The Role of Inflammation in CMML Pathobiology and Progression

Chan O, Renneville A, Padron E. Chronic myelomonocytic leukemia diagnosis and management. Leukemia. 2021;35(6):1552–62.

Article  PubMed  Google Scholar 

Patnaik MM, Tefferi A. Chronic myelomonocytic leukemia: 2024 update on diagnosis, risk stratification and management. Am J Hematol. 2024;99(6):1142–65.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Niyongere S, Lucas N, Zhou JM, Sansil S, Pomicter AD, Balasis ME, et al. Heterogeneous expression of cytokines accounts for clinical diversity and refines prognostication in CMML. Leukemia. 2019;33(1):205–16.

Article  CAS  PubMed  Google Scholar 

Barreyro L, Will B, Bartholdy B, Zhou L, Todorova TI, Stanley RF, et al. Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS. Blood. 2012;120(6):1290–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mangaonkar AA, Patnaik MM. Role of the bone marrow immune microenvironment in chronic myelomonocytic leukemia pathogenesis: novel mechanisms and insights into clonal propagation. Leuk Lymphoma. 2022;63(8):1792–800.

Article  CAS  PubMed  Google Scholar 

Zhao HG, Deininger M. Always stressed but never exhausted: how stem cells in myeloid neoplasms avoid extinction in inflammatory conditions. Blood. 2023;141(23):2797–812.

CAS  PubMed  PubMed Central  Google Scholar 

Montalban-Bravo G, Darbaniyan F, Kanagal-Shamanna R, Ganan-Gomez I, Class CA, Sasaki K, et al. Type I interferon upregulation and deregulation of genes involved in monopoiesis in chronic myelomonocytic leukemia. Leuk Res. 2021;101:106511.

Article  CAS  PubMed  Google Scholar 

Shi H, Wang Y, Li R, Xing W, Yang FC, Bai J, et al. Alteration in the Cytokine Secretion of Bone Marrow Stromal Cells from Patients with Chronic Myelomonocytic Leukemia Contribute to Impaired Hematopoietic Supportive Activity. Stem Cells Int. 2018;2018:5921392.

Article  PubMed  PubMed Central  Google Scholar 

Yang H, Bueso-Ramos C, DiNardo C, Estecio MR, Davanlou M, Geng QR, et al. Expression of PD-L1, PD-L2, PD-1 and CTLA4 in myelodysplastic syndromes is enhanced by treatment with hypomethylating agents. Leukemia. 2014;28(6):1280–8.

Article  CAS  PubMed  Google Scholar 

Bauer M, Jäkel N, Wilfer A, Haak A, Eszlinger M, Kelemen K, et al. Prognostic impact of the bone marrow tumor microenvironment, HLA-I and HLA-Ib expression in MDS and CMML progression to sAML. Oncoimmunology. 2024;13(1):2323212.

Article  PubMed  PubMed Central  Google Scholar 

Pinho S, Frenette PS. Haematopoietic stem cell activity and interactions with the niche. Nat Rev Mol Cell Biol. 2019;20(5):303–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Galán-Díez M, Cuesta-Domínguez Á, Kousteni S. The Bone Marrow microenvironment in health and Myeloid Malignancy. Cold Spring Harb Perspect Med. 2018;8(7).

Swann JW, Olson OC, Passegué E. Made to order: emergency myelopoiesis and demand-adapted innate immune cell production. Nat Rev Immunol. 2024;24(8):596–613.

Article  CAS  PubMed  Google Scholar 

Sasaki Y, Guo YM, Goto T, Ubukawa K, Asanuma K, Kobayashi I, et al. IL-6 generated from human hematopoietic stem and progenitor cells through TLR4 signaling promotes emergency granulopoiesis by regulating transcription factor expression. J Immunol. 2021;207(4):1078–86.

Article  CAS  PubMed  Google Scholar 

Fasouli ES, Katsantoni E. JAK-STAT in early hematopoiesis and leukemia. Front Cell Dev Biol. 2021;9:669363.

Article  PubMed  PubMed Central  Google Scholar 

Zhao JL, Ma C, O’Connell RM, Mehta A, DiLoreto R, Heath JR, et al. Conversion of danger signals into cytokine signals by hematopoietic stem and progenitor cells for regulation of stress-induced hematopoiesis. Cell Stem Cell. 2014;14(4):445–59.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Padron E, Painter JS, Kunigal S, Mailloux AW, McGraw K, McDaniel JM, et al. GM-CSF-dependent pSTAT5 sensitivity is a feature with therapeutic potential in chronic myelomonocytic leukemia. Blood. 2013;121(25):5068–77.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ng LG, Liu Z, Kwok I, Ginhoux F. Origin and Heterogeneity of Tissue Myeloid Cells: A Focus on GMP-Derived Monocytes and Neutrophils. Annu Rev Immunol. 2023;41:375–404.

Article  CAS  PubMed  Google Scholar 

Yáñez A, Coetzee SG, Olsson A, Muench DE, Berman BP, Hazelett DJ, et al. Granulocyte-Monocyte progenitors and Monocyte-Dendritic cell progenitors independently produce functionally distinct monocytes. Immunity. 2017;47(5):890-902.e4.

Article  PubMed  PubMed Central  Google Scholar 

Guilliams M, Mildner A, Yona S. Developmental and functional heterogeneity of monocytes. Immunity. 2018;49(4):595–613.

Article  CAS  PubMed  Google Scholar 

Dhawan A, Padron E. Abnormal monocyte differentiation and function in chronic myelomonocytic leukemia. Curr Opin Hematol. 2022;29(1):20–6.

Article  CAS  PubMed  Google Scholar 

Selimoglu-Buet D, Wagner-Ballon O, Saada V, Bardet V, Itzykson R, Bencheikh L, et al. Characteristic repartition of monocyte subsets as a diagnostic signature of chronic myelomonocytic leukemia. Blood. 2015;125(23):3618–26.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Talati C, Zhang L, Shaheen G, Kuykendall A, Ball M, Zhang Q, et al. Monocyte subset analysis accurately distinguishes CMML from MDS and is associated with a favorable MDS prognosis. Blood. 2017;129(13):1881–3.

Article  CAS  PubMed  Google Scholar 

Alaggio R, Amador C, Anagnostopoulos I, Attygalle AD, Araujo IBO, Berti E, et al. The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms. Leukemia. 2022;36(7):1720-48.

Xu JJ, Chalk AM, Wall M, Langdon WY, Smeets MF, Walkley CR. Srsf2(P95H/+) co-operates with loss of TET2 to promote myeloid bias and initiate a chronic myelomonocytic leukemia-like disease in mice. Leukemia. 2022;36(12):2883–93.

Article  CAS  PubMed  Google Scholar 

Yamazaki J, Jelinek J, Lu Y, Cesaroni M, Madzo J, Neumann F, et al. TET2 Mutations Affect Non-CpG Island DNA Methylation at Enhancers and Transcription Factor-Binding Sites in Chronic Myelomonocytic Leukemia. Cancer Res. 2015;75(14):2833–43.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang Q, Zhao K, Shen Q, Han Y, Gu Y, Li X, et al. Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6. Nature. 2015;525(7569):389–93.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ben-Crentsil NA, Mohammed Ismail W, Balasis ME, Newman H, Quintana A, Binder M, et al. RNA Shielding of p65 Is Required to Potentiate Oncogenic Inflammation in TET2-Mutated Clonal Hematopoiesis. Cancer Discov. 2024;14(12):2509–31.

Article  PubMed  PubMed Central  Google Scholar 

Picot T, Aanei CM, Flandrin Gresta P, Noyel P, Tondeur S, Tavernier Tardy E, et al. Evaluation by Flow Cytometry of Mature Monocyte Subpopulations for the Diagnosis and Follow-Up of Chronic Myelomonocytic Leukemia. Front Oncol. 2018;8:109.

Article  PubMed  PubMed Central  Google Scholar 

Hofer TP, van de Loosdrecht AA, Stahl-Hennig C, Cassatella MA, Ziegler-Heitbrock L. 6-Sulfo LacNAc (Slan) as a Marker for Non-classical Monocytes. Front Immunol. 2019;10:2052.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Deschamps P, Wacheux M, Gosseye A, Morabito M, Pages A, Lyne AM, et al. CXCL8 secreted by immature granulocytes inhibits WT hematopoiesis in chronic myelomonocytic leukemia. J Clin Invest. 2024;134(22).

Lucas N, Duchmann M, Rameau P, Noel F, Michea P, Saada V, et al. Biology and prognostic impact of clonal plasmacytoid dendritic cells in chronic myelomonocytic leukemia. Leukemia. 2019;33(10):2466–80.

Comments (0)

No login
gif