The Cardioprotective Effects of Adiponectin in Diabetes

Khoramipour K, Chamari K, Hekmatikar AA, Ziyaiyan A, Taherkhani S, Elguindy NM, Bragazzi NL. Adiponectin: structure, physiological functions, role in diseases, and effects of nutrition. In: Nutrients (Vol. 13, Issue 4). MDPI AG; 2021. https://doi.org/10.3390/nu13041180.

Chapter  Google Scholar 

Mao Y, Zhong W. Serum adiponectin concentrations as a risk factor for cardiovascular complications in type 1 diabetes. Diabetes Res Clin Pract. 2023;200 https://doi.org/10.1016/j.diabres.2023.110700.

Wang Y, Ma XL, Lau WB. Cardiovascular adiponectin resistance: the critical role of adiponectin receptor modification. In: Trends in endocrinology and metabolism (Vol. 28, Issue 7, pp. 519–530). Elsevier Inc.; 2017. https://doi.org/10.1016/j.tem.2017.03.004.

Chapter  Google Scholar 

Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa JI, Hotta K, Shimomura I, Nakamura T, Miyaoka K, Kuriyama H, Nishida M, Yamashita S, Okubo K, Matsubara K, Muraguchi M, Ohmoto Y, Funahashi T, Matsuzawa Y. Paradoxical decrease of an Adipose-specific protein, adiponectin in obesity. Biochem Biophys Res Commun. 1999;257(1):79–83. https://doi.org/10.1006/BBRC.1999.0255.

Article  CAS  PubMed  Google Scholar 

Forsblom C, Thomas MC, Moran J, Saraheimo M, Thorn L, Wadén J, Gordin D, Frystyk J, Flyvbjerg A, Groop PH. Serum adiponectin concentration is a positive predictor of all-cause and cardiovascular adip in type 1 diabetes. J Intern Med. 2011;270(4):346–55. https://doi.org/10.1111/j.1365-2796.2011.02406.x.

Article  CAS  PubMed  Google Scholar 

Han Y, Sun Q, Chen W, Gao Y, Ye J, Chen Y, Wang T, Gao L, Liu Y, Yang Y. New advances of adiponectin in regulating obesity and related metabolic syndromes. Journal of Pharmaceutical Analysis. 2024;14(5) https://doi.org/10.1016/j.jpha.2023.12.003.

Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest. 2006;116(7):1784–92. https://doi.org/10.1172/JCI29126.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, Yamashita S, Noda M, Kita S, Ueki K, Eto K, Akanuma Y, Froguel P, Foufelle F, Ferre P, Carling D, Kimura S, Nagai R, Kahn BB, Kadowaki T. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med. 2002;8(11):1288–95. https://doi.org/10.1038/nm788.

Article  CAS  PubMed  Google Scholar 

Sharma A, Mah M, Ritchie RH, de Blasio MJ. The adiponectin signaling pathway - A therapeutic target for the cardiac complications of type 2 diabetes? In: Pharmacology and therapeutics, vol. 232. Elsevier Inc; 2022. https://doi.org/10.1016/j.pharmthera.2021.108008.

Chapter  Google Scholar 

Kalkman HO. An explanation for the adiponectin paradox. In: Pharmaceuticals (Vol. 14, issue 12). MDPI; 2021. https://doi.org/10.3390/ph14121266.

Chapter  Google Scholar 

Matsuda K, Fujishima Y, Maeda N, Mori T, Hirata A, Sekimoto R, Tsushima Y, Masuda S, Yamaoka M, Inoue K, Nishizawa H, Kita S, Ranscht B, Funahashi T, Shimomura I. Positive feedback regulation between adiponectin and T-cadherin impacts adiponectin levels in tissue and plasma of male mice. Endocrinology (United States). 2015;156(3):934–46. https://doi.org/10.1210/en.2014-1618.

Article  CAS  Google Scholar 

Tishinsky JM, Robinson LE, Dyck DJ. Insulin-sensitizing properties of adiponectin. Biochimie. 2012;94(10):2131–6. https://doi.org/10.1016/J.BIOCHI.2012.01.017.

Article  CAS  PubMed  Google Scholar 

Zhao S, Kusminski CM, Scherer PE. Adiponectin, leptin and cardiovascular disorders. In: Circulation research (Vol. 128, issue 1, pp. 136–149). Lippincott Williams and Wilkins; 2021. https://doi.org/10.1161/CIRCRESAHA.120.314458.

Chapter  Google Scholar 

Ljubic S, Boras J, Jazbec A, Phd B, Lovrencic MV, Vidjak V, Jurisic Erzen D, Mileta D. Adiponectin has different mechanisms in type 1 and type 2 diabetes with C-peptide link. Clinical and Investigative Medicine. 2009;32(4):E271–9.

Article  CAS  PubMed  Google Scholar 

Kern PA, Ranganathan S, Wood L, Ranganathan G, Li C, Ranganathan Adipose G. Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am J Physiol Endocrinol Metab. 2001;280(5):E745–51. http://www.ajpendo.orgE745

Furuta M, Tamai M, Hanabusa T, Yamamoto Y, Nanjo K, Sanke T. Serum adiponectin is associated with fasting serum C-peptide in non-obese diabetic patients. Diabetes Res Clin Pract. 2006;72(3):302–7. https://doi.org/10.1016/j.diabres.2005.10.026.

Article  CAS  PubMed  Google Scholar 

Cnop M, Havel PJ, Utzschneider KM, Carr DB, Sinha MK, Boyko EJ, Retzlaff BM, Knopp RH, Brunzell JD, Kahn SE. Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex. Diabetologia. 2003;46(4):459–69. https://doi.org/10.1007/s00125-003-1074-z.

Article  CAS  PubMed  Google Scholar 

Karas MG, Benkeser D, Arnold AM, Bartz TM, Djousse L, Mukamal KJ, Ix JH, Zieman SJ, Siscovick DS, Tracy RP, Mantzoros CS, Gottdiener JS, Defilippi CR, Kizer JR. Relations of plasma total and high-molecular-weight adiponectin to new-onset heart failure in adults ≥65 years of age (from the cardiovascular health study). Am J Cardiol. 2014;113(2):328–34. https://doi.org/10.1016/j.amjcard.2013.09.027.

Article  CAS  PubMed  Google Scholar 

Teijeira-Fernandez E, Eiras S, Grigorian-Shamagian L, Fernandez A, Adrio B, Gonzalez-Juanatey JR. Epicardial adipose tissue expression of adiponectin is lower in patients with hypertension. J Hum Hypertens. 2008;22:856–63.

Article  CAS  PubMed  Google Scholar 

Menzaghi C, Trischitta V. The adiponectin paradox for all-cause and cardiovascular mortality. Diabetes. 2018;67(1):12–22. https://doi.org/10.2337/dbi17-0016.

Article  CAS  PubMed  Google Scholar 

Nishizawa H, Shimomura I, Kishida K, Maeda N, Kuriyama H, Nagaretani H, Matsuda M, Kondo H, Furuyama N, Kihara S, Nakamura T, Tochino Y, Funahashi T, Matsuzawa Y. Androgens Decrease Plasma Adiponectin, an Insulin-Sensitizing Adipocyte-Derived Protein. Diabetes. 2002;51(9):2734–41. https://doi.org/10.2337/diabetes.51.9.2734.

Article  CAS  PubMed  Google Scholar 

Milewicz A, Zatonska K, Demissie M, Jêdrzejuk D, Dunajska K, Ilow R, Lwow F. Serum adiponectin concentration and cardiovascular risk factors in climacteric women. Gynecol Endocrinol. 2005;20(2):68–73. https://doi.org/10.1080/09513590400020989.

Article  CAS  PubMed  Google Scholar 

Matsui S, Yasui T, Tani A, Kato T, Kunimi K, Uemura H, Kuwahara A, Matsuzaki T, Irahara M. Difference in the ratio of high-molecular weight (HMW) to total adiponectin and HMW adiponectin in late post-menopausal women. J Endocrinol Investig. 2013;36(11):982–5. https://doi.org/10.3275/9001. Epub 2013 Jun 10

Article  CAS  Google Scholar 

Everson-Rose SA, Barinas-Mitchell EJM, el Khoudary SR, Huang HH, Wang Q, Janssen I, Thurston RC, Jackson EA, Lewis ME, Karvonen-Gutierrez C, Mancuso P, Derby CA. Adipokines and subclinical cardiovascular disease in post-menopausal women: study of women’s health across the nation. J Am Heart Assoc. 2021;10(7):e019173. https://doi.org/10.1161/JAHA.120.019173.

Article  PubMed  PubMed Central  Google Scholar 

Maahs DM, Ogden LG, Snell-Bergeon JK, Kinney GL, Wadwa RP, Hokanson JE, Dabelea D, Kretowski A, Eckel RH, Rewers M. Determinants of serum adiponectin in persons with and without type 1 diabetes. Am J Epidemiol. 2007;166(6):731–40. https://doi.org/10.1093/aje/kwm125.

Article  PubMed  Google Scholar 

Frystyk J, Tarnow L, Krarup Hansen T, Parving HH, Flyvbjerg A. Increased serum adiponectin levels in type 1 diabetic patients with microvascular complications. Diabetologia. 2005;48(9):1911–8. https://doi.org/10.1007/s00125-005-1850-z.

Article  CAS  PubMed  Google Scholar 

Pham MN, Kolb H, Mandrup-Poulsen T, Battelino T, Ludvigsson J, Pozzilli P, Roden M, Schloot NC. Serum adipokines as biomarkers of beta-cell function in patients with type 1 diabetes: positive association with leptin and resistin and negative association with adiponectin. Diabetes Metab Res Rev. 2013;29(2):166–70. https://doi.org/10.1002/dmrr.2378.

Article  CAS  PubMed  Google Scholar 

Richards AA, Stephens T, Charlton HK, Jones A, Macdonald GA, Prins JB, Whitehead JP. Adiponectin multimerization is dependent on conserved lysines in the collagenous domain: evidence for regulation of multimerization by alterations in posttranslational modifications. Mol Endocrinol. 2006;20(7):1673–87. https://doi.org/10.1210/me.2005-0390.

Article  CAS  PubMed  Google Scholar 

Combs TP, Snell-Bergeon JK, Maahs DM, Bergman BC, Lamarche M, Iberkleid L, AbdelBaky O, Tisch R, Scherer PE, Marliss EB. Adiponectin-SOGA dissociation in type 1 diabetes. J Clin Endocrinol Metab. 2015;100(8):E1065–73. https://doi.org/10.1210/jc.2015-1275.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brown JEP, Onyango DJ, Dunmore SJ. Resistin down-regulates insulin receptor expression, and modulates cell viability in rodent pancreatic beta-cells. FEBS Lett. 2007;581(17):3273–6. https://doi.org/10.1016/j.febslet.2007.06.031.

Article  CAS  PubMed 

Comments (0)

No login
gif