Roth GA, Mensah GA, Johnson CO et al (2020) Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019: Update From the GBD 2019 Study. J Am Coll Cardiol 76:2982–3021. https://doi.org/10.1016/j.jacc.2020.11.010

Article  PubMed  PubMed Central  Google Scholar 

Naghavi M, Ong KL, Aali A et al (2024) Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet, 403(10440):2100–2132. https://doi.org/10.1016/s0140-6736(24)00367-2

Liu Y, Li L, Wang Z, Zhang J, Zhou Z (2023) Myocardial ischemia-reperfusion injury; Molecular mechanisms and prevention. Microvasc Res 149:104565. https://doi.org/10.1016/j.mvr.2023.104565

Article  PubMed  Google Scholar 

Sagris M, Antonopoulos AS, Theofilis P et al (2022) Risk factors profile of young and older patients with myocardial infarction. Cardiovasc Res 118(10):2281–2292. https://doi.org/10.1093/cvr/cvab264

Article  CAS  PubMed  Google Scholar 

Salari N, Morddarvanjoghi F, Abdolmaleki A et al (2023) The global prevalence of myocardial infarction: a systematic review and meta-analysis. BMC Cardiovasc Disord 23(1):206. https://doi.org/10.1186/s12872-023-03231-w

Article  PubMed  PubMed Central  Google Scholar 

Fang M, Xiang FL, Braitsch CM, Yutzey KE (2016) Epicardium-derived fibroblasts in heart development and disease. J Mol Cell Cardiol 91:23–27. https://doi.org/10.1016/j.yjmcc.2015.12.019

Article  CAS  PubMed  Google Scholar 

Humeres C, Frangogiannis NG (2019) Fibroblasts in the infarcted, remodeling, and, failing heart. JACC Basic Transl Sci 4(3):449–467. https://doi.org/10.1016/j.jacbts.2019.02.006

Article  PubMed  PubMed Central  Google Scholar 

Richardson WJ, Holmes JW (2015) Why is infarct expansion such an elusive therapeutic target? J Cardiovasc Transl Res 8(7):421–430. https://doi.org/10.1007/s12265-015-9652-2

Article  PubMed  PubMed Central  Google Scholar 

Frantz S, Hundertmark MJ, Schulz-Menger J, Bengel FM, Bauersachs J (2022) Left ventricular remodelling post-myocardial infarction: pathophysiology, imaging, and novel therapies. Eur Heart J 43(27):2549–2561. https://doi.org/10.1093/eurheartj/ehac223

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jaworska-Wilczynska M, Trzaskoma P, Szczepankiewicz AA, Hryniewiecki T (2016) Pericardium: structure and function in health and disease. Folia Histochem Cytobiol 54(3):121–125. https://doi.org/10.5603/FHC.a2016.0014

Article  PubMed  Google Scholar 

Ruiz-Villalba A, Simon AM, Pogontke C et al (2015) Interacting resident epicardium-derived fibroblasts and recruited bone marrow cells form myocardial infarction scar. J Am Coll Cardiol 65:2057–2066. https://doi.org/10.1016/j.jacc.2015.03.520

Article  PubMed  Google Scholar 

Jensen CH, Johnsen RH, Eskildsen T et al (2024) Pericardial delta like non-canonical NOTCH ligand 1 (Dlk1) augments fibrosis in the heart through epithelial to mesenchymal transition. Clin Transl Med 14(2):e1565. https://doi.org/10.1002/ctm2.1565

Article  CAS  PubMed  PubMed Central  Google Scholar 

LindseyML, Brunt KR, Kirk JA et al (2021) Guidelines for in vivo mouse models of myocardial infarction. Am J Physiol Heart Circ Physiol 321(6): pp. H1056-h1073 https://doi.org/10.1152/ajpheart.00459.2021

De Villiers C, Riley PR (2020) Mouse models of myocardial infarction: comparing permanent ligation and ischaemia-reperfusion. Dis Model Mech 13:11. https://doi.org/10.1242/dmm.046565

Article  CAS  Google Scholar 

von Scheidt M, Zhao Y, Kurt Z et al (2017) Applications and limitations of mouse models for understanding human atherosclerosis. Cell Metab 25(2):248–261. https://doi.org/10.1016/j.cmet.2016.11.001

Article  CAS  Google Scholar 

Martin TP, MacDonald EA, Elbassioni AAM et al (2022) Preclinical models of myocardial infarction: from mechanism to translation. Br J Pharmacol 179(5):770–791. https://doi.org/10.1111/bph.15595

Article  CAS  PubMed  Google Scholar 

Bassat E, Perez DE, Tzahor E (2021) Myocardial infarction techniques in adult mice. Methods Mol Biol 2158:3–21. https://doi.org/10.1007/978-1-0716-0668-1_1

Article  CAS  PubMed  Google Scholar 

He Y, Pan X, Liu Z et al (2025) METTL3 silencing suppresses cardiac fibrosis post myocardial infarction via m6A modification of SMOC2. J Cell Mol Med 29(17):e70829. https://doi.org/10.1111/jcmm.70829

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo CH, Wang QQ, Li JQ et al (2025) BMP1 inhibitor UK383367 improves MI-induced cardiac remodeling and fibrosis in mice via ameliorating macrophage polarization and mitochondrial dysfunction. Acta Pharmacol Sin. https://doi.org/10.1038/s41401-025-01655-y

Article  PubMed  PubMed Central  Google Scholar 

Chang T, Jin Y, Fan C et al (2025) N-acetylglucosaminyltransferase V attenuates myocardial infarction by mediating the insulin-like growth factor 1 receptor signaling pathway. J Transl Int Med 13(3):281–294. https://doi.org/10.1515/jtim-2025-0021

Article  PubMed  PubMed Central  Google Scholar 

Wang M, Zhao C, Li T et al (2025) Hypoxia-conditioned cardiomyocyte-derived exosomes attenuate myocardial injury via ANP-mediated M2 macrophage polarization. Gen Physiol Biophys 44(5):377–389. https://doi.org/10.4149/gpb_2025022

Article  CAS  PubMed  Google Scholar 

Feng J, Li Y, Li Y et al (2024) Versican promotes cardiomyocyte proliferation and cardiac repair. Circulation 149(13):1004–1015. https://doi.org/10.1161/circulationaha.123.066298

Article  CAS  PubMed  Google Scholar 

Li J, Sun S, Zhu D et al (2024) Inhalable stem cell exosomes promote heart repair after myocardial infarction. Circulation 150(9):710–723. https://doi.org/10.1161/circulationaha.123.065005

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ahn D, Cheng L, Moon C, Spurgeon H, Lakatta EG, Talan MI (2004) Induction of myocardial infarcts of a predictable size and location by branch pattern probability-assisted coronary ligation in C57BL/6 mice. Am J Physiol Heart Circ Physiol 286(3):H1201–H1207. https://doi.org/10.1152/ajpheart.00862.2003

Article  CAS  PubMed  Google Scholar 

Isidoro CA, Deniset JF (2023) Pericardial immune cells and their evolving role in cardiovascular pathophysiology. Can J Cardiol 39(8):1078–1089. https://doi.org/10.1016/j.cjca.2023.05.017

Article  PubMed  Google Scholar 

Deniset JF, Belke D, Lee WY et al (2019) Gata6(+) pericardial cavity macrophages relocate to the injured heart and prevent cardiac fibrosis. Immunity 51(1):131–140e5. https://doi.org/10.1016/j.immuni.2019.06.010

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu X, Newland SA, Zhao TX et al (2021) Innate Lymphoid Cells Promote Recovery of Ventricular Function After Myocardial Infarction. J Am Coll Cardiol 78(11):1127–1142. https://doi.org/10.1016/j.jacc.2021.07.018

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fatehi Hassanabad A, Belke DD, Turnbull J et al (2021) An intact pericardium ischemic rodent model. J Vis Exp. https://doi.org/10.3791/62720

Article  PubMed  Google Scholar 

Horckmans M, Bianchini M, Santovito D et al (2018) Pericardial adipose tissue regulates granulopoiesis, fibrosis, and cardiac function after myocardial infarction. Circulation 137(9):948–960. https://doi.org/10.1161/circulationaha.117.028833

Article  PubMed  Google Scholar 

Mylonas K, Jackson-Jones L, Andrews J et al (2019) The pericardium promotes cardiac repair and remodelling post-myocardial infarction

Jin H, Liu K, Huang X et al (2022) Genetic Lineage Tracing of Pericardial Cavity Macrophages in the Injured Heart. Circ Res 130(11):1682–1697. https://doi.org/10.1161/circresaha.122.320567

Article