Sbardella E, Isidori AM, Arnaldi G et al (2018) Approach to hyponatremia according to the clinical setting: consensus statement from the Italian society of endocrinology (SIE), Italian society of nephrology (SIN), and Italian association of medical oncology (AIOM). J Endocrinol Invest 41:3–19. https://doi.org/10.1007/s40618-017-0776-x

Article  CAS  PubMed  Google Scholar 

Spasovski G, Vanholder R, Allolio B et al (2014) Clinical practice guideline on diagnosis and treatment of hyponatraemia. Eur J Endocrinol 170:G1-47. https://doi.org/10.1530/EJE-13-1020

Article  CAS  PubMed  Google Scholar 

Verbalis JG, Goldsmith SR, Greenberg A et al (2013) Diagnosis, evaluation, and treatment of hyponatremia: expert panel recommendations. Am J Med 126:S1–S42. https://doi.org/10.1016/j.amjmed.2013.07.006

Article  PubMed  Google Scholar 

Corona G, Giuliani C, Parenti G et al (2013) Moderate hyponatremia is associated with increased risk of mortality: evidence from a meta-analysis. PLoS ONE 8:e80451. https://doi.org/10.1371/journal.pone.0080451

Article  CAS  PubMed  PubMed Central  Google Scholar 

Corona G, Norello D, Parenti G et al (2018) Hyponatremia, falls and bone fractures: a systematic review and meta-analysis. Clin Endocrinol (Oxf) 89:505–513. https://doi.org/10.1111/cen.13790

Article  PubMed  Google Scholar 

Suárez V, Norello D, Sen E et al (2020) Impairment of neurocognitive functioning, motor performance, and mood stability in hospitalized patients with euvolemic moderate and profound hyponatremia. Am J Med 133:986-993.e5. https://doi.org/10.1016/j.amjmed.2019.12.056

Article  CAS  PubMed  Google Scholar 

Ahluwalia V, Wade JB, Thacker L et al (2013) Differential impact of hyponatremia and hepatic encephalopathy on health-related quality of life and brain metabolite abnormalities in cirrhosis. J Hepatol 59:467–473. https://doi.org/10.1016/j.jhep.2013.04.023

Article  CAS  PubMed  PubMed Central  Google Scholar 

Corona G, Giukiani C, Parenti G et al (2016) The economic burden of hyponatremia: systematic review and meta-analysis. Am J Med 129:823-835.e4. https://doi.org/10.1016/j.amjmed.2016.03.007

Article  PubMed  Google Scholar 

Greenberg A, Verbalis JG, Amin AN et al (2015) Current treatment practice and outcomes. Report of the hyponatremia registry. Kidney Int 88:167–177. https://doi.org/10.1038/ki.2015.4

Article  PubMed  PubMed Central  Google Scholar 

Tzoulis P, Waung JA, Bagkeris E et al (2016) Real-life experience of tolvaptan use in the treatment of severe hyponatraemia due to syndrome of inappropriate antidiuretic hormone secretion. Clin Endocrinol 84:620–626. https://doi.org/10.1111/cen.12943

Article  CAS  Google Scholar 

Mohmand HK, Issa D, Ahmad Z et al (2007) Hypertonic saline for hyponatremia: risk of inadvertent overcorrection. Clin J Am Soc Nephrol 2:1110–1117. https://doi.org/10.2215/CJN.00910207

Article  PubMed  Google Scholar 

Garrahy A, Dineen R, Hannon AM et al (2019) Continuous versus bolus infusion of hypertonic saline in the treatment of symptomatic hyponatremia caused by SIAD. J Clin Endocrinol Metab 104:3595–3602. https://doi.org/10.1210/jc.2019-00044

Article  PubMed  Google Scholar 

Rondon-Berrios H, Tandukar S, Mor MK et al (2018) Urea for the treatment of hyponatremia. Clin J Am Soc Nephrol 13:1627–1632. https://doi.org/10.2215/CJN.04020318

Article  CAS  PubMed  PubMed Central  Google Scholar 

Decaux G, Gankam Kengne F, Couturier B et al (2014) Actual therapeutic indication of an old drug: urea for treatment of severely symptomatic and mild chronic hyponatremia related to SIADH. J Clin Med 3:1043–1049. https://doi.org/10.3390/jcm3031043

Article  PubMed  PubMed Central  Google Scholar 

Nervo A, D’Angelo V, Rosso D et al (2019) Urea in cancer patients with chronic SIAD-induced hyponatremia: old drug, new evidence. Clin Endocrinol (Oxf) 90:842–848. https://doi.org/10.1111/cen.13966

Article  CAS  PubMed  Google Scholar 

Phillips GB, Schwartz R, Gabuzda GJ, Davidson CS (1952) The syndrome of impending hepatic coma in patients with cirrhosis of the liver given certain nitrogenous substances. N Engl J Med 247:239–246. https://doi.org/10.1056/NEJM195208142470703

Article  CAS  PubMed  Google Scholar 

Bioletto F, Varaldo E, Prencipe N et al (2023) Long-term efficacy of empagliflozin as an add-on treatment for chronic SIAD: a case report and literature review. Hormones (Athens). https://doi.org/10.1007/s42000-023-00430-0

Article  PubMed  Google Scholar 

Perelló-Camacho E, Pomares-Gómez FJ, López-Penabad L et al (2022) Clinical efficacy of urea treatment in syndrome of inappropriate antidiuretic hormone secretion. Sci Rep 12:10266. https://doi.org/10.1038/s41598-022-14387-4

Article  CAS  PubMed  PubMed Central  Google Scholar