Royal jelly: a predictive, preventive and personalised strategy for novel treatment options in non-communicable diseases

World Health Organization. Heads of state commit to noncommunicable disease global compact to save 50 million lives by 2030. 2022; Available from: https://www.who.int/news/item/21-09-2022-heads-of-state-commit-to-noncommunicable-disease-global-compact-to-save-50-million-lives-by-2030. Accessed 27 Jan 2023

Wang Y, Wang J. Modelling and prediction of global non-communicable diseases. BMC Public Health. 2020;20:1–13.

Article  Google Scholar 

Furman D, Campisi J, Verdin E, Carrera-Bastos P, Targ S, Franceschi C, et al. Chronic inflammation in the etiology of disease across the life span. Nat Med Nature Res. 2019;25:1822–32.

Article  CAS  Google Scholar 

Soomro S. Oxidative stress and inflammation. Open J Immunol Scientific Research Publishing Inc. 2019;09:1–20.

Article  CAS  Google Scholar 

Mafra D, Borges NA, Lindholm B, Shiels PG, Evenepoel P, Stenvinkel P. Food as medicine: targeting the uraemic phenotype in chronic kidney disease. Nat Rev Nephrol. 2021;17:153–71.

Câmara JS, Albuquerque BR, Aguiar J, Corrêa RCG, Gonçalves JL, Granato D, et al. Food bioactive compounds and emerging techniques for their extraction: polyphenols as a case study. Foods. 2021;10:1–34.

Google Scholar 

Sugiyama T, Takahashi K, Mori H. Royal jelly acid, 10-hydroxy-trans-2-decenoic acid, as a modulator of the innate immune responses Endocr Metab Immune Disord Drug Targets. United Arab Emirates. 2012;12:368–76.

CAS  Google Scholar 

Bogdanov S. The royal jelly book. Royal jelly and bee brood: harvest, composition, quality. Bee Prod Sci. 2017;1:1–13.

Google Scholar 

Kocot J, Kiełczykowska M, Luchowska-Kocot D, Kurzepa J, Musik I. Antioxidant potential of propolis, bee pollen, and royal jelly: possible medical application. Oxid Med Cell Longev. 2018;2018:7074209.

Kanelis D, Tananaki C, Liolios V, Dimou M, Goras G, Rodopoulou MA, et al. A suggestion for royal jelly specifications. Arh Hig Rada Toksikol. 2015;66:275–84.

Article  PubMed  Google Scholar 

Abu-Serie MM, Habashy NH. Two purified proteins from royal jelly with in vitro dual anti-hepatic damage potency: major royal jelly protein 2 and its novel isoform X1. Int J Biol. 2019;128:782–95. https://doi.org/10.1016/j.ijbiomac.2019.01.210.

Article  CAS  Google Scholar 

Ali FEM, Saad Eldien HM, Mostafa NAM, Almaeen AH, Marzouk MRA, Eid KM, et al. The impact of royal jelly against hepatic ischemia/reperfusion-induced hepatocyte damage in rats: the role of cytoglobin, Nrf-2/HO-1/COX-4, and P38-MAPK/NF-κB-p65/TNF-α Signaling Pathways. Curr Mol Pharmacol. 2021;14:88–100.

Article  CAS  PubMed  Google Scholar 

Aslan A, Beyaz S, Gok O, Can MI, Parlak G, Ozercan IH, et al. Royal jelly abrogates flouride-induced oxidative damage in rat heart tissue by activating of the nrf-2/NF-κB and bcl-2/bax pathway. Toxicol Mech Methods. 2021;31:644–54. https://doi.org/10.1080/15376516.2021.1950249.

Article  CAS  PubMed  Google Scholar 

Miyata Y, Araki K, Ohba K, Mastuo T, Nakamura Y, Yuno T, et al. Oral intake of royal jelly improves anti-cancer effects and suppresses adverse events of molecular targeted therapy by regulating TNF-α and TGF-β in renal cell carcinoma: a preliminary study based on a randomized double-blind clinical trial. Mol Clin Oncol. 2020;13:1–8.

Article  Google Scholar 

Aslan A, Beyaz S, Gok O, Can MI, Parlak G, Ozercan IH, et al. Royal jelly abrogates flouride-induced oxidative damage in rat heart tissue by activating of the nrf-2/NF-κB and bcl-2/bax pathway. Toxicol Mech Methods. 2021;31:644–54.

Article  CAS  PubMed  Google Scholar 

Almeer RS, Soliman D, Kassab RB, AlBasher GI, Alarifi S, Alkahtani S, et al. Royal jelly abrogates cadmium-induced oxidative challenge in mouse testes: involvement of the Nrf2 pathway. Int J Mol Sci. 2018;19:3979.

Article  PubMed  PubMed Central  Google Scholar 

Jenkhetkan W, Thitiorul S, Jansom C, Ratanavalachai T. Molecular and cytogenetic effects of Thai royal jelly: modulation through c-MYC, h-TERT, NRF2, HO-1, BCL2, BAX and cyclins in human lymphocytes in vitro. Mutagenesis. 2017;32:525–31.

Article  CAS  PubMed  Google Scholar 

Golubnitschaja O, Watson ID, Topic E, Sandberg S, Ferrari M, Costigliola V. Position paper of the EPMA and EFLM: a global vision of the consolidated promotion of an integrative medical approach to advance health care. EPMA J. 2013;4:12.

Article  PubMed  PubMed Central  Google Scholar 

Denisow B, Denisow-Pietrzyk M. Biological and therapeutic properties of bee pollen: a review. J Sci Food Agric. 2016;96:4303–9.

Article  CAS  PubMed  Google Scholar 

Fratini F, Cilia G, Mancini S, Felicioli A. Royal Jelly: an ancient remedy with remarkable antibacterial properties. Microbiol Res. 2016;192:130–41. https://doi.org/10.1016/j.micres.2016.06.007.

Article  CAS  PubMed  Google Scholar 

Cao LF, Zheng HQ, Pirk CWW, Hu FL, Xu ZW. High royal jelly-producing honeybees (Apis mellifera ligustica) (Hymenoptera: Apidae) in China. J Econ Entomol. 2016;109:510–4.

Article  CAS  PubMed  Google Scholar 

Li X, Huang C, Xue Y. Contribution of lipids in honeybee (Apis mellifera) royal jelly to health. J Med Food. 2013;16:96–102.

Article  CAS  PubMed  Google Scholar 

Khalifa SAM, Elashal MH, Yosri N, Du M, Musharraf SG, Nahar L, et al. Bee pollen: Current status and therapeutic potential. Nutrients. 2021;13:1–15.

Article  Google Scholar 

Chen Y-F, Wang K, Zhang Y-Z, Zheng Y-F, Hu F-L. In vitro anti-inflammatory effects of three fatty acids from royal jelly. Mediat Inflamm. 2016;2016:3583684.

Article  Google Scholar 

Yamaga M, Tani H, Yamaki A, Tatefuji T, Hashimoto K. Metabolism and pharmacokinetics of medium chain fatty acids after oral administration of royal jelly to healthy subjects. RSC Adv Royal Soc Chem. 2019;9:15392–401.

Article  CAS  Google Scholar 

Ramadan MF, Al-Ghamdi A. Bioactive compounds and health-promoting properties of royal jelly: a review. J Funct Foods. 2012;4:39–52. https://doi.org/10.1016/j.jff.2011.12.007.

Article  CAS  Google Scholar 

Melliou E, Chinou I. Chemistry and bioactivity of royal jelly from Greece. J Agric Food Chem. 2005;53:8987–92.

Article  CAS  PubMed  Google Scholar 

Isdorov VA, Bakier S, Grzech I. Gas chromatographic–mass spectrometric investigation of volatile and extractable compounds of crude royal jelly. J Chromatogr B. 2012;885–886:109–16.

Article  Google Scholar 

Uthaibutra V, Kaewkod T, Prapawilai P, Pandith H. Yingmanee Tragoolpua Inhibition of skin pathogenic bacteria, antioxidant and anti-inflammatory activity of royal jelly from northern Thailand. Molecules. 2023;28(3):28.

Article  Google Scholar 

Liu J-R, Yang Y-C, Shi L-S, Peng C-C. Antioxidant properties of royal jelly associated with larval age and time of harvest. J Agric Food Chem. 2008;56:11447–52.

Article  CAS  PubMed  Google Scholar 

Garcia-Amoedo LH, De Almeida-Muradian LB. Physicochemical composition of pure and adulterated royal jelly. Quim Nova. 2007;30:257–9.

Article  CAS  Google Scholar 

López-Gutiérrez N, Aguilera-Luiz MDM, Romero-González R, Vidal JLM, Garrido Frenich A. Fast analysis of polyphenols in royal jelly products using automated TurboFlowTM-liquid chromatography-Orbitrap high resolution mass spectrometry. J Chromatogr B. 2014;973:17–28.

Article  Google Scholar 

Kanbur M, Eraslan G, Silici S, Karabacak M. Effects of sodium fluoride exposure on some biochemical parameters in mice: evaluation of the ameliorative effect of royal jelly applications on these parameters. Food Chem Toxicol an Int J Publ Br Ind Biol Res Assoc. 2009;47:1184–9.

Article  CAS  Google Scholar 

Negri G, Teixeira EW, Alves MLTMF, De Camargo CarmelloMoreti AC, Otsuk IP, Borguini RG, et al. Hydroxycinnamic acid amide derivatives, phenolic compounds and antioxidant activities of extracts of pollen samples from Southeast Brazil. J Agric Food Chem. 2011;59:5516–22.

Article  CAS  PubMed  Google Scholar 

Durazzo A, Lucarini M, Plutino M, Lucini L, Aromolo R, Martinelli E, et al. Bee products: a representation of biodiversity, sustainability, and health. Life. 2021;11:1–32.

Article  Google Scholar 

Arct J, Pytkowska K. Flavonoids as components of biologically active cosmeceuticals. Clin Dermatol. 2008;26:347–57.

Article  PubMed  Google Scholar 

Manzo LP, De-Faria FM, Dunder RJ, Rabelo-Socca EA, Consonni SR, De Almeida ACA, et al. Royal jelly and its dual role in TNBS colitis in mice. Sci World J. 2015;2015:1–7.

Article  Google Scholar 

Kolayli S, Sahin H, Can Z, Yildiz O, Malkoc M, Asadov A. A member of complementary medicinal food: Anatolian royal jellies, their chemical compositions, and antioxidant properties. J Evidence-Based Complement Altern Med. 2016;21:43–8.

Article  Google Scholar 

Malekinejad H, Ahsan S, Delkhosh-Kasmaie F, Cheraghi H, Rezaei-Golmisheh A, Janbaz-Acyabar H. A cardioprotective effect of royal jelly on paclitaxel-induced cardio-toxicity in rats. Iran J Basic Med Sci. 2016;19:221–7.

PubMed  PubMed Central  Google Scholar 

Klaudiny J, Bachanová K, Kohútová L, Dzúrová M, Kopernický J, Majtán J. Expression of larval jelly antimicrobial peptide defensin1 in Apis mellifera colonies. Biologia. 2012;67:200–11.

Article  CAS  Google Scholar 

Khoshpey B, Djazayeri S, Amiri F, Malek M, Hosseini AF, Hosseini S, et al. Effect of royal jelly intake on serum glucose, apolipoprotein A-I (ApoA-I), apolipoprotein B (ApoB) and ApoB/ApoA-I ratios in patients with type 2 diabetes: a randomized, double-blind clinical trial study. Can J Diabetes. 2016;40:324–8. https://doi.org/10.1016/j.jcjd.2016.01.003.

Article  PubMed  Google Scholar 

ShakibKhoob M, Hosseini SM, Kazemi S. In vitro and in vivo antioxidant and anticancer potentials of royal jelly for dimethylhydrazine-induced colorectal cancer in Wistar rats. Oxid Med Cell Longev. 2022;2022:9506026.

Google Scholar 

Mostafa RE, Shaffie NM, Allam RM. Protective effects of royal jelly and Echinacea against moxifloxacin-induced renal and hepatic injury in rats. Drug Chem Toxicol. 2022;1–10.

Viuda-Martos M, Ruiz-Navajas Y, Fernández-López J, Pérez-Álvarez JA. Functional properties of honey, propolis, and royal jelly. J Food Sci. 2008;73:117–24.

Article  Google Scholar 

Brazil. Regulamentos Técnicos de Identidade e Qualidade de apitoxina, cera de abelha, geléia real, geléia real liofilizada, pólen apícola, própolis e extrato de própolis. BRAZIL. 2001;97:11.

Kocot J, Kiełczykowska M, Luchowska-Kocot D, Kurzepa J, Musik I. Antioxidant potential of propolis, bee pollen, and royal jelly: possible medical application. Oxid Med Cell Longev. 2018;2018:7074209.

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