Cost-Effectiveness of Non-pharmacological Interventions for Mild Cognitive Impairment and Dementia: A Systematic Review of Economic Evaluations and a Review of Reviews

Prince M, A W, Guerchet, M, Ali, G, Wu, Y, Prina, M. World Alzheimer Report 2015, The Global Impact of Dementia: An analysis of prevalence, incidence, cost and trends. 2015;

Wittenberg R, Knapp M, Hu B, Comas-Herrera A, King D, Rehill A, et al. The costs of dementia in England. Int J Geriatr Psychiatry. 2019;34(7):1095–103.

Article  PubMed  PubMed Central  Google Scholar 

Nickel F, Barth J, Kolominsky-Rabas PL. Health economic evaluations of non-pharmacological interventions for persons with dementia and their informal caregivers: a systematic review. BMC Geriatr. 2018;18(1):69.

Nichols E, Steinmetz JD, Vollset SE, Fukutaki K, Chalek J, Abd-Allah F, et al. Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019. Lancet Public Health. 2022;7(2):e105–25.

Article  Google Scholar 

World Health Organisation. Dementia [Internet]. 2021 [accessed 2021 Jun 1]. https://www.who.int/news-room/fact-sheets/detail/dementia. Accessed 2023 Jul 11.

Meads DM, Martin A, Griffiths A, Kelley R, Creese B, Robinson L, et al. Cost-effectiveness of dementia care mapping in care-home settings: evaluation of a randomised controlled trial. Appl Health Econ Health Policy. 2020;18(2):237–47.

Article  PubMed  Google Scholar 

National Institute for Health and Care Excellence (NICE). Dementia: assessment, management and support for people living with dementia and their carers | Guidance | NICE [Internet]. NICE; 2018. https://www.nice.org.uk/guidance/ng97. Accessed 2023 Sep 18.

Alves J, Magalhaes R, Thomas R. Is there evidence for cognitive intervention in Alzheimer Disease? A systematic review of efficacy, feasibility and cost-effectiveness. Alzheimer Dis Assoc Disord. 2013;27(3):195–203.

Article  PubMed  Google Scholar 

Pimouguet C, Lavaud T, Dartigues JF, Helmer C. Dementia case management effectiveness on health care costs and resource utilization: a systematic review of randomized controlled trials. J Nutr Health Aging. 2010;14(8):669–76.

Article  CAS  PubMed  Google Scholar 

Livingston G, Kelly L, Lewis-Holmes E, Baio G, Morris S, Patel N, et al. A systematic review of the clinical effectiveness and cost-effectiveness of sensory, psychological and behavioural interventions for managing agitation in older adults with dementia. Health Technol Assess. 2014;18(39):1–226, v–vi.

Robinson L, Hutchings D, Dickinson HO, Corner L, Beyer F, Finch T, et al. Effectiveness and acceptability of non-pharmacological interventions to reduce wandering in dementia: a systematic review. Int J Geriatr Psychiatry. 2007;22(1):9–22.

Article  CAS  PubMed  Google Scholar 

Clarkson P, Davies L, Jasper R, Loynes N, Challis D. A systematic review of the economic evidence for home support interventions in dementia. Value Health. 2017;20(8):1198–209.

Article  PubMed  Google Scholar 

NHS England. NHS commissioning » Who is considered a carer? [Internet]. 2023. https://www.england.nhs.uk/commissioning/comm-carers/carers/. Accessed 11 Jul 11.

Page MJ, Moher D, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. PRISMA 2020 explanation and elaboration: Updated guidance and exemplars for reporting systematic reviews. The BMJ. 2021;372:n160.

Gauthier S, Reisberg B, Zaudig M, Petersen RC, Ritchie K, Brioch K, et al. Mild cognitive impairment. Lancet. 2006;367(9527):1979.

Article  Google Scholar 

Husereau D, Drummond M, Petrou S, Carswell C, Moher D, Greenberg D, et al. Consolidated health economic evaluation reporting standards (CHEERS)-explanation and elaboration: a report of the ISPOR health economic evaluation publication guidelines good reporting practices task force. Value Health. 2013Mar;16(2):231–50.

Article  PubMed  Google Scholar 

Shea BJ, Reeves BC, Wells G, Thuku M, Hamel C, Moran J, et al. AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both. BMJ Online. 2017;358:1–9.

Google Scholar 

Cheng Q, Graves N, Pacella RE. Economic evaluations of guideline-based care for chronic wounds: a systematic review. Appl Health Econ Health Policy. 2018;16(5):633–51.

Article  PubMed  Google Scholar 

Woods RT, Bruce E, Edwards RT, Elvish R, Hoare Z, Hounsome B, et al. REMCARE: reminiscence groups for people with dementia and their family caregivers—effectiveness and costeffectiveness pragmatic multicentre randomised trial. Health Technol Assess. 2012;16(48):v–116.

Article  CAS  PubMed  Google Scholar 

D’Amico F, Rehill A, Knapp M, Aguirre E, Donovan H, Hoare Z, et al. Maintenance cognitive stimulation therapy: an economic evaluation within a randomized controlled trial. J Am Med Dir Assoc. 2015;16(1):63–70.

Article  PubMed  Google Scholar 

D’Amico F, Rehill A, Knapp M, Lowery D, Cerga-Pashoja A, Griffin M, et al. Cost-effectiveness of exercise as a therapy for behavioural and psychological symptoms of dementia within the EVIDEM-E randomised controlled trial. Int J Geriatr Psychiatry. 2016;31(6):656–65.

Article  PubMed  Google Scholar 

Orgeta V, Leung P, Yates L, Kang S, Hoare Z, Henderson C, et al. Individual cognitive stimulation therapy for dementia: a clinical effectiveness and cost-effectiveness pragmatic, multicentre, randomised controlled trial. Health Technol Assess. 2015;19(64):7–73.

Article  Google Scholar 

Spector A, Charlesworth G, King M, Lattimer M, Sadek S, Marston L, et al. Cognitive-behavioural therapy for anxiety in dementia: pilot randomised controlled trial. Br J Psychiatry. 2015;206(6):509–16.

Article  PubMed  Google Scholar 

Ballard C, Corbett A, Orrell M, Williams G, Moniz-Cook E, Romeo R, et al. Impact of person-centred care training and person-centred activities on quality of life, agitation, and antipsychotic use in people with dementia living in nursing homes: a cluster-randomised controlled trial. PLoS Med. 2018;15(2):1–18.

Article  Google Scholar 

Lamb SE, Mistry D, Alleyne S, Atherton N, Brown D, Copsey B, et al. Aerobic and strength training exercise programme for cognitive impairment in people with mild to moderate dementia: The DAPA RCT. Health Technol Assess. 2018;22(28):1–201.

Article  PubMed  PubMed Central  Google Scholar 

Brown H, D’Amico F, Knapp M, Orrell M, Rehill A, Vale L, et al. A cost effectiveness analysis of maintenance cognitive stimulation therapy (MCST) for people with dementia: examining the influence of cognitive ability and living arrangements. Aging Ment Health. 2019;23(5):602–7.

Article  PubMed  Google Scholar 

Livingston G, Barber J, Marston L, Stringer A, Panca M, Hunter R, et al. Clinical and cost-effectiveness of the Managing Agitation and Raising Quality of Life (MARQUE) intervention for agitation in people with dementia in care homes: a single-blind, cluster-randomised controlled trial. Lancet Psychiatry. 2019;6(4):293–304.

Article  PubMed  Google Scholar 

Romeo R, Zala D, Knapp M, Orrell M, Fossey J, Ballard C. Improving the quality of life of care home residents with dementia: Cost-effectiveness of an optimized intervention for residents with clinically significant agitation in dementia. Alzheimers Dement. 2019Feb 1;15(2):282–91.

Article  PubMed  Google Scholar 

Howard R, Gathercole R, Bradley R, Harper E, Davis L, Pank L, et al. The effectiveness and cost-effectiveness of assistive technology and telecare for independent living in dementia: a randomised controlled trial. Age Ageing. 2021;50(3):882–90.

Article  PubMed  PubMed Central  Google Scholar 

Pizzo E, Wenborn J, Burgess J, Mundy J, Orrell M, King M, et al. Cost-utility analysis of community occupational therapy in dementia (COTiD-UK) versus usual care: Results from VALID, a multi-site randomised controlled trial in the UK. PLoS ONE. 2022;17(2): e0262828.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Menn P, Holle R, Kunz S, Donath C, Lauterberg J, Leidl R, et al. Dementia care in the general practice setting: a cluster randomized trial on the effectiveness and cost impact of three management strategies. Value Health. 2012;15(6):851–9.

Article  PubMed  Google Scholar 

Mostardt S, Matusiewicz D, Schröer W, Wasem J, Neumann A. Efficacy and cost effectiveness of case management in patients with dementia. Z Gerontol Geriatr. 2012;45(7):642–6.

Article  CAS  PubMed  Google Scholar 

Michalowsky B, Xie F, Eichler T, Hertel J, Kaczynski A, Kilimann I, et al. Cost-effectiveness of a collaborative dementia care management—results of a cluster-randomized controlled trial. Alzheimers Dement. 2019;15(10):1296–308.

Article  PubMed  Google Scholar 

Rädke A, Michalowsky B, Thyrian J, Eichler T, Xie F, Hoffmann W. Who benefits most from collaborative dementia care from a patient and payer perspective? A subgroup cost effectiveness analysis. J Alzheimers Dis. 2020;74:449–62.

Article  PubMed  Google Scholar 

MacNeil Vroomen J, Bosmans JE, Eekhout I, Joling KJ, Van Mierlo LD, Meiland FJM, et al. The cost-effectiveness of two forms of case management compared to a control group for persons with dementia and their informal caregivers from a societal perspective. PLoS ONE. 2016;11(9):1–20.

Article  Google Scholar 

El Alili M, Smaling HJA, Joling KJ, Achterberg WP, Francke AL, Bosmans JE, et al. Cost-effectiveness of the Namaste care family program for nursing home residents with advanced dementia in comparison with usual care: A cluster-randomized controlled trial. BMC Health Serv Res. 2020;20(1):1–11.

Article  Google Scholar 

van Santen J, Meiland FJM, Dröes RM, van Straten A, Bosmans JE. Health & Social Care in the Community. 2022. Cost-effectiveness of exergaming compared to regular day-care activities in dementia: Results of a randomised controlled trial in The Netherlands.

van de Ven G, Draskovic I, van Herpen E, Koopmans RTCM, Donders R, Zuidema SU, et al. The economics of dementia-care mapping in nursing homes: a cluster-randomised controlled trial. PLoS ONE. 2014;9(1): e86662.

Article  PubMed  PubMed Central  Google Scholar 

Williams KN, Ayyagari P, Perkhounkova Y, Bott MJ, Herman R, Bossen A. Costs of a staff communication intervention to reduce dementia behaviors in nursing home care. J Nurs Home Res Sci. 2017;3:22–7.

PubMed  PubMed Central  Google Scholar 

Jennings LA, Laffan AM, Schlissel AC, Colligan E, Tan Z, Wenger NS, et al. Health care utilization and cost outcomes of a comprehensive dementia care program for medicare beneficiaries. JAMA Intern Med. 2019;179(2):161–6.

Article  PubMed  Google Scholar 

Pizzi LT, Jutkowitz E, Prioli KM, Lu EY, Babcock Z, McAbee-Sevick H, et al. Cost-benefit analysis of the COPE program for persons living with dementia: toward a payment model. Innov Aging. 2022;6(1):igab042.

Article  PubMed  Google Scholar 

Pizzi LT, Prioli KM, Jutkowitz E, Piersol CV, Lyketsos CG, Abersone I, et al. Economic analysis of the tailored activity program: a nonpharmacological approach to improve quality of life in people living with dementia and their caregivers. J Appl Gerontol Off J South Gerontol Soc. 2023;42(7):1433–44.

Article  Google Scholar 

Jutkowitz E, Pizzi LT, Shewmaker P, Alarid-Escudero F, Epstein-Lubow G, Prioli KM, et al. Cost effectiveness of non-drug interventions that reduce nursing home admissions for people living with dementia. Alzheimers Dement J Alzheimers Assoc. 2023;19(9):3867–93.

Laakkonen ML, Kautiainen H, Hölttä E, Savikko N, Tilvis RS, Strandberg TE, et al. Effects of Self-management groups for people with dementia and their spouses—randomized controlled trial. J Am Geriatr Soc. 2016;64(4):752–60.

Article  PubMed  Google Scholar 

Rosenvall A, Saaksvuori L, Finne-Soveri H, Linnosmaa I, Malmivaara A. Potential cost savings for selected non-pharmacological treatment strategies for patients with alzheimer’s disease in Finland. J Rehabil Med. 2020;52(9):jrm00106.

Pitkäl̈a KH, Pöysti MM, Laakkonen ML, Tilvis RS, Savikko N, Kautiainen H, et al. Effects of the Finnish Alzheimer Disease Exercise Trial (FINALEX): a randomized controlled trial. JAMA Intern Med. 2013;173(10):894–901.

Comments (0)

No login
gif