorsal horns and pain hypersensitivity. Neurochem Res 46(7):1771–1780

Article  CAS  PubMed  Google Scholar 

Guo RJ, Li HL, Li XY et al (2018) (2018) Downregulation of neuroligin1 ameliorates postoperative pain through inhibiting neuroligin1/postsynaptic density 95-mediated synaptic targeting of α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor GluA1 subunits in rat dorsal horns. Mol Pain 14:1744806918766745

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dunah AW, Standaert DG (2021) Dopamine D1 receptor dependent trafficking of striatal NMDA glutamate receptors to the postsynaptic membrane. J Neurosci 21(15):5546–5558

Article  Google Scholar 

Guo RJ, Zhao YJ, Zhang MJ et al (2014) Down-regulation of stargazin inhibits the enhanced surface delivery of α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor GluR1 subunit in rat dorsal horn and ameliorates postoperative pain. Anesthesiology 121(3):609–619

Article  CAS  PubMed  Google Scholar 

Litwack ED, Babey R, Buser R et al (2004) Identification and characterization of two novel brain-derived immunoglobulin superfamily members with a unique structural organization. Mol Cell Neurosci 25(2):263–274

Article  CAS  PubMed  Google Scholar 

Fujimura Y, Iwashita M, Matsuzaki F et al (2006) MDGA1, an IgSF molecule containing a MAM domain, heterophilically associates with axon- and muscle-associated binding partners through distinct structural domains. Brain Res 1101(1):12–19

Article  CAS  PubMed  Google Scholar 

Eisenach JC (1999) Muscarinic-mediated analgesia. Life Sci 64(6–7):549–554

Article  CAS  PubMed  Google Scholar 

Connor SA, Ammendrup-Johnsen I, Kishimoto Y et al (2017) Loss of synapse repressor MDGA1 enhances perisomatic inhibition, confers resistance to network excitation, and impairs cognitive function. Cell Rep 21(13):3637–3645

Article  CAS  PubMed  Google Scholar 

Pettem KL, Yokomaku D, Takahashi H et al (2013) Interaction between autism-linked MDGAs and neuroligins suppresses inhibitory synapse development. J Cell Biol 200(3):321–336

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hossain MR, Jamal M, Tanoue Y et al (2020) MDGA1-deficiency attenuates prepulse inhibition with alterations of dopamine and serotonin metabolism: An ex vivo HPLC-ECD analysis. Neurosci Lett 716:134677

Article  CAS  PubMed  Google Scholar 

Phelps CE, Navratilova E, Porreca F (2021) Cognition in the chronic pain experience: preclinical insights. Trends Cogn Sci 25(5):365–376

Article  PubMed  PubMed Central  Google Scholar 

O’Gara BP, Gao L, Marcantonio ER et al (2021) Sleep, pain, and cognition: modifiable targets for optimal perioperative brain health. Anesthesiology 135(6):1132–1152

Article  PubMed  Google Scholar 

Chanda S, Hale WD, Zhang B et al (2017) Unique versus redundant functions of neuroligin genes in shaping excitatory and inhibitory synapse properties. J Neurosci 37(29):6816–6836

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hale WD, Südhof TC, Huganir RL (2023) Engineered adhesion molecules drive synapse organization. Proc Natl Acad Sci USA 120(3):e2215905120

Article  CAS  PubMed  PubMed Central  Google Scholar 

Halff EF, Hannan S, Kwanthongdee J et al (2022) Phosphorylation of neuroligin-2 by PKA regulates its cell surface abundance and synaptic stabilization. Sci Signal 15(739):eabg2505

Article  CAS  PubMed  Google Scholar 

Zhang W, Chen Y, Qin J et al (2022) Prolonged sevoflurane exposure causes abnormal synapse development and dysregulates beta-neurexin and neuroligins in the hippocampus in neonatal rats. J Affect Disord 312(2022):22–29

Article  CAS  PubMed  Google Scholar 

Halff EF, Szulc BR, Lesept F et al (2019) SNX27-mediated recycling of neuroligin-2 regulates inhibitory signaling. Cell Rep 29(9):2599–2607

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo C (2021) Ma YY (2021) Calcium permeable-AMPA receptors and excitotoxicity in neurological disorders. Front Neural Circuits 15:711564

Article  CAS  PubMed  PubMed Central  Google Scholar 

Miyagi Y, Fujiwara K, Hikishima K et al (2022) Altered calcium permeability of AMPA receptor drives NMDA receptor inhibition in the hippocampus of murine obesity models. Mol Neurobiol 59(8):4902–4925