Alfaris N, Alqahtani AM, Alamuddin N, Rigas G. Global Impact of Obesity. Gastroenterol Clin North Am [Internet]. [cited 2025 Jun 24] 2023;52(2):277–93. Available from: https://pubmed.ncbi.nlm.nih.gov/37197873/
Piñar-Gutierrez A, García-Fontana C, García-Fontana B, Muñoz-Torres M. Obesity and Bone Health: A Complex Relationship. Int J Mol Sci [Internet]. 2022 Aug 1 [cited 2025 Jun 24];23(15). Available from: https://pubmed.ncbi.nlm.nih.gov/35955431/
Lespessailles E, Paccou J, Javier RM, Thomas T, Cortet B, Endocrine Society. Obesity, bariatric surgery, and fractures. J Clin Endocrinol Metab. 2019;104:4756–68.
Elmaleh-Sachs A, Schwartz JL, Bramante CT, Nicklas JM, Gudzune KA, Jay M. Obesity Management in Adults. JAMA [Internet]. 2023[cited 2025 Jun 24];330(20):2000–15. Available from: https://pubmed.ncbi.nlm.nih.gov/38015216/
Paccou J, Compston JE. Bone health in adults with obesity before and after interventions to promote weight loss. Lancet Diabetes Endocrinol [Internet]. 2024 [cited 2025 Jun 24];12(10). Available from: https://pubmed.ncbi.nlm.nih.gov/39053479/
Bredella MA, Lin E, Gerweck AV, Landa MG, Thomas BJ, Torriani M, et al. Determinants of bone microarchitecture and mechanical properties in obese men. J Clin Endocrinol Metab. 2012;97(11):4115–22.
Article CAS PubMed Central PubMed Google Scholar
Evans AL, Paggiosi MA, Eastell R, Walsh JS. Bone density, microstructure and strength in obese and normal weight men and women in younger and older adulthood. J Bone Miner Res. 2015;30(5):920–8.
Turcotte AF, O’Connor S, Morin SN, Gibbs JC, Willie BM, Jean S, et al. Association between obesity and risk of fracture, bone mineral density and bone quality in adults: a systematic review and meta-analysis. PLoS ONE. Public Library of Science 2021. https://doi.org/10.1371/journal.pone.0252487.
Johansson H, Kanis JA, Odén A, McCloskey E, Chapurlat RD, Christiansen C, et al. A meta-analysis of the association of fracture risk and body mass index in women. J Bone Miner Res. 2014;29(1):223–33.
Chan MY, Frost SA, Center JR, Eisman JA, Nguyen TV. Relationship between body mass index and fracture risk is mediated by bone mineral density. J Bone Miner Res. 2014;29(11):2327–35.
Marchasson G, Philippoteaux C, Legroux-Gérot I, Hélène B, Cortet B, Paccou J. Bone mineral density T-scores comparison between obese and non-obese individuals included in a Fracture Liaison Service following a recent fragility fracture. Arch Osteoporos. 2024. https://doi.org/10.1007/s11657-024-01379-2.
Prieto-Alhambra D, Premaor MO, Fina Avilés F, Hermosilla E, Martinez-Laguna D, Carbonell-Abella C, et al. The association between fracture and obesity is site-dependent: a population-based study in postmenopausal women. J Bone Miner Res. 2012;27(2):294–300.
Compston JE, Watts NB, Chapurlat R, Cooper C, Boonen S, Greenspan S, et al. Obesity is not protective against fracture in postmenopausal women: Glow. Am J Med. 2011;124(11):1043–50.
Article PubMed Central PubMed Google Scholar
Premaor MO, Compston JE, Fina Avilés F, Pagès-Castellà A, Nogués X, Díez-Pérez A, et al. The association between fracture site and obesity in men: a population-based cohort study. J Bone Miner Res. 2013;28(8):1771–7.
Prieto-Alhambra D, Premaor MO, Avilés FF, Castro AS, Javaid MK, Nogués X, et al. Relationship between mortality and bmi after fracture: a population-based study of men and women aged ≥40 years. J Bone Miner Res. 2014;29(8):1737–44.
Dorner TE, Rieder A, Elsevier Ireland Ltd. Obesity paradox in elderly patients with cardiovascular diseases. Int J Cardiol. 2012;155:56–65.
Hooker ER, Shrestha S, Lee CG, Cawthon PM, Abrahamson M, Ensrud K, et al. Obesity and falls in a prospective study of older men: the Osteoporotic Fractures in Men Study. J Aging Health. 2017;29(7):1235–50.
Neri SGR, Harvey LA, Tiedemann A, Gadelha AB, Lima RM. Obesity and falls in older women: mediating effects of muscle quality, foot loads and postural control. Gait Posture. 2020;1(77):138–43.
Khosla S, Samakkarnthai P, Monroe DG, Farr JN, Nature Research. Update on the pathogenesis and treatment of skeletal fragility in type 2 diabetes mellitus. Nat Rev Endocrinol. 2021;17:685–97.
Article CAS PubMed Central PubMed Google Scholar
Wang H, Ba Y, Xing Q, Du JL. Diabetes mellitus and the risk of fractures at specific sites: a meta-analysis. BMJ Open. 2019;9(1):1.
Adami G, Gatti D, Rossini M, Orsolini G, Pollastri F, Bertoldo E, et al. Risk of fragility fractures in obesity and diabetes: a retrospective analysis on a nation-wide cohort. Osteoporos Int. 2020Nov 1;31(11):2113–22.
Article CAS PubMed Google Scholar
Donini LM, Busetto L, Bischoff SC, Cederholm T, Ballesteros-Pomar MD, Batsis JA, et al. Definition and diagnostic criteria for sarcopenic obesity: ESPEN and EASO consensus statement. Obes Facts. 2022;15(3):321–35.
Article PubMed Central PubMed Google Scholar
Prado CM, Batsis JA, Donini LM, Gonzalez MC, Siervo M, Nature Research. Sarcopenic obesity in older adults: a clinical overview. Nat Rev Endocrinol. 2024;20:261–77.
Article PubMed Central PubMed Google Scholar
Scott D, Seibel M, Cumming R, Naganathan V, Blyth F, Le Couteur DG, et al. Sarcopenic obesity and its temporal associations with changes in bone mineral density, incident falls, and fractures in older men: the Concord Health and Ageing in Men Project. J Bone Miner Res. 2017;32(3):575–83.
Article CAS PubMed Google Scholar
Gandham A, Mesinovic J, Jansons P, Zengin A, Bonham MP, Ebeling PR, et al. Falls, fractures, and areal bone mineral density in older adults with sarcopenic obesity: a systematic review and meta-analysis. Obes Rev. 2021. https://doi.org/10.1111/obr.13187.
Rinonapoli G, Pace V, Ruggiero C, Ceccarini P, Bisaccia M, Meccariello L, et al. Obesity and bone: a complex relationship. Int J Mol Sci. MDPI 2021. https://doi.org/10.3390/ijms222413662.
LT H-P, UD N, TV N. News and Reviews. J Clin Endocrinol Metab [Internet]. 2014 Dec [cited 2025 Jun 24];99(12):30A-31A. Available from: https://academic.oup.com/jcem/article-lookup/doi.org/10.1210/jc.2014-v99i12-30A
Sornay-Rendu E, Boutroy S, Vilayphiou N, Claustrat B, Chapurlat RD. In obese postmenopausal women, bone microarchitecture and strength are not commensurate to greater body weight: the OS des femmes de Lyon (OFELY) study. J Bone Miner Res. 2013;28(7):1679–87.
Article CAS PubMed Google Scholar
Ishii S, Cauley JA, Greendale GA, Nielsen C, Karvonen-Gutierrez C, Ruppert K, et al. Pleiotropic effects of obesity on fracture risk: the study of women’s health across the nation. J Bone Miner Res. 2014;29(12):2561–70.
Bouxsein ML, Szulc P, Munoz F, Thrall E, Sornay-Rendu E, Delmas PD. Contribution of trochanteric soft tissues to fall force estimates, the factor of risk, and prediction of hip fracture risk. J Bone Miner Res. 2007;22(6):825–31.
Gillespie LD, Robertson MC, Gillespie WJ, Sherrington C, Gates S, Clemson LM, et al. Interventions for preventing falls in older people living in the community. Vol. 2012, Cochrane Database of Systematic Reviews. John Wiley and Sons Ltd; 2012.
Mignardot JB, Olivier I, Promayon E, Nougier V. Obesity impact on the attentional cost for controlling posture. PLoS ONE. 2010. https://doi.org/10.1371/journal.pone.0014387.
Article PubMed Central PubMed Google Scholar
Earthman CP, Beckman LM, Masodkar K, Sibley SD. The link between obesity and low circulating 25-hydroxyvitamin D concentrations: Considerations and implications. Vol. 36, International Journal of Obesity. Int J Obes (Lond); 2012. p. 387–96.
Carrageta DF, Oliveira PF, Alves MG, Monteiro MP, Blackwell Publishing Ltd. Obesity and male hypogonadism: tales of a vicious cycle. Obes Rev. 2019;20:1148–58.
Zhu K, Hunter M, James A, Lim EM, Cooke BR, Walsh JP. Relationship between visceral adipose tissue and bone mineral density in Australian baby boomers. Osteoporos Int. 2020;31(12):2439–48.
Article CAS PubMed Google Scholar
Cohen A, Dempster DW, Recker RR, Lappe JM, Zhou H, Zwahlen A, et al. Abdominal fat is associated with lower bone formation and inferior bone quality in healthy premenopausal women: a transiliac bone biopsy study. J Clin Endocrinol Metab. 2013;98(6):2562–72.
Article CAS PubMed Central PubMed Google Scholar
Tencerova M, Duque G, Beekman KM, Corsi A, Geurts J, Bisschop PH, et al. The impact of interventional weight loss on bone marrow adipose tissue in people living with obesity and its connection to bone metabolism. Nutrients. Multidisciplinary Digital Publishing Institute (MDPI) 2023. https://doi.org/10.3390/nu15214601.
Li G, Compston JE, Leslie WD, Thabane L, Papaioannou A, Lau A, et al. Relationship between obesity and risk of major osteoporotic fracture in postmenopausal women: taking frailty into consideration. J Bone Miner Res. 2020;35(12):2355–62.
Article CAS PubMed Google Scholar
Lucey AJ, Paschos GK, Cashman KD, Martínéz JA, Thorsdottir I, Kiely M. Influence of moderate energy restriction and seafood consumption on bone turnover in overweight young adults. Am J Clin Nutr. 2008;87(4):1045–52.
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