Desmethylglycitein Attenuates Scopolamine-Induced Cognitive Deficits via Nrf-2 Activation and IL-1β Suppression

Callizot N, Estrella C, Burlet S, Henriques A, Brantis C, Barrier, Campanari ML, Verwaerde P. AZP2006, a new promising treatment for Alzheimer’s and related diseases. Sci Rep. 2021;11(1):16806.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mahdi O, Baharuldin MTH, Nor NHM, Chiroma SM, Jagadeesan S, Moklas MAM. Chemicals used for the induction of AD-like cognitive dysfunctions in rodents. Biomed Res Ther. 2019;6(11):3460–84.

Article  Google Scholar 

Ballard C, Aarsland D, Cummings J, O’Brien J, Mills R, Molinuevo JL, Fladby T, Williams G, Doherty P, Corbett A, sultana J. Drug repositioning and repurposing for AD. Nat Rev Neurol. 2020;16(12):661–73.

Article  PubMed  PubMed Central  Google Scholar 

Murphy MP, LeVine H III. AD and the amyloid-β peptide. J Ad. 2010;19(1):311–23.

Google Scholar 

Rajmohan R, Reddy PH. Amyloid-beta and phosphorylated tau accumulations cause abnormalities at synapses of AD neurons. J Ad. 2017;57(4):975–99.

CAS  Google Scholar 

Tamagno E, Guglielmotto M, Vasciaveo V, Tabaton M. Oxidative stress and beta-amyloid in AD. Which comes first: the chicken or the egg? Antioxidants. 2021;10(9):1479.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oda A, Tamaoka A, Araki W. Oxidative stress up-regulates presenilin 1 in lipid rafts in neuronal cells. J Neurosci Res. 2010;88(5):1137–45.

Article  CAS  PubMed  Google Scholar 

De Plano LM, Calabrese G, Rizzo MG, Oddo S, Caccamo A. The role of the transcription factor Nrf2 in AD: therapeutic opportunities. Biomolecules. 2023;13(3):549.

Article  PubMed  PubMed Central  Google Scholar 

Ionescu-Tucker A, Cotman CW. Emerging roles of oxidative stress in brain aging and Alzheimer’s disease. Neurobiol Aging. 2021;107:86–95.

Article  CAS  PubMed  Google Scholar 

Ramos-Martínez IE, Rodríguez MC, Cerbón M, Ramos-Martínez JC, Ramos-Martínez EG. Role of the cholinergic anti-inflammatory reflex in central nervous system diseases. IJMS. 2021;22(24):13427.

Article  PubMed  PubMed Central  Google Scholar 

Yiannopoulou KG, Papageorgiou SG. Current and future treatments in Alzheimer disease: an update. J Cent Nerv Syst Dis. 2020;12:1179573520907397.

Article  PubMed  PubMed Central  Google Scholar 

Hoffman L, Bloemer J. Side effects of drugs used in the treatment of AD. In: Side Effects of Drugs Annual. Vol. 43. Elsevier; 2021. pp. 71–7.

Google Scholar 

Kumari N, Anand S, Shah K, Chauhan NS, Sethiya NK, Singhal M. Emerging Role of Plant-Based Bioactive Compounds as Therapeutics in Parkinson’s Disease. Molecules. 2023;28(22):7588.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Soni M, Rahardjo TBW, Soekardi R, Sulistyowati Y, Yesufu-Udechuku A, Irsan A, Hogervorst E. Phytoestrogens and cognitive function: a review. Maturitas. 2014;77(3):209–20.

Article  CAS  PubMed  Google Scholar 

Wei J, Yang F, Gong C, Shi X, Wang G. Protective effect of daidzein against streptozotocin-induced AD via improving cognitive dysfunction and oxidative stress in rat model. J Biochem & Molecular Tox. 2019;33(6):e22319.

Article  Google Scholar 

Inaba K, Ebihara K, Senda M, Yoshino R, Sakuma C, Koiwai K, Takaya D, Watanabe C, Watanabe A, Kawashima Y, Fukuzawa K, Niwa R. Molecular action of larvicidal flavonoids on ecdysteroidogenic glutathione S-transferase Noppera-bo in Aedes aegypti. BMC Biol. 2022;20(1):43.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ionescu-Tucker A, Cotman CW. Emerging roles of oxidative stress in brain aging and Alzheimer’s disease. Neurobiol Aging. 2021;107:86–95.

Article  CAS  PubMed  Google Scholar 

Abdul-Muneer PM, Chandra N, Haorah J. Interactions of oxidative stress and neurovascular inflammation in the pathogenesis of traumatic brain injury. Mol Neurobiol. 2015;51:966–79.

Article  CAS  Google Scholar 

Calsolaro V, Edison P. Neuroinflammation in Alzheimer’s disease: Current evidence and future directions. Alzheimers Dement. 2016;12:719–32.

Article  PubMed  Google Scholar 

Ko YH, Kwon SH, Kim SK, Lee BR, Hur KH, Kim YJ, Kim SE, Lee SY, Jang CG. Protective effects of 6, 7, 4′-trihydroxyisoflavone, a major metabolite of daidzein, on 6-hydroxydopamine-induced neuronal cell death in SH-SY5Y human neuroblastoma cells. Arch Pharm Res. 2012;42(12):1081–91.

Article  Google Scholar 

Cheng F, Li W, Zhou Y, Shen J, Wu Z, Liu G, Lee PW, Tang Y. admetSAR: a comprehensive source and free tool for assessment of chemical ADMET properties. J Chem Inf Model. 2012;2012:3099–105.

Article  Google Scholar 

Yadang FSA, Nguezeye Y, Kom CW, Betote PHD, Mamat A, Tchokouaha LRY, Taiwé GS, Agbor GA, Bum EN. Scopolamine-Induced Memory Impairment in Mice: Neuroprotective Effects of Carissa edulis (Forssk.) Valh (Apocynaceae) Aqueous Extract. Int J Ad. 2020;2020(1):6372059.

Google Scholar 

Kanika, Singh L. Mitigating cognitive deficits with teriflunomide: unraveling PI3K-modulated behavioral outcomes in mice. Mol Biol Rep. 2024;51(1):572.

Article  CAS  PubMed  Google Scholar 

Justin-Thenmozhi A, Dhivya Bharathi M, Kiruthika R, Manivasagam T, Borah A, Essa MM. Attenuation of aluminum chloride-induced neuroinflammation and caspase activation through the AKT/GSK-3β pathway by hesperidin in wistar rats. Neurotox Res. 2018;34:463–76.

Article  CAS  PubMed  Google Scholar 

Guo YY, Liu SB, Cui GB, Ma L, Feng B, Xing JH, Yang Q, Li XQ, Wu YM, Xiong LZ, Zhao MG. Acute stress induces down-regulation of large-conductance Ca2+-activated potassium channels in the lateral amygdala. J Physiol. 2012;590(4):875–86.

Article  CAS  PubMed  Google Scholar 

Arora V, Chopra K. Possible involvement of oxido-nitrosative stress induced neuro-inflammatory cascade and monoaminergic pathway: underpinning the correlation between nociceptive and depressive behaviour in a rodent model. J Affect Disord. 2013;151:1041–52.

Article  CAS  PubMed  Google Scholar 

Querfurth HW, LaFerla FM. Mechanisms of disease. N Engl J Med. 2010;362(4):329–44.

Article  CAS  PubMed  Google Scholar 

Dubois B, Hampel H, Feldman HH, Scheltens P, Aisen P, Andrieu S, Bakardjian H, Benali H, Bertram L, Blennow K, Broich K, Washington DC. Preclinical AD: definition, natural history, and diagnostic criteria. Alzheimer’s Dementia. 2016;12(3):292–323.

Article  PubMed  PubMed Central  Google Scholar 

Pedrinolla A, Venturelli M, Fonte C, Munari D, Benetti MV, Rudi D, Tamburin S, Muti E, Zanolla L, Smania N, Schena F. Exercise training on locomotion in patients with AD: a feasibility study. J Ad. 2018;61(4):1599–609.

Google Scholar 

Cedervall Y, Halvorsen K, Åberg AC. A longitudinal study of gait function and characteristics of gait disturbance in individuals with AD. Gait Posture. 2014;39(4):1022–7.

Article  PubMed  Google Scholar 

Rajashri K, Mudhol S, Serva Peddha M, Borse BB. Neuroprotective effect of spice oleoresins on memory and cognitive impairment associated with scopolamine-induced AD in rats. Acs Omega. 2020;5(48):30898–905.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nuhu F, Bhandari S. Oxidative stress and cardiovascular complications in chronic kidney disease, the impact of anemia. Pharmaceuticals. 2018;11(4):103.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mandal PK, Shukla D, Tripathi M, Ersland L. Cognitive improvement with glutathione supplement in AD: a way forward. J Ad. 2019;68(2):531–5.

Google Scholar 

Bradley-Whitman MA, Lovell MA. Biomarkers of lipid peroxidation in Alzheimer disease (AD): an update. Arch Toxicol. 2015;89:1035–44.

Article  CAS  PubMed  PubMed Central 

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