Guan Q. A comprehensive review and update on the pathogenesis of inflammatory bowel disease. J Immunol Res. 2019;2019:7247238. https://doi.org/10.1155/2019/7247238.
Article CAS PubMed PubMed Central Google Scholar
Annese V. Genetics and epigenetics of IBD. Pharmacol Res. 2020;159:104892. https://doi.org/10.1016/j.phrs.2020.104892.
Article CAS PubMed Google Scholar
Lee SH, Kwon JE, Cho ML. Immunological pathogenesis of inflammatory bowel disease. Intest Res. 2018;16:26–42. https://doi.org/10.5217/ir.2018.16.1.26.
Article PubMed PubMed Central Google Scholar
Kim DH, Cheon JH. Pathogenesis of inflammatory bowel disease and recent advances in biologic therapies. Immune Netw. 2017;17:25–40. https://doi.org/10.4110/in.2017.17.1.25.
Article PubMed PubMed Central Google Scholar
Feng Z, Kang G, Wang J, et al. Breaking through the therapeutic ceiling of inflammatory bowel disease: Dual-targeted therapies. Biomed Pharmacother. 2023;158: 114174. https://doi.org/10.1016/j.biopha.2022.114174.
Article CAS PubMed Google Scholar
Sahu P, Kedia S, Ahuja V, Tandon RK. Diet and nutrition in the management of inflammatory bowel disease. Indian J Gastroenterol. 2021;40:253–64. https://doi.org/10.1007/s12664-021-01163-x.
Yadav A, Yadav R, Sharma V, Dutta U. A comprehensive guide to assess gut mycobiome and its role in pathogenesis and treatment of inflammatory bowel disease. Indian J Gastroenterol. 2024;43:112–28. https://doi.org/10.1007/s12664-023-01510-0.
Wark G, Samocha-Bonet D, Ghaly S, Danta M. The role of diet in the pathogenesis and management of inflammatory bowel disease: A review. Nutrients. 2020;13:135. https://doi.org/10.3390/nu13010135.
Article CAS PubMed PubMed Central Google Scholar
Naik RG, Purcell SA, Gold SL, et al. From evidence to practice: A narrative framework for integrating the Mediterranean diet into inflammatory bowel disease management. Nutrients. 2025;17:470. https://doi.org/10.3390/nu17030470.
Article CAS PubMed PubMed Central Google Scholar
Nani A, Murtaza B, Sayed Khan A, Khan NA, Hichami A. Antioxidant and anti-inflammatory potential of polyphenols contained in Mediterranean diet in obesity: Molecular mechanisms. Molecules. 2021;26:985. https://doi.org/10.3390/molecules26040985.
Article CAS PubMed PubMed Central Google Scholar
Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;29:n71. https://doi.org/10.1136/bmj.n71.
Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan-a web and mobile app for systematic reviews. Syst Rev. 2016;5:210. https://doi.org/10.1186/s13643-016-0384-4.
Article PubMed PubMed Central Google Scholar
Posit team (2025). RStudio: integrated development environment for R. Posit Software, PBC, Boston, MA. URL http://www.posit.co/.
Sterne JAC, Savović J, Page MJ, et al. Rob 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366:l4898.
GA Wells, B Shea, D O'Connell, J Peterson, V Welch, M Losos, P Tugwell. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp
Erol Doğan Ö, Karaca Çelik KE, Baş M, Alan EH, Çağın YF. Effects of Mediterranean diet, curcumin, and resveratrol on mild-to-moderate active ulcerative colitis: A multicenter randomized clinical trial. Nutrients. 2024;16:1504. https://doi.org/10.3390/nu16101504.
Article CAS PubMed PubMed Central Google Scholar
Strauss JC, Haskey N, Ramay HR, et al. Weighted gene co-expression network analysis identifies a functional guild and metabolite cluster mediating the relationship between mucosal inflammation and adherence to the Mediterranean diet in ulcerative colitis. Int J Mol Sci. 2023;24:7323. https://doi.org/10.3390/ijms24087323.
Article CAS PubMed PubMed Central Google Scholar
Lewis JD, Sandler RS, Brotherton C, et al. A randomized trial comparing the specific carbohydrate diet to a Mediterranean diet in adults with Crohn’s disease. Gastroenterology. 2021;161:837-52.e9. https://doi.org/10.1053/j.gastro.2021.05.047.
Article CAS PubMed PubMed Central Google Scholar
Chicco F, Magrì S, Cingolani A, et al. Multidimensional impact of Mediterranean diet on IBD patients. Inflamm Bowel Dis. 2021;27:1–9. https://doi.org/10.1093/ibd/izaa097.
Article PubMed PubMed Central Google Scholar
El Amrousy D, Elashry H, Salamah A, Maher S, Abd-Elsalam SM, Hasan S. Adherence to the Mediterranean diet improved clinical scores and inflammatory markers in children with active inflammatory bowel disease: A randomized trial. J Inflamm Res. 2022;29:2075–86. https://doi.org/10.2147/JIR.S349502.
Chen SY, Gray B, Williams KM, et al. Mo1730 specific carbohydrate diet versus Mediterranean diet in adult patients with mild to moderate ulcerative colitis: A randomized controlled-feeding trial. Gastroenterology. 2024;166:S-1087.
Pasta A, Formisano E, Calabrese F, et al. The use of the Crohn’s disease exclusion diet (CDED) in adults with Crohn’s disease: A randomized controlled trial. Eur J Clin Invest. 2025;55: e14389. https://doi.org/10.1111/eci.14389.
Article CAS PubMed Google Scholar
Haskey N, Estaki M, Ye J, et al. A mediterranean diet pattern improves intestinal inflammation concomitant with reshaping of the bacteriome in ulcerative colitis: A randomised controlled trial. J Crohns Colitis. 2023;17:1569–78. https://doi.org/10.1093/ecco-jcc/jjad073.
Article PubMed PubMed Central Google Scholar
Godny L, Elial-Fatal S, Arrouasse J, et al. Mechanistic implications of the Mediterranean diet in patients with newly diagnosed Crohn’s disease: Multiomic results from a prospective cohort. Gastroenterology. 2025;168:952-64.e2. https://doi.org/10.1053/j.gastro.2024.12.031.
Article CAS PubMed Google Scholar
Abreu MT, Devkota S, Issokson K. A mediterranean diet for Crohn’s disease: Embracing colorful diversity to improve the microbiome. Gastroenterology. 2025;168:872–4.
Article CAS PubMed Google Scholar
Aharoni-Frutkoff Y, Plotkin L, Pollak D, et al. Whole food diet induces remission in children and young adults with mild to moderate Crohn’s disease and is more tolerable than exclusive enteral nutrition: A randomized controlled trial. Gastroenterology. 2025;169:1462-74.e2. https://doi.org/10.1053/j.gastro.2025.06.011.
Yogev D, Turner D. The pivotal ‘P’s of inflammatory bowel disease: prediction and prevention. United European Gastroenterol J. 2024;12:423–4. https://doi.org/10.1002/ueg2.12519.
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