Thompson LDR, Bishop JA (2022) Update from the 5th edition of the World Health Organizatio classification of head and neck tumors: nasal Cavity, paranasal sinuses and skull base. Head Neck Pathol 16:1–18

Article  PubMed  PubMed Central  Google Scholar 

Ozolek JA, Hunt JL (2006) Tumor suppressor gene alterations in respiratory epithelial adenomatoid hamartoma (REAH): comparison to sinonasal adenocarcinoma and inflamed sinonasal mucosa. Am J Surg Pathol 30:1576–1580

Article  PubMed  Google Scholar 

Baneckova M, Michal M, Laco J, Leivo I, Ptakova N, Horakova M et al (2020) Immunohistochemical and genetic analysis of respiratory epithelial adenomatoid hamartomas and seromucinous hamartomas: Are they precursor lesions to sinonasal low-grade tubulopapillary adenocarcinomas? Hum Pathol 97:94–102

Article  CAS  PubMed  Google Scholar 

Wenig BM, Heffner DK (1995) Respiratory epithelial adenomatoid hamartomas of the sinonasal tract and nasopharynx: a clinicopathologic study of 31 cases. Ann Otol Rhinol Laryngol 104:639–645

Article  CAS  PubMed  Google Scholar 

Heffner DK, Hyams VJ, Hauck KW, Lingeman C (1982) Low-grade adenocarcinoma of the nasal cavity and paranasal sinuses. Cancer 50:312–322

Article  CAS  PubMed  Google Scholar 

Purgina B, Bastaki JM, Duvvuri U, Seethala RR (2015) A subset of sinonasal non-intestinal type adenocarcinomas are truly seromucinous adenocarcinomas: a morphologic and immunophenotypic assessment and description of a novel pitfall. Head Neck Pathol 9:436–446

Article  PubMed  PubMed Central  Google Scholar 

Rooper LM, Thompson LDR, Gagan J, Hwang JSG, London NR, Mikula MW et al (2022) Low-grade non-intestinal-type sinonasal adenocarcinoma: a histologically distinctive but molecularly heterogeneous entity. Mod Pathol 35:1160–1167

Article  CAS  PubMed  Google Scholar 

Khan RA, Chernock RD, Lewis JS Jr (2011) Seromucinous Hamartoma of the nasal cavity: a report of two cases and review of the literature. Head Neck Pathol 5:241–247

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rooper LM, Agaimy A, Dickson BC, Dueber JC, Eberhart CG, Gagan J et al (2021) DEK-AFF2 carcinoma of the sinonasal region and skull base: detailed clinicopathologic characterization of a distinctive entity. Am J Surg Pathol 45:1682–1693

Article  PubMed  Google Scholar 

Mehrad M, Stelow EB, Bishop JA, Wang X, Haynes W, Oliver D et al (2020) Transcriptionally active HPV and targetable EGFR mutations in sinonasal inverted papilloma: An association between low-risk HPV, condylomatous morphology, and cancer risk? Am J Surg Pathol 44:340–346

Article  PubMed  Google Scholar 

Udager AM, McHugh JB, Goudsmit CM, Weigelin HC, Lim MS, Elenitoba-Johnson KSJ et al (2018) Human papillomavirus (HPV) and somatic EGFR mutations are essential, mutually exclusive oncogenic mechanisms for inverted sinonasal papillomas and associated sinonasal squamous cell carcinomas. Ann Oncol 29:466–471

Article  CAS  PubMed  Google Scholar 

Hart SA, Hang JF, Chernock RD, Mikula MW, Rooper L, Amin SE et al (2025) DEK::AFF2 fusion sinonasal and skull base nonkeratinizing squamous cell carcinoma: a clinical outcome study compared with conventional sinonasal squamous cell carcinoma. Am J Surg Pathol 49:130–137

Article  PubMed  Google Scholar 

Kuo YJ, Lewis JS Jr., Truong T, Yeh YC, Chernock RD, Zhai C et al (2022) Nuclear expression of AFF2 C-terminus is a sensitive and specific ancillary marker for DEK::AFF2 carcinoma of the sinonasal tract. Mod Pathol 35:1587–1595

Article  CAS  PubMed  Google Scholar 

Nudell J, Chiosea S, Thompson LD (2014) Carcinoma ex-Schneiderian papilloma (malignant transformation): a clinicopathologic and immunophenotypic study of 20 cases combined with a comprehensive review of the literature. Head Neck Pathol 8:269–286

Article  PubMed  PubMed Central  Google Scholar 

Brown NA, Plouffe KR, Yilmaz O, Weindorf SC, Betz BL, Carey TE et al (2021) TP53 mutations and CDKN2A mutations/deletions are highly recurrent molecular alterations in the malignant progression of sinonasal papillomas. Mod Pathol 34:1133–1142

Article  CAS  PubMed  Google Scholar 

Bishop JA, Guo TW, Smith DF, Wang H, Ogawa T, Pai SI et al (2013) Human papillomavirus-related carcinomas of the sinonasal tract. Am J Surg Pathol 37:185–192

Article  PubMed  PubMed Central  Google Scholar 

Oliver JR, Lieberman SM, Tam MM, Liu CZ, Li Z, Hu KS et al (2020) Human papillomavirus and survival of patients with sinonasal squamous cell carcinoma. Cancer 126:1413–1423

Article  PubMed  Google Scholar 

Thompson LD (2017) Small round blue cell tumors of the sinonasal tract: a differential diagnosis approach. Mod Pathol 30:S1–S26

Article  PubMed  Google Scholar 

Jo VY, Chau NG, Hornick JL, Krane JF, Sholl LM (2017) Recurrent IDH2 R172X mutations in sinonasal undifferentiated carcinoma. Mod Pathol 30:650–659

Article  CAS  PubMed  Google Scholar 

Dogan S, Chute DJ, Xu B, Ptashkin RN, Chandramohan R, Casanova-Murphy J et al (2017) Frequent IDH2 R172 mutations in undifferentiated and poorly-differentiated sinonasal carcinomas. J Pathol 242:400–408

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rooper LM, Bishop JA, Faquin WC, Foss RD, Gallia GL, Jo VY et al (2022) Sinonasal tumors with neuroepithelial differentiation (olfactory carcinoma): delineation of their pathologic and clinical features with insights into their relationship to olfactory neuroblastoma and sinonasal carcinoma. Am J Surg Pathol 46:1025–1035

Article  PubMed  Google Scholar 

Rooper LM, Agaimy A, Bell D, Gagan J, Gallia GL, Jo VY et al (2024) Recurrent Wnt pathway and ARID1A alterations in sinonasal olfactory carcinoma. Mod Pathol 37:100448

Article  CAS  PubMed  Google Scholar 

Agaimy A, Hartmann A, Antonescu CR, Chiosea SI, El-Mofty SK, Geddert H et al (2017) SMARCB1 (INI-1)-deficient sinonasal carcinoma: a series of 39 cases expanding the morphologic and clinicopathologic spectrum of a recently described entity. Am J Surg Pathol 41:458–471

Article  PubMed  PubMed Central  Google Scholar 

Shah AA, Jain D, Ababneh E, Agaimy A, Hoschar AP, Griffith CC et al (2020) SMARCB1 (INI-1)-deficient adenocarcinoma of the sinonasal tract: a potentially under-recognized form of sinonasal adenocarcinoma with occasional yolk sac tumor-like features. Head Neck Pathol 14:465–472

Article  PubMed  Google Scholar 

Agaimy A, Jain D, Uddin N, Rooper LM, Bishop JA (2020) SMARCA4-deficient sinonasal carcinoma: a series of 10 cases expanding the genetic spectrum of SWI/SNF-driven sinonasal malignancies. Am J Surg Pathol 44:703–710

Article  PubMed  Google Scholar 

French CA, Rahman S, Walsh EM, Kuhnle S, Grayson AR, Lemieux ME et al (2014) NSD3-NUT fusion oncoprotein in NUT midline carcinoma: implications for a novel oncogenic mechanism. Cancer Discov 4:928–941

Article  CAS  PubMed  PubMed Central  Google Scholar 

Farooq A, Kerper AL, Boland JM, Lo YC (2024) Nuclear protein in testis (NUT) carcinoma: a comprehensive immunohistochemical analysis of 57 cases with consideration of interpretation and pitfall recognition. Arch Pathol Lab Med 148:898–904

Article  CAS  PubMed  Google Scholar 

Haack H, Johnson LA, Fry CJ, Crosby K, Polakiewicz RD, Stelow EB et al (2009) Diagnosis of NUT midline carcinoma using a NUT-specific monoclonal antibody. Am J Surg Pathol 33:984–991

Article  PubMed  PubMed Central  Google Scholar 

Bishop JA, Alaggio R, Zhang L, Seethala RR, Antonescu CR (2015) Adamantinoma-like Ewing family tumors of the head and neck: a pitfall in the differential diagnosis of basaloid and myoepithelial carcinomas. Am J Surg Pathol 39:1267–1274

Article  PubMed  PubMed Central  Google Scholar 

Fritchie KJ, Ameline B, Andrei V, Griffith C, Shah AA, Dermawan JK et al (2023) DNA methylation profiling distinguishes adamantinoma-like Ewing sarcoma from conventional Ewing sarcoma. Mod Pathol 36:100301

Article  CAS  PubMed  PubMed Central